Preoperative platelet distribution width-to-platelet count ratio as a prognostic factor in patients with glioblastoma multiforme

Abstract Background Evidence indicates that preoperative fibrinogen/prealbumin (FPR), neutrophil lymphocyte ratio/prealbumin ratio (NLR/PA) and platelet distribution width-to-platelet count ratio (PDW/PLT) possess prognostic potential in numerous malignancies. However, their roles in bladder cancer remain unclear. In this study, we investigated the association between FPR, NLR/PA versus PDW/PLT and the prognosis in bladder cancer patients. Methods The clinical data of 147 patients with bladder cancer treated in Nantong cancer hospital from January 2009 to August 2014 were retrospectively analyzed. According to ROC curve, the optimal critical value of FPR, NLR/PA and PDW/PLT were 0.1084, 0.1045 and 0.1210 respectively. The patients were followed up for 5 years to observe the survival of the patients, and the clinicopathological data were statistically analyzed. Cox regression analysis was used for univariate and multivariate analysis. Finally, on this basis, the nomogram is constructed for internal verification. Results All patients were followed up for 5 years. A total of 102 patients survived with a survival rate of 69.4%, 45 patients died with a mortality rate of 30.6%. Further stratified analysis showed that the group with low FPR, low NLR/PA and low PDW/PLT had the best prognosis, while the group with high FPR, high NLR/PA and high PDW/PLT had the worst prognosis. Cox multivariate analysis showed that preoperative FPR, NLR/PA and PDW/PLT were independent risk factors for tumor progression (p = 0.007, p = 0.013, p = 0.000). The decrease of FPR, NLR/PA and PDW/PLT can significantly prolong OS and PFS in patients with bladder cancer. In internal validation, the c-index of the nomogram was 0.8140 (95% CI: 0.7577–0.8703). Conclusions Preoperative FPR and NLR/PA versus PDW/PLT can be an independent prognostic factor in bladder cancer patients and are associated with clinicopathological characteristics. They have a specific value in assessing the prognosis of bladder cancer patients.

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Prognostic value of platelet distribution width and mean platelet volume in patients with laryngeal cancer

Future Oncology ◽

10.2217/fon-2020-0658 ◽

2021 ◽

Author(s):

Erliang Guo ◽

Cong Zhang ◽

Lunhua Guo ◽

Kaibin Song ◽

Guohui Wang ◽

...

Keyword(s):

Platelet Count ◽

Laryngeal Cancer ◽

Mean Platelet Volume ◽

Poor Prognosis ◽

Recurrence Free Survival ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Distribution Width ◽

Free Survival ◽

Count Ratio

Aims: To investigate the prognostic relevance of platelet volume indices for survival in laryngeal cancer. Patients & methods: The study included 640 patients with laryngeal cancer. We analyzed the optimal cutoff values through receiver operating characteristic analysis, then analyzed the univariate factor and multivariate variables. Kaplan–Meier curves and log-rank tests were conducted to compare the overall survival (OS) and recurrence-free survival rates between the groups. Results: In multivariate analysis, elevated platelet distribution width (PDW) and PDW/platelet count ratio were significantly correlated with poor prognosis for OS; however, elevated mean platelet volume (MPV) and MPV/platelet count ratio suggested a notable correlation with favorable prognosis for OS. Meanwhile, elevated PDW and decreased MPV were significantly correlated with poor prognosis for recurrence-free survival. Conclusions: Our findings indicate that elevated PDW and decreased MPV could serve as independent biomarkers for worse survival in laryngeal cancer.

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Platelet Distribution Width to Platelet Count Ratio as an Index of Severity of Illness

The Indian Journal of Pediatrics ◽

10.1007/s12098-017-2432-z ◽

2017 ◽

Vol 85 (1) ◽

pp. 10-14

Author(s):

Pragati Purbiya ◽

Zainab Mohammedi Golwala ◽

Ayush Manchanda ◽

V. Sreenivas ◽

Jacob M. Puliyel

Keyword(s):

Platelet Count ◽

Severity Of Illness ◽

Platelet Distribution Width ◽

Distribution Width ◽

Count Ratio ◽

Index Of Severity

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The use of platelet count, mean platelet volume, platelet distribution width, and platecrit levels for predicting survival in respiratory intensive care unit

Annals of Medical Research ◽

10.5455/annalsmedres.2020.04.334 ◽

2021 ◽

Vol 28 (5) ◽

pp. 874

Author(s):

Seda Guzeldag ◽

Zuhal Simsek ◽

Kaniye Aydin

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Platelet Count ◽

Mean Platelet Volume ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Distribution Width ◽

Respiratory Intensive Care Unit

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A pattern of platelet indices as a potential marker for prediction of pre-eclampsia among pregnant women attending a Tertiary Hospital, Ethiopia: A case-control study

PLoS ONE ◽

10.1371/journal.pone.0259543 ◽

2021 ◽

Vol 16 (11) ◽

pp. e0259543

Author(s):

Solomon Gebre Bawore ◽

Wondimagegn Adissu ◽

Berhanu Niguse ◽

Yilma Markos Larebo ◽

Nigussie Abebe Ermolo ◽

...

