scholarly journals Effects of organic zinc supplementation in weaned calves

2016 ◽  
Vol 85 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Sylva Dresler ◽  
Josef Illek ◽  
Ladislav Zeman
Keyword(s):  
Metabolic Profile ◽  
Zinc Supplementation ◽  
Serum Zinc ◽  
Treated Group ◽  
Serum Immunoglobulin ◽  
Control Group ◽  
Sod Activity ◽  
Organic Zinc ◽  
Zinc Concentrations ◽  
Organic Zn

The aim of the study was to investigate the effect of organic zinc supplementation in calves on serum zinc (Zn) concentrations, selected metabolic profile indicators and serum immunoglobulin (Ig) concentrations. The trial included 2 groups (n = 10) of weaned female calves. The Zn-Methionin calves (group Zn-Met) were supplemented with 30 mg Zn-Met/kg dry matter (DM)/day (BIOPLEX® Zn, Alltech, USA) for 90 days; the control calves (group C) received the same diet without organic zinc supplementation. Compared to the control group, organic Zn treatment significantly increased serum Zn concentration (P < 0.05), superoxide dismutase (SOD) activity (P < 0.01) and total Ig (P < 0.01) in the group Zn-Met at the beginning (7 days from the start of Zn-Met supplementation) of the trial. At the end of the trial (day 90) serum total protein (TP) (P < 0.05), albumin (P < 0.01), urea (P < 0.01), SOD (P < 0.01), copper (Cu) (P < 0.05), Zn (P < 0.01) and Ig (P < 0.05) concentrations were significantly higher in the Zn-Met calves. In the control group alkaline phosphatase (ALP) activity was significantly (P < 0.01) higher on day 90. A positive correlation between zinc concentrations, ALP, and SOD activities in serum, and a negative correlation between zinc and copper concentrations were demonstrated. Dietary Zn-Met supplementation in calves markedly influenced the metabolic profile and serum immunoglobulin concentrations. Compared to the control group, the Zn supplemented group showed a significantly (P < 0.05) lower ALP and significantly greater SOD serum activity (P < 0.01) at the end of the trial. Total Ig concentrations were significantly higher in the Zn treated group (day 7: P < 0.01 vs. day 90: P < 0.05).

scholarly journals Insect Crude Thoraxial Antigen-G Extracted from Apis mellifera to Enhance Serum Immunoglobulin of Goats: An Entomology Contribution in Animal Science

2019 ◽  
Vol 20 (2) ◽  
pp. 133
Author(s):  
Wisje Lusia Toar ◽  
Laurentius Rumokoy ◽  
Ivonne Maria Untu ◽  
Geertruida Assa
Keyword(s):  
Apis Mellifera ◽  
Serum Antibody ◽  
Treated Group ◽  
Serum Immunoglobulin ◽  
Control Group ◽  
Immunoglobulin Level ◽  
Animal Science ◽  
Serum Immunoglobulin Level ◽  
Pathogenic Microbes

This research was conducted to evaluate the influence of insect crude thoraxial antigen-G (CTA) extracted from Apis mellifera L. (Hymenoptera: Apidae) to enhance goat’s serum immunoglobulin level. The first part of this study was the determination of insect CTA proportion level. The insects were collected from four different places: Tomohon, Minahasa, North-Minahasa and Manado areas. The second part of the study was the application of A. mellifera CTA substance on serum immunoglobulin level classification. In this part, twelve young goats handled with traditional maintenance.  The animals experiment were divided in two groups: control group and the other treated with 100 µg CTA extract. The proportion of serum immunoglobulins level of goats was detected at 14th days after immunization with insects CTA extract, and compared with the animals immunoglobulin levels at the starting day of treatment.  The data of CTA extract proportion level of the insects collected were subjected to statistically analysis using the general linear model (GLM) procedure of SPSS 22. Concerning the classification level of the animal treated with CTA was statistically analyzed according to Mann-Whitney test. The results showed that the proportion level of thoraxial antigens-G of A. mellifera from all areas observed were not significant different (P>0.05). This crude thoraxial antigens-G of this insect were able to increase serum antibody level of the experiment animal after 14 days of immunization. The immunoglobulin level qualification of animals in treated group were significant higher (P<0.05) than in control group. We concluded that the CTA extract of the Apis mellifera could be empowered to improve the young goat immunity against the pathogenic microbes in their environment. 

