Association of fatty acids in serum phospholipids with hay fever, specific and total immunoglobulin E

The dietary intake of certain fatty acids might contribute to the development of allergic diseases such as hay fever and asthma. We investigated the association between the concentrations of fifteen fatty acids in serum phospholipids, as a marker of dietary intake and metabolism, and hay fever, allergic sensitisation and total IgE in adults. Data from a population-based cross-sectional study on respiratory health, including the measurement of fatty acids in the serum phospholipids of 740 adults between 20 and 64 years of age, were analysed. Positive associations were found between hay fever and arachidonic acid, and allergic sensitisation and oleic acid. No other fatty acids showed any association with hay fever or allergic sensitisation. Elevated levels of total IgE were not related to fatty acids. Concentrations of long-chain n-3 fatty acids, trans fatty acids or saturated fatty acids in serum phospholipids were not associated with allergic diseases in adults in this study. The present result on the association between hay fever and arachidonic acid is consistent with current hypotheses but warrants further research.

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Plasma Fatty Acids in Zambian Adults with HIV/AIDS: Relation to Dietary Intake and Cardiovascular Risk Factors

Journal of Nutrition and Metabolism ◽

10.1155/2015/635817 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8 ◽

Cited By ~ 4

Author(s):

Christopher K. Nyirenda ◽

Edmond K. Kabagambe ◽

John R. Koethe ◽

James N. Kiage ◽

Benjamin H. Chi ◽

...

Keyword(s):

Fatty Acids ◽

Arachidonic Acid ◽

Dietary Intake ◽

Plasma Levels ◽

Saturated Fatty Acids ◽

Cvd Risk ◽

Cross Sectional ◽

Pufa Intake ◽

Aids Progression ◽

Hiv Aids

Objective. To determine whether 24 hr dietary recalls (DR) are a good measure of polyunsaturated fatty acid (PUFA) intake when compared to plasma levels, and whether plasma PUFA is associated with markers of HIV/AIDS progression and cardiovascular disease (CVD) risk.Methods. In a cross-sectional study among 210 antiretroviral therapy-naïve HIV-infected adults from Lusaka, Zambia, we collected data on medical history and dietary intake using 24 hr DR. We measured fatty acids and markers of AIDS progression and CVD risk in fasting plasma collected at baseline.Results. PUFA intakes showed modest correlations with corresponding plasma levels; Spearman correlations were 0.36(p<0.01)for eicosapentaenoic acid and 0.21(p=0.005)for docosahexaenoic acid. While there were no significant associations(p>0.05)between total plasma PUFA and C-reactive protein (CRP) or lipid levels, plasma arachidonic acid was inversely associated with CRP and triglycerides and positively associated with HDL-C, CD4+ T-cell count, and plasma albumin(p<0.05). Plasma saturated fatty acids (SFA) were positively associated with CRP (β= 0.24; 95% CI: 0.08 to 0.40,p=0.003) and triglycerides (β= 0.08; 95% CI: 0.03 to 0.12,p<0.01).Conclusions. Our data suggest that a single DR is inadequate for assessing PUFA intake and that plasma arachidonic acid levels may modulate HIV/AIDS progression and CVD risk.

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Serum phospholipid fatty acid profile and dietary intake in an adult Mediterranean population with cystic fibrosis

British Journal Of Nutrition ◽

10.1079/bjn20051655 ◽

2006 ◽

Vol 96 (2) ◽

pp. 343-349 ◽

Cited By ~ 34

Author(s):

Gabriel Olveira ◽

Antonio Dorado ◽

Casilda Olveira ◽

Alicia Padilla ◽

Gemma Rojo-Martínez ◽

...

Keyword(s):

Cystic Fibrosis ◽

Fatty Acids ◽

Fatty Acid ◽

Dietary Intake ◽

Fatty Acid Profile ◽

Phospholipid Fatty Acid ◽

Saturated Fatty Acids ◽

Pancreatic Insufficiency ◽

Mediterranean Population ◽

Serum Phospholipids

The relative importance of the usual diet in serum phospholipids in subjects with cystic fibrosis (CF) has been poorly studied. To compare the fatty acid profile in serum phospholipids from adult CF subjects with that of healthy subjects, and determine the role of the normal diet in this profile, we studied thirty-seven adult CF subjects with stable pulmonary disease and thirty-seven healthy controls matched for age, sex and nutritional status. A dietary questionnaire was obtained, anthropometric data were recorded, and the fatty acid profile measured by GLC. Compared with the controls, the percentages of myristic, palmitoleic and stearic acids and total MUFA were significantly higher in the CF group, and DHA, linoleic acid, total PUFA and n−6 fatty acids were significantly lower in the CF group. The CF subjects with worse pulmonary function and with pancreatic insufficiency had significantly lower levels of linoleic and n−6 fatty acids. The total energy intake was significantly higher in the CF subjects, although the energy distribution in the CF subjects and the controls was not different for the carbohydrates, lipids and proteins. No differences were detected in fat intake for MUFA (51 (sd 4) v. 52 (sd 4) %) or saturated fatty acids (33·5 (sd 5) v. 31·2 (sd 3·8) %), but the PUFA were slightly lower in the CF subjects (15·4 (sd 4·5) v. 17·4 (sd 4·2) %; P=0·02). The usual dietary intake of fatty acids by adult CF subjects does not appear to explain the difference in the fatty acid profile compared with controls. This suggests an abnormal fatty acid metabolism in CF subjects.

