Spray dried nanospheres for inclusion complexes of cefpodoxime proxetil with β-cyclodextrin, 2-hydroxypopyl- β-cyclodextrin and methyl-β-cyclodextrin: Improved dissolution and enhanced antibacterial activity

2021 ◽  
pp. 1-45
Author(s):  
Gülsel Yurtdaş-Kırımlıoğlu
Keyword(s):  
Antibacterial Activity ◽  
Inclusion Complexes ◽  
Cefpodoxime Proxetil ◽  
Spray Dried

scholarly journals Inclusion Complexes of Concentrated Orange Oils and β-Cyclodextrin: Physicochemical and Biological Characterizations

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5109
Author(s):  
Cynthia Torres-Alvarez ◽  
Sandra Castillo ◽  
Eduardo Sánchez-García ◽  
Carlos Aguilera González ◽  
Sergio Arturo Galindo-Rodríguez ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Antibacterial Activity ◽  
Minimum Inhibitory Concentration ◽  
Antifungal Activity ◽  
Inclusion Complexes ◽  
Inhibitory Concentration ◽  
Entrapment Efficiency ◽  
Ft Ir ◽  
Ir Analysis

Concentrated orange oils (5x, 10x, 20x) are ingredients used in different industries as components of flavors and aromas due to their great organoleptic qualities. This research focuses on the search for alternative uses for their application through encapsulation in inclusion complexes with β-cyclodextrin (β–CD). Inclusion complexes of concentrated orange oils (COEO) and β–CD were developed by the co-precipitated method in ratios of 4:96, 12:88, and 16:84 (w/w, COEO: β–CD). The best powder recovery was in the ratio 16:84 for the three oils, with values between 82% and 84.8%. The 20x oil in relation 12:88 showed the highest entrapment efficiency (89.5%) with 102.3 mg/g of β–CD. The FT-IR analysis may suggest an interaction between the oil and the β–CD. The best antioxidant activity was observed in the ratio 12:88 for the three oils. The antifungal activity was determined for all the inclusion complexes, and the 10x fraction showed the highest inhibition at a concentration of 10 mg/mL in ratios 12:88 and 16:84. Antibacterial activity was determined by the minimum inhibitory concentration (MIC) and was found at a concentration of 1.25 mg/mL in ratios 12:88 and 16:84 for 5x and 20x oils.

scholarly journals The Comparison of the Effects of Β-Cyclodextrin Complex and Derivative Complex with Silver Nanoparticles on Cotton Fabric

2021 ◽  
Author(s):  
CAGLA SARI ◽  
BUKET ARIK
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Inclusion Complexes ◽  
Color Change ◽  
Crosslinking Agent ◽  
Xrd Analysis ◽  
Cotton Fabrics ◽  
Cyclodextrin Complex ◽  
Antibacterial Textiles ◽  
Cotton Sample

Abstract In this study, sulfated β-cyclodextrin (S-β-CD) which is a β-cyclodextrin derivative was obtained by chemical treatment of natural β-cyclodextrin (β-CD) with sulfuric acid. Afterwards, β-CD and S-β-CD were applied to cotton fabrics. In different treatments, β-CD and S-β-CD were bonded to cotton fabrics with EDTA crosslinking agent. Then, all the fabrics were treated with antibacterial agent silver nanoparticles (AgNPs) and inclusion complexes were formed. The aims of this study were to increase the washing stability and the antibacterial activity against microorganisms and to compare the effects of β-CD complex and derivative complex with silver nanoparticles on treated cotton samples. So, for this purpose, the properties of the treated samples like antibacterial activity, washing stability, add-on, tensile strength, handle, thickness and color change were tested and compared to each other. In addition, characterization analyzes such as SEM, EDX and FT-IR were performed on the samples and XRD analysis was performed to characterize the AgNPs. As a result of the study, it was observed that AgNPs alone were not sufficient to obtain antibacterial textiles with strong antibacterial effect and good washing stability. The inclusion complexes formed with β-CD and S-β-CD had much more effective antibacterial activity and more robust washing stability. In addition, when the physical properties except stiffness and yellowness were considered besides antibacterial activity and washing stability, the treatment of derivative β-CD complex with AgNPs and crosslinking this complex to cotton sample by means of EDTA was found to be the most favorable method.

scholarly journals Development and Evaluation of Antimicrobial and Modulatory Activity of Inclusion Complex of Euterpe oleracea Mart Oil and β-Cyclodextrin or HP-β-Cyclodextrin

2020 ◽  
Vol 21 (3) ◽  
pp. 942 ◽  
Author(s):  
Thalita Sévia Soares de Almeida Magalhães ◽  
Pollyana Cristina de Oliveira Macedo ◽  
Stephany Yumi Kawashima Pacheco ◽  
Sofia Santos da Silva ◽  
Euzébio Guimarães Barbosa ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Inclusion Complexes ◽  
Biological Response ◽  
Physicochemical Characteristics ◽  
Euterpe Oleracea ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
E Coli ◽  
Nonpolar Compounds ◽  
Euterpe Oleracea Mart

