Phytochemicals, Antihemolytic, Anti-inflammatory, Antioxidant, and Antibacterial Activities from Thymus Algeriensis

2021 ◽  
pp. 1-14
Author(s):  
Mouna Mokhtari ◽  
Sonia Chabani ◽  
Soumia Mouffouk ◽  
Mohamed-Cherif Aberkane ◽  
Ammar Dibi ◽  
...  
Keyword(s):  
Antibacterial Activities ◽  
Thymus Algeriensis ◽  
Anti Inflammatory

scholarly journals Thymus algeriensis and Artemisia herba-alba Essential Oils: Chemical Analysis, Antioxidant Potential and In Vivo Anti-Inflammatory, Analgesic Activities, and Acute Toxicity

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6780
Author(s):  
Khadija El Ouahdani ◽  
Imane Es-safi ◽  
Hamza Mechchate ◽  
Mohammed Al-zahrani ◽  
Ashraf Ahmed Qurtam ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Free Radical ◽  
Medicinal Plants ◽  
Essential Oils ◽  
Iron Reduction ◽  
Radical Scavenging ◽  
Bioactive Molecules ◽  
Potential Toxicity ◽  
Thymus Algeriensis ◽  
Anti Inflammatory

The study of bioactive molecules of natural origin is a focus of current research. Thymus algeriensis and Artemisia herba-alba are two medicinal plants widely used by the Moroccan population in the traditional treatment of several pathologies linked to inflammation. This study aimed to evaluate the single and combined antioxidant, anti-inflammatory and analgesic effects of the essential oils extracted from these two medicinal plants, and also their potential toxicity. Essential oils were extracted using hydro-distillation in a Clevenger-type apparatus. The antioxidant activity was evaluated by two methods: the scavenging of the free radical DPPH, and the reduction in iron. Anti-inflammatory activity was evaluated by evaluating the edema development induced by carrageenan injecting, while the analgesic power was evaluated according to the number of abdominal contortions induced by the intraperitoneal injection of acetic acid (0.7%). The acute oral toxicity was performed to assess the potential toxicity of the studied EOs, followed by an analysis of the blood biochemical parameters. The results of the two antioxidant tests indicated that our extract mixture exhibits good iron reduction capacity and very interesting DPPH free radical scavenging power, with an IC50 of around 4.38 ± 0.98 μg/mL higher than that of the benchmark antioxidant, BHT. The anti-inflammatory test demonstrated that the mixture administered orally at a dose of 150 mg/kg has a better activity, exceeding that of 1% Diclofenac, with a percentage of maximum inhibition of the edema of 89.99 ± 4.08. The number of cramps in the mice treated with the mixture at a dose of 150 mg/kg is significantly lower (29.80 ± 1.92) than those of the group treated with Tramadol (42.00 ± 2.70), respectively. The toxicity results show no signs of toxicity with an LD50 greater than 150 mg/Kg. These interesting results show that the two plants’ EOs had an important anti-inflammatory, analgesic, and antioxidant activity, and also a powerful synergistic effect, which encourages further in-depth investigations on their pharmacological proprieties.

scholarly journals A brief review on Triazin-pyridazinones: Synthesis and biological activities

2017 ◽  
Vol 17 (43) ◽  
pp. 28-33 ◽  
Author(s):  
M Asif
Keyword(s):  
Biological Activities ◽  
Antibacterial Activities ◽  
Reference Standards ◽  
Anti Inflammatory

A series of substituted triazin-pyridazine compounds were exhibited diverse types of biological activities and synthesized by different methods. These compounds were mainly tested for their anti-inflammatory, anticancer, antifungal and antibacterial activities. These substituted triazin-pyridazine compounds have mild to potent activities on compare with their appropriate reference standards.

scholarly journals The anti-inflammatory and antibacterial activities of Amaryllidaceae alkaloids

2003 ◽  
Vol 69 (3) ◽  
pp. 448-449 ◽  
Author(s):  
E.E. Elgorashi ◽  
S. Zschocke ◽  
J. van Staden ◽  
J.N. Eloff
Keyword(s):  
Antibacterial Activities ◽  
Amaryllidaceae Alkaloids ◽  
Anti Inflammatory

scholarly journals Identification of Synthetic Host Defense Peptide Mimics That Exert Dual Antimicrobial and Anti-Inflammatory Activities

2012 ◽  
Vol 19 (11) ◽  
pp. 1784-1791 ◽  
Author(s):  
Abhigyan Som ◽  
Nicolás Navasa ◽  
Avital Percher ◽  
Richard W. Scott ◽  
Gregory N. Tew ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Lipoteichoic Acid ◽  
Antibacterial Activities ◽  
Innate Immune Responses ◽  
Content Type ◽  
Host Defense Peptide ◽  
Anti Inflammatory ◽  
Molecular Patterns

