scholarly journals Determinants of influenza vaccine hesitancy among pregnant women in Europe: a systematic review

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Gbadebo Collins Adeyanju ◽  
Elena Engel ◽  
Laura Koch ◽  
Tabea Ranzinger ◽  
Imtiaz Bin Mohammed Shahid ◽  
...  
Keyword(s):  
Systematic Review ◽  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Pregnant Women ◽  
Healthcare Providers ◽  
Primary Objective ◽  
World Health ◽  
Vaccine Hesitancy ◽  
Cochrane Central Register ◽  
Adequate Knowledge

Abstract Background Pregnant women are at high risk for severe influenza. However, maternal influenza vaccination uptake in most World Health Organization (WHO) European Region countries remains low, despite the presence of widespread national recommendations. An influenza vaccination reduces influenza-associated morbidity and mortality in pregnancy, as well as providing newborns with protection in their first months. Potential determinants of vaccine hesitancy need to be identified to develop strategies that can increase vaccine acceptance and uptake among pregnant women. The primary objective of the systematic review is to identify the individual determinants of influenza vaccine hesitancy among pregnant women in Europe, and how to overcome the hesitancy. Methods Databases were searched for peer-reviewed qualitative and quantitative studies published between 2009 and 2019 inclusive. Databases included PubMed via MEDLINE, Cochrane Central Register for Controlled Trials, PsycINFO, SAGE Journals, Taylor and Francis and Springer nature. These covered themes including psychology, medicine, and public health. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) approach, 11 studies were eligible and analyzed for significant determinants of influenza vaccine hesitancy among pregnant women in Europe. Results The most commonly reported factors were psychological aspects, for example concerns about safety and risks to mother and child, or general low risk perception of becoming ill from influenza. Doubts about the effectiveness of the vaccine and a lack of knowledge about this topic were further factors. There was also influence of contextual factors, such as healthcare workers not providing adequate knowledge about the influenza vaccine or the pregnant lady stating their antivaccine sentiment. Conclusion Health promotion that specifically increases knowledge among pregnant women about influenza and vaccination is important, supporting a valid risk judgment by the pregnant lady. The development of new information strategies for dialogue between healthcare providers and pregnant women should form part of this strategy.

scholarly journals Determinants of Influenza Vaccine Hesitancy among Pregnant Women in Europe: A Systematic Review

2021 ◽  
Author(s):  
Gbadebo Collins Adeyanju ◽  
Elena Engel ◽  
Laura Koch ◽  
Tabea Ranzinger ◽  
Imtiaz Bin Mohammed Shahid ◽  
...  
Keyword(s):  
Systematic Review ◽  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Pregnant Women ◽  
Healthcare Providers ◽  
Primary Objective ◽  
World Health ◽  
Vaccine Hesitancy ◽  
Cochrane Central Register ◽  
Adequate Knowledge

Abstract Background Pregnant women are at high risk for severe influenza, but maternal influenza vaccination uptake in most World Health Organization (WHO) European Region countries remains low, despite the presence of widespread national recommendations. An influenza vaccination reduces influenza-associated morbidity and mortality in pregnancy, as well as provides newborns with protection in their first months. Potential determinants of vaccine hesitancy need to be identified to develop strategies that can increase vaccine acceptance and uptake among pregnant women. The primary objective of the systematic review is to identify the individual determinants of influenza vaccine hesitancy among pregnant women in Europe and how to overcome the hesitancy. Methods Databases were searched for peer-reviewed qualitative and quantitative studies published between 2009 and 2019. These included PubMed via MEDLINE, Cochrane Central Register for Controlled Trials, PsycINFO, SAGE Journals, Taylor & Francis and Springer nature, covering the areas of psychology, medicine, and public health. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) approach, 11 studies were eligible and analyzed for significant determinants of influenza vaccine hesitancy among pregnant women in Europe. Results The most reported factors were psychological aspects, for example concerns about safety and risks to mother and child, or general low risk perception of becoming ill from influenza. Doubts about the effectiveness of the vaccine and a lack of knowledge about this topic were further factors. There was also influence of contextual factors such as healthcare workers not providing adequate knowledge about the influenza vaccine or stating their anti-vaccine sentiment. Conclusion To overcome influenza vaccine hesitancy among pregnant women, it seems essential to increase the knowledge about influenza and the respective vaccination and to provide information for a valid risk judgment. The development of new information strategies for dialogue between healthcare providers and pregnant women should form part of this strategy.

