Quercetin Antagonizes Esophagus Cancer by Modulating miR-1-3p/TAGLN2 Pathway-Dependent Growth and Metastasis

2021 ◽  
pp. 1-10
Author(s):  
Yuyin Wang ◽  
Xia Chen ◽  
Jun Li ◽  
Chenmei Xia
Keyword(s):  
Esophagus Cancer ◽  
Dependent Growth

scholarly journals Toxic Animal-Based Medicinal Materials Can Be Effective in Treating Endometriosis: A Scoping Review

Toxins ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 145
Author(s):  
Su-In Hwang ◽  
Young-Jin Yoon ◽  
Soo-Hyun Sung ◽  
Ki-Tae Ha ◽  
Jang-Kyung Park
Keyword(s):  
Side Effects ◽  
Clinical Studies ◽  
Malignant Tumors ◽  
Experimental Studies ◽  
Herbal Medicines ◽  
Treatment Method ◽  
Reproductive Age ◽  
Dependent Growth ◽  
Gynecological Disorder ◽  
Preclinical And Clinical Studies

Animal toxins and venoms have recently been developed as cancer treatments possessing tumor cell growth-inhibitory, antiangiogenesis, and proapoptotic effects. Endometriosis is a common benign gynecological disorder in reproductive-age women, and no definite treatment for this disorder is without severe side effects. As endometriosis and malignant tumors share similar characteristics (progressive, invasive, estrogen-dependent growth, and recurrence), animal toxins and venoms are thought to be effective against endometriosis. The objective of this study was to outline studies using toxic animal-based medicinal materials (TMM) as endometriosis treatment and to explore its clinical applicability. Preclinical and clinical studies using TMM were searched for in four databases from inception to October 2020. A total of 20 studies of TMM on endometriosis were included. In eight clinical studies, herbal medicines containing TMM were effective in relieving symptoms of endometriosis, with no side effects. In twelve experimental studies, the main therapeutic mechanisms of TMM against endometriosis were proapoptotic, antiangiogenesis, estrogen level-reducing, and possible anti-inflammatory effects. TMM are thus considered promising sources for the development of an effective treatment method for endometriosis. Further studies are needed to clarify the therapeutic mechanism of TMM against endometriosis and to provide sufficient grounds for clinical application.

Simulation of Cell Cycle Dependent Growth and Metabolism in Animal Cell Fermentation

1995 ◽  
Vol 28 (3) ◽  
pp. 326-329
Author(s):  
B. Szperalski ◽  
F. Geipel ◽  
U. Behrendt ◽  
J. Wahl
Keyword(s):  
Cell Cycle ◽  
Animal Cell ◽  
Dependent Growth ◽  
Cycle Dependent

scholarly journals A microbiota–root–shoot circuit favours Arabidopsis growth over defence under suboptimal light

Nature Plants ◽  
2021 ◽  
Author(s):  
Shiji Hou ◽  
Thorsten Thiergart ◽  
Nathan Vannier ◽  
Fantin Mesny ◽  
Jörg Ziegler ◽  
...  
Keyword(s):  
Stress Responses ◽  
Photosynthetically Active Radiation ◽  
Bacterial Community Composition ◽  
Light Condition ◽  
Long Distance ◽  
Active Radiation ◽  
Light Manipulation ◽  
Growth Deficiency ◽  
Dependent Growth ◽  
Control Light

AbstractBidirectional root–shoot signalling is probably key in orchestrating stress responses and ensuring plant survival. Here, we show that Arabidopsis thaliana responses to microbial root commensals and light are interconnected along a microbiota–root–shoot axis. Microbiota and light manipulation experiments in a gnotobiotic plant system reveal that low photosynthetically active radiation perceived by leaves induces long-distance modulation of root bacterial communities but not fungal or oomycete communities. Reciprocally, microbial commensals alleviate plant growth deficiency under low photosynthetically active radiation. This growth rescue was associated with reduced microbiota-induced aboveground defence responses and altered resistance to foliar pathogens compared with the control light condition. Inspection of a set of A. thaliana mutants reveals that this microbiota- and light-dependent growth–defence trade-off is directly explained by belowground bacterial community composition and requires the host transcriptional regulator MYC2. Our work indicates that aboveground stress responses in plants can be modulated by signals from microbial root commensals.

scholarly journals In Situ Hyperspectral Raman Imaging: A New Method to Investigate Sintering Processes of Ceramic Material at High-temperature

2019 ◽  
Vol 9 (7) ◽  
pp. 1310 ◽  
Author(s):  
Kerstin Hauke ◽  
Johannes Kehren ◽  
Nadine Böhme ◽  
Sinje Zimmer ◽  
Thorsten Geisler
Keyword(s):  
High Temperature ◽  
Raman Imaging ◽  
In Situ Studies ◽  
Kinetic Information ◽  
Novel Approach ◽  
In Situ Investigation ◽  
Dependent Growth ◽  
Micrometer Scale ◽  
Sintering Processes

In the last decades, Raman spectroscopy has become an important tool to identify and investigate minerals, gases, glasses, and organic material at room temperature. In combination with high-temperature and high-pressure devices, however, the in situ investigation of mineral transformation reactions and their kinetics is nowadays also possible. Here, we present a novel approach to in situ studies for the sintering process of silicate ceramics by hyperspectral Raman imaging. This imaging technique allows studying high-temperature solid-solid and/or solid-melt reactions spatially and temporally resolved, and opens up new avenues to study and visualize high-temperature sintering processes in multi-component systems. After describing in detail the methodology, the results of three application examples are presented and discussed. These experiments demonstrate the power of hyperspectral Raman imaging for in situ studies of the mechanism(s) of solid-solid or solid-melt reactions at high-temperature with a micrometer-scale resolution as well as to gain kinetic information from the temperature- and time-dependent growth and breakdown of minerals during isothermal or isochronal sintering.

Experimental observation of viscoelastic fluid–structure interactions

2017 ◽  
Vol 813 ◽  
Author(s):  
Anita A. Dey ◽  
Yahya Modarres-Sadeghi ◽  
Jonathan P. Rothstein
Keyword(s):  
Flow Instability ◽  
Reynolds Numbers ◽  
Time Dependent ◽  
Flexible Structure ◽  
Fluid Inertia ◽  
Fluid Structure Interactions ◽  
Periodic Oscillations ◽  
Fluid Structure ◽  
Dependent Growth ◽  
First Time

It is well known that when a flexible or flexibly mounted structure is placed perpendicular to the flow of a Newtonian fluid, it can oscillate due to the shedding of separated vortices. Here, we show for the first time that fluid–structure interactions can also be observed when the fluid is viscoelastic. For viscoelastic fluids, a flexible structure can become unstable in the absence of fluid inertia, at infinitesimal Reynolds numbers, due to the onset of a purely elastic flow instability. Nonlinear periodic oscillations of the flexible structure are observed and found to be coupled to the time-dependent growth and decay of viscoelastic stresses in the wake of the structure.

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