scholarly journals Dental and metabolic effects of lactitol in the diet of laboratory rats

1989 ◽  
Vol 61 (1) ◽  
pp. 17-24 ◽  
Author(s):  
T. H. Grenby ◽  
A. Phillips

1. Because so little is known about the properties of lactitol as a possible alternative bulk sweetener to sucrose, it was tested in two large-scale experiments in laboratory rats. Matched groups of caries-active Osborne-Mendel rats were fed on uniform diets containing lactitol and compared with a sucrose control in both experiments, plus a xylitol control in the first experiment.2. In the early stages of the experiments weight gains and food utilization were better on the sucrose than on the lactitol regimens. Body-fat storage was higher on the sucrose than on the polyol regimens.3. At the end of 8 weeks the mandibular molars were examined for dental plaque accumulation and dental caries. The dental caries scores when 160 g sucrose/kg in the diet was replaced by lactitol were lower by a highly significant margin, bringing them down to the same low level as those on a 160 g xylitol/kg regimen.4. Testing lactitol in a manufactured food product, shortbread biscuits, in comparison with ordinary sucrose biscuits, showed differences in plaque scores (significant) and caries levels (highly significant), with 60% fewer lesions on the lactitol regimen.5. The results confirm the low cariogenic potential of lactitol, but show metabolic differences compared with sucrose.

2000 ◽  
Vol 84 (4) ◽  
pp. 565-574 ◽  
Author(s):  
T. H. Grenby ◽  
M. Mistry

The objective of the study was to examine the cariogenic potentials of maltodextrins and glucose syrups (two glucose polymers derived from starch) using a range of techniquesin vitroand in laboratory animals. The experimental methods used were: (1) measurement of acid production from glucose syrups and maltodextrins by human dental plaque micro-organisms; (2) evaluation of the role salivary α-amylase in degrading oligosaccharides (degree of polymerisation >3) in the glucose polymers, estimating the products by HPLC; (3) assessment of the fermentability of trioses relative to maltose; (4) measurement of dental caries levels in three large-scale studies in laboratory rats fed on diets containing the glucose polymers. It was found that acid production from the glucose polymers increased as their higher saccharide content fell. Salivary α-amylase rapidly degraded the oligosaccharides (degree of polymerisation >3), mainly to maltose and maltotriose. In the presence of oral micro-organisms, maltotriose took longer to ferment than maltose, but by the end of a 2 h period the total amount of acid produced was the same from both. Incorporated into the diets in solid form, the glucose syrups and maltodextrins were associated with unexpectedly high levels of dental caries. In conclusion, the findings were unforeseen in the light of earlier data that a glucose syrup was less cariogenic than sucrose.


Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2711
Author(s):  
Fiona S. Atkinson ◽  
Jouhrah Hussain Khan ◽  
Jennie C. Brand-Miller ◽  
Joerg Eberhard

Sugary carbohydrate foods have long been associated with increased risk of dental caries formation, but the dental health impact of starchy carbohydrates, particularly those with a high glycemic index (GI), has not been well examined. Aim: To investigate the effect of different starchy foods varying in their GI, on acute changes in dental plaque pH. Methods: In a series of sub-studies in healthy adults, common starchy carbohydrate foods, including white bread, instant mashed potatoes, canned chickpeas, pasta, breakfast cereals, white rice, and an oral glucose solution were consumed in fixed 25 g available carbohydrate portions. The change in dental plaque pH was assessed postprandially over 1 h and capillary plasma glucose was measured at regular intervals over 2 h. Results: Higher GI starchy foods produced greater acute plaque pH decreases and larger overall postprandial glucose responses compared to lower GI starchy foods (white bread compared with canned chickpeas: −1.5 vs. −0.7 pH units, p = 0.001, and 99 ± 8 mmol/L min vs. 47 ± 7 mmol/L min, p = 0.026). Controlling for other food factors (food form and nutritional composition), lower GI versions of matched food pairs produced smaller plaque pH excursions compared to higher GI versions of the same food. Using linear regression analysis, the GI value of starchy carbohydrate foods explained 60% of the variation in maximum plaque pH nadir and 64% of the variation in overall acute dental plaque pH excursion (p < 0.01). Conclusion: The findings imply that starchy foods, in particular those with a higher GI, may play a role in increasing the risk of dental caries.


2015 ◽  
Vol 28 (17) ◽  
pp. 6743-6762 ◽  
Author(s):  
Catherine M. Naud ◽  
Derek J. Posselt ◽  
Susan C. van den Heever

Abstract The distribution of cloud and precipitation properties across oceanic extratropical cyclone cold fronts is examined using four years of combined CloudSat radar and CALIPSO lidar retrievals. The global annual mean cloud and precipitation distributions show that low-level clouds are ubiquitous in the postfrontal zone while higher-level cloud frequency and precipitation peak in the warm sector along the surface front. Increases in temperature and moisture within the cold front region are associated with larger high-level but lower mid-/low-level cloud frequencies and precipitation decreases in the cold sector. This behavior seems to be related to a shift from stratiform to convective clouds and precipitation. Stronger ascent in the warm conveyor belt tends to enhance cloudiness and precipitation across the cold front. A strong temperature contrast between the warm and cold sectors also encourages greater post-cold-frontal cloud occurrence. While the seasonal contrasts in environmental temperature, moisture, and ascent strength are enough to explain most of the variations in cloud and precipitation across cold fronts in both hemispheres, they do not fully explain the differences between Northern and Southern Hemisphere cold fronts. These differences are better explained when the impact of the contrast in temperature across the cold front is also considered. In addition, these large-scale parameters do not explain the relatively large frequency in springtime postfrontal precipitation.