scholarly journals Barriers of Influenza Vaccination Intention and Behavior – A Systematic Review of Influenza Vaccine Hesitancy, 2005 – 2016

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0170550 ◽  
Author(s):  
Philipp Schmid ◽  
Dorothee Rauber ◽  
Cornelia Betsch ◽  
Gianni Lidolt ◽  
Marie-Luisa Denker
Keyword(s):  
Systematic Review ◽  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Vaccine Hesitancy ◽  
And Behavior

scholarly journals Efficacy and safety of cyclosporine in the management of coronavirus disease 2019: A protocol for systematic review and meta-analysis

2021 ◽  
Author(s):  
Ibtihal Abdallah ◽  
Mohamed Aabdien ◽  
Mohammed Danjuma
Keyword(s):  
Systematic Review ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Random Effect ◽  
Primary Objective ◽  
Clinical Severity ◽  
World Health ◽  
Cochrane Central Register ◽  
Meta Analyses

Introduction Cyclosporine may improve the clinical course and outcomes of Coronavirus disease 2019 (COVID-19) due to its antiviral and anti-cytokine effects as shown in vitro. A few ongoing trials are exploring the benefit of adding it to the standard of care (SOC) of COVID-19 patients. Objectives The primary objective is to evaluate the severity of COVID-19, determined by oxygen saturation, intensive care unit (ICU) admission, or the World Health Organization COVID-19 clinical severity scale in patients treated with oral or intravenous cyclosporine added to SOC compared SOC alone or placebo. Secondary objectives include mortality, length of hospitalization, length of ICU stay, and laboratory measurements as well as the safety outcomes of cyclosporine. Methodology A systematic review and meta-analysis of randomized clinical trials and observational studies that compared cyclosporine to placebo or SOC in COVID-19 patients will be conducted. PubMed, EMBASE, Web of Science, Cochrane Central Register of Controlled Trials, Google Scholar, and ClinicalTrials.gov will be explored for studies that satisfy pre-specified inclusion criteria. Quality assessment of all included studies will be performed. Meta-analyses will be done utilizing random effect models to estimate the effect of cyclosporine on the severity of COVID-19. Heterogeneity will be assessed utilizing Q statistics. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines will be followed. Results The result of this synthesis will inform potential changes in the management of COVID-19 patients, especially regarding the role of calcineurin inhibitors. Additionally, it will serve as hypothesis generating for potential future prospective studies.

scholarly journals The Prevalence of Seasonal Influenza Vaccination in Pregnant Women Referring to Tertiary Hospitals of Kerman, Iran

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Mehran Nakhaeizadeh ◽  
Solmaz Bahar ◽  
Ali Khalooei
Keyword(s):  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Pregnant Women ◽  
Vaccination Coverage ◽  
Healthcare Providers ◽  
Coverage Rate ◽  
Related Factors ◽  
Cross Sectional ◽  
Vaccination Coverage Rate ◽  
Tertiary Hospitals

Background: Influenza vaccination is the most effective strategy to prevent comorbidity and mortality of this infection in pregnant women. Objectives: The current study aimed at evaluating the influenza vaccination rate and its related factors among pregnant women. Methods: The current cross-sectional study was conducted on 520 pregnant women referring to antenatal clinics of tertiary hospitals affiliated to Kerman University of Medical Sciences from January to April 2019 in Kerman city, Iran. The collected data through a form distributed among the subjects were analyzed using SPSS version 22. Results: The influenza vaccination coverage rate was 30.0% (95% confidence interval (CI): 26.1 - 34.1) among the pregnant women. Age older than 30 years (AOR = 3.79; 95%CI: 1.55 - 9.24), being employed (AOR = 2.44; 95%CI: 1.01 - 5.88), having an underlying chronic disease (AOR = 4.39; 95%CI: 1.33 - 14.51), receiving recommendation to undergo influenza vaccination (AOR = 65.76; 95%CI: 11.04 - 391.48), and having good knowledge of influenza vaccine (AOR = 9.64; 95%CI: 3.87 - 24.02) increased the likelihood of receiving influenza vaccine. Conclusions: The current study highlighted that the influenza vaccination coverage rate was suboptimal. Also, findings of the current study suggested that influenza vaccination, as an important component of antenatal care services, should be considered by health policymakers. Furthermore, educating pregnant women and healthcare providers can improve compliance with influenza vaccination.

