Recent development of imidazole derivatives as potential anticancer agents

Cancer, one of the key health problems globally, is a group of related diseases that share a number of characteristics primarily the uncontrolled growth and invasive to surrounding tissues. Chemotherapy is one of the ways for the treatment of cancer which uses one or more anticancer agents as per chemotherapy regimen. Limitations of most anticancer drugs due to a variety of reasons such as serious side effects, drug resistance, lack of sensitivity and efficacy etc. generate the necessity towards the designing of novel anticancer lead molecules. In this regard, the synthesis of biologically active heterocyclic molecules is an appealing research area. Among heterocyclic compounds, nitrogen containing heterocyclic molecules has fascinated tremendous consideration due to broad range of pharmaceutical activity. Imidazoles, extensively present in natural products as well as synthetic molecules, have two nitrogen atoms, and are five membered heterocyclic rings. Because of their countless physiological and pharmacological characteristics, medicinal chemists are enthused to design and synthesize new imidazole derivatives with improved pharmacodynamic and pharmacokinetic properties. The aim of this present chapter is to discuss the synthesis, chemistry, pharmacological activity, and scope of imidazole-based molecules in anticancer drug development. Finally, we have discussed the current challenges and future perspectives of imidazole-based derivatives in anticancer drug development.

Development of professional standards in the area of medical and biological waste management for workers of 3-4 skill levels

Issues related to the updating of professional standards for workers of 3-4 skill levels are relevant for all sectors of the national economy. In this study, we have analyzed the qualifications and training of the main participants in the labor market in the field of biomedical waste management in health care organizations, agriculture and veterinary medicine, food and biotechnology industries, food trade, hospitality sectors, tourism, as well as other organizations in which medico-biological waste is generated. The purpose of this work is to analyze the algorithm for updating professional standards for management of medical and biological waste specialists. In the course of updating the Professional standard Worker in the area of medical and biological waste management, employees of the Department of Industrial Ecology of the Saint Petersburg Chemical and Pharmaceutical University of the Ministry of Health of the Russian Federation made a proposal to supplement the labor functions of this standard with new competencies and a new qualification Specialist in medical waste management, formed in the organizations of pharmaceutical activity.

L’inventario della spezieria di Giovanni Zavanti al Cairo (1732)

The inventory of the apothecary Giovanni Zavanti, a Venetian pharmacist who worked in Cairo in the 1730s, was drawn up by the Egyptian city’s British Consulate in 1732. Since this institution ensured formal juridical protection to the English shopkeepers of the Levant Company, but devoted little attention to their need for health care, this historical source can be considered a rare testimony of European medical-pharmaceutical activity in the Levant. The inventory’s importance is also connected with the specific political and socio-cultural context of Egypt, the most economically important province of the Ottoman Empire. Substantial groups of English, French and Dutch merchants lived in the Muslim society of Cairo and were officially represented by their respective nations in the eighteenth century. The Venetian, also active in Cairo, could not count on the protection of their State institutions during the Turco-Venetian conflicts (1645–1718). In this complex context, Zavanti tried to take advantage of his professional activity and built up different socio-cultural relations to defend his properties and commercial interests. He was in contact with fellow countrymen, Arabic Christians of Egypt, Jews, Turkish officials and the Franciscan confraternity Custodia Terrae Santae. As second-generation immigrants from Venice, the Zavantis experienced a difficult process of cultural integration in Egypt.

On the need to amend the sanction of the Article 235 of the Criminal Code of the Russian Federation “Unlawful practice of medical and pharmaceutical activity”

The study of educational, monographic, and other specialized literature testifies ti the fact that questions of imposition of penalty for committing an offence stipulated by the Article 235 of the Criminal Code of the Russian Federation have not been comprehensively examined. This article analyzes the practice of imposition of penalty under the Article 235 of the Criminal Code of the Russian Federation. The object of this research is the social relations arising in the context of imposition of penalty for unlawful practice of medical and pharmaceutical activity. The subject of this research is the sanction of the Article 235 of the Criminal Code of the Russian Federation. The author considers the coercive measures applied to persons found guilty of committing an offence under the Article 235 of the Criminal Code of the Russian Federation. The acquired results contain scientific novelty and practical significance, and can be used for improving the criminal law. The author determines the following relevant issues associated with imposition of penalty under the Article 235 of the Criminal Code of the Russian Federation: high instance of inflicting a fine as a form of punishment; absence of practice of imposition of punishment in form of restriction of freedom or forfeiture to hold certain posts or carry out particular activity. The makes recommendations for improving the sanction of the Article 235 of the Criminal Code of the Russian Federation, taking into consideration the analysis of the legislation of CIS countries and domestic law enforcement practice.

A review on the pharmaceutical activity of Solanum surattense

The traditional medicinal plants are believed to be an impotent source of phytochemicals with potential therapeutic effects, and caring for different diseases. The plant Solanum surattense has active phytochemicals like saponins, alkaloid, phenols, solamargine, solasurine, solasonine, gum, ascorbic acid, sterols, torvoside K, torvoside L, khasianine, glycosides, flavonoids, aculeatiside A, solamargine, glycoalkaloid, steroidal compound, steroidal alkaloids, polyphenol (caffeic acid), coumarins (esculentin and aesculin), steroids (carpesterol, campesterol, daucosterol, stigmasterol, cycloortanol, and cholesterol), triterpinins, and sapogenin. This medicinal plant is widespread in pharmaceutics and still presents a large source of active phytochemicals with different activity such as antimicrobial, anti-larvicidal, anthelmintic, antimalarial, antioxidant, antidiabetic, anti-asthmatic, and anti-cancerous. This review of the literature revealed new researches on the phytochemicals of S. surattense that how the active phytochemicals are performed different activities on the molecular level in vital aspects.

