scholarly journals Toxic Animal-Based Medicinal Materials Can Be Effective in Treating Endometriosis: A Scoping Review

Toxins ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 145
Author(s):  
Su-In Hwang ◽  
Young-Jin Yoon ◽  
Soo-Hyun Sung ◽  
Ki-Tae Ha ◽  
Jang-Kyung Park
Keyword(s):  
Side Effects ◽  
Clinical Studies ◽  
Malignant Tumors ◽  
Experimental Studies ◽  
Herbal Medicines ◽  
Treatment Method ◽  
Reproductive Age ◽  
Dependent Growth ◽  
Gynecological Disorder ◽  
Preclinical And Clinical Studies

Animal toxins and venoms have recently been developed as cancer treatments possessing tumor cell growth-inhibitory, antiangiogenesis, and proapoptotic effects. Endometriosis is a common benign gynecological disorder in reproductive-age women, and no definite treatment for this disorder is without severe side effects. As endometriosis and malignant tumors share similar characteristics (progressive, invasive, estrogen-dependent growth, and recurrence), animal toxins and venoms are thought to be effective against endometriosis. The objective of this study was to outline studies using toxic animal-based medicinal materials (TMM) as endometriosis treatment and to explore its clinical applicability. Preclinical and clinical studies using TMM were searched for in four databases from inception to October 2020. A total of 20 studies of TMM on endometriosis were included. In eight clinical studies, herbal medicines containing TMM were effective in relieving symptoms of endometriosis, with no side effects. In twelve experimental studies, the main therapeutic mechanisms of TMM against endometriosis were proapoptotic, antiangiogenesis, estrogen level-reducing, and possible anti-inflammatory effects. TMM are thus considered promising sources for the development of an effective treatment method for endometriosis. Further studies are needed to clarify the therapeutic mechanism of TMM against endometriosis and to provide sufficient grounds for clinical application.

scholarly journals Natural Polyphenols Targeting Senescence: A Novel Prevention and Therapy Strategy for Cancer

2020 ◽  
Vol 21 (2) ◽  
pp. 684 ◽  
Author(s):  
Yan Bian ◽  
Juntong Wei ◽  
Changsheng Zhao ◽  
Guorong Li
Keyword(s):  
Side Effects ◽  
Tumor Microenvironment ◽  
Cancer Prevention ◽  
Human Health ◽  
Clinical Studies ◽  
Natural Polyphenols ◽  
Therapy Strategy ◽  
Anti Cancer ◽  
Preclinical And Clinical Studies ◽  
Prevention And Therapy

Cancer is one of the most serious diseases endangering human health. In view of the side effects caused by chemotherapy and radiotherapy, it is necessary to develop low-toxic anti-cancer compounds. Polyphenols are natural compounds with anti-cancer properties and their application is a considerable choice. Pro-senescence therapy is a recently proposed anti-cancer strategy and has been shown to effectively inhibit cancer. It is of great significance to clarify the mechanisms of polyphenols on tumor suppression by inducing senescence. In this review, we delineated the characteristics of senescent cells, and summarized the mechanisms of polyphenols targeting tumor microenvironment and inducing cancer cell senescence for cancer prevention and therapy. Although many studies have shown that polyphenols effectively inhibit cancer by targeting senescence, it warrants further investigation in preclinical and clinical studies.

scholarly journals A Review Study on the Effect of Iranian Herbal Medicines on Opioid Withdrawal Syndrome

2015 ◽  
Vol 20 (4) ◽  
pp. 302-309 ◽  
Author(s):  
Marzieh Ebrahimie ◽  
Mahmoud Bahmani ◽  
Hedayatollah Shirzad ◽  
Mahmoud Rafieian-Kopaei ◽  
Kourosh Saki
Keyword(s):  
Side Effects ◽  
Medicinal Plants ◽  
Withdrawal Syndrome ◽  
Experimental Studies ◽  
Herbal Medicines ◽  
Morphine Withdrawal ◽  
Mentha Piperita ◽  
Synthetic Drugs ◽  
Important Challenge ◽  
Opioid Withdrawal Syndrome