scholarly journals Effect of inorganic and organic zinc supplementation on coccidial infections in goat kids

2011 ◽  
Vol 80 (2) ◽  
pp. 131-137 ◽  
Author(s):  
Petra Strnadová ◽  
Vlasta Svobodová ◽  
Leoš Pavlata ◽  
Ľubica Mišurová ◽  
Rudolf Dvořák
Keyword(s):  
Zinc Oxide ◽  
Plasma Concentration ◽  
Blood Plasma ◽  
Clinical Symptoms ◽  
Clinical Signs ◽  
Control Group ◽  
Organic Zinc ◽  
Highest Weight ◽  
Weight Gains ◽  
Zinc Concentrations

The aim of this study was to identify the effect of zinc-enriched diet fed to goats and their kids on the number of Coccidia oocysts shed by kids, on clinical signs of coccidiosis, weight gains, and kids’ blood plasma concentration of zinc. A total of 22 goat kids were divided into 4 groups of 5 or 6 animals. Goats and kids from the control group did not receive any additional zinc, the second group was supplemented with inorganic zinc (zinc oxide), the third group was given zinc lactate, and the fourth group received chelated zinc. Samples of kids’ faeces were taken weekly from 3 to 9 weeks of their age (a total of 7 samples were taken). Samples of faeces were examined by a quantitative method to detect the number of oocysts. Kids were weighed weekly and their blood was taken in order to determine zinc concentrations in blood plasma. Animals from the group supplemented with zinc chelate and zinc lactate shed a significantly (p ≤ 0.05) lower number of oocysts (13.4% and 11.9%, respectively) compared to the number of oocyst shed by control and zinc oxide supplemented groups (25% and 49.7%, respectively). Shedding of oocysts was not accompanied by clinical symptoms of coccidiosis in any of the groups. Kids supplemented with zinc chelate showed significantly highest weight gains and blood plasma concentration of zinc (p ≤ 0.05) as compared to control and inorganic zinc supplemented groups. Organic zinc is to be recommended to be used as a prophylaxis against coccidiosis in goat kids.

scholarly journals Metal excretion and magnesium retention in patients with intermittent claudication treated with intravenous disodium EDTA

1996 ◽  
Vol 42 (12) ◽  
pp. 1938-1942 ◽  
Author(s):  
B Guldager ◽  
P J Jørgensen ◽  
P Grandjean
Keyword(s):  
Intermittent Claudication ◽  
Controlled Trial ◽  
Serum Zinc ◽  
Blood Lead ◽  
Treated Group ◽  
The Body ◽  
Control Group ◽  
Disodium Edta ◽  
Double Blind ◽  
Blood Concentrations

Abstract Sixty patients with intermittent claudication participated in a double-blind placebo-controlled trial of 20 courses of intravenous chelation therapy with 3 g of disodium EDTA vs placebo during 5-9 weeks. After the first infusion, the 24-h urinary excretion of lead and zinc was approximately 25-fold higher in the EDTA-treated group; relative differences for copper and calcium were smaller. Urinary magnesium excretion in the EDTA-treated group was one-third less than in the control group. After the treatment period, the blood lead concentration had decreased by approximately 73% and the serum zinc concentration by approximately 34%; other changes in blood concentrations were negligible. The loss of essential minerals and the possible redistribution of lead in the body may constitute a disadvantage that should be taken into account in repeated intravenous EDTA treatment.

scholarly journals Zinc Supplementation as Adjunctive Therapy in Adults with Tuberculosis in Calabar, Nigeria: A Randomized Controlled Trial

2019 ◽  
pp. 1-13
Author(s):  
Regina I. Ejemot-Nwadiaro ◽  
Edisua H. Itam ◽  
Emmanuel N. Ezedinachi
Keyword(s):  
Zinc Supplementation ◽  
Intervention Group ◽  
Serum Zinc ◽  
Drug Regimen ◽  
Haematological Parameters ◽  
Control Group ◽  
Tb Treatment ◽  
Zinc Levels ◽  
The Impact ◽  
Serum Zinc Levels

