Analgesic Activity ofDalbergia lanceolaria. Bark Extract in Swiss Albino Mice

2005 ◽  
Vol 43 (8) ◽  
pp. 723-725 ◽  
Author(s):  
A.V. Misar ◽  
Mrudula Kale ◽  
Maruti Joshi ◽  
A.M. Mujumdar
Keyword(s):  
Analgesic Activity ◽  
Bark Extract ◽  
Swiss Albino Mice ◽  
Albino Mice

Membrane stabilizing, thrombolytic, analgesic, anti-diarrheal and CNS activities of Polyalthia longifolia (Sonn.)

2014 ◽  
Vol 4 (3) ◽  
pp. 104-109
Author(s):  
Ridwan Islam ◽  
Md. Al Amin Sikder ◽  
Rafeeq Alam Khan ◽  
Mansoor Ahmed ◽  
Mohammad A. Rashid
Keyword(s):  
Analgesic Activity ◽  
Castor Oil ◽  
Methanol Extract ◽  
Bark Extract ◽  
Tail Flick ◽  
Swiss Albino Mice ◽  
Tail Flick Latency ◽  
Albino Mice ◽  
Polyalthia Longifolia ◽  
Crude Methanol Extract

Different fractions of Polialthia longifolia (Sonn.) bark were evaluated for membrane stabilizing, thrombolytic, analgesic, anti-diarrheal and CNS de-pressant activities upon oral administration at 200 and 400 mg/kg body weight. The membrane stabilizing activity was assessed by heat and hypo-tonic solution. Carbon tetrachloride fraction of methanol extract of P. longi-folia bark demonstrated strong membrane stabilizing activity, while the crude methanol extract demonstrated mild to moderate thrombolytic activi-ty in human blood specimen. The analgesic activity was assessed by tail im-mersion and formalin-induced pain method in Swiss-albino mice. The crude methanol extract of P. longifolia bark exhibited significant peripheral and central analgesic activity, since inhibited chemical induced writhing at 200 mg/kg and increased tail flick latency time both at 200 and 400 mg/kg. The anti-diarrheal activity of the bark extract was assessed by using castor oil induced diarrhea in mice however significant anti-diarrheal activity was not revealed. The CNS inhibitory activity of the methanol extract was assessed in Swiss albino mice where it reduced phenobarbitone sodium induced sleep-ing time at 400 mg/kg.

scholarly journals Methanol, ethyl acetate and n-hexane extracts of Tragia involucrata L. leaves exhibit anxiolytic, sedative and analgesic activity in Swiss albino mice

Heliyon ◽  
2021 ◽  
Vol 7 (1) ◽  
pp. e05814
Author(s):  
Md. Shofiqul Islam ◽  
Samiron Sana ◽  
Md. Ehsanul Haque ◽  
S.M. Mushiur Rahman ◽  
Abdus Samad ◽  
...  
Keyword(s):  
Ethyl Acetate ◽  
Analgesic Activity ◽  
Swiss Albino Mice ◽  
Hexane Extracts ◽  
Albino Mice

scholarly journals HPLC characterization, acute and sub-acute toxicity evaluation of bark extract of Rhizophora mucronata in Swiss Albino mice

Heliyon ◽  
2020 ◽  
Vol 6 (1) ◽  
pp. e03108
Author(s):  
Jairaman Chitra ◽  
Syed Ali Mohamed Yacoob ◽  
Sivanesan Senthil Kumar ◽  
Anuradha Venkataraman ◽  
Rajagopalan Vijayaraghavan ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Bark Extract ◽  
Rhizophora Mucronata ◽  
Toxicity Evaluation ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals Ficus hispida Bark Extract Prevents Nociception, Inflammation, and CNS Stimulation in Experimental Animal Model

2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Md. Sariful Islam Howlader ◽  
Md. Afjalus Siraj ◽  
Shubhra Kanti Dey ◽  
Arpona Hira ◽  
Arif Ahmed ◽  
...  
Keyword(s):  
Experimental Animal ◽  
Antinociceptive Activity ◽  
Bark Extract ◽  
Thermal Stimulus ◽  
Hot Plate ◽  
Swiss Albino Mice ◽  
Tail Immersion ◽  
Ficus Hispida ◽  
Albino Mice ◽  
Anti Inflammatory

Background. Ficus hispida is traditionally used in the ailment of pain, inflammation, and neurological disorders. The present study set out to evaluate the in vivo antinociceptive, anti-inflammatory, and sedative activity of the ethanol extract of Ficus hispida bark (EFHB). Methods. The antinociceptive activity of EFHB was evaluated by using acetic acid induced writhing, formalin, hot plate, and tail immersion methods in Swiss albino mice. Its anti-inflammatory activity was assessed by using carrageenan and histamine induced rat paw oedema test in Wister rats. The central stimulating activity was studied by using pentobarbital induced hypnosis, hole cross, and open field tests in Swiss albino mice. Results. EFHB demonstrated antinociceptive activity both centrally and peripherally. It showed 62.24% of writhing inhibition. It significantly inhibited licking responses in early (59.29%) and late phase (71.61%). It increased the reaction time to the thermal stimulus in both hot plate and tail immersion. It inhibited the inflammation to the extent of 59.49%. A substantial increase in duration of sleep up to 60.80 min and decrease of locomotion up to 21.70 at 400 mg/kg were also observed. Conclusion. We found significant dose dependent antinociceptive, anti-inflammatory, and sedative properties of EFHB in experimental animal models.