Addiction is a chronic and recurring disease that recurrence phenomenon is the most important challenge in treatment of this disease. Recent experiences have shown that synthetic drugs have undesirable side effects. Recent studies on medicinal plants have shown that they might be effective in treatment of different stages of addiction with lower side effects and costs. The aim of this study was to review the effects of medicinal plants in the treatment of morphine addiction in experimental animals. In this review article, by using keywords of morphine, withdrawal, and plants or herbal medicine in databases of indexing cites, desired articles were obtained since 1994. Inclusion criteria for selecting articles were the articles related to application of medicinal plants in decreasing symptoms resulting from morphine withdrawal were selected. Results of this study on experimental studies have shown that medicinal plants such as Trachyspermum copticum L and Melissa officinalis decrease the symptoms of withdrawal syndrome in a dose-dependent. Also, medicinal plants like Avena sativa, Hypericum perforatu, Passiflora incarnate, Valeriana officinalis, Satureja hortensis L, and Mentha piperita can have effects on behavior, emotions, and other problems of addicts, decreasing withdrawal symptoms. Results of this study showed that medicinal plants can be effective in controlling deprivation, decreasing dependency creation, and possibly detoxification of opioid addicts.

scholarly journals Review of Clinical Studies on Karnini Yonivyapad vis-a-vis Cervical Erosion

2021 ◽  
pp. 64-70
Author(s):  
Tiwari Richa ◽  
Pushpalatha Buduru ◽  
Bharathi K
Keyword(s):  
Side Effects ◽  
Clinical Studies ◽  
Vaginal Discharge ◽  
Age Groups ◽  
Reproductive Age ◽  
Common Condition ◽  
Women Of Reproductive Age ◽  
Secondary Infertility ◽  
External Application ◽  
Modern System

Cervical erosion is a most common condition seen in women of reproductive age groups. Its prevalence is between 50-85% of all the gynecological conditions. In modern system of medicine diathermy cauterization or cryosurgery are generally advised for treatment but these procedures have their own side effects and complications like excessive vaginal discharge, secondary infertility, bleeding per vagina, infection, stenosis etc.. So still it is one of the most troublesome diseases for patients as well as for gynaecologists. Due to the serious consequences of the disease it is the need of hour to develop an accurate therapy for pathological erosion. This is an attempt to throw some more light on the clinical studies on cervical erosion. On cervical erosion total eight clinical studies in PG level has been completed out at National Institute of Ayurveda, Jaipur. Out of eight clinical studies, five works on Kshara Karma Karma (application of caustics), two works on Agnikarma (cauterization), two works on Kushthadi churna, one work on kushthadi varti, one work on Virechana. The drugs and procedures used in the research studies have chedana, Bhedan, Sosahana, Lekhana, Shodhana, Shothaghna, Raktprasadana, Vrana Shodhana (ulcer cleansing), Vrana Ropana (ulcer healer), krimihara, Kushtaghna (anti-dermatosis), Kandughna (anti-pruritic) properties. Maximum studies are carried out on Bahya Parimarjana (external application).

scholarly journals The importance of androgen receptors in breast cancer

2021 ◽  
Author(s):  
Irina Niță ◽  
Cornelia Nițipir ◽  
Ștefania Andreea Toma ◽  
Alexandra Maria Limbău ◽  
Edvina Pîrvu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mechanism Of Action ◽  
Clinical Studies ◽  
Triple Negative ◽  
Recent Literature ◽  
Malignant Tumors ◽  
Molecular Subtype ◽  
Independent Prognostic Marker ◽  
Preclinical And Clinical Studies ◽  
Common Malignancy

Background and aim. Breast cancer (BC) is the most common malignancy among women worldwide, and one of the leading causes of cancer-related deaths in females. For the breast malignant tumors there are numerous targeted therapies, depending on the receptors expressed. Regulating the process of epithelial-mesenchyme transcription, the steroid nuclear receptors are important in invasion and progression of BC cells. Till now, it is known that androgen receptor (AR) is present in about 60-80% of BC cells but, unfortunately, there is no targeted therapy available yet.  Methods. We revised the recent literature that included the AR mechanism of action in patients diagnosed with breast cancer, the preclinical, retrospective and clinical studies and the aspects related to the prognosis of these patients, depending on the molecular subtype. Results. A total of 12 articles were eligible for this review. AR positivity was assessed using immunohistochemistry. Herein, neither 1 nor 10% cut-points were robustly prognostic. AR was an independent prognostic marker of BC outcome, especially in triple negative BC group. Conclusion. AR is a potential targeted pathway which can improve the prognostic of AR positive patients with BC. Further preclinical and clinical studies are necessary to clarify the mechanism of action and to establish the drugs which can be used, either alone or in combination.

