Effects of Calcium-Binding Peptide from Tilapia Scale Protein Hydrolysates on Calcium Absorption in Caco-2 Cells

2016 ◽  
Vol 25 (8) ◽  
pp. 1213-1220 ◽  
Author(s):  
Yuan Lu ◽  
Ruiyan Nie ◽  
Feng Li ◽  
Zunying Liu
Keyword(s):  
Calcium Binding ◽  
Calcium Absorption ◽  
Protein Hydrolysates ◽  
Binding Peptide ◽  
Tilapia Scale

Isolation of a Calcium-binding Peptide from Chlorella Protein Hydrolysates

2010 ◽  
Vol 15 (4) ◽  
pp. 282-286 ◽  
Author(s):  
So-Jeong Jeon ◽  
Ji-Hye Lee ◽  
Kyung-Bin Song
Keyword(s):  
Calcium Binding ◽  
Protein Hydrolysates ◽  
Binding Peptide

Isolation of a novel calcium-binding peptide from wheat germ protein hydrolysates and the prediction for its mechanism of combination

2018 ◽  
Vol 239 ◽  
pp. 416-426 ◽  
Author(s):  
Li Wang ◽  
Yuanyuan Ding ◽  
Xinxia Zhang ◽  
Yongfu Li ◽  
Ren Wang ◽  
...  
Keyword(s):  
Calcium Binding ◽  
Wheat Germ ◽  
Protein Hydrolysates ◽  
Binding Peptide

Isolation of a calcium-binding peptide from bovine serum protein hydrolysates

2012 ◽  
Vol 21 (6) ◽  
pp. 1663-1667 ◽  
Author(s):  
Dong-Won Choi ◽  
Ji-Hye Lee ◽  
Ho-Hyun Chun ◽  
Kyung Bin Song
Keyword(s):  
Serum Protein ◽  
Calcium Binding ◽  
Bovine Serum ◽  
Protein Hydrolysates ◽  
Binding Peptide ◽  
Bovine Serum Protein

Isolation of a calcium-binding peptide from tilapia scale protein hydrolysate and its calcium bioavailability in rats

2014 ◽  
Vol 6 ◽  
pp. 575-584 ◽  
Author(s):  
Da Chen ◽  
Xinmin Mu ◽  
Hai Huang ◽  
Ruiyan Nie ◽  
Zunying Liu ◽  
...  
Keyword(s):  
Calcium Binding ◽  
Protein Hydrolysate ◽  
Binding Peptide ◽  
Calcium Bioavailability ◽  
Tilapia Scale

scholarly journals Functional Calcium Binding Peptides from Pacific Cod (Gadus macrocephalus) Bone: Calcium Bioavailability Enhancing Activity and Anti-Osteoporosis Effects in the Ovariectomy-Induced Osteoporosis Rat Model

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1325 ◽  
Author(s):  
Kai Zhang ◽  
Bafang Li ◽  
Qianru Chen ◽  
Zhaohui Zhang ◽  
Xue Zhao ◽  
...  
Keyword(s):  
Serum Calcium ◽  
Rat Model ◽  
Calcium Binding ◽  
Calcium Absorption ◽  
Intestinal Calcium Absorption ◽  
Pacific Cod ◽  
Pacific Cod Gadus Macrocephalus ◽  
Calcium Bioavailability ◽  
Gadus Macrocephalus ◽  
Binding Peptides

Calcium binding peptides from Pacific cod (Gadus macrocephalus) bone have attracted attention due to their potential effects on bone health. In this study, calcium binding peptides (CBP) were prepared from Pacific cod bone by trypsin and neutral protease. Ultraviolet spectra, circular dichroism (CD), and Fourier transform infrared spectroscopy (FTIR) revealed that carboxyl and amino groups in CBP could bind to Ca2+, and form the peptide-calcium complex (CBP-Ca). Single-pass intestinal perfusion (SPIP) experiments indicated that the intestinal calcium absorption was significantly enhanced (p < 0.01) in CBP-Ca treated Wistar rats. The anti-osteoporosis activity of CBP-Ca was investigated in the ovariectomized (OVX) Wistar rat model. The administration of CBP-Ca significantly (p < 0.01) improved the calcium bioavailability, trabecular bone structure, bone biomechanical properties, bone mineral density, and bone mineralization degree. CBP-Ca notably (p < 0.01) increased serum calcium, however, it remarkably (p < 0.01) reduced the levels of osteocalcin (OCN), bone alkaline phosphatase (BALP), tartrate-resistant acid phosphatase isoform 5b (TRAP5b), and C-telopeptide of type I collagen (CTX-1) in serum. Results suggested that the cod bone derived CBP could bind with calcium, improve the intestinal calcium absorption, calcium bioavailability, and serum calcium, then reduce the bone turnover rate, and thus ameliorate osteoporosis.

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