scholarly journals Vitamin A as an anti-inflammatory agent

2002 ◽  
Vol 61 (3) ◽  
pp. 397-400 ◽  
Author(s):  
Ram Reifen

Vitamin A is necessary for normal differentiation of epithelial tissues, the visual process and reproduction, and is vital for the optimal maintenance and functioning of the innate and adaptive immune system. Vitamin A deficiency is one of the most profuse nutritional deficiencies worldwide. It is associated with increased susceptibility to infectious diseases in both man and animal models. Vitamin A also has a role as an anti-inflammatory agent. Supplementation with vitamin A has been found to be beneficial in a number of inflammatory conditions, including skin disorders such as acne vulgaris, broncho-pulmonary dysplasia and some forms of precancerous and cancer states. The present review suggests that vitamin A deficiency induces inflammation and aggravates existing inflammatory states. Supplementation with vitamin A in selected cases could ameliorate inflammation. The two main mechanisms which appear to be involved in the prevention of disease are the effects of vitamin A on the immune system and the effect on epithelial integrity.

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Lauren Lemieux ◽  
Vijaya Surampudi

Abstract Objectives Introduction: Biliopancreatic diversion (BPD) is a surgical procedure that causes weight loss via volume restriction and malabsorption. It is now rarely performed due to the risk of severe nutritional deficiencies including Vitamin A (1). Methods Case Description: A 68-year-old female status-post BPD in 1987 was referred for vitamin A deficiency. She initially had diminished night vision that progressed to left eye blindness by the time of her diagnosis in 2013. She was treated with oral vitamin A 100,000 IU daily; however, levels did not normalize, and her retinopathy progressed. She was later treated with intramuscular vitamin A and developed injection site rashes (Figure 1) thought to be due to an injection site reaction versus type IV hypersensitivity. Over time her vitamin A levels improved but her vision did not. Results Vitamin A deficiency is a preventable complication of BPD and can lead to permanent vision loss. A study of 376 BPD patients found that 1 year after surgery vitamin A levels were low in 52% and 4 years this increased to 69% despite supplementation compliance (2). Vitamin A injection site rashes have been reported in one case series of 3 patients (3), and skin testing revealed sensitivity to polysorbate 80. This is an emulsifier found in injectable vitamin A palmitate, other parental medications and some vaccines (3). Conclusions Vitamin screening is important in post-bariatric surgery patients. Rash following intramuscular vitamin A is uncommon and should be closely monitored for progressive allergic reaction and potential for reactions to other medications that contain similar components. Funding Sources None. Supporting Tables, Images and/or Graphs


2014 ◽  
Vol 27 (3) ◽  
pp. 301-310 ◽  
Author(s):  
Dixis Figueroa Pedraza ◽  
Márcia Cristina Sales

OBJECTIVE: To estimate the isolated and combined prevalence of anemia, vitamin A deficiency and zinc deficiency in pre-school children, as well as the distribution of isolated deficiencies according to gender, age and prior supplementation with vitamin A. METHODS: Cross-sectional study with pre-school children in the state of Paraíba, Brazil. Analysis of the average concentrations of hemoglobin, serum retinol and serum zinc, according to gender, age and previous vitamin A supplementation of children were carried out as well as the risk of simultaneous occurrence of micronutrient deficiencies in the presence of these deficiencies. RESULTS: The prevalence of anemia, vitamin A deficiency and zinc deficiency were 15.4%, 23.3% and 13.8%, respectively. The anemia was significantly associated with age (p<0.01). Children previously supplemented by vitamin A had higher serum retinol concentrations than children without supplements, an effect that was not observed for concentrations of hemoglobin or serum zinc. The prevalence of anemia associated with vitamin A deficiency was 5.8%, with the chance of vitamin A deficiency and anemia coexist 2.21 times (95%CI=1.03-4.84) higher in the case of vitamin A deficiency or anemia rather than in the absence of these conditions. CONCLUSION: The high prevalence of micronutrient deficiencies which are important in child growth, as well as the coexistence of nutritional deficiencies, point out the need to strengthen nutrition intervention strategies that consider this issue.