ABSTRACTA group of synthetic antimicrobial oligomers, inspired by naturally occurring antimicrobial peptides, were analyzed for the ability to modulate innate immune responses to Toll-like receptor (TLR) ligands. These synthetic mimics of antimicrobial peptides (SMAMPs) specifically reduced cytokine production in response toStaphylococcus aureusand theS. aureuscomponent lipoteichoic acid (LTA), a TLR2 agonist. Anti-inflammatory SMAMPs prevented the induction of tumor necrosis factor (TNF), interleukin 6 (IL-6), and IL-10 in response toS. aureusor LTA, but no other TLR2 ligands. We show that these SMAMPs bind specifically to LTAin vitroand prevent its interaction with TLR2. Importantly, the SMAMP greatly reduced the induction of TNF and IL-6in vivoin mice acutely infected withS. aureuswhile simultaneously reducing bacterial loads dramatically (4 log10). Thus, these SMAMPs can eliminate the damage induced by pathogen-associated molecular patterns (PAMPs) while simultaneously eliminating infectionin vivo. They are the first known SMAMPs to demonstrate anti-inflammatory and antibacterial activitiesin vivo.

scholarly journals Wound Healing and Anti-Inflammatory Effect in Animal Models ofCalendula officinalisL. Growing in Brazil

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Leila Maria Leal Parente ◽  
Ruy de Souza Lino Júnior ◽  
Leonice Manrique Faustino Tresvenzol ◽  
Marina Clare Vinaud ◽  
José Realino de Paula ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Chorioallantoic Membrane ◽  
Ethanolic Extract ◽  
Immunohistochemical Analysis ◽  
Antibacterial Activities ◽  
Cutaneous Wounds ◽  
Annual Herb ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Calendula officinalisis an annual herb from Mediterranean origin which is popularly used in wound healing and as an anti-inflammatory agent. In this study, the ethanolic extract, the dichloromethane, and hexanic fractions of the flowers from plants growing in Brazil were produced. The angiogenic activity of the extract and fractions was evaluated through the chorioallantoic membrane and cutaneous wounds in rat models. The healing activity of the extract was evaluated by the same cutaneous wounds model through macroscopic, morphometric, histopathologic, and immunohistochemical analysis. The antibacterial activity of the extract and fractions was also evaluated. This experimental study revealed thatC. officinalispresented anti-inflammatory and antibacterial activities as well as angiogenic and fibroplastic properties acting in a positive way on the inflammatory and proliferative phases of the healing process.

scholarly journals Synthesis of quinoline attached-furan-2(3H)-ones having anti-inflammatory and antibacterial properties with reduced gastro-intestinal toxicity and lipid peroxidation

2011 ◽  
Vol 76 (12) ◽  
pp. 1617-1626 ◽  
Author(s):  
Mohammad Alam ◽  
Priya Sarkar ◽  
Asif Husain ◽  
Akranth Marella ◽  
M.S. Zaman ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Phosphorus Oxychloride ◽  
Antibacterial Properties ◽  
Antibacterial Activities ◽  
Dimethyl Formamide ◽  
Significant Activity ◽  
Acylation Reaction ◽  
Reaction Conditions ◽  
E Coli ◽  
Anti Inflammatory

A series of 3-[2-chloroquinolin-3-yl)methylene]-5-aryl-furan-2(3H)-ones {3(a-p)} were synthesized. The required 3-(substitutedbenzoyl) propionic acids {2(a-d)} were prepared under Friedal Craft acylation reaction conditions. The substituted 2-chloroquinoline-3-carbaldehydes {1(a-d)} were synthesized by reaction of substitutedphenylethanone-oxime with phosphorus oxychloride in presence of dimethyl formamide using the Vilsmeir Haack reaction method. These compounds were screened for their anti-inflammatory and antibacterial activities along with their ulcerogenic and lipid peroxidation potentials. The compounds that showed significant anti-inflammatory activity were further screened for their analgesic activity. The compounds were less toxic in terms of ulcerogenicity as compared to a standard, which was also supported by lipid peroxidation studies. The antibacterial activities were performed against Staphylococcus aureus and Escherichia coli. Compounds 3f, 3n and 3o showed significant activity against both S. aureus and E. coli having an MIC value of 6.25?g mL-1.

scholarly journals Preparation of Polysaccharides from Ramulus mori, and Their Antioxidant, Anti-Inflammatory and Antibacterial Activities

Molecules ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 856 ◽  
Author(s):  
Wansha Yu ◽  
Hu Chen ◽  
Zhonghuai Xiang ◽  
Ningjia He
Keyword(s):  
Glucuronic Acid ◽  
Antibacterial Activities ◽  
Molar Ratio ◽  
Process Conditions ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Melting Temperatures ◽  
Anti Inflammatory ◽  
C 50 ◽  
Solid Liquid

The extraction of Ramulus mori polysaccharides (RMPs) was optimized using response surface methodology (RSM). The optimal process conditions, which gave the highest yield of RMPs (6.25%) were 80 °C, 50 min, and a solid–liquid ratio of 1:40 (g/mL), with the extraction performed twice. The RMPs contained seven monosaccharides, namely, mannose, rhamnose; glucuronic acid, glucose, xylose, galactose, and arabinose, in a 1.36:2.68:0.46:328.17:1.53:21.80:6.16 molar ratio. The glass transition and melting temperatures of RMPs were 83 and 473 °C, respectively. RMPs were α-polysaccharides and had surfaces that resembled a porous sponge, as observed by scanning electron microscopy. RMPs inhibited the proliferation of Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa and showed antioxidant activity (assessed by three different methods), although it was generally weaker than that of vitamin C. RMPs showed anti-inflammatory activity in a concentration-dependent manner. This study provides a basis for exploring the potential uses of RMPs.

Sign in / Sign up

Export Citation Format

Share Document