Thyroid function abnormalities and antithyroid antibody prevalence in pregnant women at high risk for gestational diabetes mellitus

2006 ◽  
Vol 22 (5) ◽  
pp. 261-266 ◽  
Author(s):  
Mukesh M. Agarwal ◽  
Gurdeep S. Dhatt ◽  
John Punnose ◽  
Bassam Bishawi ◽  
Reem Zayed
2018 ◽  
Author(s):  
George Simeakis ◽  
Evangelia Vogiatzi ◽  
Panagiota Konstantakou ◽  
Evangelia Zapanti ◽  
Katerina Saltiki ◽  
...  

2009 ◽  
pp. 73-86
Author(s):  
Renata Tambelli ◽  
Manuela Errante

- In this review are discussed the main researches about high-risk pregnancy and, particularly, gestational diabetes mellitus (GDM). The results of these researches highlight that pregnant women with GDM are extremely vulnerable, anxious and worried. However there are not many clinical studies about the effect of GDM on the quality of mother-child relationship.


Author(s):  
Deepti Khenwar ◽  
Juhi Agarwal ◽  
Sushruta Shriastava

Background: Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance of variable severity with onset or first recognition during the present pregnancy. It affects 7% of all pregnancies worldwide and in India it ranges from 6 to 9% in rural and 12 to 21% in urban area. The aim of this study was to compare the DIPSI criteria with the two-step method (Carpenter and Couston criteria.) and to study merits and demerits of one step and two step tests for GDM.Methods: A total 400 pregnant women of gestational age between 24-28 weeks attending antenatal clinic at this study tertiary care center were enrolled in this study. 200 pregnant women were enrolled in each of the study group (Group I OGTT and Group II DIPSI).Results: In Group I (OGTT) screening 47 (23.5%) were tested positive. In Group II cases, screening test results were found positive among 44 (22%). Out of 95 high-risk pregnant women 38 (40%) were positive for GDM by OGTT and 34 (35.78%) were positive by DIPSI. Out of 305 non high-risk pregnant women, 9 (2.95%) were positive for GDM by OGTT and 10 (3.27%) were positive by DIPSI.Conclusions: Present study concludes that DIPSI is the test which can predict GDM in population comparable to another test like OGTT. Also, India’s major population reside in rural areas, ANC are mostly conducted by ANM, therefore screening test should be easy to perform and interpret.


2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Carmelo Capula ◽  
Eusebio Chiefari ◽  
Anna Vero ◽  
Biagio Arcidiacono ◽  
Stefania Iiritano ◽  
...  

Recent Italian guidelines exclude women <35 years old, without risk factors for gestational diabetes mellitus (GDM), from screening for GDM. To determine the effectiveness of these measures with respect to the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria, we evaluated 2,448 pregnant women retrospectively enrolled in Calabria, southern Italy. GDM was diagnosed following the IADPSG 2010 criteria. Among 538 women <35 years old, without risk factors, who would have not been tested according to the Italian guidelines, we diagnosed GDM in 171 (31.8%) pregnants (7.0% of total pregnants). Diagnosis was made at baseline (55.6%), 1 hour (39.8%), or 2 hours (4.7%) during OGTT. Despite of appropriate treatment, GDM represented a risk factor for cesarean section, polyhydramnios, increased birth weight, admission to neonatal intensive care units, and large for gestational age. These outcomes were similar to those observed in GDM women at high risk for GDM. In conclusion, Italian recommendations failed to identify 7.0% of women with GDM, when compared to IADPSG criteria. The risk for adverse hyperglycaemic-related outcomes is similar in low-risk and high-risk pregnants with GDM. To limit costs of GDM screening, our data suggest to restrict OGTT to two steps (baseline and 1 hour).


Author(s):  
Srividya Nemani ◽  
Vamsi Krishna Kurumeti

Background: The most common endocrine conditions encountered in pregnancy are gestational diabetes mellitus (GDM) and thyroid disease which have been known to mutually exist and impact each other to variable extents.Methods: A Cross sectional study was conducted from September 2019 to February 2020 among 150 pregnant women (75 women with GDM and 75 women without GDM) with 24-28 weeks of gestation in a tertiary care hospital. Thyroid function tests (Serum TSH, FT4 and TPO antibodies) were evaluated in all the pregnant women. All the information regarding family history of diabetes mellitus, GDM and thyroid disease was determined in both groups and analyzed by statistical methods in SPSS trial version 21.Results: Obtained data showed that TSH level (p=0.14) and anti- TPO (p=0.04) in women with GDM were more than in euglycemic pregnant women and FT4 (p≤0.001) level was lower. There is higher prevalence of hypothyroidism among GDM patients compared to that of euglycaemic women (29.3% vs 14.6%). TPO Ab was positive among 29.3% of GDM and 8% of the normal pregnant women (p<0.05). High prevalence of hypothyroidism was noticed among TPO Ab positive patients in both the groups, but more in the GDM group comparatively indicating that TPO Ab positivity is associated with a higher risk of hypothyroidism in GDM (p<0.05).Conclusions: The high prevalence of thyroid disorders and autoimmunity among GDM group warrants the importance of evaluating thyroid function in pregnant women with impaired glucose tolerance, in view of their increased risk of hypothyroidism.


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