Study of controlled-release floating tablets of dipyridamole using the dry-coated method

2017 ◽  
Vol 44 (1) ◽  
pp. 116-124 ◽  
Author(s):  
Kai Chen ◽  
Haoyang Wen ◽  
Feifei Yang ◽  
Yibin Yu ◽  
Xiumei Gai ◽  
...  
Keyword(s):  
Controlled Release ◽  
Floating Tablets

Floating tablets from mesoporous silica nanoparticles

2014 ◽  
Vol 2 (47) ◽  
pp. 8298-8302 ◽  
Author(s):  
Prasanna Lakshmi Abbaraju ◽  
Anand kumar Meka ◽  
Siddharth Jambhrunkar ◽  
Jun Zhang ◽  
Chun Xu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Dissolution Rate ◽  
Mesoporous Silica Nanoparticles ◽  
Floating Tablets

Floating tablets were prepared using hydrophobic (curcumin) and hydrophilic (captopril) drug loaded mesoporous silica nanoparticles respectively, leading to an improved dissolution rate of curcumin and controlled release for captopril.

A novel automated alternating current biosusceptometry method to characterization of controlled-release magnetic floating tablets of metronidazole

2013 ◽  
Vol 40 (8) ◽  
pp. 1123-1131 ◽  
Author(s):  
Priscileila Colerato Ferrari ◽  
Dany Bruno Borella dos Santos Grossklauss ◽  
Matheus Alvarez ◽  
Fabiano Carlos Paixão ◽  
Uilian Andreis ◽  
...  
Keyword(s):  
Controlled Release ◽  
Alternating Current ◽  
Floating Tablets

scholarly journals Preparation and characterization of Starch–Urea–Borate: A new floating polymer

2019 ◽  
Vol 9 (2) ◽  
pp. 280-284
Author(s):  
Rada Santosh Kumar ◽  
K.P.R. Chowdary
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery Systems ◽  
Guar Gum ◽  
Ion Exchange Resin ◽  
Delivery Systems ◽  
Matrix Tablets ◽  
Floating Tablets ◽  
Gastric Residence Time ◽  
Pharmaceutical Ingredients

In recent years considerable attention has been focused on the development of new drug delivery systems known as controlled release drug delivery systems. Such interest is based largely on the fact that the controlled release products have established and retained place in the market based on their uniqueness and their clinical advantages in the practices of medicine. The major types of controlled release systems include matrix tablets, floating tablets, swellable tablets,  coated beads, microcapsules and microspheres, mucoadhesive systems, ion exchange resin complexes, osmotic pressure controlled release systems, transdermal systems etc. The principle of floating tablets offers a simple and practical approach to achieve increased gastric residence time to enhance the bioavailability and to obtain controlled release. Floating tablets are designed based on gas generating principle. Design of floating tablets needs a strong matrix forming polymer. Several polymers such as various viscosity grades of hydroxypropylmethyl cellulose (HPMC), Carbopol 934P, Eudragit RL, calcium alginate, chitosan, xanthan gum, guar gum, ethyl cellulose etc., have been used in the design of floating tablets of various active pharmaceutical ingredients (APIs). Though these polymers are available for floating tablets, there is a continued need to develop new, effective and efficient polymers for controlled release floating tablets.The overall objective of the investigation is to develop new, efficient and safe polymer as floating matrix former for floating systems. Keywords: Floating, Matrix, Polymers, Starch-urea-borate.

Formulation and in vitro Evaluation of Effervescent Bilayer Floating Controlled Release Tablets of Clarithromycin and Famotidine

2021 ◽  
pp. 4391-4398
Author(s):  
Murad Alam ◽  
Kifayat Ullah Shah ◽  
Kamran Ahmad Khan ◽  
Asif Nawaz ◽  
Hadia Bibi ◽  
...  
Keyword(s):  
Controlled Release ◽  
Hydroxypropyl Methylcellulose ◽  
Lag Time ◽  
Fickian Diffusion ◽  
Sustained Drug Release ◽  
Floating Tablets ◽  
Weight Variation ◽  
H Pylori ◽  
Controlled Release Tablets

