Vitamin B12 deficiency: Is it underestimated in pregnant women?

2006 ◽  
Vol 85 (2) ◽  
pp. 241-242 ◽  
Author(s):  
Robert H. Glew ◽  
Denis M. McCarthy ◽  
Dorothy J. Vanderjagt
Keyword(s):  
Vitamin B12 ◽  
Pregnant Women ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency

Frequency of Vitamin B12 Deficiency in Pregnant Women with Gestational Diabetes Mellitus

2021 ◽  
Vol 15 (10) ◽  
pp. 2753-2755
Author(s):  
Shazia Jamil ◽  
Naveed Mahmood ◽  
Israr-ul- Haque ◽  
Rabiah Haque ◽  
Muhammad Imran-ul-Hasan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Vitamin B12 ◽  
Pregnant Women ◽  
Vitamin B12 Deficiency ◽  
Group I ◽  
B12 Deficiency ◽  
Vitamin B 12 ◽  
Group Ii

Objective: To determine the prevalence of vitamin B-12 deficiency in pregnant women with gestational diabetes mellitus. Study Design: Retrospective study Place and Duration of Study: Department of Medicine, OMC Hospital, Jail Road Lahore from January, 2020 to December, 2020. Methods: Two hundred and thirty pregnant females were enrolled age between 18-45 years. Detailed demographics of enrolled cases age, gestational age, gravidity and body mass index were recorded after taking informed written consent. Among 230 cases, 100 women were non GDM (group I) and 130 had gestational diabetes mellitus (group II). Blood samples were taken from all the patients for measuring vitamin B12 status. Vitamin B12 was defined as <300 pg/ml. Results: Mean age of the patients in group I was 31.64±7.45 years with mean BMI 25.88±8.65 kg/m2 while mean age among GDM group was 34.55±5.71 years with mean BMI 27.36±9.44 kg/m2. Mean gestational age in group I was 33.72±4.21 weeks and in group II 35.08±9.27 weeks. In group I 20 (20%) had vitamin B12 deficiency and in group II rate ofvitamin B12 deficiency was high among 90 (69.2%) cases. We found a significantly relation between vitamin B12 and GDM with p value <0.0007. Conclusion: The prevalence of vitamin B-12 deficiency among pregnant women of gestational diabetes mellitus was significantly high as compared to normal pregnant women. Keywords: Pregnant Women, Gestational Diabetes Mellitus, Vitamin B12 deficiency

RELATIONSHIP OF MATERNAL VITAMIN B12 STATUS IN PREGNANCY WITH PRETERM BIRTH AND MATERNAL HEALTH RISKS

2020 ◽  
pp. 32-38
Author(s):  
VICTORIA LAZAROVA SPASOVA ◽  
LILIA IVANOVA KOLEVA ◽  
MARIETA ANTONOVA POPOVA ◽  
VALENTINA BOYANOVA PETKOVA ◽  
MILEN VENTZISLAVOV DIMITROV
Keyword(s):  
Preterm Birth ◽  
Vitamin B12 ◽  
Pregnant Women ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
Inverse Association ◽  
Maternal Vitamin ◽  
B12 Deficiency ◽  
The Impact ◽  
In Pregnancy

Vitamin B12 is known to be vital for cell growth and population during pregnancy. This retrospective and prospective case−control study was aimed to disclose a health risk for pregnant women with vitamin B12 deficiency, as well as the one of the preterm birth. The main tasks set and performed in this research were as follows: to compare the obstetrics anamnesis between the women who gave birth on term and women who gave birth before term; to find the prevalence of vitamin B12 insufficiency in pregnancy; to determine its association with preterm birth and low birth weight; to examine its association with spontaneous abortions, and to investigate its relationship with obesity and hemoglobin levels in pregnant women. The conducted investigation involved 107 women who gave birth before the 37th week of gestation and 101 women who gave birth after the 37th week of gestation at the outpatient clinic of the University Hospital "Maichin Dom" in Bulgaria. Our study revealed a correlation between maternal vitamin B12 deficiency, overweight and low hemoglobin level. Our results showed no significant correlation between serum vitamin B12 level and the risk of preterm birth. However, we found an inverse association between vitamin B12 level and overweight before pregnancy and at the time of giving birth. As well there was confirmed the strong connection between meat consumption and vitamin B12 level. The paper emphasizes that the deficiency of the vitamin occurs most likely in the women with inadequate diets. Such a deficiency is actually confirmed to have serious health consequences for pregnant women and their offspring. Therefore further profound and numerous studies should be performed to properly assess the correlation between vitamin B12 and preterm birth, as well as to understand better the impact of vitamin B12 over pregnant women. Key words: vitamin B12, preterm birth, pregnancy, overweight, hemoglobin.

