Common genetic variants of homocysteine metabolism in ischemic stroke: a case-control study

2005 ◽  
Vol 12 (8) ◽  
pp. 614-618 ◽  
Author(s):  
M. Linnebank ◽  
M. Montenarh ◽  
H. Kolsch ◽  
A. Linnebank ◽  
K. Schnez ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Genetic Variants ◽  
Case Control Study ◽  
Case Control ◽  
Common Genetic Variants ◽  
Control Study

Association between CPR-related genetic variants and risk of ischemic stroke: a nested case-control study

2019 ◽  
Vol 41 (12) ◽  
pp. 1090-1096
Author(s):  
Yao Zhu ◽  
Shu-Chang Hu ◽  
Pei-Wen Zheng ◽  
Ming-Juan Jin ◽  
Meng-Ling Tang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Genetic Variants ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Control Study

scholarly journals Relation of Genetic Variation in the Gene Coding for C-Reactive Protein with Its Plasma Protein Concentrations: Findings from the Women’s Health Initiative Observational Cohort

2009 ◽  
Vol 55 (2) ◽  
pp. 351-360 ◽  
Author(s):  
Cathy C Lee ◽  
Nai-chieh Yuko You ◽  
Yiqing Song ◽  
Yi-Hsiang Hsu ◽  
JoAnn Manson ◽  
...  
Keyword(s):  
Genetic Variants ◽  
Case Control Study ◽  
Geometric Mean ◽  
Case Control ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Health Initiative ◽  
Common Genetic Variants ◽  
Observational Cohort ◽  
Control Study

Abstract Background: Although common genetic variants of the CRP gene (C-reactive protein, pentraxin related) have been associated with plasma concentrations of high-sensitivity CRP (hsCRP) in several cohorts of European Americans, relatively few studies have comprehensively assessed this association in well-characterized multiethnic populations. Methods: In a case–control study of diabetes nested in the Women’s Health Initiative Observational Cohort, we comprehensively evaluated the association of genetic variation in CRP with plasma hsCRP concentrations. Thirteen haplotype-tagging single-nucleotide polymorphisms (tSNPs) were identified and subsequently genotyped in 3782 postmenopausal women. Results: The allele frequencies for these tSNPs and the haplotype blocks defined by these tSNPs varied significantly by ethnic group (P < 0.0001). Consistent with prior studies of whites, rs3093068, rs1130864, and rs1417938 were significantly associated with higher hsCRP concentrations (geometric-mean increase per minor-allele change, 1.20–1.25 mg/L), and rs1205 and rs1800947 were significantly associated with lower hsCRP values (decrease of 1.28–1.48 mg/L). The associations with rs3093068 and rs1205 appeared to be stronger in Asians/Pacific Islanders than in whites (geometric-mean increase, 1.65 mg/L vs 1.25 mg/L, respectively). Minor alleles at rs3093075 and rs3093059 were associated with substantially increased hsCRP concentrations, whereas rs1800947 was associated with lower hsCRP values. All haplotype-based association results tended to be consistent with the associations seen with single CRP SNPs. Conclusions: Our large multiethnic case–control study of postmenopausal women provides evidence that common genetic variants in the CRP gene are substantially associated with plasma hsCRP concentrations in this case–control subcohort. The data also suggest ethnic variations in these associations.

scholarly journals Correlation between matrix metalloproteinase-2 polymorphisms and first and recurrent atherosclerotic ischemic stroke events: a case–control study

2021 ◽  
Vol 49 (6) ◽  
pp. 030006052110229
Author(s):  
Ying Li ◽  
Qing-rong Ouyang ◽  
Juan Li ◽  
Xiao-rong Chen ◽  
Lin-lin Li ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Matrix Metalloproteinase ◽  
Chinese Population ◽  
Case Control Study ◽  
Case Control ◽  
Matrix Metalloproteinase 2 ◽  
Odds Ratios ◽  
Control Study

