The longitudinal piezoelectric response of [001] poled rhombohedral and orthorhombic Pb(In1/2Nb1/2)O3–Pb(Mg1/3Nb2/3)O3–PbTiO3 crystals were investigated with respect to DC bias electric field, being in the range of -2~15 kV/cm. For rhombohedral crystals with compositions far away from morphotropic phase boundary (MPB), the piezoelectric response generally decreased with increasing positive DC bias field, while for crystals with MPB compositions, the piezoelectric response firstly decreased and then increased as function of DC bias. The piezoelectric response was found to decrease drastically when DC bias larger than phase transition field. On the other hand, the piezoelectric response was slightly enhanced for all the crystals as function of negative DC bias prior to the depolarization. To explain the obtained results, the field dependent piezoelectric coefficients in domain engineered crystals were analyzed based on thermodynamic approach.