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Evaluation of Nutrient Intake and Food Consumption among Dutch Toddlers

Nutrients ◽

10.3390/nu13051531 ◽

2021 ◽

Vol 13 (5) ◽

pp. 1531

Author(s):

Elly Steenbergen ◽

Anne Krijger ◽

Janneke Verkaik-Kloosterman ◽

Liset E. M. Elstgeest ◽

Sovianne ter Borg ◽

...

Keyword(s):

Fatty Acids ◽

Dietary Intake ◽

Food Consumption ◽

Dietary Habits ◽

Saturated Fatty Acids ◽

Dietary Guidelines ◽

Food Groups ◽

Milk Products ◽

Health Council ◽

Dutch Health

Improving dietary habits at a young age could prevent adverse health outcomes. The aim was to gain insight into the adequacy of the dietary intake of Dutch toddlers, which may provide valuable information for preventive measures. Data obtained from the Dutch National Food Consumption Survey 2012–2016 were used, which included 672 children aged one to three years. Habitual intakes of nutrients were evaluated according to recommendations set by the Dutch Health Council. Specific food groups were evaluated according to the Dutch food-based dietary guidelines. For most nutrients, intakes were estimated to be adequate. High intakes were found for saturated fatty acids, retinol, iodine, copper, zinc, and sodium. No statement could be provided on the adequacy of intakes of alpha-linoleic acids, N-3 fish fatty acids, fiber, and iron. 74% of the toddlers used dietary supplements, and 59% used vitamin D supplements specifically. Total median intakes of vegetables, bread, and milk products were sufficient. Consumption of bread, potatoes and cereals, milk products, fats, and drinks consisted largely of unhealthy products. Consumption of unfavorable products may have been the cause of the observed high and low intakes of several nutrients. Shifting towards a healthier diet that is more in line with the guidelines may positively affect the dietary intake of Dutch toddlers and prevent negative health impacts, also later in life.

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Mode of action of choline. III. Metabolism of nonessential fatty acids in choline-deficient rats

Canadian Journal of Biochemistry ◽

10.1139/o69-097 ◽

1969 ◽

Vol 47 (6) ◽

pp. 619-630 ◽

Cited By ~ 2

Author(s):

A. Chalvardjian

Keyword(s):

Fatty Acids ◽

Thin Layer ◽

Saturated Fatty Acids ◽

Monounsaturated Fatty Acids ◽

Serum Triglycerides ◽

Hepatic Lipids ◽

Layer Chromatography ◽

Serum Phospholipids ◽

Early Alteration ◽

Initial Change

To investigate the increase in ratio of C16 to C18 nonessential fatty acids in hepatic triglycerides of choline-deficient rats, two groups of rats fed, respectively, a choline-deficient and a choline-supplemented diet for 3–4 days were injected either with 1-14C-acetate intraperitoneally or with a mixture of 9,10-3H-palmitate and 18-14C-stearate intravenously. The choline-deficient and choline-supplemented rats were killed 3 h after labelled acetate injection. Further groups of choline-deficient and choline-supplemented rats were killed at intervals of 1 min to 6 h after injection with labelled palmitate and stearate. Extracts of lipids from livers and sera were analyzed by gas–liquid and thin-layer chromatography. In the choline-deficient rats injected with 1-14C-acetate the ratio of C16 to C18 labelled fatty acids incorporated into hepatic and serum triglycerides was increased and the ratio of those incorporated into hepatic and serum phospholipids was decreased. The ratio of monounsaturated fatty acids to saturated fatty acids incorporated into the triglycerides and phospholipids of liver and serum of the choline-deficient rats was decreased compared to that of the choline-supplemented rats. Similar differences between the two groups of rats were evident in the hepatic lipids of animals injected with 3H-palmitate and 14C-stearate. The early alteration of the ratios of hepatic nonessential fatty acids suggests that the initial change is a decreased desaturation of fatty acids.