scholarly journals Antioxidant and Anti-Inflammatory Properties of Mastiha: A Review of Preclinical and Clinical Studies

Antioxidants ◽  
2019 ◽  
Vol 8 (7) ◽  
pp. 208 ◽  
Author(s):  
Papada ◽  
Kaliora
Keyword(s):  
Clinical Studies ◽  
Research Evidence ◽  
Case Reports ◽  
English Literature ◽  
Experimental Studies ◽  
Individual Case ◽  
Search Terms ◽  
Large Populations ◽  
Anti Inflammatory ◽  
Preclinical And Clinical Studies

Nowadays both scientists and consumers have an increasing interest for natural products as preventing and healing factors without side effects. Mastiha, is a natural product of the Mediterranean basin with several health benefits as investigated the last decades. The present review summarises the research evidence from preclinical and clinical studies regarding the antioxidant and anti-inflammatory potential of Mastiha. MEDLINE, COHRANE and search terms “Mastiha”, “Mastic gum”, “Chios mastic” and “Pistacia lentiscus” were used. We limited our search by selecting only articles written in English literature, published between 2003 and 2019 that were experimental studies on Mastiha resinous exudate (review articles and individual case reports were excluded). Additional searches were performed using “oxidative stress” and “inflammation”. A total of 19 studies met our criteria and were included in this review. Currently, there are more preclinical than clinical data available. Taken all together, the antioxidant potential of Mastiha is most probably owed to the inhibition of protein kinase, while its anti-inflammatory capacity may be the result of the inhibition of NF-κB activation. Further clinical studies in large populations are necessary.

The analgesic potential of cannabinoids

2018 ◽  
Vol 5 (6) ◽  
pp. 341-357 ◽  
Author(s):  
Jaseena Elikottil, MBBS ◽  
Pankaj Gupta, MD ◽  
Kalpna Gupta, PhD
Keyword(s):  
Side Effects ◽  
Signaling Pathways ◽  
Clinical Studies ◽  
Severe Pain ◽  
Experimental Studies ◽  
Opioid Therapy ◽  
Current Data ◽  
Chronic Opioid Therapy ◽  
Analgesic Agents ◽  
History Of

Historically and anecdotally cannabinoids have been used as analgesic agents. In recent years, there has been an escalating interest in developing cannabis-derived medications to treat severe pain. This review provides an overview of the history of cannabis use in medicine, cannabinoid signaling pathways, and current data from preclinical as well as clinical studies on using cannabinoids as potential analgesic agents. Clinical and experimental studies show that cannabis-derived compounds act as antiemetic, appetite modulating, and analgesic agents. However, the efficacy of individual products is variable and dependent upon the route of administration. As opioids are the only therapy for severe pain, analgesic ability of cannabinoids may provide a much-needed alternative to opioids. Moreover, cannabinoids act synergistically with opioids and act as opioid sparing agents, allowing lower doses and fewer side effects from chronic opioid therapy. Thus, rational use of cannabis-based medications deserves serious consideration to alleviate the suffering of patients due to severe pain.

New Trends On Biological Activities And Clinical Studies Of Quinolinic Analogues: A Review

2021 ◽  
Vol 22 ◽  
Author(s):  
Sandra Elizabeth Barbosa da Silva ◽  
José Arion da Silva Moura ◽  
Tiago Rafael de Sousa Nunes ◽  
Ivan da Rocha Pitta ◽  
Marina Galdino da Rocha Pitta
Keyword(s):  
Side Effects ◽  
Clinical Studies ◽  
Biological Activities ◽  
Mechanisms Of Action ◽  
Antimalarial Drugs ◽  
New Drugs ◽  
Phase Iii ◽  
Synthetic Compounds ◽  
Preclinical And Clinical Studies ◽  
Natural And Synthetic

: The quinolinic ring, present in several molecules, has a great diversity of biological activities. Therefore, this ring is in the structure composition of several candidates of drugs in preclinical and clinical studies, thus, it is necessary the grouping of these results to facilitate the design of new drugs. For this reason, some of the activities were selected for this review, such as: antimalarial, antimicrobial, anticancer, anti-inflammatory, antidiabetic, anti-rheumatic and antiviral. All publications of scientific articles chosen are dated between 2000 and 2020. In addition to presenting the structures of some natural and synthetic compounds with their activities, we list the clinical studies of phases III and IV of antimalarial drugs containing the quinoline nucleus and phase III clinical studies of hydroxychloroquine and chloroquine to assess their possible role in COVID-19. Finally, we show some of the mechanisms of action, as well as the side effects of some of the quinolinic derivatives.