Introduction: Tuberculosis (TB) still remains a leading killer from a single infectious agent worldwide, especially in Asia and Africa. Achieving the Sustainable Development Goal (SDG) 3 will be contingent on addressing ways of reducing the impact of TB to the health, socio-economic and health system of populations most at risk. Micronutrients supplementation is increasingly being recognized as having great potentials to that effect. Objective: This study thus assessed the potential benefits or otherwise of zinc supplementation on tuberculosis treatment outcomes in Calabar, Nigeria. Methods: Eligible patients (81) out of the 182 assessed were randomized to receive anti-TB drug regimen plus oral administration of individual zinc, 25 mg daily for 60 days (intervention group), while the control group received anti-tuberculosis drug regimen only for 60 days. Both qualitative and quantitative data were collected. Clinical examination, Karnofsky performance scale index, direct sputum examination, anthropometric measurements and blood collection for haematological and zinc assessment were carried out before and 2 months after anti-TB treatment began.  Difference in treatment effects between and within groups for continuous variables was tested using t-test. Mantel-Haenszel summary estimate of the relative risk (RR) was used to test the clinical effectiveness of the intervention. The Pearson test was applied to determine the correlation between variables. Main Results: The mean serum zinc levels at 2 months of TB treatment were significantly higher in the intervention group (14.4 ± 0.37µmol/L) in comparison with the control (12.9 ± 0.37 µmol/L); (p = 0.004). A significant difference (p = 0.010) in the serum concentrations of zinc was observed between the two groups when adjustments were made for TB-HIV co-infection. Risk reduction of about 41% for acid fast bacilli (AFB) positivity (RR: 0.59; 95% CI 0.23 to 1.46) was observed after 2 months of anti-TB treatment in favour of the intervention group. Similarly, intervention group had significantly (p = 0.005) lower proportion of patients with serum zinc levels < 10.7 µmol/L (intervention: 5; Control 10) and (p = 0.030) BMI < 18.5 kg /m2 below the lower ranges ((intervention: 9; Control 16). There was a significant improvement in the haematological parameters as evidenced by significant higher proportion of patients in the intervention group than the control group with values above the lower ranges for these parameters with risk reductions in favour of the intervention group for lower ranges as 34%, 12%, 73% and 58% respectively for haemoglobin, albumin, serum total protein and globulins. Conclusion: Irrespective of HIV status in individuals with tuberculosis, zinc micronutrient supplementation significantly increases clinical outcomes, haematological parameters, improves nutritional status as proxied by anthropometric indices and leads to faster sputum smear conversion. The study adds to the growing body of evidence in support of the beneficial role of zinc in TB control.

scholarly journals Changes in the Antioxidant and Mineral Status of Rabbits After Administration of Dietary Zinc and/or Thyme Extract

2021 ◽  
Vol 8 ◽  
Author(s):  
Katarína Kucková ◽  
L'ubomíra Grešáková ◽  
Margaréta Takácsová ◽  
Anna Kandričáková ◽  
L'ubica Chrastinová ◽  
...  
Keyword(s):  
Antioxidant Response ◽  
Control Group ◽  
Dietary Zinc ◽  
Mineral Status ◽  
Treatment Groups ◽  
Organic Zinc ◽  
Zn Content ◽  
Total Antioxidant ◽  
Organic Zn ◽  
The Impact

This study was aimed at determining the impact of organic zinc (Zn) and thyme extract (TE) administration, given alone or together for 6 weeks, on the antioxidant and mineral status (Zn, Cu, Fe, and Mn) in the plasma and tissues of growing rabbits. A total of 96 rabbits of age 35 days were randomly assigned to one of four treatment groups: a control group (C), a Zn group supplemented with dietary zinc (50 mg/kg), a TE group receiving thyme extract applied in drinking water (1 ml/L), and a Zn + TE group treated with both additives. Lipid peroxidation in the plasma was influenced by Zn intake and in the kidney was affected by both the Zn and TE treatment (P &lt; 0.05). Zn supplementation led to a significant increase in glutathione peroxidase activity (P = 0.017), total antioxidant capacity (P = 0.009) and total thiol groups level (P = 0.047) in the kidney, with the highest values occurring in rabbits receiving the combination Zn + TE. Administration of TE influenced Zn content in the kidney (P &lt; 0.001), while zinc intake decreased Cu concentration in muscle (P = 0.021). In conclusion, the simultaneous administration of organic Zn and TE positively affected the antioxidant response of kidneys and can be used for improving the antioxidant status of growing rabbits.

scholarly journals Anticancer activity of ylang-ylang essential oil in Ehrlich Ascites Carcinoma cell-treated mice