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Dietary Intake, Nutritional Adequacy and Food Sources of Total Fat and Fatty Acids, and Relationships with Personal and Family Factors in Spanish Children Aged One to <10 Years: Results of the EsNuPI Study

Nutrients ◽

10.3390/nu12082467 ◽

2020 ◽

Vol 12 (8) ◽

pp. 2467

Author(s):

Casandra Madrigal ◽

María José Soto-Méndez ◽

Rosaura Leis ◽

Ángela Hernández-Ruiz ◽

Teresa Valero ◽

...

Keyword(s):

Fatty Acids ◽

Dietary Intake ◽

Pediatric Population ◽

Essential Fatty Acids ◽

Saturated Fatty Acids ◽

Meat Products ◽

Food Sources ◽

Food And Agriculture ◽

Food And Agriculture Organization ◽

Total Fat

We aimed to determine the usual intake of total fat, fatty acids (FAs), and their main food sources in a representative cohort of the Spanish pediatric population aged 1 to <10 years (n = 707) who consumed all types of milk and an age-matched cohort who consumed adapted milk over the last year (including follow-on formula, toddler’s milk, growing-up milk, and fortified and enriched milks) (n = 741) who were participants in the EsNuPI study (in English, Nutritional Study in the Spanish Pediatric Population). Dietary intake, measured through two 24 h dietary recalls, was compared to the European Food Safety Authority (EFSA) and the Food and Agriculture Organization of the United Nations (UN-FAO) recommendations. Both cohorts showed a high intake of saturated fatty acids (SFAs), according to FAO recommendations, as there are no numerical recommendations for SFAs at EFSA. Also, low intake of essential fatty acids (EFAs; linoleic acid (LA) and α-linolenic acid (ALA)) and long-chain polyunsaturated fatty acids (LC-PUFA) of the n-3 series, mainly docosahexaenoic acid (DHA) were observed according to EFSA and FAO recommendations. The three main sources of total fat and different FAs were milk and dairy products, oils and fats, and meat and meat products. The consumption of adapted milk was one of the main factors associated with better adherence to the nutritional recommendations of total fat, SFAs, EFAs, PUFAs; and resulted as the main factor associated with better adherence to n-3 fatty acids intake recommendations. Knowledge of the dietary intake and food sources of total fat and FAs in children could help in designing and promoting effective and practical age-targeted guidelines to promote the consumption of EFA- and n-3 PUFA-rich foods in this stage of life.

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β-Subunit–Dependent Modulation of hSlo BK Current by Arachidonic Acid

Journal of Neurophysiology ◽

10.1152/jn.00700.2006 ◽

2007 ◽

Vol 97 (1) ◽

pp. 62-69 ◽

Cited By ~ 28

Author(s):

X. Sun ◽

D. Zhou ◽

P. Zhang ◽

E. G. Moczydlowski ◽

G. G. Haddad

Keyword(s):

Fatty Acids ◽

Arachidonic Acid ◽

Conformational Changes ◽

Unsaturated Fatty Acids ◽

Saturated Fatty Acids ◽

Nordihydroguaiaretic Acid ◽

Bk Channels ◽

Bk Channel ◽

Β Subunit ◽

Α Subunit

In this study, we examined the effect of arachidonic acid (AA) on the BK α-subunit with or without β-subunits expressed in Xenopus oocytes. In excised patches, AA potentiated the hSlo-α current and slowed inactivation only when β2/3 subunit was co-expressed. The β2-subunit–dependent modulation by AA persisted in the presence of either superoxide dismutase or inhibitors of AA metabolism such as nordihydroguaiaretic acid and eicosatetraynoic acid, suggesting that AA acts directly rather than through its metabolites. Other cis unsaturated fatty acids (docosahexaenoic and oleic acid) also enhanced hSlo-α + β2 currents and slowed inactivation, whereas saturated fatty acids (palmitic, stearic, and caprylic acid) were without effect. Pretreatment with trypsin to remove the cytosolic inactivation domain largely occluded AA action. Intracellularly applied free synthetic β2-ball peptide induced inactivation of the hSlo-α current, and AA failed to enhance this current and slow the inactivation. These results suggest that AA removes inactivation by interacting, possibly through conformational changes, with β2 to prevent the inactivation ball from reaching its receptor. Our data reveal a novel mechanism of β-subunit–dependent modulation of BK channels by AA. In freshly dissociated mouse neocortical neurons, AA eliminated a transient component of whole cell K+ currents. BK channel inactivation may be a specific mechanism by which AA and other unsaturated fatty acids influence neuronal death/survival in neuropathological conditions.