The development of floating tablets with required buoyancy, lag time, and controlling release behaviour of drugs at target site is truly interesting and challenging task for researchers. Current study is concerned with the designing of effervescent floating controlled release tablets of clarithromycin and famotidine to treat peptic ulcer due to Helicobacter pylori (H. pylori) infection. Five formulations (F1-F5) were prepared, among which three formulations were of bilayered tablets while the remaining were included as plain tablets. These tablets were prepared by direct compression method using hydroxypropyl methylcellulose (HPMC) K100M, HPMC K4M and sodium bicarbonate as swelling and floating agents respectively. The qualitative tests such as thickness, hardness, weight variation, friability and uniformity of content were performed to ensure the quality of prepared tablets. The floating lag time of all formulations ranged from 14 to 20 seconds. The effervescent floating tablets with HPMC K4M (F1, F3 & F5) attained the total floating time of more than 12 hours, while tablets prepared with HPMC K100M (F2 & F4) achieved the total floating time of less than 7 hours. This difference in floating behaviour could be due to the variation in compaction and flow properties of the two polymers. The formulations with HPMC K100M (F2 & F4) have comparatively more sustained drug release properties when compared to F1, F3 and F4 using HPMC K4M as swelling and floating polymers. This could be attributed to better compaction of HPMC K100M. The prepared tablets follow non-Fickian diffusion kinetics. Overall, these floating controlled release effervescent bilayer and plain tablets may enhance the compliance and therapeutic outcomes of clarithromycin and famotidine in treatment of H. pylori.

scholarly journals Gastro retentive Drug Delivery of Cyclobenzaprine Hydrochloride

2018 ◽  
Vol 2 (1) ◽  
pp. 01-03
Author(s):  
Swathi chilukala
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
In Vitro Release ◽  
Wet Granulation ◽  
Floating Tablets ◽  
Compression Properties ◽  
Weight Variation ◽  
Vitro Release ◽  
Gastro Retentive

Drugs that are easily absorbed from the GI tract and have a short half-life are eliminated quickly from the blood circulation, require frequent dosing. To avoid this problem, the oral controlled release formulations are being developed. Gastro-retentive dosage forms have the potential from use as controlled release systems. The purpose of this research is to develop the gastro retentive drug delivery system of centrally acting alpha adrenergic agonist cyclobenzaprine Hydrochloride (cyclobenzaprine HCl). It is well absorbed from the upper part of the GIT, due to short gastric residence time the bioavailability is low and hence it is need to develop a dosage form that releases the drug in stomach using gastro retentive system. Different formulations of cyclobenzaprine HCl gastro-retentive floating tablets were prepared by wet granulation method using various concentrations of HPMC K4M / HPMC K100M and combination of Psyllium husk and HPMC K100M as matrix forming agent. Sodium bicarbonate and citric acid were used as a gas generating agent that helps in maintaining the buoyancy. The prepared cyclobenzaprine HCl gastro-retentive floating granules were subjected to pre-compression properties to comply with pharmacopoeial limits and the prepared gastro-retentive floating tablets were characterized for weight variation, hardness, thickness and friability drug content, swelling studies. The floating lag time of all formulation is good and the Total floating time of all the formulations was >12 hours. The tablets were evaluated for in vitro release characteristics for 12hrs in 0.1N HCl at 37 oC and from this in vitro release studies the formulations F-5, F-9 and F-15 exhibited good controlled release profile of about 96.0%, 94.5% and 95.0% when compared with other formulations while floating on the dissolution medium.

scholarly journals Formulation and optimization of carbamazepine floating tablets by 23 - factorial design employing Starch-Urea-Borate: A new floating polymer

2019 ◽  
Vol 9 (2) ◽  
pp. 285-295
Author(s):  
Rada Santosh Kumar ◽  
K.P.R. Chowdary
Keyword(s):  
Gastric Emptying ◽  
Controlled Release ◽  
Dosage Form ◽  
Delayed Gastric Emptying ◽  
Modified Starch ◽  
Major Objective ◽  
Floating Tablets ◽  
Gastric Residence Time ◽  
23 Factorial Design ◽  
Floating Systems

Several approaches are currently used to retain the dosage form in the stomach. These include bioadhesive systems, swelling and expanding systems, floating systems   and other delayed gastric emptying devices. The principle of floating tablets offers a simple and practical approach to achieve increased gastric residence time to enhance the bioavailability and to obtain controlled release. Floating tablets are designed based on gas generating principle. Design of floating tablets needs a strong matrix forming polymer. Though several polymers are available for floating tablets, there is a continued need to develop new, effective and efficient polymers for controlled release floating tablets. The major objective of the investigation is to evaluate starch-urea-borate, a new modified starch as a floating matrix former in the design of controlled release floating tablets. Keywords: Optimisation, Carbamazepine, Starch-Urea-Borate, Floating Tablets

scholarly journals DEVELOPMENT OF COPROCESSED EXCIPIENTS OF XANTHAN GUM AND ACACIA GUM AS A CONTROLLED RELEASE MATRIX FOR FAMOTIDINE FLOATING TABLETS

2020 ◽  
pp. 192-196
Author(s):  
UNSYURA DHIPA BUDAYA ◽  
SILVIA SURINI
Keyword(s):  
Controlled Release ◽  
Xanthan Gum ◽  
Release Kinetics ◽  
Fine Powder ◽  
Natural Polymers ◽  
Floating Tablets ◽  
Acacia Gum ◽  
Release Studies ◽  
Zero Order Release ◽  
Floating Tablet