The British projects conducted in Ethiopia under the auspices of the I. B. P. have collected a vast amount of information concerning the peoples in Begemedir province, a highland area. This background served well as baseline data to establish the value of an applied nutrition project covering a broad range of activities. In the project township, Debarek, a polyclinic was introduced. Special attention was given to nutrition education for the under-fives by using several approaches. Other activities included nutrition education in the school and polyclinic, investigations into treatment of goitre and vitamin A deficiency, market garden schemes and improvements in poultry keeping. The only input in the control town Adi Arkai was a polyclinic set up by the Ethiopian Ministry of Health. Information about Debarek (the target community) and Adi Arkai (control) was also obtained from government statistics and surveys carried out by the Gondar Public Health College in 1968. The Project carried out censuses in 1970 and again in 1972. The evidence collected in the two communities over this period, while insufficient to establish any long-term trend, showed clearly a similar population structure. The most marked characteristics were the imbalance in the sex-ratio (67 males per 100 females Debarek, 86/100 in Adi Arkai) which reflected mobility, and the employment of about 80 % of the labour force in the tertiary or service sector, which reflected the economic function of the towns. On the other hand, religious groupings appeared to be remarkably stable and were an important aspect of the pattern of authority in the community. The monitoring of births and deaths during the Project gave accurate data for the first time. Crude birth rates in Debarek and Adi Arkai were 42 and 50 per thousand, crude death rates 19 and 35 per thousand, and infant mortality rates 229 and 198 per thousand live births respectively. A number of indicators of nutritional status were employed. Within a stratified sample of families three-day individual food intakes were measured on six occasions during 1969 and again at the conclusion of the Project in 1972. Energy intakes were consistently low, being about 70 % of the 1973 F. A. O./W. H. O. recommendations. Measurements made on these families, and on schoolchildren, of height, mass, skinfold thickness and arm circumference demonstrated that the people are small and underweight, with very little body fat. Clinical examinations revealed few overt signs of nutritional deficiencies, except for vitamin A and goitre. Evaluation was achieved by comparing anthropometric, mortality, and morbidity data from the Project and control towns. The most significant changes observed in the Project town were a 38 % reduction in the infant mortality rate, an improvement in the mass for age data for under-fives, and a reduction in the prevalence of vitamin A deficiency and goitre. Assessment of nutritional knowledge, its application, and effectiveness was attempted on selected groups. The achievements and failures of applied nutrition programmes are discussed in relation to the underlying economic basis of malnutrition, i.e. poverty.


1996 ◽  
Vol 17 (4) ◽  
pp. 1-5 ◽  
Author(s):  
Lars A. Hanson ◽  
Ursula Wiedermann ◽  
Rifat Ashraf ◽  
Shakila Zaman ◽  
Ingegrad Adlerberth ◽  
...  

Human milk is a very complex fluid with a number of components and multiple functions. New functions are continually being identified. It is clear that human milk can affect the immune system of the breasfed infant. This results both in enhanced vaccine responses and, at times, down-regulation of other immune reactivities, such as transplant rejection and the risk of developing certain immunologic diseases, such as type I diabetes. Breastfeeding presumably gives the infant the possibility for an optimal immune response by providing good nutrition, including a decreased risk of vitamin A deficiency. The control of the intestinal flora and the anti-inflammatory effects of maternal milk also increase the possibilities for an adequate immune response in the infant. Further study is needed of the roles of idiotypic and anti-idiotypic antibodies, growth factors, cytokines, and various anti-inflammatory factors in the maternal milk in the infant's host defence.


2009 ◽  
Vol 12 (5) ◽  
pp. 624-629 ◽  
Author(s):  
Madhu B Singh ◽  
Ranjana Fotedar ◽  
J Lakshminarayana