scholarly journals Influenza vaccination during pregnancy and influencing factors in Korea: A multicenter questionnaire study of pregnant women and obstetrics and gynecology doctors

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Byung Soo Kang ◽  
San Ha Lee ◽  
Woo Jeng Kim ◽  
Jeong Ha Wie ◽  
In Yang Park ◽  
...  
Keyword(s):  
Influenza Vaccination ◽  
Pregnant Women ◽  
Influencing Factors ◽  
World Health ◽  
Obstetrics And Gynecology ◽  
Health Authorities ◽  
The Government ◽  
Vaccine Information ◽  
Health Organization ◽  
Maternal Influenza

Abstract Background Although the World Health Organization and health authorities in most countries recommend that pregnant women receive inactivated influenza virus vaccines, coverage remains low. This study aimed to investigate (1) the proportion of pregnant women who received an influenza vaccination and influencing factors and (2) the proportion of obstetrics and gynecology (OBGYN) doctors who routinely recommend influenza vaccination to pregnant women and influencing factors. Methods Two separate, anonymized questionnaires were developed for physicians and pregnant and postpartum women and were distributed to multicenters and clinics in South Korea. The proportions of women who received influenza vaccination during pregnancy and OBGYN doctors who routinely recommend the influenza vaccine to pregnant women were analyzed. Independent influencing factors for both maternal influenza vaccination and OBGYN doctors’ routine recommendations to pregnant women were analyzed using log-binomial regression analysis. Results The proportion of self-reported influenza vaccination during pregnancy among 522 women was 63.2%. Pregnancy-related independent factors influencing maternal influenza vaccination were “(ever) received information about influenza vaccination during pregnancy” (OR 8.9, 95% CI 4.17–19.01), “received vaccine information about from OBGYN doctors” (OR 11.44, 95% CI 5.46–24.00), “information obtained from other sources” (OR 4.38, 95% CI 2.01–9.55), and “second/third trimester” (OR 2.41, 95% CI 1.21–4.82).. Among 372 OBGYN doctors, 76.9% routinely recommended vaccination for pregnant women. Independent factors effecting routine recommendation were “working at a private clinic or hospital” (OR 5.33, 95% CI 2.44–11.65), “awareness of KCDC guidelines” (OR 3.11, 95% CI 1.11–8.73), and “awareness of the 2019 national free influenza vaccination program for pregnant women” (OR 4.88, 95% CI 2.34–10.17). OBGYN doctors most commonly chose ‘guidelines proposed by the government or public health (108, 46%) and academic committees (59, 25%), as a factor which expect to affect the future recommendation Conclusion This study showed that providing information about maternal influenza vaccination, especially by OBGYN doctors, is crucial for increasing vaccination coverage in pregnant women. Closer cooperation between the government and OBGYN academic societies to educate OBGYN doctors might enhance routine recommendations.

Influenza Vaccine Efficacy and Effectiveness in Pregnant Women: Systematic Review and Meta-analysis

2019 ◽  
Vol 24 (2) ◽  
pp. 229-240 ◽  
Author(s):  
Trang Ho Thu Quach ◽  
Nicholas Alexander Mallis ◽  
José F. Cordero
Keyword(s):  
Systematic Review ◽  
Influenza Vaccine ◽  
Pregnant Women ◽  
Vaccine Efficacy ◽  
Meta Analysis

scholarly journals Mobile phone communication for improving uptake of antiretroviral therapy in HIV-infected pregnant women: updated systematic review and meta-analysis

2021 ◽  
Author(s):  
Jacques L. Tamuzi ◽  
Gomer Lulendo ◽  
Patrick Mbuesse ◽  
Thierry Ntambwe
Keyword(s):  
Systematic Review ◽  
Mobile Phone ◽  
Pregnant Women ◽  
Hiv Testing ◽  
Text Messaging ◽  
Post Partum ◽  
Meta Analysis ◽  
Cochrane Central Register ◽  
Hiv Exposed ◽  
Mobile Phone Communication

