Adsorption of tetracycline by Nicandra physaloides (L.) Gaertn seed gum and Nicandra physaloides(L.) Gaertn seed gum/Carboxymethyl chitosan aerogel

2021 ◽  
pp. 1-29
Author(s):  
Liubo Li ◽  
Yanhui Li ◽  
Meixiu Li ◽  
Yong Sun ◽  
Huimin Wang ◽  
...  
Keyword(s):  
Carboxymethyl Chitosan ◽  
Seed Gum

Carboxymethyl-hexanoyl Chitosan Nanodroplets for Ultrasonic Imaging and Drug Delivery to Tumor

2018 ◽  
Vol 24 (15) ◽  
pp. 1682-1688 ◽  
Author(s):  
Yu Jinsui ◽  
Situ Bing ◽  
Luo Muhua ◽  
Li Yue ◽  
Liao Jianyi ◽  
...  
Keyword(s):  
Ultrasound Imaging ◽  
Tumor Therapy ◽  
Carboxymethyl Chitosan ◽  
Great Promise ◽  
Ovarian Cancer Cells ◽  
Mechanical Index ◽  
Surface Charges ◽  
Particle Structure ◽  
Drug Release Profile ◽  
Hexanoyl Chitosan

Introduction: Although a great many strategies have been proposed for tumor-targeted chemotherapy, current delivery methods of anticancer drugs present limited success with inevitable systemic toxicity. The aim of this study was to develop a new kind of theranostic carrier for targeted tumor therapy. Methods: Prior to prepare CHC-PFP-DOX, carboxymethyl-hexanoyl chitosan (CHC) was synthesized by acylation of carboxymethyl chitosan. To develop CHC-PFP, perfluoropentane (PFP), an ultrasound gas precursor, was simultaneously encapsulated into the hydrophobic inner cores of pre-formulated CHC micelle in aqueous phase via using the oil in water (O/W) emulsion method. The size distribution and surface charges of these nanodroplets were measured and the morphology was observed by transmission electron microscopy (TEM). For ultrasound imaging application, in vitro model was established to evaluate the imaging of CHC-PFP-DOX under different concentration and mechanical index. After that, the anti-tumor effect of ultrasound combined with CHC-PFPDOX on ovarian cancer cells was investigated. Results: The resulting CHC-PFP-DOX had a nano-sized particle structure, with hydrophobic anticancer DOX/PFP inner cores and a hydrophilic carboxymethyl chitosan polymer outer shell. The favorable nano-scaled size offers the potential to extravagate from veins and accumulate in tumor tissues via enhanced permeation and retention (EPR) effect. Additionally, CHC-PFP-DOX showed the ability to serve as ultrasound imaging agent at body temperature. Notably, it exhibited an ultrasound-triggered drug release profile through the external ultrasound irradiation. Further study demonstrated that ultrasound combined with CHC-PFP-DOX can improve the killing effect of chemotherapy for tumor. Conclusion: CHC-PFP-DOX holds great promise in simultaneous cancer-targeting ultrasound imaging and ultrasound- mediated delivery for cancer chemotherapy.

Formulation of Extended-Release Beads of Lamotrigine Based on Alginate and Cassia fistula Seed Gum by QbD Approach

2020 ◽  
Vol 17 (5) ◽  
pp. 422-437
Author(s):  
Dixita Jain ◽  
Akshay Sodani ◽  
Swapnanil Ray ◽  
Pranab Ghosh ◽  
Gouranga Nandi
Keyword(s):  
Drug Release ◽  
Factorial Design ◽  
Extended Release ◽  
Polymer Concentration ◽  
Green Manufacturing ◽  
Full Factorial Design ◽  
Cassia Fistula ◽  
Negative Environmental Impact ◽  
Seed Gum ◽  
Full Factorial

Aim: This study was focused on the formulation of the multi-unit extended-release peroral delivery device of lamotrigine for better management of epilepsy. Background: The single-unit extended-release peroral preparations often suffer from all-or-none effect. A significant number of multi-unit delivery systems have been reported as a solution to this problem. But most of them are found to be composed of synthetic, semi-synthetic or their combination having physiological toxicity as well as negative environmental impact. Therefore, fabrication and formulation of multi-unit extended-release peroral preparations with natural, non-toxic, biodegradable polymers employing green manufacturing processes are being appreciated worldwide. Objective: Lamotrigine-loaded extended-release multi-unit beads have been fabricated with the incorporation of a natural polysaccharide Cassia fistula seed gum in calcium-cross-linked alginate matrix employing a simple green process and 23 full factorial design. Methods: The total polymer concentration, polymer ratio and [CaCl2] were considered as independent formulation variables with two different levels of each for the experiment-design. The extended-release beads were then prepared by the ionotropic gelation method using calcium chloride as the crosslinkerions provider. The beads were then evaluated for drug encapsulation efficiency and drug release. ANOVA of all the dependent variables such as DEE, cumulative % drug release at 2h, 5h, 12h, rate constant and dissolution similarity factor (f2) was done by 23 full factorial design using Design-Expert software along with numerical optimization of the independent variables in order to meet USP-reference release profile. Results: The optimized batch showed excellent outcomes with DEE of 84.7 ± 2.7 (%), CPR2h of 8.41± 2.96 (%), CPR5h of 36.8± 4.7 (%), CPR12h of 87.3 ± 3.64 (%) and f2 of 65.9. Conclusion: This approach of the development of multi-unit oral devices utilizing natural polysaccharides might be inspiring towards the world-wide effort for green manufacturing of sustained-release drug products by the QbD route.

Preparation, Characterization and Antibacterial Activity of Quaternized Carboxymethyl Chitosan/Organic Rectorite Nanocomposites

2013 ◽  
Vol 9 (2) ◽  
pp. 278-282 ◽  
Author(s):  
Xiaoyun Li ◽  
Yang Han ◽  
Haoquan Zhong ◽  
Weijie Ye ◽  
Bo Liu ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Carboxymethyl Chitosan

Emulsifying properties of Chinese quince seed gum in oil-in-water emulsions

LWT ◽  
2021 ◽  
Vol 147 ◽  
pp. 111560
Author(s):  
Ye-Tong Yao ◽  
Wen-Yue Wang ◽  
Hua-Min Liu ◽  
Li-Xia Hou ◽  
Xue-De Wang
Keyword(s):  
Emulsifying Properties ◽  
Oil In Water ◽  
Chinese Quince ◽  
Seed Gum

Smart flame retardant coating containing carboxymethyl chitosan nanoparticles decorated graphene for obtaining multifunctional textiles

Cellulose ◽  
2021 ◽  
Author(s):  
Emad S. Goda ◽  
Mahmoud H. Abu Elella ◽  
Sang Eun Hong ◽  
Bidhan Pandit ◽  
Kuk Ro Yoon ◽  
...  
Keyword(s):  
Flame Retardant ◽  
Chitosan Nanoparticles ◽  
Carboxymethyl Chitosan

Bifunctional scaffolds of hydroxyapatite/poly(dopamine)/carboxymethyl chitosan with osteogenesis and anti-osteosarcoma effect

2021 ◽  
Author(s):  
Mengyu Yao ◽  
Qingxia Zou ◽  
Wenwu Zou ◽  
Zhenze Xie ◽  
Zhihao Li ◽  
...  
Keyword(s):  
Bone Tumor ◽  
Tumor Therapy ◽  
Carboxymethyl Chitosan

Bifunctional scaffolds prepared by hydroxyapatite/poly(dopamine)/carboxymethyl chitosan with good osteogenesis and anti-osteosarcoma effect is promising for bone tumor therapy.

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