Controlled release of curcumin from thiolated starch-coated iron oxide magnetic nanoparticles: An in vitro evaluation

2017 ◽  
Vol 66 (7) ◽  
pp. 349-358 ◽  
Author(s):  
Chinmayee Saikia ◽  
Monoj K. Das ◽  
Anand Ramteke ◽  
Tarun K. Maji
Drug Research ◽  
2017 ◽  
Vol 68 (05) ◽  
pp. 280-285 ◽  
Author(s):  
Marziyeh Salehiabar ◽  
Hamed Nosrati ◽  
Soodabeh Davaran ◽  
Hossein Danafar ◽  
Hamidreza Manjili

AbstractNatural L-aspartic acid coated iron oxide magnetic nanoparticles (Asp@IONPs) were prepared by a one pot, in-situ and green co–precipitation method in an aqueous medium. Functionalized iron oxide magnetic nanoparticles (IONPs) were characterized by Vibrating Sample Magnetometer (VSM), X-ray diffraction (XRD), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM) and Transmission electron microscopy (TEM) techniques. Cellular toxicity of IONPs was also investigated on HEK-293 cell lines. The results showed that the zeta potential of Asp@IONPs was about −21.1 mV and the average size was 17.80±3.09 nm. Cell toxicity results show that as prepared IONPs are biocompatible. Asp@IONPs show the possibility of using these nanoparticles in the development of in vitro and in vivo biomedical fields due to do not possess a toxic effect, good ζ-potential and related small and narrow size distribution.


Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2026
Author(s):  
Cristian Iacoviță ◽  
Ionel Fizeșan ◽  
Stefan Nitica ◽  
Adrian Florea ◽  
Lucian Barbu-Tudoran ◽  
...  

Increasing the biocompatibility, cellular uptake, and magnetic heating performance of ferromagnetic iron-oxide magnetic nanoparticles (F-MNPs) is clearly required to efficiently induce apoptosis of cancer cells by magnetic hyperthermia (MH). Thus, F-MNPs were coated with silica layers of different thicknesses via a reverse microemulsion method, and their morphological, structural, and magnetic properties were evaluated by multiple techniques. The presence of a SiO2 layer significantly increased the colloidal stability of F-MNPs, which also enhanced their heating performance in water with almost 1000 W/gFe as compared to bare F-MNPs. The silica-coated F-MNPs exhibited biocompatibility of up to 250 μg/cm2 as assessed by Alamar Blues and Neutral Red assays on two cancer cell lines and one normal cell line. The cancer cells were found to internalize a higher quantity of silica-coated F-MNPs, in large endosomes, dispersed in the cytoplasm or inside lysosomes, and hence were more sensitive to in vitro MH treatment compared to the normal ones. Cellular death of more than 50% of the malignant cells was reached starting at a dose of 31.25 μg/cm2 and an amplitude of alternating magnetic field of 30 kA/m at 355 kHz.


2021 ◽  
pp. 089270572098557
Author(s):  
M Abu-Abdeen ◽  
O Saber ◽  
E Mousa

A solvent thermal method which depends on a thermal process under critical temperature and pressure was used to prepare cobalt iron oxide magnetic nanoparticles with a molar ratio 2. The prepared particles were in the form of nanoparticles with diameter ranging from 5 to 10 nm and with amorphous structure. Magnetic hysteresis behavior with saturation magnetization 36.31 emu/g and coercivity 4 Oe were observed for the nanoparticles. Polyvinyl alcohol was loaded with different concentrations of cobalt iron oxide nanoparticles using casting technique. Hysteresis loops for the polymer films were observed and both the saturation magnetization and coercivity were increased from 0.36 to 16.03 emu/g and 115 to 293 Oe for samples containing 5 and 20 wt% of nanoparticles, respectively. The elastic modulus of films was increased from 2.7 to 4.9 GPa for unloaded and loaded samples with 20 wt%, respectively. The storage modulus of the polymer films was found to obey the percolation behavior.


Author(s):  
Chang-Mao Hung ◽  
Chiu-Wen Chen ◽  
Yu-Zhe Jhuang ◽  
Cheng-Di Dong

AbstractIn this study, the oxidation of methylene blue (MB) over iron oxide magnetic nanoparticles (Fe


2013 ◽  
Vol 779-780 ◽  
pp. 1674-1677 ◽  
Author(s):  
Dan Lian Huang ◽  
Guang Ming Zeng ◽  
Piao Xu ◽  
Cui Lai ◽  
Mei Hua Zhao ◽  
...  

Immobilized microbe technologies are expected to be effectively used in wastewater treatment. Removal of heavy-metals from wastewater by immobilized Phanerochaete chrysosporium (Pc) with Ca-alginate and iron oxide magnetic nanoparticles (MNPs) was studied. The results showed that a biosorbent as Pc immobilized by Ca-alginate and iron oxide magnetic nanoparticles was successfully developed. And the iron oxide magnetic nanoparticles played an important role in the increase of biosorption capacity of Pc. Energy dispersive spectrometer (EDS) analysis confirmed that metal ions adsorbed to the surface of the biosorbents were partly transmitted to the interior of biosorbents, mainly embedded with iron oxide nanoparticles and Ca-alginate. Moreover, it was found that MNPs-Ca-alginate immobilized Pc showed a good affinity to various heavy metals, such as Pb(II), Zn(II), Cd(II) or Mg(II) and so on. The results proved the high efficiency of the biosorbents for heavy-metal removal and its potential application in the treatment of metal-containing wastewater.


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