2013 ◽  
Vol 26 (21) ◽  
pp. 8378-8391 ◽  
Author(s):  
Yi Zhang ◽  
Rucong Yu ◽  
Jian Li ◽  
Weihua Yuan ◽  
Minghua Zhang

Abstract Given the large discrepancies that exist in climate models for shortwave cloud forcing over eastern China (EC), the dynamic (vertical motion and horizontal circulation) and thermodynamic (stability) relations of stratus clouds and the associated cloud radiative forcing in the cold season are examined. Unlike the stratus clouds over the southeastern Pacific Ocean (as a representative of marine boundary stratus), where thermodynamic forcing plays a primary role, the stratus clouds over EC are affected by both dynamic and thermodynamic factors. The Tibetan Plateau (TP)-forced low-level large-scale lifting and high stability over EC favor the accumulation of abundant saturated moist air, which contributes to the formation of stratus clouds. The TP slows down the westerly overflow through a frictional effect, resulting in midlevel divergence, and forces the low-level surrounding flows, resulting in convergence. Both midlevel divergence and low-level convergence sustain a rising motion and vertical water vapor transport over EC. The surface cold air is advected from the Siberian high by the surrounding northerly flow, causing low-level cooling. The cooling effect is enhanced by the blocking of the YunGui Plateau. The southwesterly wind carrying warm, moist air from the east Bay of Bengal is uplifted by the HengDuan Mountains via topographical forcing; the midtropospheric westerly flow further advects the warm air downstream of the TP, moistening and warming the middle troposphere on the lee side of the TP. The low-level cooling and midlevel warming together increase the stability. The favorable dynamic and thermodynamic large-scale environment allows for the formation of stratus clouds over EC during the cold season.


2010 ◽  
Vol 138 (4) ◽  
pp. 1368-1382 ◽  
Author(s):  
Jeffrey S. Gall ◽  
William M. Frank ◽  
Matthew C. Wheeler

Abstract This two-part series of papers examines the role of equatorial Rossby (ER) waves in tropical cyclone (TC) genesis. To do this, a unique initialization procedure is utilized to insert n = 1 ER waves into a numerical model that is able to faithfully produce TCs. In this first paper, experiments are carried out under the idealized condition of an initially quiescent background environment. Experiments are performed with varying initial wave amplitudes and with and without diabatic effects. This is done to both investigate how the properties of the simulated ER waves compare to the properties of observed ER waves and explore the role of the initial perturbation strength of the ER wave on genesis. In the dry, frictionless ER wave simulation the phase speed is slightly slower than the phase speed predicted from linear theory. Large-scale ascent develops in the region of low-level poleward flow, which is in good agreement with the theoretical structure of an n = 1 ER wave. The structures and phase speeds of the simulated full-physics ER waves are in good agreement with recent observational studies of ER waves that utilize wavenumber–frequency filtering techniques. Convection occurs primarily in the eastern half of the cyclonic gyre, as do the most favorable conditions for TC genesis. This region features sufficient midlevel moisture, anomalously strong low-level cyclonic vorticity, enhanced convection, and minimal vertical shear. Tropical cyclogenesis occurs only in the largest initial-amplitude ER wave simulation. The formation of the initial tropical disturbance that ultimately develops into a tropical cyclone is shown to be sensitive to the nonlinear horizontal momentum advection terms. When the largest initial-amplitude simulation is rerun with the nonlinear horizontal momentum advection terms turned off, tropical cyclogenesis does not occur, but the convectively coupled ER wave retains the properties of the ER wave observed in the smaller initial-amplitude simulations. It is shown that this isolated wave-only genesis process only occurs for strong ER waves in which the nonlinear advection is large. Part II will look at the more realistic case of ER wave–related genesis in which a sufficiently intense ER wave interacts with favorable large-scale flow features.