Objective The aim of this systematic review is to provide some evidence on the use of mobile phone communication for improving ARV adherence during pregnancy, as well as to investigate whether text messaging on mobile phones could improve follow up in HIV exposed infants. Methods We did a systematic review and meta-analysis, using CENTRAL (Cochrane Central Register of Controlled Trials), Scopus, MEDLINE via PubMed, Web of Science, and CINAHL to search for studies in English published between 5 may 2016 to May 2021 that assessed the effects of mobile phone in HIV infected pregnant women. We used MetaPro version 3.0 to compute the OR 2 and RR and their 95%CI. We performed random-effects model meta analysis for estimating pooled outcomes. Results Nine studies were included in the meta-analysis. The pooled maternal postpartum retention was (OR 2.20, 95%CI: 1.55 to 3.13, I2 = 53.20%, P < 0.001). In the same line, the pooled odds of ART uptake was (OR 1.5, 95%CI: 1.07 to 2.11, I2 =0%, P = 0.020) and we found statistically significant impact of mobile phone on HIV testing at 6 weeks and above among HIV exposed children (OR 1.89, 95%CI: 1.04 to 3. 48, I2 = OR 1.89, 95%CI: 1.04 to 3. 48, I2 =88.04%, P = 0.032). Conclusion In comparison to our previous review, this updated review focuses on moderate evidence for mobile phone communication in HIV-infected pregnant women. The results showed that using a mobile phone improved maternal post-partum retention, ART uptake, and infant HIV testing at 6 weeks and older.

scholarly journals The impact of inclusion, dose and duration of pyrazinamide (PZA) on efficacy and safety outcomes in tuberculosis: systematic review and meta-analysis protocol

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
James D. Millard ◽  
Elizabeth A. Mackay ◽  
Laura J. Bonnett ◽  
Geraint R. Davies
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Meta Analysis ◽  
World Health ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Efficacy And Safety ◽  
Safety Outcomes ◽  
Meta Regression ◽  
Indirect Comparisons

Abstract Background Pyrazinamide (PZA) is a key component of current and future regimens for tuberculosis (TB). Inclusion of PZA at higher doses and for longer durations may improve efficacy outcomes but must be balanced against the potential for worse safety outcomes. Methods We will search for randomised and quasi-randomised clinical trials in adult participants with and without the inclusion of PZA in TB treatment regimens in the Cochrane infectious diseases group’s trials register, Cochrane central register of controlled trials (CENTRAL), MEDLINE, EMBASE, LILACS, the metaRegister of Controlled Trials (mRCT) and the World Health Organization (WHO) international clinical trials registry platform. One author will screen abstracts and remove ineligible studies (10% of which will be double-screened by a second author). Two authors will review full texts for inclusion. Safety and efficacy data will be extracted to pre-piloted forms by one author (10% of which will be double-extracted by a second author). The Cochrane risk of bias tool will be used to assess study quality. The study has three objectives: the association of (1) inclusion, (2) dose and (3) duration of PZA with efficacy and safety outcomes. Risk ratios as relative measures of effect for direct comparisons within trials (all objectives) and proportions as absolute measures of effect for indirect comparisons across trials (for objectives 2 and 3) will be calculated. If there is insufficient data for direct comparisons within trials for objective 1, indirect comparisons between trials will be performed. Measures of effect will be pooled, with corresponding 95% confidence intervals and p values. Meta-analysis will be performed using the generalised inverse variance method for fixed effects models (FEM) or the DerSimonian-Laird method for random effects models (REM). For indirect comparisons, meta-regression for absolute measures against dose and duration data will be performed. Heterogeneity will be quantified through the I2-statistic for direct comparisons and the τ2 statistic for indirect comparisons using meta-regression. Discussion The current use of PZA for TB is based on over 60 years of clinical trial data, but this has never been synthesised to guide rationale use in future regimens and clinical trials. Systematic review registration: International Prospective Register of Systematic Reviews (PROSPERO) CRD42019138735

scholarly journals Do Turkish Gynecologists and Obstetricians recommend pregnant women the influenza vaccine?