2020 ◽  
Vol 11 (4) ◽  
pp. 5752-5762
Author(s):  
Ajay P Malgi ◽  
Vijaykumar P Rasal ◽  
Vishal Shivalingappa Patil ◽  
Priyanka P Patil ◽  
Shamanad P Mallapur ◽  
...  
Keyword(s):  
Essential Oil ◽  
Complex Mixture ◽  
Ehrlich Ascites Carcinoma ◽  
Treated Group ◽  
Ehrlich Carcinoma ◽  
Control Group ◽  
Sod Activity ◽  
Standard Drug ◽  
Chemical Structures ◽  
Essential Components

Essential oils are secondary metabolites contains a complex mixture of with a diverse array of chemical structures, play a crucial role in the management of complex diseases like cancer via synergistic and antagonism effect. essential oil (YYEO) extracted from the flowers of Cananga is renowned forits fragrance, contained more than 150 essential components within it, and utilized in various diseases and cosmetics. Traditionally YYEO is being used as an aphrodisiac, , , antiseptic, in food and beverages as a fragrance agent. Due to the presence of a complex mixture of essential components in YYEO, we aimed the current study to assess the anticancer potential against Ehrlich Carcinoma (EAC) bearing mice. In antioxidant, growth, body weight, biochemical, , and serum estimation was evaluated with subsequent of the liver. 5- (5- FU) was used as a standard drug. YYEO showed potent antioxidant activity by DPPH assay. YYEO significantly reversed the , lymphocytes, WBC, and RBC numbers in the treated group compared with the disease control group. YYEO administration has restored the imbalanced levels of antioxidant such as MDA, GSH, and SOD activity. YYEO reversed the of the liver altered by the EAC in mice. In conclusion, a complex mixture of contained in YYEO could be the potent anticancer therapy in the future. Further studies are needed to identify the active principles and the mechanism involved in this activity.

Effect of graded concentration of organic Zinc (Zinc glycinate) on antioxidants status and immune response in commercial broilers

2015 ◽  
Author(s):  
K. Sridhar ◽  
D. Nagalakshmi ◽  
D. Srinivasa Rao ◽  
S. V. Rama Rao
Keyword(s):  
Immune Response ◽  
Antioxidant Status ◽  
Basal Diet ◽  
Cell Mediated Immunity ◽  
Broiler Chicks ◽  
Sod Activity ◽  
Organic Zinc ◽  
Antibody Titres ◽  
Peroxidase Enzyme ◽  
Organic Zn

One hundred and twenty day old commercial broiler chicks were randomly allotted to 4 dietary groups, with 6 replicates of 5 birds in each and reared for 42 days under uniform management conditions to study the effect of organic zinc (zinc glycinate; Zn-gly) supplemented at lower levels (30, 20 and 10 ppm) on antioxidant status and immune response in comparison to NRC (1994) recommended levels (40 ppm) of Zn supplemented from inorganic source (ZnSO4). The dietary treatments were corn soybean meal basal diet supplemented with 40 ppm Zn from ZnSO4 (inorganic) (control) and 30, 20 and 10 ppm Zn from Zn-gly (organic). Antioxidant enzyme levels and antibody titres against New castle disease (ND) vaccine (humoral immunity) were estimated on 35th d and oxidative stress markers from liver on 42nd d. On 40th d, the cell mediated immunity (CMI) was assessed as cutaneous basophilic hypertrophy to phytohemagglutinin-P (PHA-P). The lipid peroxidation in haemolysate (P<0.05) lowered in birds with 30 ppm Zn supplemented as Zn-gly compared to 20 and 10 ppm Zn from Zn-gly and 40 ppm Zn from ZnSO4. The Glutathione peroxidase enzyme activity was higher (P<0.05) with 30 ppm Zn as Zn-gly compared to control. The CMI was sgnificantly (P<0.05) high at 30 ppm Zn supplemented as Zn-gly compared to 40 ppm Zn as ZnSO4 and other organic Zn groups. The SOD activity, humoral and cell mediated immune resonse when fed 20 ppm Zn as Zn-gly was comparable to those on 40 ppm Zn as ZnSO4. The results of the study indicated that reducing the level of Zn from inorganic source (40 ppm) to 50 % (20 ppm) supplementation from Zn-gly can result in comparable immune and antioxidant status in broiler chicks.

scholarly journals The Effect of Zinc Supplementation on Sleep Quality of ICU Nurses: A Double Blinded Randomized Controlled Trial

