A systematic review of aphasia therapy provided in the early period of post-stroke recovery

Aphasiology ◽  
2021 ◽  
pp. 1-34
Author(s):  
Ryan S. Husak ◽  
Sarah E. Wallace ◽  
Robert C. Marshall ◽  
Evy G. Visch-Brink
Keyword(s):  
Systematic Review ◽  
Early Period ◽  
Stroke Recovery ◽  
Post Stroke ◽  
Aphasia Therapy

scholarly journals 4047 EEG as a Predictor of Post-Stroke Recovery: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 4 (s1) ◽  
pp. 71-71
Author(s):  
Amanda Vatinno ◽  
Viswanathan Ramakrishnan ◽  
Annie Simpson ◽  
Heather Bonilha ◽  
Na Jin Seo
Keyword(s):  
Systematic Review ◽  
Clinical Outcome ◽  
Outcome Measure ◽  
Meta Analysis ◽  
Stroke Recovery ◽  
Lesion Volume ◽  
Behavioral Impairment ◽  
Post Stroke ◽  
Prognostic Accuracy ◽  
Clinical Outcome Measure

OBJECTIVES/GOALS: The objective of this study is to perform a systematic review and meta-analysis on the prognostic utility of electroencephalography (EEG) in stroke recovery. METHODS/STUDY POPULATION: A literature search was conducted using three electronic databases, including PubMed, Scopus, and CINAHL. Key search terms were “EEG,” “stroke,” and “rehabilitation”. Only peer-reviewed journal articles published in English that examined the relationship between EEG and a standardized clinical outcome measure(s) at a later time in stroke patients were included. Two independent raters completed data extraction and assessed methodological quality of the studies with the Downs and Black form. A linear meta-regression was performed across subsets of individual studies that utilized a common clinical outcome measure to determine the association between EEG and clinical outcome while adjusting for sample size and study quality. RESULTS/ANTICIPATED RESULTS: 56 papers met the inclusion criteria and were included in the systematic review. The prognostic value of EEG was evidenced at both the acute and chronic stages of stroke. The addition of EEG enhanced prognostic accuracy more than initial clinical assessment scores and/or lesion volume alone. In the meta-analysis, a subset of 10 papers that utilized the National Institutes of Health Stroke Scale (NIHSS) and a subset of 7 papers that utilized the Modified Rankin Scale (MRS) were included. Analysis demonstrated an association between EEG and the subsequent clinical outcome measures. DISCUSSION/SIGNIFICANCE OF IMPACT: Currently, prognosis is largely based on initial behavioral impairment level. However, post-stroke recovery outcomes are heterogeneous despite similar initial clinical presentations. Uncertain prognosis makes it difficult for clinicians to develop personalized treatment plans for patients. Improved prognosis for recovery may guide clinical management for stroke survivors by helping clinicians determine the maximally efficient course of treatment and care. This study suggests that prognostic accuracy may be enhanced using EEG.

Abstract NS14: Independent Speech and Language Practice with Aphasia Computer Software is an Acceptable Alternative to Face to Face Therapy in the Long Term Post Stroke

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
Rebecca Palmer ◽  
Gail Paterson ◽  
Audrey Delaney ◽  
Helen Hughes ◽  
Pam Enderby
Keyword(s):  
Technical Assistance ◽  
Controlled Trial ◽  
Stroke Recovery ◽  
Speech And Language ◽  
Structured Interviews ◽  
Language Practice ◽  
Face To Face ◽  
Post Stroke ◽  
Acceptable Alternative ◽  
Aphasia Therapy

Background: Speech and language therapy (SLT) for aphasia can be difficult to access in the later stages of stroke recovery, despite evidence of continued improvement with sufficient therapeutic intensity. Computerized aphasia therapy has been reported to be useful for independent language practice, providing new opportunities for continued rehabilitation. The success of this option depends on its acceptability to patients and carers. The purpose of this study was to investigate factors that affect the acceptability of computerized aphasia therapy. Methods: A qualitative study was carried out alongside a pilot randomized controlled trial of computer aphasia therapy versus usual care for people more than 6 months post stroke. A SLT tailored computer exercises to individual needs. Participants practised 3 times a week for 5 months at home with monthly volunteer support. Semi structured interviews were conducted with 14 participants who received the intervention and 10 carers. Questions from a topic guide were presented and answered using picture, gesture, and written support. Interviews were audio recorded, transcribed verbatim and analysed thematically. Three research SLTs identified and cross checked themes and subthemes emerging from the data. Results: Benefits and disadvantages, need for help/support and comparisons with face to face therapy were key themes. The independence, flexibility, and repetition afforded by the computer was viewed as beneficial and the personalised exercises motivated participants to practise. Participants and carers perceived improvements in word finding and confidence talking. Computer practice could cause fatigue and interference with other commitments. Four participants with severe aphasia did not perceive any improvement. Support from carers/volunteers for motivation and technical assistance was seen as important. Participants generally preferred face to face therapy, however, using a computer for independent language practice was viewed as an acceptable alternative. Conclusions: Independent computerized aphasia therapy is acceptable to stroke survivors. Acceptability can be maximised by personalised exercises, access to support and consideration of aphasia severity, fatigue and life style.