Objective To determine the associations between matrix metalloproteinase-2 (MMP-2, encoded by the MMP2 gene) 1306C/T and 735C/T polymorphisms and first and recurrent ischemic stroke in a Chinese population. Methods Patients with first and recurrent ischemic stroke were included. Serum MMP-2 was measured, and MMP2 1306C/T and 735C/T polymorphisms were detected. The associations between MMP2 1306C/T and 735C/T polymorphisms and first and recurrent ischemic stroke were analyzed. Results Serum MMP-2 in patients with first and recurrent ischemic stroke was significantly higher compared with controls, and patients with recurrent ischemic stroke had higher MMP-2 than those with first ischemic stroke. The frequency of the CC genotype and C allele of MMP2 735C/T was highest in patients with recurrent ischemic stroke, followed by patients with first ischemic stroke, and controls. Conversely, the genotype and allele of MMP2 1306C/T did not significantly differ between groups. The CC genotype of MMP2 735C/T was independently associated with first and recurrent ischemic stroke (odds ratios = 1.45 and 1.64, respectively), as was the C allele of MMP2 735C/T (odds ratios = 1.68 and 1.77, respectively). Conclusions The CC genotype and C allele of MMP2 735C/T were associated with first and recurrent ischemic stroke in a Chinese population.

scholarly journals The impact of genetic variants inIL1R2on cervical cancer risk among Uygur females from China: A case-control study

2018 ◽  
Vol 7 (1) ◽  
pp. e00516 ◽  
Author(s):  
Fanglin Niu ◽  
Tianchang Wang ◽  
Jing Li ◽  
Mengdan Yan ◽  
Dianzhen Li ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Case Control Study ◽  
Case Control ◽  
Cervical Cancer Risk ◽  
The Impact ◽  
Control Study

scholarly journals Genetic Variants in PTGS1 and NOS3 Genes Increase the Risk of Upper Gastrointestinal Bleeding: A Case–Control Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Marcela Forgerini ◽  
Gustavo Urbano ◽  
Tales Rubens de Nadai ◽  
Sabrina Setembre Batah ◽  
Alexandre Todorovic Fabro ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastrointestinal Bleeding ◽  
Genetic Variants ◽  
Case Control Study ◽  
Upper Gastrointestinal Bleeding ◽  
Case Control ◽  
Gastrointestinal Disorders ◽  
Increased Risk ◽  
Upper Gastrointestinal ◽  
Control Study

Objective: To assess the association between PTGS1 and NOS3 variant alleles and the risk to develop upper gastrointestinal bleeding (UGIB) secondary to complicated peptic disease.Methods: A case–control study was conducted in a Brazilian complex hospital from July 2016 to March 2020. Case: Patients with UGIB diagnosis. Control: Patients admitted for surgery not related to gastrointestinal disorders. Variables: UGIB (outcome), genetic variants in PTGS1 and NOS3 genes (independent), and sex, age, schooling, ethnicity, previous history of gastrointestinal disorders, Helicobacter pylori serology, comorbidity, drug therapy, and lifestyle (confounding). The single-nucleotide polymorphisms (SNPs) of the PTSG1 gene (rs1330344, rs3842787, rs10306114, and rs5788) and NOS3 gene (rs2070744 and rs1799983) were determined using the real-time polymerase chain reaction. Helicobacter pylori serology was determined through the chemiluminescence technique. Logistic regression models were built and deviations of allelic frequencies from Hardy–Weinberg equilibrium were verified.Results: 200 cases and 706 controls were recruited. Carriers of the AG genotype of rs10306114 (OR: 2.55, CI 95%: 1.13–5.76) and CA + AA genotypes of rs5788 (OR: 2.53, CI 95%: 1.14–5.59) were associated with an increased risk for the UGIB development. In nonsteroidal anti-inflammatory drugs (NSAIDs) users, the six variants evaluated modified the magnitude of the risk of UGIB, whereas in low-dose aspirin (LDA) users, an increased risk of UGIB was observed for four of them (rs1330344, rs10306114, rs2070744, and rs1799983). Personal ulcer history (p-value: < 0.001); Helicobacter pylori infection (p-value: < 0.011); NSAIDs, LDA, and oral anticoagulant use (p-value: < 0.001); and alcohol intake (p-value: < 0.001) were also identified as independent risk factors for UGIB.Conclusion: This study presents two unprecedented analyses within the scope of the UGIB (rs10306114 and rs2070744), and our findings showing an increased risk of UGIB in the presence of the genetic variants rs10306114 and rs5788, regardless of the drug exposure. Besides, the presence of the evaluated variants might modify the magnitude of the risk of UGIB in LDA/NSAIDs users. Therefore, our data suggest the need for a personalized therapy and drug use monitoring in order to promote patient safety.

Sign in / Sign up

Export Citation Format

Share Document