Quantification of zinc concentrations in serum, milk and faeces of dairy cattle as a measure of effective zinc supplementation for management of facial eczema

Author(s):  
WA Mason ◽  
EL Cuttance ◽  
RA Laven ◽  
P Jamieson ◽  
SR Davis
1991 ◽  
Vol 31 (2) ◽  
pp. 183 ◽  
Author(s):  
CL White ◽  
BS Chandler ◽  
DW Peter

The effects of post-partum supplements of zinc (Zn) on the Zn status and growth of 40 ewes and their newborn lambs grazing grass-clover pastures were studied. A control group received no supplemental Zn; supplemented ewes received Zn as an intra-ruminal Zn pellet and lambs received a Zn pellet at weaning followed by an oral Zn drench. Zinc concentrations in pastures ranged from 10 mg/kg in autumn to >20 mg/kg in winter. Zinc supplementation increased the concentration of Zn in milk but had no effect on Zn in plasma or wool of ewes or lambs and no effect on weight gain or wool production. Zinc supplements had no adverse effects on the copper concentration of tissues or milk. Zinc supplied as pellets increased the activity of glutathione peroxidase in blood. The results indicate that, at least when pasture quality and quantity is too poor for sheep to gain weight, Zn requirements for growth and wool production of lactating ewes and lambs can be met on pastures containing 10-20 mg Zn/kg.


Author(s):  
C.A. Morris ◽  
N.R. Towers ◽  
H.J. Tempero

Facial eczema (FE) is a disease of grazing ruminants caused by ingesting spores of the fungus Pithomyces chartarum. The spores contain a toxic compound, sporidesmin, which causes liver injury, sensitivity to sunlight and reduced performance in susceptible dairy cattle. The extent of production losses is summarised. Research at Ruakura has demonstrated that the resistance of animals to FE is inherited, with a heritability estimate of 0.31 in dairy cattle. Genetic progress in dairy cattle could bc achieved by progeny testing young bulls, and selecting for use as sires those with the most resistant progeny. However, work over the last decade in sheep at Ruakura has demonstrated the success of selection based on performance testing (i.e. dosing potential sires themselves and using those that are most resistant to the challenge). In January 1990 we began to develop a performance test for use in the preliminary screening of young dairy bulls for FE resistance. The details of these tests are described. Keywords facial eczema, dairy cattle, performance testing, production loss


2016 ◽  
Vol 85 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Sylva Dresler ◽  
Josef Illek ◽  
Ladislav Zeman

The aim of the study was to investigate the effect of organic zinc supplementation in calves on serum zinc (Zn) concentrations, selected metabolic profile indicators and serum immunoglobulin (Ig) concentrations. The trial included 2 groups (n = 10) of weaned female calves. The Zn-Methionin calves (group Zn-Met) were supplemented with 30 mg Zn-Met/kg dry matter (DM)/day (BIOPLEX® Zn, Alltech, USA) for 90 days; the control calves (group C) received the same diet without organic zinc supplementation. Compared to the control group, organic Zn treatment significantly increased serum Zn concentration (P < 0.05), superoxide dismutase (SOD) activity (P < 0.01) and total Ig (P < 0.01) in the group Zn-Met at the beginning (7 days from the start of Zn-Met supplementation) of the trial. At the end of the trial (day 90) serum total protein (TP) (P < 0.05), albumin (P < 0.01), urea (P < 0.01), SOD (P < 0.01), copper (Cu) (P < 0.05), Zn (P < 0.01) and Ig (P < 0.05) concentrations were significantly higher in the Zn-Met calves. In the control group alkaline phosphatase (ALP) activity was significantly (P < 0.01) higher on day 90. A positive correlation between zinc concentrations, ALP, and SOD activities in serum, and a negative correlation between zinc and copper concentrations were demonstrated. Dietary Zn-Met supplementation in calves markedly influenced the metabolic profile and serum immunoglobulin concentrations. Compared to the control group, the Zn supplemented group showed a significantly (P < 0.05) lower ALP and significantly greater SOD serum activity (P < 0.01) at the end of the trial. Total Ig concentrations were significantly higher in the Zn treated group (day 7: P < 0.01 vs. day 90: P < 0.05).


2010 ◽  
Vol 129 (1-3) ◽  
pp. 1-12 ◽  
Author(s):  
J.M. DeFrain ◽  
M.T. Socha ◽  
D.J. Tomlinson ◽  
A.R. Hittmann ◽  
B.J. McKay

Author(s):  
Helen F Goode ◽  
J Kelleher ◽  
B E Walker

It is doubtful if the measurement of plasma or serum zinc is of value in assessing zinc status. Leucocyte zinc has been suggested as an alternative since it may be representative of tissue zinc stores; but in many studies poorly defined cell populations make interpretation difficult. This paper describes detailed techniques for the isolation and analysis of pure populations of neutrophils, lymphocytes and monocytes. Zinc concentrations (± 1SD) in normal subjects were 1·;26 ± 0·;27 nmol/mg protein, 1·;85 ± 0·;32 nmol/mg protein and 2·;58 ±0·;65 nmol/mg protein in neutrophils, lymphocytes and monocytes respectively. Fasting caused a significant decrease in neutrophil and lymphocyte zinc, and an increase in monocyte zinc. Supplementation of zinc-replete subjects with 135 mg zinc/day for 3 weeks had no significant effect on cellular zinc concentrations.


2010 ◽  
Vol 391 (5) ◽  
pp. 513-518 ◽  
Author(s):  
Nidhi Saini ◽  
Walter Schaffner

Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder in which oxidative stress is implicated as a major causative factor. Mutations in the gene encoding Parkin, a ubiquitin ligase, are responsible for a familial form of PD. In a Drosophila disease model lacking Parkin (park25 null mutant), we tested the effect of zinc supplementation. Zinc is an essential trace metal and a component of many enzymes and transcriptional regulators. Unlike copper and iron, zinc is not redox-active and under most conditions serves as an antioxidant. We find that the condition of parkin mutants raised on zinc-supplemented food is greatly improved. At zinc concentrations where controls begin to show adverse effects as a result of the metal supplement, parkin mutants perform best, as manifested in a higher frequency of reaching adulthood, extended lifespan and improved motoric abilities.


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