Atmosphere ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 914
Author(s):  
Tao Chen ◽  
Da-Lin Zhang

In view of the limited predictability of heavy rainfall (HR) events and the limited understanding of the physical mechanisms governing the initiation and organization of the associated mesoscale convective systems (MCSs), a composite analysis of 58 HR events over the warm sector (i.e., far ahead of the surface cold front), referred to as WSHR events, over South China during the months of April to June 2008~2014 is performed in terms of precipitation, large-scale circulations, pre-storm environmental conditions, and MCS types. Results show that the large-scale circulations of the WSHR events can be categorized into pre-frontal, southwesterly warm and moist ascending airflow, and low-level vortex types, with higher frequency occurrences of the former two types. Their pre-storm environments are characterized by a deep moist layer with >50 mm column-integrated precipitable water, high convective available potential energy with the equivalent potential temperature of ≥340 K at 850 hPa, weak vertical wind shear below 400 hPa, and a low-level jet near 925 hPa with weak warm advection, based on atmospheric parameter composite. Three classes of the corresponding MCSs, exhibiting peak convective activity in the afternoon and the early morning hours, can be identified as linear-shaped, a leading convective line adjoined with trailing stratiform rainfall, and comma-shaped, respectively. It is found that many linear-shaped MCSs in coastal regions are triggered by local topography, enhanced by sea breezes, whereas the latter two classes of MCSs experience isentropic lifting in the southwesterly warm and moist flows. They all develop in large-scale environments with favorable quasi-geostrophic forcing, albeit weak. Conceptual models are finally developed to facilitate our understanding and prediction of the WSHR events over South China.


2009 ◽  
Vol 137 (11) ◽  
pp. 4030-4046 ◽  
Author(s):  
Daniel F. Steinhoff ◽  
Saptarshi Chaudhuri ◽  
David H. Bromwich

Abstract A case study illustrating cloud processes and other features associated with the Ross Ice Shelf airstream (RAS), in Antarctica, is presented. The RAS is a semipermanent low-level wind regime primarily over the western Ross Ice Shelf, linked to the midlatitude circulation and formed from terrain-induced and large-scale forcing effects. An integrated approach utilizes Moderate Resolution Imaging Spectroradiometer (MODIS) satellite imagery, automatic weather station (AWS) data, and Antarctic Mesoscale Prediction System (AMPS) forecast output to study the synoptic-scale and mesoscale phenomena involved in cloud formation over the Ross Ice Shelf during a RAS event. A synoptic-scale cyclone offshore of Marie Byrd Land draws moisture across West Antarctica to the southern base of the Ross Ice Shelf. Vertical lifting associated with flow around the Queen Maud Mountains leads to cloud formation that extends across the Ross Ice Shelf to the north. The low-level cloud has a warm signature in thermal infrared imagery, resembling a surface feature of turbulent katabatic flow typically ascribed to the RAS. Strategically placed AWS sites allow assessment of model performance within and outside of the RAS signature. AMPS provides realistic simulation of conditions aloft but experiences problems at low levels due to issues with the model PBL physics. Key meteorological features of this case study, within the context of previous studies on longer time scales, are inferred to be common occurrences. The assumption that warm thermal infrared signatures are surface features is found to be too restrictive.


2010 ◽  
Vol 10 (13) ◽  
pp. 6435-6459 ◽  
Author(s):  
N. D. Gordon ◽  
J. R. Norris

Abstract. Clouds play an important role in the climate system by reducing the amount of shortwave radiation reaching the surface and the amount of longwave radiation escaping to space. Accurate simulation of clouds in computer models remains elusive, however, pointing to a lack of understanding of the connection between large-scale dynamics and cloud properties. This study uses a k-means clustering algorithm to group 21 years of satellite cloud data over midlatitude oceans into seven clusters, and demonstrates that the cloud clusters are associated with distinct large-scale dynamical conditions. Three clusters correspond to low-level cloud regimes with different cloud fraction and cumuliform or stratiform characteristics, but all occur under large-scale descent and a relatively dry free troposphere. Three clusters correspond to vertically extensive cloud regimes with tops in the middle or upper troposphere, and they differ according to the strength of large-scale ascent and enhancement of tropospheric temperature and humidity. The final cluster is associated with a lower troposphere that is dry and an upper troposphere that is moist and experiencing weak ascent and horizontal moist advection. Since the present balance of reflection of shortwave and absorption of longwave radiation by clouds could change as the atmosphere warms from increasing anthropogenic greenhouse gases, we must also better understand how increasing temperature modifies cloud and radiative properties. We therefore undertake an observational analysis of how midlatitude oceanic clouds change with temperature when dynamical processes are held constant (i.e., partial derivative with respect to temperature). For each of the seven cloud regimes, we examine the difference in cloud and radiative properties between warm and cold subsets. To avoid misinterpreting a cloud response to large-scale dynamical forcing as a cloud response to temperature, we require horizontal and vertical temperature advection in the warm and cold subsets to have near-median values in three layers of the troposphere. Across all of the seven clusters, we find that cloud fraction is smaller and cloud optical thickness is mostly larger for the warm subset. Cloud-top pressure is higher for the three low-level cloud regimes and lower for the cirrus regime. The net upwelling radiation flux at the top of the atmosphere is larger for the warm subset in every cluster except cirrus, and larger when averaged over all clusters. This implies that the direct response of midlatitude oceanic clouds to increasing temperature acts as a negative feedback on the climate system. Note that the cloud response to atmospheric dynamical changes produced by global warming, which we do not consider in this study, may differ, and the total cloud feedback may be positive.


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