Effectiveness of maternal vaccination with quadrivalent inactivated influenza vaccine in pregnant women and their infants in 2019-2020

Background: We investigated pregnant women, community leaders, healthcare workers (HCWs) and programme managers’ perceptions of maternal vaccination in Kampala, Uganda. Methods: We conducted focus group discussions, key informant interviews and in-depth discussions with HCWs (3), community leaders (3), pregnant women (8) and programme managers (10) between November 2019 and October 2020. Data were analysed thematically. Results: Pregnant women, community leaders and some HCWs had limited maternal immunisation knowledge. There was confusion over what constitutes a vaccine. Pregnant women may not receive vaccines because of mistrust of government; use of expired vaccines; reliance on traditional medicine; religious beliefs; fear of side effects; HCWs attitudes; and logistical issues. The key facilitators of maternal vaccination were a desire to prevent diseases, positive influences from HCWs and information about vaccine side effects. Community leaders and some pregnant women highlighted that pregnant women do not make decisions about maternal vaccination independently and are influenced by different individuals, including other pregnant women, older people, partners, relatives (parents), community leaders, HCWs and the government. Conclusions: Our results indicate that public health messaging should target all community members, including partners and parents of pregnant women as well as HCWs, to improve knowledge of and confidence in maternal vaccines.

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Not for industry only: medical students and office-based academic detailing the PIVOT (Pregnant women Influenza Vaccine Optimization Team) initiative

Advances in Medical Education and Practice ◽

10.2147/amep.s72384 ◽

2015 ◽

pp. 323 ◽

Cited By ~ 3

Author(s):

Daina Blitz ◽

Jonathan Mallen ◽

Jill Rabin ◽

Robert Silverman ◽

Thomas Kwiatkowski ◽

...

Keyword(s):

Medical Students ◽

Influenza Vaccine ◽

Pregnant Women ◽

Academic Detailing

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Influenza Vaccine Efficacy and Effectiveness in Pregnant Women: Systematic Review and Meta-analysis

Maternal and Child Health Journal ◽

10.1007/s10995-019-02844-y ◽

2019 ◽

Vol 24 (2) ◽

pp. 229-240 ◽

Cited By ~ 1

Author(s):

Trang Ho Thu Quach ◽

Nicholas Alexander Mallis ◽

José F. Cordero

Keyword(s):

Systematic Review ◽

Influenza Vaccine ◽

Pregnant Women ◽

Vaccine Efficacy ◽

Meta Analysis

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Determinants of influenza vaccine hesitancy among pregnant women in Europe: a systematic review

European Journal of Medical Research ◽

10.1186/s40001-021-00584-w ◽

2021 ◽

Vol 26 (1) ◽

Author(s):

Gbadebo Collins Adeyanju ◽

Elena Engel ◽

Laura Koch ◽

Tabea Ranzinger ◽

Imtiaz Bin Mohammed Shahid ◽

...

Keyword(s):

Systematic Review ◽

Influenza Vaccine ◽

Influenza Vaccination ◽

Pregnant Women ◽

Healthcare Providers ◽

Primary Objective ◽

World Health ◽

Vaccine Hesitancy ◽

Cochrane Central Register ◽

Adequate Knowledge

Abstract Background Pregnant women are at high risk for severe influenza. However, maternal influenza vaccination uptake in most World Health Organization (WHO) European Region countries remains low, despite the presence of widespread national recommendations. An influenza vaccination reduces influenza-associated morbidity and mortality in pregnancy, as well as providing newborns with protection in their first months. Potential determinants of vaccine hesitancy need to be identified to develop strategies that can increase vaccine acceptance and uptake among pregnant women. The primary objective of the systematic review is to identify the individual determinants of influenza vaccine hesitancy among pregnant women in Europe, and how to overcome the hesitancy. Methods Databases were searched for peer-reviewed qualitative and quantitative studies published between 2009 and 2019 inclusive. Databases included PubMed via MEDLINE, Cochrane Central Register for Controlled Trials, PsycINFO, SAGE Journals, Taylor and Francis and Springer nature. These covered themes including psychology, medicine, and public health. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) approach, 11 studies were eligible and analyzed for significant determinants of influenza vaccine hesitancy among pregnant women in Europe. Results The most commonly reported factors were psychological aspects, for example concerns about safety and risks to mother and child, or general low risk perception of becoming ill from influenza. Doubts about the effectiveness of the vaccine and a lack of knowledge about this topic were further factors. There was also influence of contextual factors, such as healthcare workers not providing adequate knowledge about the influenza vaccine or the pregnant lady stating their antivaccine sentiment. Conclusion Health promotion that specifically increases knowledge among pregnant women about influenza and vaccination is important, supporting a valid risk judgment by the pregnant lady. The development of new information strategies for dialogue between healthcare providers and pregnant women should form part of this strategy.

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