AbstractObjectiveTo assess the magnitude of three micronutrient deficiency disorders (iron, vitamin A and iodine), nutritional deficiencies and their association with related factors.Material and MethodsUsing the three-stage sampling technique, a study was conducted in twenty-eight villages of Jodhpur district. A total of 1193 women, 384 pregnant, 400 lactating and 409 non-pregnant non-lactating controls (15 years and above, women who have not attained their family status) were examined for three micronutrient deficiency disorders, nutritional deficiencies, dietary and associated factors.ResultsMajority of the women were anaemic. Anaemia was higher among pregnant and lactating women (80·7 %). Severe anaemia was three-fold higher among pregnant and lactating women in comparison to controls (4·1 %). Vitamin A deficiency was observed to be higher among pregnant women (8·8 %). A high proportion of women (80·8 %) consumed salt, having inadequate iodine content. Median urinary iodine values were less in pregnant and lactating women than the WHO cut-off points. Consumption of pulses and legumes was low besides leafy vegetables. Average intake of nutrients showed deficiency of protein and energy, iron and folic acid and vitamin A deficiency. Anaemia and iodine deficiency disorder were found to be inversely proportional to education and income.ConclusionsThe proportion of anaemia in this study was higher in comparison to national-level studies besides the low consumption of normal iodised salt. Only 19 % of salt samples had adequate iodine content, which calls for caution. In addition to iodisation of salt, the study suggests the development of nutritional packages utilising local dietary aspects.


1995 ◽  
Vol 73 (6) ◽  
pp. 754-758 ◽  
Author(s):  
Michael E. K. Moffatt

Since the Nutrition Canada Survey (1973) there has been clear evidence that Aboriginal people have low intakes of many nutrients such as iron, vitamin D, calcium, folate, vitamin A, and fluoride. Recent surveys suggest that the situation has not changed. Children are most likely to be affected clinically. More than half of Aboriginal children in some subpopulations in Manitoba suffer a period of iron deficiency, which may affect development. Nutritional rickets is still a common problem in Manitoba. We have seen cases of megaloblastic anemia due to folate deficiency. The relationship of the well-described low folate intake in pregnancy and birth defects has received no attention for the Aboriginal population. In a recent survey of Inuit children, dental caries of the primary teeth were present in over 70% of children, with a mean DMF (decayed, missing, and filled) index of 1.8 teeth in children under 2 and 9.5 in children 6 to 8 years. Although clinical vitamin A deficiency is not seen, there is now good evidence that subclinical deficiency increases susceptibility to infections. Although not all Aboriginal populations suffer all of these deficiencies, the problems are sufficiently widespread to suggest this is an urgent problem. It will not be solved simply by education. There must be a political will and a coordinated effort to make a balanced diet available to all at an affordable cost.Key words: North American Indian, nutrition, iron deficiency, rickets.


2020 ◽  
Author(s):  
Leandar Litov ◽  
Peicho Petkov ◽  
Miroslav Rangelov ◽  
Nevena Ilieva ◽  
Elena Lilkova ◽  
...  

ABSTRACTTimely control of the cytokine release syndrome (CRS) at the severe stage of COVID-19 is key to improving the treatment success and reducing the mortality rate. The inhibition of the activity of the two key cytokines, IFNγ and IL-6, can significantly reduce or even reverse the development of the cytokine storm. The objective of our investigations is to reveal the anti-inflammatory potential of heparin for prevention and suppression of the development of CRS in acute COVID-19 patients.The effect of low-molecular-weight heparin (LMWH) on IFNγ signalling inside the stimulated WISH cells was investigated by measuring its antiproliferative activity and the translocation of phosphorylated STAT1 in the nucleus. The mechanism of heparin binding to IFNγ and IL-6 and therefore inhibition of their activity was studied by means of extensive molecular-dynamics simulations. We find that LMWH binds with high affinity to IFNγ and is able to inhibit fully the interaction with its cellular receptor. It also influences the biological activity of IL-6 by binding to either IL-6 or IL-6/IL-6Rα thus preventing the formation of the IL-6/IL-6Rα/gp130 signaling complex. Our conclusion is that heparin is a potent anti-inflammatory agent that can be used in acute inflammatory conditions, due to its potential to inhibit both IFN γ and IL-6 signalling pathways. Based on our results and available clinical observations, we suggest the administration of LMWH to COVID-19 patients in the initial stages of the acute phase. The beginning of the treatment and the dosage should be based on a careful follow-up of the platelet count and the D-dimer, IL-6, IFN, T-cells, and B-cells levels.


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