Objective: Controlled release floating tablets require excipients, which act as a matrix to control the release of the active drug and facilitatethe tablet floating in the gastric milieu. One potential excipient is coprocessed excipients of xanthan gum and acacia gum (Co-XG-GA), which isa physical modification of the two natural polymers. In this study, we produced several Co-XG-GA and used them as matrices in floating tabletformulations.Methods: Several coprocessed excipients were prepared from xanthan gum and acacia gum at ratios of 1:1, 1:2, 2:1, 1:3, and 3:1. The obtainedexcipients were then characterized physically, chemically, and functionally. The coprocessed excipients were then formulated in floating tablets usingfamotidine as the drug model. The floating tablets were then evaluated in terms of the tablet floating capabilities and the drug release in HCl mediumat pH 1.2 for 8 h.Results: Our results showed that the coprocessed excipients were a fine powder, odorless, and a grayish-white color. The excipients had a goodswelling index, fairly large viscosity, and good gel strength; hence, they were suitable to be applied as the matrices of floating tablet formulations. Thefloating tablets of F2, which contained the Co-XG-GA 1:2, demonstrated the best characteristics with 8.33±0.58 min of floating lag time and 24 h oftotal floating time. Further release studies revealed that the famotidine floating tablets, which used Co-XG-GA (F1–F5) as matrices, controlled drugrelease with zero-order release kinetics and could be used for controlled release dosage forms.Conclusion: Collectively, our results indicate that the Co-XG-GA can be applied as matrices in controlled release floating tablets

Synthesis and Characterization of calcium Starch: A New Controlled Release Polymer for floating tablets of Losartan Potassium

2021 ◽  
pp. 219-226
Author(s):  
K. Naga Prathyusha ◽  
B. Hemalatha ◽  
K. Padmalatha
Keyword(s):  
Controlled Release ◽  
Potato Starch ◽  
Oral Dosage ◽  
Losartan Potassium ◽  
Direct Compression ◽  
Compression Technique ◽  
Floating Tablets ◽  
Floating Drug Delivery ◽  
Floating Drug Delivery System

Losartan potassium is used to treat high blood pressure (hypertension). The present study was aimed to prepare a floating drug delivery system to design a controlled release oral dosage form of Losartan potassium. This helps to overcome the demerit of limited residence time of the drug in the gastrointestinal track and hence to increase the duration of release. Hence objective of the present study is to develop Losartan potassium floating tablets by direct compression method using calcium starch as release retarding polymer. The calcium starch was synthesized by gelatinizing potato starch in the presence of sodium hydroxide and cross linking by treatment with calcium chloride. The micromeritic properties studies indicated that calcium starch is a promising pharmaceutical excipient in tablets. Floating tablets of Losartan potassium was formulated by direct compression technique, using different concentration of calcium starch and compared with HPMC K-100 as release retard polymer. As the amount of calcium starch in the tablet increased, the drug release decreased. The formulation F5 containing 125 mg calcium starch showed better controlled release of 76.38% after 12 hours.

scholarly journals Floating tablets of hydralazine hydrochloride: optimization and evaluation

2013 ◽  
Vol 49 (4) ◽  
pp. 811-819
Author(s):  
Kondi Vanitha ◽  
Mohan Varma ◽  
Alluri Ramesh
Keyword(s):  
Controlled Release ◽  
Ethyl Cellulose ◽  
Methyl Cellulose ◽  
Fickian Diffusion ◽  
Release Mechanism ◽  
Wet Granulation ◽  
Drug Release Profile ◽  
Floating Tablets ◽  
Hydralazine Hydrochloride

Hydralazine hydrochloride has a half-life of 2 to 4 hours with an oral bioavailability of 26-50%. Since hydralazine has a demethylating effect on various suppressor genes, it can be used in various types of cancer to support chemotherapy. The purpose of this study was to optimize and evaluate floating tablets of hydralazine hydrochloride designed to prolong the gastric residence time and to provide controlled release of the drug for 14 h. The floating tablets of hydralazine hydrochloride were prepared by the wet granulation method. Semi-synthetic polymers of hydroxy propyl methyl cellulose (HPMC K100M) and ethyl cellulose were used as the release retarding agents. A 2² factorial design was applied to systematically optimize the drug release profile. The concentrations of HPMC K100M and ethyl cellulose were optimized to provide controlled release of hydralazine for 14h. Non-Fickian diffusion release transport was confirmed as the release mechanism for the optimized formulation and the predicted values agreed well with the experimental values. Drug excipient compatibility studies were investigated by FTIR, DSC and XRD. These data indicate that there were no chemical interactions between the drug and the polymer. In vivo X-ray imaging showed floating tablet performance in rabbits.

Sign in / Sign up

Export Citation Format

Share Document