2020 ◽  
Vol 2 (1) ◽  
pp. 16-23
Author(s):  
Irem Akdemir Kalkan ◽  
Ayşe Nur Usturalı Mut ◽  
Gule Cinar ◽  
Fatih Keskin ◽  
Kemal Osman Memikoglu ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Pregnant Women ◽  
Social Insurance ◽  
Viral Infections ◽  
Multivariate Logistic Regression Analysis ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Vaccination Rates ◽  
Immunization Rates

Objective: Influenza is a systemic infectious disease. It is recommended that all pregnant women receive the influenza vaccine because the mortality of the disease is high during pregnancy. However, the rates of influenza vaccination in pregnant women are low. This study aims to estimate the rate at which Turkish gynecologists and obstetricians (GOs) recommend the influenza vaccine to their pregnant patients.. Materials and Methods: This study was designed as a cross-sectional survey. The sample size was calculated to be 364 based on 95% confidence interval and 5% margin of error. The data were collected through a questionnaire consisting of 17 questions, which was distributed through social media. The final study group included in the research consisted of 384 GOs. Results:The mean age of the GOs that participated in the study was 39.7 years (SD = 10.2). 43.5% of the GOs reported that they recommended the influenza vaccine to pregnant women who had consulted with them, while 62.8% reported that at least 50% of the pregnant women they had recommended the vaccine rejected it. According to multivariate logistic regression analysis, three factors increased the rate of GOs’ not to recommend influenza vaccination: the GOs’ age, not receiving influenza vaccination themselves, and not knowing the social insurance reimbursement for the vaccine. Conclusion: Vaccination of pregnant women is necessary because of the increased mortality risk of influenza during pregnancy. Even though GOs are not in charge of vaccinating their patients during their routine pregnancy follow-up, they can contribute to vaccination rates by recommending the vaccine. Physicians’ application of scientific knowledge and transferring it to their patients can contribute to increased adult immunization rates. Conclusion: Influenza, Influenza Vaccine, Pregnancy, Vaccination, Viral Infections

scholarly journals Are we ready when COVID-19 vaccine is available? Study on nurses′ vaccine hesitancy in Hong Kong

2020 ◽  
Author(s):  
Kin On Kwok ◽  
Kin Kit Li ◽  
Wan In Wei ◽  
Kwok Hung Tang ◽  
Samuel Yeung Shan Wong ◽  
...  
Keyword(s):  
Hong Kong ◽  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Work Stress ◽  
Research Work ◽  
Collective Responsibility ◽  
Public Hospitals ◽  
Vaccine Uptake ◽  
Vaccine Hesitancy ◽  
Public Confidence

Introduction: Nurses are considered a trustworthy source of vaccine-related information to build public confidence in vaccination. This study estimated nurses′ influenza vaccine uptake and intention to receive COVID-19 vaccine when available, and examined the corresponding psychological antecedents. Methods : A cross-sectional online survey among nurses was conducted during the main COVID-19 outbreak in Hong Kong between mid-March and late April 2020. Demographics, influenza vaccination, intention to have COVID-19 vaccine, the 5C vaccine hesitancy components (i.e., confidence, complacency, constraints, calculation, and collective responsibility), work stress and COVID-related work demands (i.e., insufficient supply of personal protective equipment, involvement in isolation rooms, and unfavorable attitudes towards workplace infection control policies) were reported. Results: The influenza vaccination coverage and the proportion intending to take COVID-19 vaccine were 49% and 63%, respectively, among 1205 eligible nurses. Influenza vaccine uptake was associated with working in public hospitals and all 5C constructs, whereas stronger COVID-19 vaccination intention was associated with younger age, more confidence, less complacency and more collective responsibility towards the vaccine. COVID-19-related demands were associated with greater work stress, and hence stronger COVID-19 vaccination intention. Conclusion: Vaccine uptake/intention was well predicted by the 5C constructs. With less work stress among nurses in the post-pandemic period, the intention to take COVID-19 vaccine will likely drop. The 5C constructs should be infused in vaccination campaigns. While a COVID-19 vaccine could be ready soon, communities are not ready to accept it. More research work is needed to boost the uptake.

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