Notch receptors in GtoPdb v.2021.2

Aberrant Notch signalling is implicated in a number of human cancers [18, 26, 13, 21], and there is intense pharmaceutical activity being directed towards achieving clinically effective Notch pathway inhibition [7, 16].

FATTY LIVER DYSTROPHY MODELING BY USING STRONTIUM SULFATE

In recent years, the problem of the increasing number of the hepatobiliary system disorders has acquired particular importance for veterinary medicine. These disorders have negative impact on normal physiology of an animal's body. It is important to continue the search for effective hepatoprotective agents. To test the pharmaceutical activity of new drugs, methods of modeling hepatopathies are constantly being improved. The study suggested a model of fatty liver dystrophy using strontium sulfate.

EXPERIENCE IN DEVELOPING A WORKING PROGRAM AND APPROBATION OF THE DISCIPLINE "BASIS OF PHARMACEUTICAL ETHICS AND DEONTOLOGY"

The article discusses the experience of creating the work programs for the disciplines "Bioethics with the basics of deontology" and "Basics of pharmaceutical ethics and deontology" at the Department of organization, economics and history of pharmacy. The relevance of addressing this topic is that in the educational process of training a pharmacist there are no disciplines that give a first-year student an idea of what he will do in his future professional life, what tasks await him, what bioethical problems he will solve in his professional life. When developing of approaches to the creation of educational and methodological complexes, the main tasks of the discipline were formulated: consideration of the main stages of the formation and development of pharmaceutical ethics as an independent discipline; analysis of the main directions of pharmaceutical ethics with the studying of practical issues of the main problematics; developing ideas about the meaning of the activities of a pharmaceutical specialist in the modern pharmaceutical market within the framework of the ethical components of the profession. Approaches are described to the development of modules of the work program, of the choice of topics for classes and of the filling of the block "Students' independent work". A list of students' practical skills is offered: annotation and abstracting, compilation of grouping tables; application of methods of analysis in the study of ethical and deontological problems; conducting discussions and polemics; solving of situational problems in professional pharmaceutical activity from the standpoint of pharmaceutical ethics and deontology. It is concluded that it is possible to use the experience of the Perm State Pharmaceutical Academy in the development of work programs for the discipline "Basics of Pharmaceutical Ethics and Deontology" by other universities.

An Overview on the Conservative Management of Endometriosis from a Naturopathic Perspective: Phytochemicals and Medicinal Plants

Background: Endometriosis is a chronic and debilitating disease, which affects millions of young women worldwide. Although medicine has incontestably evolved in the last years, there is no common ground regarding the early and accurate diagnosis of this condition, its pathogenic mechanisms, and curative treatment. Even though the spontaneous resolution of endometriosis is sometimes possible, recent reports suggested that it can be a progressive condition. It can associate chronic pelvic pain, vaginal bleeding, infertility, or malignant degenerescence. Conventional treatments could produce many side effects, and despite treatment, the symptoms may reappear. In recent years, experimental evidence suggested that plant-based medicine could exert beneficial effects on endometriosis and endometriosis-related symptoms. This study aims to highlight the pharmaceutical activity of phytochemicals and medicinal plants against endometriosis and to provide a source of information regarding the alternative treatment of this condition. Methods: For this review, we performed a research using PubMed, GoogleScholar, and CrossRef databases. We selected the articles published between January 2000 and July 2020, written in English. Results: We found 17 medicinal plants and 13 phytochemicals, which have demonstrated their beneficial effects against endometriosis. Several of their biological activities consist of antiangiogenic, anti-inflammatory effects, and oxidative-stress reduction. Conclusion: Medicinal herbs and their bioactive compounds exhibit antiangiogenic, antioxidant, sedative and pain-alleviating properties and the effects recorded until now encourage their use for the conservative management of endometriosis.

Synthesis and Hypoglycemic Activity of the Derivatives of 4-(1,3-Thiazolidine-5-Ylidene)Pyrazole-3-Carbonic Acid and its Esters

A preparatively convenient method for synthesizing a series of new (pyrazole-4-yl)methylenethiazolidine structures fictionalized by the carboxylate or carboxylic group in the 3rd position of the pyrazole cycle and by the oxo- thio- or imine groups in the 3rd and 5th positions of the thiazolidine ring is discussed. The method is based on the condensation of 4-formylpyrazole-3-carbonic acids and their ethyl esters with a series of substituted thiazolidines: 1,3-thiazolidine-2,4-dione, 4-thioxo-1,3-thiazolidine-2-one, 2-thioxo-1,3-thiazolidine-4-one, and 2-imino-1,3-thiazolidine-4-one. As seen from the biochemical investigations results, a clear hypoglycemic activity has been registered for the compounds mentioned in this work. Five of ten products have ensured a prolonged effect embracing the entire duration of the experiment. 1-Methyl-4[(4-oxo-2-thioxo-1,3-thiazolidine-5-iliden)methyl]-1H-pyrazole-3-carbonic acid caused the deepest decrease in the glucose content (by 2.0 mmole/L or 30.4 %), while in the case of the reference medicine pioglitazone, it was only by 1.35 mmole/L (23.9 %). Some dependence between the compound structure and its pharmaceutical activity was also found. The most prolonged and steady hypoglycemic activity was registered for (pyrazole-4-il)methylethiazolidines with methyl group as a substitute in the 1st position and carboxylic group – in the 3rd position. The additional introduction of the methyl and carboxylate groups into the pyrazole scaffold results in a prolonged and more in-depth hypoglycemic effect leading to the 1.4 times lesser drop in glucose concentration as compared to that after administration of the reference medicine.