scholarly journals Antinociceptive effect of methanolic extract of Murraya koenigii leaves in swiss albino mice

2020 ◽  
Vol 9 (3) ◽  
pp. 426
Author(s):  
Arunkumar J. ◽  
Vijayalakshmi M. ◽  
Yesodha S. ◽  
YousufAli A. S. ◽  
Parthiban R.
Keyword(s):  
Reaction Time ◽  
Analgesic Activity ◽  
Methanolic Extract ◽  
Control Group ◽  
Murraya Koenigii ◽  
Hot Plate ◽  
Standard Drug ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Tail Clip

Background: The objective of the study was to evaluate anti-nociceptive effect of methanolic extract of Murraya koenigii leaves on thermal and mechanical pain in swiss albino mice.Methods: Thirty adult male swiss albino mice weighing 25-30 grams were selected and allocated in to five groups. Each group consists of six animals. The control group received vehicle (10 ml/kg), standard group received morphine (10 mg/kg) and test groups received dried methanolic extract of Murraya koenigii leaves (100 mg/kg, 200 mg/kg, 400 mg/kg per oral respectively) 1 hour before placing the animal over the hot plate at temperature of 55⁰C . A cut off period of 10 sec was observed to avoid damage of the paw. The response in the form of withdrawal of paws or licking of the paws. The delay in the reaction time denotes analgesic activity. The latency was recorded before and after 15, 30, 60, 120 minutes administration of drug. After washout period of 1 month the same group of animals were utilized to evaluate the analgesic effect by tail clip method for better comparison.Results: All the doses of Murraya koenigii leaves significantly delayed reaction time in hot plate method and tail clip method. The results were comparable to that produced by standard drug morphine.Conclusions: Murraya koenigii leaves has analgesic activity which was comparable to morphine.

Analgesic and Anti-inflammatory Activity of Ficus glomerata in Experimental Animal Models

2011 ◽  
Vol 4 (3) ◽  
pp. 1501-1505
Author(s):  
Cylma Menezes ◽  
Kunal G ◽  
Reema N ◽  
Satyanarayana D ◽  
Jagadish K
Keyword(s):  
Analgesic Activity ◽  
Inflammatory Activity ◽  
Significant Activity ◽  
Paw Edema ◽  
Hot Plate ◽  
Plate Method ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Anti Inflammatory ◽  
Ficus Glomerata

The anti-inflammatory and analgesic activity of various extracts of Ficus glomerata Roxb. were evaluated in experimental animals. We have determined the anti-inflammatory and analgesic activity of various extracts of the dried fruits of Ficus glomerata by oral administration at doses of 200 and 400 mg/kg of body weight to healthy animals. The extracts were studied for their anti-inflammatory activity in carageenan induced hind paw edema in rats and the paw volume was measured plethysmometrically after 3 hours of injection. The extracts were also evaluated for analgesic activity using Eddy’s hot plate method in Swiss albino mice. The extracts of Ficus glomerata significantly reduced carageenan induced hind paw edema in rats and analgesic activity evidenced by increase in the reaction time by Eddy’s hot plate method in Swiss albino mice. The extracts showed a similar anti-inflammatory and analgesic effect comparative to the standard drugs indomethacin and diclofenac sodium respectively. The present results indicated the ethanolic extract of Ficus glomerata exhibited more significant activity than other extracts in the treatment of pain and inflammation.

scholarly journals Analgesic Activity of Dichloromethanolic Root Extract of Clutia abyssinica in Swiss Albino Mice

2017 ◽  
Vol 05 (02) ◽  
Author(s):  
Koech SC ◽  
Ouko RO ◽  
Michael NM ◽  
Ireri MM ◽  
Ngugi MP ◽  
...  
Keyword(s):  
Analgesic Activity ◽  
Root Extract ◽  
Swiss Albino Mice ◽  
Albino Mice

Screening of ten medicinal plants of Bangladesh for analgesic activity on Swiss-albino mice

2013 ◽  
Vol 13 (4) ◽  
pp. 327-332 ◽  
Author(s):  
M. A. A. Sikder ◽  
R. B. Rashid ◽  
F. Islam ◽  
A. K. M. N. Hossian ◽  
A. B. Siddique ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Analgesic Activity ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals Screening of analgesic activity of Phoenix sylvestris leaves in rodents

2018 ◽  
Vol 4 (1) ◽  
pp. 22-24
Author(s):  
Pankaj Jain ◽  
◽  
Sonika Jain ◽  
Surendra Kumar Swarnkar ◽  
Swapnil Sharma ◽  
...  
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Analgesic Activity ◽  
Leaf Extract ◽  
Methanolic Extract ◽  
Standard Drug ◽  
Swiss Albino Mice ◽  
Tail Immersion ◽  
Albino Mice ◽  
Withdrawal Reflexes

Aim: The present study evaluated the central and peripheral analgesic activity of methanolic leaf extract of Phoenix sylvestris (PSLME) in swiss albino mice. Method: Peripheral and central analgesic activity was evaluated by tail immersion and acetic acid writhing in swiss albino mice. Dextropropoxyphene was used as a standard drug in the dose of 65mg/kg body weight in both models. PSLME was tested at 100 and 500mg/kg dose level. Results: The result revealed that methanolic extract exhibit 48% and 40.5% writhing inhibition at 500 and 100 mg/kg doses whereas ~30% tail withdrawal reflexes inhibition at 500mg/kg which was analogous to the standard drug dextropropoxyphene. Conclusion: Methanolic extract of leaves of P. sylvestris possesses both peripheral and central analgesic activity in experimental animal.

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