scholarly journals Complementary and Alternative Medicine for Dysmenorrhea Caused by Endometriosis: A Review of Utilization and Mechanism

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Ying Guo ◽  
Fang-Yuan Liu ◽  
Ying Shen ◽  
Jia-Yue Xu ◽  
Liang-Zhen Xie ◽  
...  
Keyword(s):  
Alternative Medicine ◽  
Complementary And Alternative Medicine ◽  
Adverse Reactions ◽  
High Efficiency ◽  
Experimental Studies ◽  
Reproductive Age ◽  
Secondary Dysmenorrhea ◽  
Gynecological Disorder ◽  
Surgical Treatments ◽  
Complementary And Alternative

Endometriosis (EM) is a common and benign estrogen-dependent gynecological disorder among women of reproductive age, and secondary dysmenorrhea is one of the more severe symptoms. However, the mechanism behind the development of dysmenorrhea is poorly understood, and there is a lack of effective methods for diagnosing and treating EM dysmenorrhea. In this regard, complementary and alternative medicine (CAM) has recently come into widespread use due to its limited adverse reactions and high efficiency. This review updates the progress of CAM in the treatment of EM dysmenorrhea and seeks to identify the therapeutic efficacy as well as the mechanisms behind these effects based on the available clinical and experimental studies. According to the literature, CAM therapy for EM dysmenorrhea, including herbs (herbal prescriptions, extracts, and patents), acupuncture, and Chinese herbal medicine enema (CHM enema), is effective for relieving dysmenorrhea with fewer unpleasant side effects when compared to hormonal and surgical treatments. In addition, we discuss and analyze the existing gaps in the literature. We hope to provide some instructive suggestions for clinical treatment and experimental research in the future.

The effect of the herbal medicine on severity of cyclic mastalgia: a systematic review and meta-analysis

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Shirin Osouli Tabrizi ◽  
Shahla Meedya ◽  
Nafiseh Ghassab-Abdollahia ◽  
Zahra Ghorbani ◽  
Leila Jahangiry ◽  
...  
Keyword(s):  
Systematic Review ◽  
Side Effects ◽  
Herbal Medicine ◽  
Meta Analysis ◽  
Scientific Information ◽  
Herbal Medicines ◽  
Reproductive Age ◽  
Dichotomous Data ◽  
Drug Treatments ◽  
Information Database

Abstract Cyclic mastalgia is one of the most prevalent problems in women of reproductive age and sometimes it is so severe that it influences their activities and requires treatment. The available drug treatments for mastalgia are not satisfactory and most patients have inclined towards complementary and alternative medicine including herbal medicines. Therefore, in order to evaluate the effectiveness and side effects of herbal medicines conducting systematic review studies and meta-analysis seems essential, thus this systematic review was conducted with the aim of determining the effect of herbal medicines on cyclic mastalgia and its probable side effects. The databases of Pubmed, Medline, Embase, ProQuest, Scopus, Web of science, Complementary Medicine Database, SID (Scientific information database), Magiran and Iranmedex were searched from 1997 to 2020 and limited only for English and Persian languages. The studies were appraised according to the Cochrane Collaboration’s tool. Meta-analysis was conducted using RevMan software. Standardized mean difference (SMD) was calculated to assess an overall estimate of effectiveness for the continuous data. Odds ratio (OR) was calculated for dichotomous data. Thirty papers were included in the study. Meta-analysis of data demonstrated that herbal medicine was an effective method in reducing the severity of mastalgia compared to the placebo (SMD: −3.26, 95% CI: −5.05 to −1.46, p=0.00004). Subanalysis of data showed no difference between the effectiveness of herbal medicine on the severity of mastalgia compared to the pharmacologic treatment. This research demonstrated efficacy of herbal medicines in alleviating cyclic mastalgia. Therefore, these herbal medicines can be regarded as an alternative treatment for women suffering from cyclic mastalgia. However, due to the limited number of studies in relation to each specific herbal treatment, conducting further studies in this area is recommended.

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