Subclinical vitamin B12 deficiency in pregnant women attending an antenatal clinic in Nigeria

2009 ◽  
Vol 29 (4) ◽  
pp. 288-295 ◽  
Author(s):  
D. J. Vanderjagt ◽  
I. A. O. Ujah ◽  
A. Patel ◽  
J. Kellywood ◽  
M. J. Crossey ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Pregnant Women ◽  
Vitamin B12 Deficiency ◽  
Antenatal Clinic ◽  
B12 Deficiency ◽  
Subclinical Vitamin

scholarly journals Assessment of the Vitamin B12 Status of Pregnant Women in Nigeria Using Plasma Holotranscobalamin

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Dorothy J. VanderJagt ◽  
Innocent A. O. Ujah ◽  
Eugene I. Ikeh ◽  
Jessica Bryant ◽  
Victor Pam ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Pregnant Women ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Independent Risk Factor ◽  
Vitamin B12 Deficiency ◽  
Antenatal Clinic ◽  
Plasma Homocysteine ◽  
Maternal Vitamin ◽  
B12 Deficiency

Maternal vitamin B12 deficiency during pregnancy is an independent risk factor for neural tube defects and other neurological problems in infants. We determined the vitamin B12 status of 143 pregnant women in Nigeria representing all trimesters who presented to an antenatal clinic in Jos, Nigeria, using holotranscobalamin II levels (holoTCII), which is a measure of the vitamin B12 that is available for uptake into tissues. The holoTCII concentration ranged from 13 to 128 pmol/L. Using a cutoff of 40 pmol/L, 36% of the women were classified as vitamin B12-deficient. HoloTCII concentrations correlated negatively with plasma homocysteine levels (, ) and positively with red blood cell folate concentrations (, ). These data underscore the importance of supplementing pregnant women in Nigeria with vitamin B12 in order to ensure adequate vitamin B12 status and decrease the risk for neural tube defects.

Prevalence of Vitamin B12 Deficiency in Pregnant Women & Its Effect on Fetal Outcome

2017 ◽  
Vol 5 (2) ◽  
pp. 74-78
Author(s):  
Annapoorna Yalla ◽  
◽  
Sunanda Kasula ◽  
P. Ravinder ◽  
Madhavan K. Nair ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Pregnant Women ◽  
Vitamin B12 Deficiency ◽  
Fetal Outcome ◽  
B12 Deficiency

scholarly journals Vitamin B12 deficiency is linked with dyslipidemia in gestational diabetes mellitus.

2021 ◽  
Vol 29 (01) ◽  
pp. 46-52
Author(s):  
Shehmeen Khan Khanzada ◽  
Sabreena Abbas Khokhar ◽  
Fouzia Shaikh
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Vitamin B12 ◽  
Pregnant Women ◽  
Venous Blood ◽  
Vitamin B12 Deficiency ◽  
Inverse Correlation ◽  
Assay Method ◽  
B12 Deficiency

Objective: To determine the vitamin B12 deficiency and dyslipidemia in Gestational Diabetes mellitus (GDM) diagnosed pregnant women. Study Design: Observational study. Setting: Department of Biochemistry and Gynecology/Obstetrics LUMHS Hospital Jamshoro. Period: January 2018 to December 2018. Material & Methods: A sample of 216 diagnosed GDM pregnant women was selected according to study criteria. Venous blood samples were centrifuged to separate sera; that were used for the estimation of (hexokinase method), blood lipids and Vitamin B12 (ECLIA assay method) by Cobas chemistry analyzer. Statistical SPSS software 21.0 (IBM, Inc USA) was used for study research variables at 95% CI (P ≤ 0.05). Results: Age of GDM cases was 36.12±9.5 years. Mean+/-SD vitamin B12 level was noted 154.7±81.7 ng/mL (P=0.0001). Serum cholesterol, triglycerides and LDLc were elevated and HDLc was low in GDM cases (P=0.0001). Of 216 GDM cases, vitamin B12 deficiency was present in 152 (70.3%) (P=0.0001) and dyslipidemia in 50 (23.1%) (X2=452.0) (P=0.0001). Vitamin B12 shows inverse correlation with RBG (r= -0.41, P=0.005), CHOL (r= -0.25, P=0.024), TAG (r= -0.81, P=0.0001), LDLc (r= -0.797, P=0.0001) and positive correlation with HDLc (r= 0.76, P=0.0001). Conclusion: The present study finds vitamin B12 deficiency in 152 (70.3%) and dyslipidemia in 50 (23.1%). Vitamin B12 deficient GDM women show high cholesterol, triglycerides, LDLc and low HDLc. Hence, it is concluded, the vitamin B12 deficiency is linked with dyslipidemia in Gestational Diabetes mellitus.