Keyword(s):

Platelet Count ◽

Pregnant Women ◽

Mean Platelet Volume ◽

Case Control Study ◽

Case Control ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Distribution Width ◽

Platelet Indices ◽

Control Study

Introduction Preeclampsia is the most serious health risk during pregnancy for both the mother and the fetus. Even though platelet parameters are among the proposed biomarkers for the prediction of preeclampsia, the use of its indices in the diagnosis of preeclampsia is not increasing in Ethiopia. There is little information on platelet patterns in preeclampsia and normal pregnancy. The purpose of this study was to determine the pattern of platelet indices in women with preeclampsia in our study setting. Methods A case-control study was conducted among 180 pregnant women who attended anti-natal follow-ups from January 1 to April 3, 2019. An Ethylene Diamine Tetra Acetic Acid anti-coagulated venous blood was collected and analyzed using a hematology analyzer (MINDRAY®-BC-300Plus, Shenzhen China). The SPSS software version 26 was used to run the Mann Whitney U test, Kruskal-Wallis H test, and Kolmogorov-Smirnov normality test, Post-hock test augmented with Benforeni, receiver operating characteristics curve, and Spear Man rank-order correlation. A P-value of <0.05 was considered statistically significant. Results A total of 180 pregnant women were included in the study. Platelet count and platelet crit levels tend to decrease as pre-eclampsia becomes more severe. In contrast, the mean platelet volume and platelet distribution widths were significantly increased with the severity of preeclampsia (P<0.001). Platelet distribution width (rho = 0.731, p<0.001) and mean platelet volume (rho = 0.674, p<0.001) had statistically significant positive relationships with mean arterial pressure. The best metric for predicting preeclampsia was platelet distribution width (AUC = 0.986; 95%CI; 0.970, 1). Conclusions Platelet indices, including platelet count, mean platelet volume, platelet distribution width, and Platelet crit, have been identified as promising candidate markers for predicting preeclampsia in pregnant women. In the future, a serial examination of these indicators during several trimesters of pregnancy should be conducted.

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Role of platelet distribution width and plateletcrit in assessment of nonthrombocytopenic preeclampsia and eclampsia in a tertiary care hospital of Odisha: an observational study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20201795 ◽

2020 ◽

Vol 9 (5) ◽

pp. 1996

Author(s):

Kirtirekha Mohapatra ◽

Pranati Mohanty ◽

Nahida Nigar Sultana

Keyword(s):

Platelet Count ◽

Observational Study ◽

Severe Disease ◽

Tertiary Care ◽

Measurement Tool ◽

Care Hospital ◽

Platelet Distribution Width ◽

Distribution Width ◽

Platelet Indices

Background: Preeclampsia (PE) is a major cause of maternal and foetal morbidity and mortality in pregnancy. A decreased platelet count is observed during the progression of preeclampsia, and is considered a marker of the severity of preeclampsia. Considering the role of the PDW, PCT and platelet indices during the disease, the aim of this study was to evaluate the feasibility of using platelet indices as a severity marker for PE.Methods: This was a prospective, observational study, hospital-based study, from 2017-19 with 400 pregnant women being included on the basis of a predefined inclusion and exclusion criteria, through antenatal clinic, and labour room of the department of obstetrics and gynecology, S. C. B. Medical College, Cuttack, Odisha, India.Results: Study found that platelet count and plateletcrit showed a significant negative correlation with MAP whereas platelet distribution width showed a maximum positive correlation. In the preeclampsia group, subjects with PCT <0.22% were at risk of developing severe disease with a sensitivity of 53.5% and a high specificity of 85.5%. The AUC of 0.75 showed that it has a good predictability. In the eclampsia group, subjects with PCT <0.16% had a risk of developing severe disease with a sensitivity of 89.5% and specificity of 73.7%. The AUC 0.9 shows PCT to be a good predictor for assessing severity of eclampsia.Conclusions: This study suggests that platelet distribution width and plateletcrit are useful in risk evaluation of preeclampsia. These are a valid measurement tool to predict the severe progression of PE even when normal platelet counts are observed.

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