2017 ◽  
Vol 66 (4) ◽  
pp. 191-200 ◽  
Author(s):  
Afshin Gholipour Baradari ◽  
Abbas Alipour ◽  
Ali Mahdavi ◽  
Hassan Sharifi ◽  
Seyed Mahmood Nouraei ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Zinc Supplementation ◽  
Controlled Trial ◽  
Intervention Group ◽  
Serum Zinc ◽  
Zinc Level ◽  
Control Group ◽  
Serum Zinc Level ◽  
Randomized Controlled

This study examined the effect of zinc supplementation on the sleep quality (SQ) of intensive care unit (ICU) nurses. In a double-blind, randomized controlled trial, 54 ICU nurses were randomly assigned to the intervention group ( n = 27) that received 220 mg zinc sulfate capsules every 72 hours for 1 month and the control group ( n = 26) that received placebo. Sleep quality of ICU nurses was measured by calculating the total quality sleep score using the Pittsburgh Sleep Quality Index (PSQI). The serum zinc level was a secondary outcome. All measurements were calculated at both baseline and 1 month after intervention. The total PSQI, subjective SQ, and sleep latency scores for the intervention group were significantly lower than the control group, which means that the SQ of ICU nurses in the intervention group improved from baseline. The serum zinc level of the intervention group at the end of the study was significantly higher than the control group, which means that zinc supplementation improved participants’ serum zinc level. Based on these findings, the researcher suggested that zinc supplementation could be associated with better SQ, subjective SQ, and sleep latency in this group of workers.

Zinc supplementation of lactating ewes and weaned lambs grazing improved mediterranean pastures

1991 ◽  
Vol 31 (2) ◽  
pp. 183 ◽  
Author(s):  
CL White ◽  
BS Chandler ◽  
DW Peter
Keyword(s):  
Weight Gain ◽  
Copper Concentration ◽  
Zinc Supplementation ◽  
Post Partum ◽  
Control Group ◽  
Wool Production ◽  
Pasture Quality ◽  
Zinc Concentrations ◽  
Zinc Supplements ◽  
Zn Status

The effects of post-partum supplements of zinc (Zn) on the Zn status and growth of 40 ewes and their newborn lambs grazing grass-clover pastures were studied. A control group received no supplemental Zn; supplemented ewes received Zn as an intra-ruminal Zn pellet and lambs received a Zn pellet at weaning followed by an oral Zn drench. Zinc concentrations in pastures ranged from 10 mg/kg in autumn to >20 mg/kg in winter. Zinc supplementation increased the concentration of Zn in milk but had no effect on Zn in plasma or wool of ewes or lambs and no effect on weight gain or wool production. Zinc supplements had no adverse effects on the copper concentration of tissues or milk. Zinc supplied as pellets increased the activity of glutathione peroxidase in blood. The results indicate that, at least when pasture quality and quantity is too poor for sheep to gain weight, Zn requirements for growth and wool production of lactating ewes and lambs can be met on pastures containing 10-20 mg Zn/kg.

Tissue zinc status and drug elimination in patients with chronic liver disease

1990 ◽  
Vol 78 (6) ◽  
pp. 547-549 ◽  
Author(s):  
Michael Barry ◽  
P. W. N. Keeling ◽  
John Feely
Keyword(s):  
Hepatic Cirrhosis ◽  
Serum Zinc ◽  
Zinc Content ◽  
Control Group ◽  
Zinc Status ◽  
Antipyrine Clearance ◽  
Zinc Depletion ◽  
Antipyrine Kinetics ◽  
Healthy Control ◽  
Zinc Concentrations

1. The zinc status and drug-metabolizing ability of 15 patients with histologically diagnosed hepatic cirrhosis were studied. Zinc status was assessed using both serum and leucocyte zinc concentrations, and drug-metabolizing ability was assessed by antipyrine kinetics. 2. Patients with cirrhosis were found to have lower serum and leucocyte zinc concentrations when compared with a healthy control group. 3. Leucocyte zinc content and antipyrine clearance were correlated. Those patients with the lowest leucocyte zinc content had the greatest impairment of drug metabolism. Antipyrine elimination and serum zinc concentrations were not correlated. 4. Leucocyte zinc concentrations and antipyrine clearance were not influenced by the severity of liver dysfunction, as assessed by using the Child Turcotte classification. 5. These results suggest that tissue zinc depletion in some patients with hepatic cirrhosis may explain in part the impaired capacity to metabolize drugs.

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