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Telomere Length in Healthy Adults Is Positively Associated With Polyunsaturated Fatty Acids, Including Arachidonic Acid, and Negatively With Saturated Fatty Acids

The Journals of Gerontology Series A ◽

10.1093/gerona/glaa213 ◽

2020 ◽

Vol 76 (1) ◽

pp. 3-6

Author(s):

Varinderpal S Dhillon ◽

Permal Deo ◽

Ann Chua ◽

Phil Thomas ◽

Michael Fenech

Keyword(s):

Fatty Acids ◽

Arachidonic Acid ◽

Fatty Acid ◽

Blood Cell ◽

Telomere Length ◽

Red Blood Cell ◽

Blood Cells ◽

Saturated Fatty Acids ◽

Fatty Acid Status ◽

Acid Status

Abstract Lymphocyte telomere length (LTL) is a biomarker of aging that may be modified by dietary factors including fat. Red blood cell fatty acid status is a well-validated indicator of long-term dietary intake of fat from various sources. Recent findings from epidemiological studies of LTL in relation to fatty acids in red blood cells are not conclusive. The present study was carried out to investigate if red blood cell fatty acid status in 174 healthy older South Australians is associated with LTL. Lymphocyte telomere length was measured by real-time qPCR and fatty acid content in red blood cells was measured by gas chromatography. Our results indicate that the majority of saturated fatty acids and monounsaturated fatty acids are negatively associated with LTL, whereas polyunsaturated fatty acids are positively associated with LTL. Multiple regression analysis revealed that arachidonic acid (C20:4n-6) is significantly, independently, positively correlated with LTL (β = 0.262; p = .000). The significant association of fatty acids, particularly C20:4n-6, with telomere length warrants further research.

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Dietary intake of fatty acids and antioxidants and hay fever risk in adults — results from a prospective study

Allergo Journal ◽

10.1007/bf03370361 ◽

2004 ◽

Vol 13 (8) ◽

pp. 520-521

Author(s):

Gabriele Nagel ◽

Alexandra Nieters ◽

Nikolaus Becker ◽

Jakob Linseisen

Keyword(s):

Fatty Acids ◽

Dietary Intake ◽

Prospective Study ◽

Hay Fever ◽

A Prospective Study

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Correlation between Total Serum Immunoglobulin E (IgE) and Absolute Eosinophil Count (AEC) in Allergic Diseases In Children

VIMS Health Science Journal ◽

10.46858/vimshsj.7102 ◽

2020 ◽

Vol 7 (1) ◽

pp. 5-9

Author(s):

Dr. Mayank Surana ◽

Dr. Vineeta Pande ◽

Dr. Sharad Agarkhedkar ◽

Dr. Ajit Teegala

Keyword(s):

Atopic Dermatitis ◽

Bronchial Asthma ◽

Eosinophil Count ◽

Immunoglobulin E ◽

Allergic Diseases ◽

Total Ige ◽

Serum Ige ◽

Absolute Eosinophil Count ◽

Serum Total Ige ◽

Total Immunoglobulin

Allergy, is a clinical expression of soluble factors like IgE, histamine or eosinophils found in serum or plasma of such patients. The products that are responsible for allergy are called as Allergens. Allergens normally induce IgE production which leads to type 1 hypersensitivity response on subsequent exposure to the same allergen. The target organs are mostly nose, lung, skin and gastrointestinal tract. Atopy is also considered as a triad of Atopic dermatitis, allergic rhinitis and bronchial asthma. Raised serum IgE and AEC are proven indicators of allergic phenomenon. Various studies show relationship between serum Immunoglobulin E level and total eosinophil count in population suffering from allergic diseases. Serum total Immunoglobulin E, total eosinophil count and specific IgE are all helpful for the diagnosis and treatment of allergic diseases. Objectives: 1.To Evaluate Serum Total IgE level in Children with allergic diseases.2. To Evaluate Absolute Eosinophil Count (AEC) in children with allergic diseases.3. To Correlate Serum Total Immunoglobulin E Level and Absolute Eosinophil Count (AEC) with allergic diseases. Methodology: Cross sectional study with 100 children in the age group 2-12 years with nasopharyngeal allergies (like bronchial asthma and atopic rhinitis) and skin allergies (like atopic dermatitis, urticaria) ,eye allergies were enrolled and serum IgE levels and AEC levels was done. Results: In present study Absolute eosinophil count was raised in 58% of cases Serum IgE was raised in 54% of cases. In present study, of 58% cases with raised Absolute eosinophil count 81% (47 cases) showed raised serum IgE levels. Conclusion: Absolute eosinophil count and serum Total IgE has been considered as a significant marker of allergic state and can be used as a marker of allergic response in atopic individuals. Raised serum IgE and AEC are more in nasobronchial allergy as compare to other systemic allergies. The elevated level of serum Total IgE and Absolute Eosinophil Count both shows Significant Correlation thus can be considered as a dependable laboratory investigation in diagnosing and categorizing allergic diseases.

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