scholarly journals Effect of Diabetes on Post-stroke Recovery: A Systematic Narrative Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Seoyon Yang ◽  
Mathieu Boudier-Revéret ◽  
SuYeon Kwon ◽  
Min Yong Lee ◽  
Min Cheol Chang
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Motor Recovery ◽  
Stroke Recovery ◽  
Cochrane Library ◽  
Cognitive Recovery ◽  
Post Stroke ◽  
Patients With Diabetes ◽  
Negative Effect

Background: Patients with stroke often have comorbid diabetes. Considering its detrimental effects on brain function, diabetes may increase the risk of poor recovery.Methods: The aim of this review was to investigate the effect of diabetes on post-stroke recovery by a systematic review. Several specific aspects of post-stroke recovery, including activities of daily living (ADL), motor, cognitive, and quality of life (QOL) recovery, were examined. We searched the PubMed, SCOPUS, Embase, and Cochrane Library databases for relevant studies on the effect of diabetes on post-stroke recovery, published until May 26, 2021. A total of 52,051 potentially relevant articles were identified. After reading the titles and abstracts and assessing their eligibility based on full-text articles, 34 publications were included in this review.Results: Of 29 studies that assessed ADL recovery after stroke, 22 studies suggested that diabetes had a negative effect on recovery of ADL after stroke. Regarding motor recovery, only one out of four studies showed that diabetes had some effect on motor recovery after stroke. Of the two studies on cognitive recovery, one reported that diabetes was an independent predictor of poor cognitive recovery after stroke. Three studies on QOL reported that a poor QOL after stroke was associated with the presence of diabetes.Conclusions: The current review suggests that the post-stroke recovery of ADL seems to be poorer in patients with diabetes than patients without diabetes. Further, there are insufficient data to conclude the effect of diabetes on motor and cognitive recovery, but it may have some influence on the quality of life after stroke.Systematic Review Registration: doi: 10.37766/inplasy2021.11.0032, identifier: INPLASY2021110032.

Therapy of post-stroke depression – a systematic review

2013 ◽  
Vol 10 (02) ◽  
pp. 108-129 ◽  
Author(s):  
W. Gaebel ◽  
W. Wannagat ◽  
J. Zielasek
Keyword(s):  
Systematic Review ◽  
Large Scale ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Placebo Control ◽  
Post Stroke ◽  
Pharmacological Studies ◽  
Post Stroke Depression ◽  
Control Procedures ◽  
Antidepressant Pharmacotherapy

SummaryWe performed a systematic review of randomized placebo-controlled pharmacological and non-pharmacological trials for the therapy and prevention of post-stroke depression that have been published between 1980 and 2011. We initially identified 2 260 records of which 28 studies were finally included into this review. A meta-analytic approach was hampered by considerable differences regarding the kinds of therapeutic regimens and the study durations. Modest effects favoring treatment of post-stroke depression could be found for pharmacological treatment as well as repetitive transcranial magnetic stimulation. For the prevention of post-stroke depression, antidepressant pharmacotherapy showed promising results. However, large-scale studies with better standardized study populations, optimized placebo control procedures in non-pharmacological studies, and replication in larger follow-up studies are still necessary to find the optimal therapeutic regimens to prevent and treat post-stroke depression.

Post-stroke recovery updates

2018 ◽  
Vol 19 (1) ◽  
pp. 53-57
Author(s):  
Ana Maria Bumbea ◽  
Roxana Carmen Dumitraşcu ◽  
Bogdan Ştefan Bumbea ◽  
Anca Emanuela Muşetescu ◽  
Otilia Rogoveanu ◽  
...  
Keyword(s):  
Stroke Recovery ◽  
Post Stroke

LncRNAs a New Target for Post-Stroke Recovery

2020 ◽  
Vol 26 (26) ◽  
pp. 3115-3121
Author(s):  
Jun Yang ◽  
Jingjing Zhao ◽  
Xu Liu ◽  
Ruixia Zhu
Keyword(s):  
Ischemic Stroke ◽  
Microglial Activation ◽  
Vital Role ◽  
Stroke Recovery ◽  
Biological Processes ◽  
Current Development ◽  
Post Stroke ◽  
Cascade Processes ◽  
Non Coding Rnas ◽  
Neuron Injury

LncRNAs (long non-coding RNAs) are endogenous molecules, involved in complicated biological processes. Increasing evidence has shown that lncRNAs play a vital role in the post-stroke pathophysiology. Furthermore, several lncRNAs were reported to mediate ischemia cascade processes include apoptosis, bloodbrain barier breakdown, angiogenesis, microglial activation induced neuroinflammation which can cause neuron injury and influence neuron recovery after ischemic stroke. In our study, we first summarize current development about lncRNAs and post-stroke, focus on the regulatory roles of lncRNAs on pathophysiology after stroke. We also reviewed genetic variation in lncRNA associated with functional outcome after ischemic stroke. Additionally, lncRNA-based therapeutics offer promising strategies to decrease brain damage and promote neurological recovery following ischemic stroke. We believe that lncRNAs will become promising for the frontier strategies for IS and can open up a new path for the treatment of IS in the future.

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