A Mathematical Model of Continuous HIV Mutations Eluding Immune Defence
2002 ◽
Vol 4
(4)
◽
pp. 241-249
◽
Keyword(s):
We develop a description of HIV mutations based upon a continuum representation of the fitness of the virus, including the interaction of the virus with both specific Th1 lymphocytes as well as cross-reactive cells. This deterministic model allows a straightforward measure of the diversity of viral population and reproduces the observed increase in diversity as the disease progresses in an untreated patient. We use the diversity threshold theory, extending the modelling to track mutations on a continuum. When the diversity threshold is exceeded, the host immune system collapses.
2018 ◽
Vol 461
(2)
◽
pp. 1378-1390
◽
1996 ◽
Vol 04
(04)
◽
pp. 479-502
◽
Keyword(s):
2020 ◽
Vol 11
(SPL1)
◽
pp. 259-261
Keyword(s):
Keyword(s):
2018 ◽
Vol 11
(1)
◽
pp. 3937-3949
2020 ◽
Vol 21
(3)
◽
pp. 245-264
◽