Alcohol Drinking Habits and Genetic Polymorphism of Alcohol Metabolism Genes in West Siberia

2001 ◽  
Vol 1 (3) ◽  
pp. 165-171 ◽  
Author(s):  
Anna Belkovets ◽  
S. Kurilovich ◽  
A. Avkenstyuk ◽  
Dharam P. Agarwal
2021 ◽  
Vol 21 (2) ◽  
pp. 117-123
Author(s):  
Mardhatillah Marsa ◽  
Yudha Nurhantari ◽  
Suhartini Suhartini ◽  
Tri Ratnaningsih

Alcohol abuse is associated with genetic factors and is influenced by certain races and ethnicities. CYP2E1, which works on the endoplasmic reticulum, produces an enzyme that plays a significant role in alcohol metabolism. In relation to it, this study aims to identify the polymorphisms of CYP2E1*5B and CYP2E1*6 genes in alcohol drinkers of Papuan Ethnics. A total of 39 Papuans were analyzed for alcohol drinking habits. Alcohol drinkers were found to be 29 people (74.4%), and 10 people (25.6%) were non-drinkers. The drinkers mainly were late teenagers (89,7%) and males (69,2%). The CYP2E1*5B genotypes were c1/c1 as 94.9% and c1/c2 as 5.1%. Meanwhile, the CYP2E1*6 T/T genotypes were 56.4%, and T/A genotypes were 43.6%. The odd ratio for CYP2E1*5B were 18,5 and 7,7 for CYP2E1*6. p0,05 for CYP2E1*5B and CYP2E1*6 gene polymorphisms for alcohol drinking behavior in the form of frequency, duration, type, and volume of alcohol consumed. Furthermore, c1/c1 and c1/c2 genotype polymorphisms were in CYP2E1*5B; T/T and T/A genotypes were in CYP2E1*6 of Papuan ethnic at Yogyakarta. In conclusion, genotype c1/c1 had 18,5 times of the possibility of being alcoholic drinkers, and genotype T/T had 7,7 times of the possibility of being alcoholic drinkers in Papuan ethnic. It indicated that the type of genotype statistically did not significantly affect alcohol drinking behavior on the subject.


2020 ◽  
Author(s):  
Joseph Malechwanzi

Alcohol drinking among young people is a major global public health concern. The situation has been aggravated further by the advent of the internet and subsequent development of social media as a tool for online alcohol marketing. Measures that aim at reducing substance abuse is a stride towards “2030 Agenda” for sustainable development goal number 3 set by the United Nation General Assembly. In this goal, attention is not only drawn to health and wellbeing but also to prevention and treatment of substance abuse. This descriptive study sought to find out the prevalence of alcohol advertisements on social media and its possible influence on alcohol drinking among Kenya’s higher vocational college students. Based on a field survey conducted in Nairobi (n=209), this study established that there was heavy presence of alcohol advertisements on social media scene in Kenya. Although statistically, there was huge gender disparity, the final results showed that there was significant association between alcohol ads on social media and college student’s possible alcohol drinking habits. This study concludes that there was heavy presence of alcohol ads on social media, and the likelihood of youth having unrestricted access to the alcoholic beverage products. This could have a far-reaching implication on their alcohol drinking habits. Therefore, the study recommends the stakeholders in public health promotions to formulate policies aimed at mitigating against the challenges posed by unrestricted access to online alcohol ads by the youth in order to prevent them from being lured into early alcohol drinking by the alcoholic beverage makers.  Keywords: Alcohol abuse; Influence; Online ads; Youth; Kenya


2020 ◽  
Author(s):  
Chiara Mazzarella ◽  
Annamaria Spina ◽  
Marcello Dallio ◽  
Antonietta Gerarda Gravina ◽  
Mario Romeo ◽  
...  

BACKGROUND Italy has been one of the first western countries seriously involved in the COVID-19 pandemic in the first months of 2020 and so that the national government was forced to impose a long lockdown period, stopping all the people aggregation outdoor and indoor activities. From a social point of view this period of domestic confinement resulted in deep changes of behaviours and lifestyles, promoting in many people the onset of psychological symptoms and signs (including anxiety, depression, insomnia, and irritability among others) already known as associated with drug and alcohol abuse OBJECTIVE this study aims to assess the variation of alcohol drinking habits in a sample of Italian citizens during the COVID-19 lockdown and to identify the psychosocial factors surrounding it, in order to assess the specific subset of the population that could need psychosocial support during these events METHODS An online anonymous questionnaire was created and submitted from 9th April 2020 to 28th April 2020 using social medias and e-mails. Questions were related to personal details such as age, work, instruction, and, moreover, to alcohol drinking habits during the lockdown, including Alcohol Use Disorders Identification Test (AUDIT C) test questions RESULTS A total of 1234 surveys were filled out by subjects with an age range from 18 to 80 years old. An increase in both anxiety and fear has been detected in most of the participants (63% and 61% respectively) with a direct (r=0.652; p<0.001) relationship between them. Participants older than 50 years showed the strongest correlation between alcohol consumption, fear, and anxiety, (r=0.830, P <0.001 and r=0.741, P<0.001, respectively). Subjects living alone experienced a stronger association between anxiety, fear, and higher level of alcohol consumption (r: 0.529; P<0.001; r: 0.628, P<0.001 respectively). Moreover, 18% of participants increased alcohol consumption drinking during the lockdown. These subjects showed a lower frequency of alcohol consumption before the lockdown in comparison to the rest of the study population (2.5±0.96 vs 3±1.03, P<0.0001 respectively). Moreover, comparing the abovementioned groups, the percentage of subjects who experienced higher alcohol assumption before the 11th of March was higher in those that didn't change their drinking behaviour during the lockdown in comparison to that portion of them that experienced a worsening of alcohol abuse (r: 30.422, P<0.0001) CONCLUSIONS according to these data, during the Italian lockdown due to COVID 19 pandemic, different kind of people experienced an increase in alcohol drinking. Several psychosocial factors are involved in determining the increase in harmful alcohol consumption during this extraordinary stressful event and they must be addressed by the healthcare support in order to avoid awful lockdown impact on human life


2006 ◽  
Vol 163 (suppl_11) ◽  
pp. S130-S130
Author(s):  
J Tolstrup ◽  
BG Nordestgaard ◽  
S Rasmussen ◽  
A Tybjaerg-Hansen ◽  
M Gronbaek

2007 ◽  
Vol 8 (3) ◽  
pp. 220-227 ◽  
Author(s):  
Janne Schurmann Tolstrup ◽  
Børge Grønne Nordestgaard ◽  
Søren Rasmussen ◽  
Anne Tybjærg-Hansen ◽  
Morten Grønbæk

2019 ◽  
Vol 70 (1) ◽  
pp. e141
Author(s):  
Fredrik Åberg ◽  
Pauli Puukka ◽  
Perttu Sahlman ◽  
Markku Nissinen ◽  
Veikko Salomaa ◽  
...  

2015 ◽  
Vol 06 (02) ◽  
pp. 195-204 ◽  
Author(s):  
Shunji Oshima ◽  
Takeshi Haseba ◽  
Akihiro Nemoto ◽  
Sachie Siiya ◽  
Tomomasa Kanda ◽  
...  

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