Chronic exposure to gamma irradiation at low-dose rates accelerates blood pressure decline associated with aging in female B6C3F1 mice

2019 ◽  
Vol 95 (3) ◽  
pp. 347-353 ◽  
Author(s):  
Daisaku Takai ◽  
Akiko Abe ◽  
Jun-ichiro Komura
Keyword(s):  
Blood Pressure ◽  
Gamma Irradiation ◽  
Chronic Exposure ◽  
Low Dose ◽  
Dose Rates ◽  
B6c3f1 Mice

scholarly journals A systems biology approach reveals neuronal and muscle developmental defects after chronic exposure to ionising radiation in zebrafish

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sophia Murat El Houdigui ◽  
Christelle Adam-Guillermin ◽  
Giovanna Loro ◽  
Caroline Arcanjo ◽  
Sandrine Frelon ◽  
...  
Keyword(s):  
Chronic Exposure ◽  
Nuclear Power ◽  
Muscle Development ◽  
Low Dose ◽  
Neuromuscular Junctions ◽  
Biological Effects ◽  
Cardiac Activity ◽  
Developmental Defects ◽  
Dose Rates ◽  
Larval Behaviour

AbstractContamination of the environment after the Chernobyl and Fukushima Daiichi nuclear power plant (NPP) disasters led to the exposure of a large number of humans and wild animals to radioactive substances. However, the sub-lethal consequences induced by these absorbed radiological doses remain understudied and the long-term biological impacts largely unknown. We assessed the biological effects of chronic exposure to ionizing radiation (IR) on embryonic development by exposing zebrafish embryo from fertilization and up to 120 hours post-fertilization (hpf) at dose rates of 0.5 mGy/h, 5 mGy/h and 50 mGy/h, thereby encompassing the field of low dose rates defined at 6 mGy/h. Chronic exposure to IR altered larval behaviour in a light-dark locomotor test and affected cardiac activity at a dose rate as low as 0.5 mGy/h. The multi-omics analysis of transcriptome, proteome and transcription factor binding sites in the promoters of the deregulated genes, collectively points towards perturbations of neurogenesis, muscle development, and retinoic acid (RA) signaling after chronic exposure to IR. Whole-mount RNA in situ hybridization confirmed the impaired expression of the transcription factors her4.4 in the central nervous system and myogenin in the developing muscles of exposed embryos. At the organ level, the assessment of muscle histology by transmission electron microscopy (TEM) demonstrated myofibers disruption and altered neuromuscular junctions in exposed larvae at 5 mGy/h and 50 mGy/h. The integration of these multi-level data demonstrates that chronic exposure to low dose rates of IR has an impact on neuronal and muscle progenitor cells, that could lead to motility defects in free swimming larvae at 120 hpf. The mechanistic understanding of these effects allows us to propose a model where deregulation of RA signaling by chronic exposure to IR has pleiotropic effects on neurogenesis and muscle development.

Hepatomas in Mice: Incidence Increased after Gamma Irradiation at Low Dose Rates

Science ◽  
1965 ◽  
Vol 148 (3666) ◽  
pp. 96-97 ◽  
Author(s):  
P. C. Nowell ◽  
L. J. Cole
Keyword(s):  
Gamma Irradiation ◽  
Low Dose ◽  
Dose Rates

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

B-Vitamins, Methylenetetrahydrofolate Reductase (MTHFR) and Hypertension

2011 ◽  
Vol 81 (4) ◽  
pp. 240-244 ◽  
Author(s):  
Mary Ward ◽  
Carol P Wilson ◽  
J J Strain ◽  
Geraldine Horigan ◽  
John M. Scott ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Low Dose ◽  
Methylenetetrahydrofolate Reductase ◽  
Genetic Determinant ◽  
Gene Encoding ◽  
Homocysteine Concentration ◽  
Homozygous Mutant ◽  
B Vitamin

Hypertension is a leading risk factor for cardiovascular disease (CVD) and stroke. A common polymorphism in the gene encoding the enzyme methylenetetrahydrofolate reductase (MTHFR), previously identified as the main genetic determinant of elevated homocysteine concentration and also recognized as a risk factor for CVD, appears to be independently associated with hypertension. The B-vitamin riboflavin is required as a cofactor by MTHFR and recent evidence suggests it may have a role in modulating blood pressure, specifically in those with the homozygous mutant MTHFR 677 TT genotype. If studies confirm that this genetic predisposition to hypertension is correctable by low-dose riboflavin, the findings could have important implications for the management of hypertension given that the frequency of this polymorphism ranges from 3 to 32 % worldwide.

Time-Dependent Effects of Low-Dose Aspirin Administration on Blood Pressure in Pregnant Women

Hypertension ◽  
1997 ◽  
Vol 30 (3) ◽  
pp. 589-595 ◽  
Author(s):  
Ramón C. Hermida ◽  
Diana E. Ayala ◽  
Manuel Iglesias ◽  
Artemio Mojón ◽  
Inés Silva ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Low Dose ◽  
Time Dependent ◽  
Dose Aspirin ◽  
Low Dose Aspirin

scholarly journals n-Butyl Benzyl Phthalate Exposure Promotes Lesion Survival in a Murine Endometriosis Model

2021 ◽  
Vol 18 (7) ◽  
pp. 3640
Author(s):  
Pooja Sharma ◽  
Jo-Yu Lynn Lee ◽  
Eing-Mei Tsai ◽  
Yu Chang ◽  
Jau-Ling Suen
Keyword(s):  
Chronic Exposure ◽  
Low Dose ◽  
Estrogenic Activity ◽  
Estrus Cycle ◽  
Endometriotic Lesion ◽  
Multiparametric Flow Cytometry ◽  
Butyl Benzyl Phthalate ◽  
Environmental Endocrine Disruptors ◽  
Lesion Growth ◽  
Gynecological Disease

Endometriosis is an inflammatory and estrogen-dependent gynecological disease associated with exposure to environmental endocrine disruptors. n-Butyl benzyl phthalate (BBP), a ubiquitous plasticizer, has weak estrogenic activity, and exposure to BBP is associated with endometriosis. We aimed to elucidate the immunomodulatory effect of BBP on endometriosis development. We previously established a surgery-induced endometriosis-like murine model. In the present study, we exposed those mice to BBP 10 days prior to surgery and 4 weeks after surgery at physiologically relevant doses to mimic human exposure. Chronic exposure to BBP did not promote the growth of endometriotic lesions; however, the lesion survival rate in BBP-treated mice did increase significantly compared with control mice. Multiparametric flow cytometry showed that BBP exposure did not affect the homeostasis of infiltrated immune subsets in lesions but did enhance CD44 (adhesion marker) expression on plasmacytoid dendritic cells (pDCs). Blocking CD44 interactions locally inhibited endometriotic lesion growth. Immunofluorescence results further confirmed that CD44 blocking inhibited pDC infiltration and reduced the frequency of CD44+ pDCs in endometriotic tissues. BBP also disrupted the estrus cycle in these mice. This study suggests that chronic exposure to low-dose BBP may promote survival of endometriotic tissue through CD44-expressing pDCs.

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