Plukenetia conophora seed oil ameliorates streptozotocin-induced hyperglycemia and oxidative stress in rats

Biomarkers ◽  
2021 ◽  
pp. 1-11
Author(s):  
Abayomi Ajayi ◽  
Victoria Badaki ◽  
Olusegun G. Adebayo ◽  
Benneth Ben-Azu
Keyword(s):  
Oxidative Stress ◽  
Seed Oil ◽  
And Oxidative Stress

Ameliorative Role of Cabernet Sauvignon Seed Oil on Hyperlipidemia, Inflammation, and Oxidative Stress in Mice

2019 ◽  
Vol 121 (10) ◽  
pp. 1800454
Author(s):  
Xiaojing Li ◽  
Yingbin Shen ◽  
Na Tang ◽  
Jianhong Zhu ◽  
Junyong Xiao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Seed Oil ◽  
Cabernet Sauvignon ◽  
And Oxidative Stress

scholarly journals Zanthoxylum bungeanum Seed Oil Attenuates LPS-Induced BEAS-2B Cell Activation and Inflammation by Inhibiting the TLR4/MyD88/NF-κB Signaling Pathway

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Jing Hou ◽  
Jun Wang ◽  
Jingyi Meng ◽  
Xiaoting Zhang ◽  
Yuanjing Niu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Molecular Docking ◽  
Western Blot ◽  
Signaling Pathway ◽  
Seed Oil ◽  
Lung Epithelial Cells ◽  
Cell Counting ◽  
Enzyme Linked Immunosorbent Assay ◽  
Zanthoxylum Bungeanum ◽  
And Oxidative Stress

Background. Zanthoxylum bungeanum seed oil (ZBSO) is a natural essential oil derived from the seeds of the Chinese medicinal plant Zanthoxylum bungeanum, which has been investigated for antitumor and anti-inflammatory effects. However, little is known regarding the effects of ZBSO in chronic obstructive pulmonary disease (COPD). Methods. In this study, lung epithelial cells (BEAS-2B) were induced by lipopolysaccharide (LPS) to establish an in vitro model of COPD, and cytotoxicity was detected by a cell counting kit 8 (CCK-8) assay. Griess test, enzyme-linked immunosorbent assay (ELISA), reverse transcriptase quantitative polymerase chain reaction (RT-qPCR), western blot, immunofluorescence, and molecular docking analyses were used to investigate the effects of ZBSO and its potential mechanisms. Results. The results showed that LPS promoted the expression of nitric oxide (NO), reactive oxygen species (ROS), malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), matrix metalloproteinase-2 (MMP-2), MMP-9, cyclooxygenase-2 (COX-2), and prostaglandin E2 (PGE2), suggesting that LPS can induce inflammation and oxidative stress in BEAS-2B cells. ZBSO inhibits the LPS-induced expression of inflammatory mediators and proinflammatory cytokines in BEAS-2B cells. The molecular docking results indicated that active components in ZBSO could successfully dock with toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), and p65. Immunofluorescence and western blot analyses further demonstrated that ZBSO repressed protein expression associated with the TLR4/MyD88/nuclear factor-κB (NF-κB) signaling pathway. Conclusions. ZBSO reduced the inflammatory response and oxidative stress induced by LPS by inhibiting the TLR4/MyD88/NF-κB signaling pathway, thereby suppressing COPD. ZBSO may represent a promising therapeutic candidate for COPD treatment.

Evaluation of rubber seed oil in feed of giant gourami Osphronemus gouramy L: Growth performance and oxidative stress

2020 ◽  
pp. 1-18
Author(s):  
Tina Purnamasari ◽  
Muhammad Agus Suprayudi ◽  
Mia Setiawati ◽  
Ichsan Ahmad Fauzi ◽  
Wasjan
Keyword(s):  
Oxidative Stress ◽  
Growth Performance ◽  
Seed Oil ◽  
Rubber Seed Oil ◽  
Rubber Seed ◽  
And Oxidative Stress

Chia Seed Oil Prevents High Fat Diet Induced Hyperlipidemia and Oxidative Stress in Mice

2020 ◽  
Vol 122 (4) ◽  
pp. 1900443
Author(s):  
Kai Han ◽  
Xin‐Yang Li ◽  
Ye‐Qi Zhang ◽  
Yong‐Lin He ◽  
Rui Hu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
High Fat Diet ◽  
Seed Oil ◽  
High Fat ◽  
Chia Seed ◽  
Chia Seed Oil ◽  
And Oxidative Stress

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

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