scholarly journals Nutritional Deficiency and Anemia in Latin America: A Collaborative Study

Blood ◽  
1971 ◽  
Vol 38 (5) ◽  
pp. 591-603 ◽  
Author(s):  
J. D. COOK ◽  
J. ALVARADO ◽  
A. GUTNISKY ◽  
M. JAMRA ◽  
J. LABARDINI ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Vitamin B12 ◽  
Pregnant Women ◽  
Latin American ◽  
Collaborative Study ◽  
Vitamin B12 Deficiency ◽  
Serum Folate ◽  
Who Criteria ◽  
True Incidence ◽  
B12 Deficiency

Abstract A collaborative study of nutritional anemia in third trimester pregnancy was performed in seven Latin American countries. Laboratory measurements included hemoglobin level, mean corpuscular hemoglobin concentration (MCHC), serum iron and iron-binding capacity, serum folate, vitamin B12 and albumin. Iron deficiency (transferrin saturation below 15%) was found in 48% of pregnant women, as compared with 21% of nonpregnant females and 3% of male controls of comparable age. The prevalence of folate deficiency (serum folate below 3 ng/ml.) was 10%, 10% and 9% in these three groups, respectively. Vitamin B12 deficiency (serum level below 80 pg/ml.) was found in 15% of pregnant women, but in less than 1% of both control groups. Anemia, as defined by current WHO criteria, was found in 38.5% of pregnant women, 17.3% of nonpregnant women and 3.9% of men. Analysis of the frequency distribution for hemoglobin levels, based on a Gaussian distribution in normal subjects, suggested that a large portion of subjects considered anemic by WHO criteria were normal and that the true incidence of anemia in pregnant and nonpregnant females was 22 and 12% respectively. Correlation analysis indicated that iron deficiency was of major importance as a cause of anemia, while folate lack was contributory only in pregnancy; no relationship could be demonstrated between vitamin B12 deficiency and anemia.

scholarly journals Prevalence of vitamin D and B12 deficiency in pregnant women in Jammu, India

2020 ◽  
Vol 8 (4) ◽  
pp. 1245
Author(s):  
Sapneet Kaur ◽  
Harleen Kaur
Keyword(s):  
Vitamin D ◽  
Vitamin B12 ◽  
Pregnant Women ◽  
Tertiary Care ◽  
Vitamin B12 Deficiency ◽  
Care Hospital ◽  
Jammu And Kashmir ◽  
Vitamin D Levels ◽  
Good Nutrition ◽  
B12 Deficiency

Background: Micronutrient deficiency is pandemic proportions among pregnant women in India, but there is scarcity of searchable data on  coexistence vitamin D status  and Vitamin B 12 in pregnant women in Jammu and Kashmir, hence we have assessed the vitamin D as well as Vitamin B12 status in pregnant women attending outpatient department in a tertiary care hospital Jammu.Methods: The study was conducted in the department of Biochemistry Government Medical College Jammu during June 2019 to February, 2020 and after obtaining informed consent, a total of 150 pregnant women, attending SMGS Hospital Jammu were screened for their vitamin D (25 OH-D) and vitamin B12 status by using Abbott architect chemiluminescent micro particle immunoassay.Results: A total of 150 pregnant women were  screened in the study , 129 (86%) were found to be having insufficient vitamin D levels in their blood (<30 ngm/dl) and 105 ( 70%)  women showed severe deficiency with vitamin D levels below 20 ngm/dl.108 (72%) pregnant women had vitamin B12 deficiency with levels below 200 pgm/ml.Conclusions: The study revealed a high prevalence of coexistence of Vitamin D and Vitamin B12 deficiency in pregnant women, despite of abundant sunshine throughout the year and also with the consideration that people of this region are well off economically and can afford good nutrition.

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