The development of inclusion complexes is used to encapsulate nonpolar compounds and improve their physicochemical characteristics. This study aims to develop complexes made up of Euterpe oleracea Mart oil (EOO) and β-cyclodextrin (β-CD) or hydroxypropyl-β-cyclodextrin (HP-β-CD) by either kneading (KND) or slurry (SL). Complexes were analyzed by molecular modeling, Fourier-transform infrared spectroscopy, scanning electron microscopy, powder X-ray diffraction, thermogravimetry analysis and differential scanning calorimetry. The antibacterial activity was expressed as Minimum Inhibitory Concentration (MIC), and the antibiotic resistance modulatory activity as subinhibitory concentration (MIC/8) against Escherichia coli, Streptomyces aureus, Pseudomonas aeruginosa and Enterococcus faecalis. Inclusion complexes with β-CD and HP-β-CD were confirmed, and efficiency was proven by an interaction energy between oleic acid and β-CD of −41.28 ± 0.57 kJ/mol. MIC values revealed higher antibacterial activity of complexes compared to the isolated oil. The modulatory response of EOO and EOO-β-CD prepared by KND as well as of EOO-β-CD and EOO-HP-β-CD prepared by SL showed a synergistic effect with ampicillin against E. coli, whereas it was not significant with the other drugs tested, maintaining the biological response of antibiotics. The antimicrobial response exhibited by the complexes is of great significance because it subsidizes studies for the development of new pharmaceutical forms.

Production of spray-dried starch molecular inclusion complexes on an industrial scale

2019 ◽  
Vol 116 ◽  
pp. 186-195 ◽  
Author(s):  
Anna Marinopoulou ◽  
Vassilis Karageorgiou ◽  
Efthimios Papastergiadis ◽  
Costas Iordanidis ◽  
Athanasios Dagklis ◽  
...  
Keyword(s):  
Inclusion Complexes ◽  
Industrial Scale ◽  
Molecular Inclusion ◽  
Spray Dried

scholarly journals Physico-chemical characterization and antibacterial activity of inclusion complexes of Hyptis martiusii Benth essential oil in β-cyclodextrin

2017 ◽  
Vol 89 ◽  
pp. 201-207 ◽  
Author(s):  
Tatianny A. Andrade ◽  
Thiago S. Freitas ◽  
Francielly O. Araújo ◽  
Paula P. Menezes ◽  
Grace Anne A. Dória ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Essential Oil ◽  
Inclusion Complexes ◽  
Chemical Characterization ◽  
Physico Chemical

scholarly journals Antimutagenic and Antibacterial Activity of β‑Cyclodextrin Clathrates with Extensive Hydrolysates of Colostrum and Whey

2020 ◽  
Vol 11 (2) ◽  
pp. 8626-8638
Keyword(s):  
Antibacterial Activity ◽  
Inclusion Complexes ◽  
Antibacterial Effect ◽  
Fold Increase ◽  
Antimutagenic Activity ◽  
Organoleptic Properties ◽  
Milk Peptides ◽  
And Staphylococcus Aureus ◽  
Peptide Fractions ◽  
Antibacterial Potential

In this study, experimental samples of extensive enzymatic hydrolysates of bovine colostrum and whey, inclusion complexes of β cyclodextrin with dairy peptides were derived. 1.6 fold increase in the degree of proteolysis was established for whey hydrolysate compared to cleaved first milk. A significant decline in the bitterness of peptide constituents of clathrates was recorded versus samples of initial extensive hydrolysates. The thermogravimetric analysis confirmed the formation of inclusion complexes of cyclic oligosaccharide with dairy peptides. The Ames test demonstrated comparable induced mutation rates for samples of hydrolysates and clathrates. Antimutagenic activity of the samples reached 23.9–28.3 % when tested on strain Salmonella typhimurium TA 98 and 19.4–21.8 % on strain TA 100. According to the impedimetric method, the antibacterial potential of extensive colostrum hydrolysate exceeded the action of cleaved whey against Escherichia coli ATCC 8739 and Staphylococcus aureus ATCC 6538. Enhanced antibacterial activity was found for whey and colostrum peptide fractions included in clathrates with a cyclic oligosaccharide. β cyclodextrin complexing preserved antimutagenic capacity, promoted antibacterial effect, and improved organoleptic properties of milk peptides. These advantages acquire maximum relevance during the clathrate upgrading of specialized nutrition formulas.

scholarly journals Inclusion Complexes of Some Substituted 4-Thiazolidinones with Activating and Deactivating Group

2019 ◽  
Vol 32 (1) ◽  
pp. 133-136
Author(s):  
Simanchal Dash
Keyword(s):  
Antibacterial Activity ◽  
Thermodynamic Properties ◽  
Inclusion Complexes ◽  
Polar Solvent ◽  
Spectral Characteristics ◽  
E Coli ◽  
Inclusion Formation ◽  
Solvent Water ◽  
Pharmaceutical Activity

Some substituted 4-thiazolidinones have been prepared by taking 2-hydrazinobenzothiazole as a staring material. Polar solvent water makes less solubility of these compounds. Hence inclusions of compounds are prepared by taking suitable ratio of compound and β-cyclodextrin. The purpose of this work is to synthesize more soluble and more bioaccesible compounds. The synthesized compounds and their inclusions are known from the study of their thermodynamic properties and spectral characteristics (UV, IR and NMR). Pharmaceutical activity of the compounds and inclusion can be performed by using the bacteria namely E. coli, S. aureus and P. vulgaris. Considering and discussing all the matters, it has been found that inclusion formation shows more antibacterial activity than simple compound.

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