Glycosyl Derivatives of Dopamine and l -dopa as Anti-Parkinson Prodrugs: Synthesis, Pharmacological Activity and In Vitro Stability Studies

2003 ◽  
Vol 11 (1) ◽  
pp. 25-36 ◽  
Author(s):  
Francesco Bonina ◽  
Carmelo Puglia ◽  
Maria Grazia Rimoli ◽  
Daniela Melisi ◽  
Giampiero Boatto ◽  
...  
Keyword(s):  
Pharmacological Activity ◽  
Stability Studies ◽  
Derivatives Of ◽  
In Vitro Stability

scholarly journals Physicochemical properties and in vitro stability studies of green synthesized gold nanoparticles using pelargonium sidoides

2020 ◽  
Vol 39 (3) ◽  
Author(s):  
U.M. Badeggi ◽  
B.A. Lawal ◽  
A.O. Akinfenwa ◽  
Y.O. Ayipo ◽  
Y. Azeh ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Zeta Potential ◽  
Biomedical Applications ◽  
Capping Agent ◽  
Stability Studies ◽  
Hybrid Particles ◽  
Pelargonium Sidoides ◽  
In Vitro Stability ◽  
532 Nm

In the present study, Pelargonium sidoides (PS) extract was used in the green synthesis of AuNPs that was characterized by UV-Vis, TEM, SAED, EDS, XRD, FTIR, and DLS. UV-Vis showed a surface plasmon resonance (SPR) at λmax of 532 nm while TEM shows that the particles are predominantly spherical and monodispersed. DLS measurement indicated the particle size and the zeta potential to be 27.20 nm and -24.0 mV respectively. The in vitro stability of the hybrid particles in different solutions and buffers (pH 7 and 9) confirmed that the particles are stable over a given period. The method employed is simple, environmentally friendly, and inexpensive. Our studies suggest that the Pelargonium sidoides-gold nanoparticles (PS-AuNPs) may be safely used in biomedical applications such as drug delivery. Keywords: Pelargonium sidoides; biosynthesis; biomedicals; capping agent; zeta potential

End‐Chain Radiolabeling and in Vitro Stability Studies of Radiolabeled Poly(hydroxy acid) Nanoparticles

1994 ◽  
Vol 83 (6) ◽  
pp. 845-851 ◽  
Author(s):  
A.M. Le Ray ◽  
M. Vert ◽  
J.C. Gautier ◽  
J.P. Benoǐt
Keyword(s):  
Hydroxy Acid ◽  
Stability Studies ◽  
In Vitro Stability

Pharmacological activity of Mexican basidiomycetes species cultivated in vitro

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
L Garza-Ocañas ◽  
E Tamez de la O ◽  
XS Ramírez-Gómez ◽  
F Garza-Ocañas ◽  
MT Zanatta Calderón ◽  
...  
Keyword(s):  
Pharmacological Activity

Kinetics of Various 99mTc-Sn-Pyrophosphate Compounds in the Rat

1977 ◽  
Vol 16 (04) ◽  
pp. 157-162 ◽  
Author(s):  
C. Schümichen ◽  
B. Mackenbrock ◽  
G. Hoffmann
Keyword(s):  
Normal Saline ◽  
Half Life ◽  
Compound A ◽  
Short Half Life ◽  
Low Concentrations ◽  
The Stability ◽  
Kinetics Of ◽  
In Vitro Stability

SummaryThe bone-seeking 99mTc-Sn-pyrophosphate compound (compound A) was diluted both in vitro and in vivo and proved to be unstable both in vitro and in vivo. However, stability was much better in vivo than in vitro and thus the in vitro stability of compound A after dilution in various mediums could be followed up by a consecutive evaluation of the in vivo distribution in the rat. After dilution in neutral normal saline compound A is metastable and after a short half-life it is transformed into the other 99mTc-Sn-pyrophosphate compound A is metastable and after a short half-life in bone but in the kidneys. After dilution in normal saline of low pH and in buffering solutions the stability of compound A is increased. In human plasma compound A is relatively stable but not in plasma water. When compound B is formed in a buffering solution, uptake in the kidneys and excretion in urine is lowered and blood concentration increased.It is assumed that the association of protons to compound A will increase its stability at low concentrations while that to compound B will lead to a strong protein bond in plasma. It is concluded that compound A will not be stable in vivo because of a lack of stability in the extravascular space, and that the protein bond in plasma will be a measure of its in vivo stability.

Rhenium-188 Labeled Hydroxyapatite and Rhenium-188 Sulfur Colloid

1997 ◽  
Vol 36 (02) ◽  
pp. 71-75 ◽  
Author(s):  
S. Glatz ◽  
S. N. Reske ◽  
K. G. Grillenberger
Keyword(s):  
Synovial Fluid ◽  
Ph Value ◽  
Surgical Removal ◽  
Radiation Synovectomy ◽  
Sulfur Colloid ◽  
Target Organs ◽  
Aseptic Conditions ◽  
In Vitro Stability ◽  
Potential Use

Summary Aim: One therapeutic approach to rheumatoid arthritis and other inflammatory arthropathies besides surgical removal of inflamed synovium is radiation synovectomy using beta-emitting radionuclides to destroy the affected synovial tissue. Up to now the major problem associated with the use of labeled particles or colloids has been considerable leakage of radionuclides from the injected joint coupled with high radiation doses to liver and other non target organs. In this study we compared 188Re labeled hydroxyapatite particles and 188Re rhenium sulfur colloid for their potential use in radiation synovectomy. Methods: To this end we varied the labeling conditions (concentrations, pH-value, heating procedure) and analyzed the labeling yield, radiochemical purity, and in vitro stability of the resulting radiopharmaceutical. Results: After optimizing labeling conditions we achieved a labeling yield of more than 80% for 188Re hydroxyapatite and more than 90% for the rhenium sulfur colloid. Both of the radiopharmaceuticals can be prepared under aseptic conditions using an autoclav for heating without loss of activity. In vitro stability studies using various challenge solutions (water, normal saline, diluted synovial fluid) showed that 188Re labeled hydroxyapatite particles lost about 80% of their activity within 5 d in synovial fluid. Rhenium sulfur colloid on the other hand proved to be very stable with a remaining activity of more than 93% after 5 d in diluted synovial fluid. Conclusion: These in vitro results suggest that 188Re labeled rhenium sulfur colloid expects to be more suitable for therapeutic use in radiation synovectomy than the labeled hydroxyapatite particles.

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