Fabrication and characterization of composite PMMA/HA scaffold using freeze casting method

2021 ◽  
pp. 1-8
Author(s):  
Gurdev Singh ◽  
Soundarapandian Santhanakrishnan
2014 ◽  
Vol 4 (3) ◽  
pp. 27-32
Author(s):  
Jeevan Singh Bisht ◽  
◽  
Akshay Dvivedi ◽  
Apurbba Kumar Sharma ◽  
◽  
...  

2018 ◽  
Vol 33 (4) ◽  
pp. 501-513 ◽  
Author(s):  
Hossein Semyari ◽  
Majid Salehi ◽  
Ferial Taleghani ◽  
Arian Ehterami ◽  
Farshid Bastami ◽  
...  

In this study, hydroxyapatite nanoparticles containing 10% doxycycline, a structural isomer of tetracycline, was prepared by the co-precipitation method. It was added to collagen solution for the preparation of the scaffold with freeze-casting method in order to develop a composite scaffold with both antibacterial and osteoinductive properties for repairing bone defects. The scaffolds were evaluated regarding their morphology, porosity, degradation and cellular response. The scaffolds for further investigation were added in a rat calvaria defect model. The study showed that after eight weeks, the bone formation was relatively higher in the collagen/nano-hydroxyapatite/doxycycline group with completely filled defect when compared with other groups. Histopathological evaluation showed that the defect in the collagen/nano-hydroxyapatite/doxycycline group was fully replaced by the new bone and connective tissue. Our results provide evidence supporting the possible applicability of doxycycline-containing scaffolds for successful bone regeneration.


2019 ◽  
Vol 45 (3) ◽  
pp. 3954-3960 ◽  
Author(s):  
Fei He ◽  
Wenjie Li ◽  
Liang Zhou ◽  
Lijuan Yang ◽  
Hongbo Zhao ◽  
...  

2012 ◽  
Vol 51 (27) ◽  
pp. 9241-9249 ◽  
Author(s):  
Mahboubeh Jafarkhani ◽  
Alireza Fazlali ◽  
Fathollah Moztarzadeh ◽  
Zoha Moztarzadeh ◽  
Masoud Mozafari

2020 ◽  
Vol 32 (12) ◽  
pp. 3113-3119
Author(s):  
P. Lavanya ◽  
N. Vijayakumari ◽  
R. Sangeetha ◽  
G. Priya

Biocomposite scaffolds of strontium-magnesium substituted hydroxyapatite (SMHA) with a mixture of chitosan/polypyrrole (CS-PPY) have been prepared by solvent casting method. The synthesized SMHA nanoparticles and biocomposite scaffold were characterized by FTIR, XRD and SEM techniques. The SEM morphology revealed the porous structure of the scaffolds designed for the muticomponents. The biomineralization and cell viability of the biocomposite were assessed via alkaline phosphatase activity and MTT assay on the osteoblast cell line. The study demonstrated improved differentiation and mineralization of osteoblast cells in the designed biocomposite scaffolds. The dye stained fluorescent microscopic photographs apparent the good scattering and permeability of cells onto the scaffolds. However, biocomposite demonstrated good antibacterial activity and the excellent biocompatibility against osteoblast cells offers a possible route for the production of a biocomposite as a viable replacement for regenerative medicine scaffolding substance.


Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1798
Author(s):  
Łukasz Łopusiewicz ◽  
Magdalena Zdanowicz ◽  
Szymon Macieja ◽  
Krzysztof Kowalczyk ◽  
Artur Bartkowiak

The preparation of biodegradable active packaging materials is still a major challenge. Here, we report the fabrication and characterization of poly(butylene succinate)-based (PBS) films enriched with a natural polyphenolic antioxidant—quercetin. The PBS-based films with various quercetin content (0.05; 0.10; 0.25 and 0.50 pph on PBS) were prepared via a solvent casting method. Physical (optical, mechanical, thermal, moisture and water sorption, water vapor and UV–vis barrier) and biofunctional (antioxidant and antibacterial against Escherichia coli and Staphylococcus aureus) film properties were tested. The migration of quercetin into model food liquid systems was determined. As a result of quercetin addition, significant changes in color, opacity and UV-blocking effect were observed. The presence of the active substance did not significantly affect the thermal properties of the PBS matrix. However, the mechanical properties of the films were slightly decreased. The films exhibited excellent free radicals (DPPH, ABTS, O2−) scavenging and some bactericidal activities. PBS-quercetin films with superior functional properties have many possibilities for active food packaging applications.


2019 ◽  
Vol 35 (4) ◽  
pp. 475-484
Author(s):  
SHIVA ARUN ◽  
◽  
PRABHA BHARTIYA ◽  
AMREEN NAZ ◽  
SUDHEER RAI ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document