In vitro antioxidant potential and in vivo effects of Schinus terebinthifolia Raddi leaf extract in diabetic rats and determination of chemical composition by HPLC-ESI-MS/MS

2018 ◽  
Vol 33 (11) ◽  
pp. 1655-1658 ◽  
Author(s):  
Camila Cristina Iwanaga ◽  
Lilian dos Anjos Oliveira Ferreira ◽  
Karine Zanoli Bernuci ◽  
Carla Maria Mariano Fernandez ◽  
Fabiana Brusco Lorenzetti ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Leaf Extract ◽  
Diabetic Rats ◽  
Antioxidant Potential ◽  
Esi Ms ◽  
In Vivo Effects

scholarly journals ANTIOXIDANT PROPERTIES OF SINAPIC ACID: IN VITRO AND IN VIVO APPROACH

2017 ◽  
Vol 10 (6) ◽  
pp. 255 ◽  
Author(s):  
Nithya R ◽  
Subramanian S
Keyword(s):  
Antioxidant Properties ◽  
Intraperitoneal Administration ◽  
Radical Scavenging ◽  
Sinapic Acid ◽  
Lipid Peroxides ◽  
Diabetic Rats ◽  
Antioxidant Potential ◽  
Protein Carbonyls

Objective: This study was aimed to evaluate the antioxidant potential of sinapic acid in both in vitro and in vivo. Recently, we have reported that oral administration of sinapic acid (3,5-dimethoxy 4-hydroxycinnamic acid) an active phyto ingredient widely distributed in rye, mustard, berries, and vegetables has been shown to ameliorate hyperglycemia.Methods: Experimental Type 2 diabetes was induced in male Wistar rats by feeding high-fat diet to induce insulin resistance followed by intraperitoneal administration of a single low dose streptozotocin (35 mg/kg body weight [bw]). Sinapic acid was administered orally at a concentration of 25 mg/kg bw/rat/day for 30 days, and its efficacy was compared with metformin. In vitro, antioxidant scavenging properties of sinapic acid were determined using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), superoxide, and nitric oxide (NO) assay.Results: Sinapic acid treatment showed a significant decline in the levels of lipid peroxides, hydroperoxides and protein carbonyls in the plasma and vital tissues of diabetic rats. The treatment also improved the antioxidant status in diabetic rats indicating the antioxidant potential of sinapic acid. In addition, the results of DPPH, ABTS, superoxide, and NO radical scavenging assays substantiate the free radical scavenging efficacy of sinapic acid.Conclusion: The results of this study evidenced that sinapic acid possess significant antioxidant properties which in turn may be responsible for its antidiabetic properties.

Chemical composition and in vitro digestibility of nine plant species from Semnan rangeland for camel in Iran

2007 ◽  
Vol 2007 ◽  
pp. 233-233 ◽  
Author(s):  
Armin Towhidi ◽  
Farnoush Rostami ◽  
Reza Masoumi
Keyword(s):  
Chemical Composition ◽  
Plant Species ◽  
Nutritive Value ◽  
Poor Quality ◽  
In Vitro Digestibility ◽  
Gross Energy ◽  
Arid Rangelands

In Iran, Javan (2001) has reported the digestibility some arid rangelands plants by bovine rumen liquor. The determination of in vivo digestibility of wheat straw implies that camel apparently digested poor quality roughages more than cattle and sheep (Cianci et al., 2004). Therefore, It is required to measure the in vitro digestibility of herbages by camel rumen liquor. In province of yazd, nutritive value of 11 different plant species for camel were determined (Towhidi, 2007). The objectives of the current study were to determine 1) the chemical composition, gross energy of the most consuming plant species from rangeland of Semnan province including Seidlitzia rosmarinu, Tamarix tetragyna, Tamarix strica, Halostachys spp, Saudea fruticosa., Alhagi camelorum, Haloxylon ammondendron., Salsola arbescola, Hammada salicornica and, 2) in vitro digestibility of the plants by camel rumen liquor.

In vitro and in vivo effects of selenium and selenium with vitamin E on platelet functions in diabetic rats relationship to platelet sorbitol and fatty acid distribution

1996 ◽  
Vol 55 (3) ◽  
pp. 263-277 ◽  
Author(s):  
Christelle Douillet ◽  
Muriel Bost ◽  
Michèle Accominotti ◽  
Françoise Borson-Chazot ◽  
Maryvonne Ciavatti
Keyword(s):  
Fatty Acid ◽  
Vitamin E ◽  
Fatty Acid Distribution ◽  
Diabetic Rats ◽  
In Vivo Effects ◽  
Platelet Functions

Terminalia catappa : Chemical composition, in vitro and in vivo effects on Haemonchus contortus

2017 ◽  
Vol 246 ◽  
pp. 118-123 ◽  
Author(s):  
L.M. Katiki ◽  
A.C.P. Gomes ◽  
A.M.E. Barbieri ◽  
P.A. Pacheco ◽  
L. Rodrigues ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Haemonchus Contortus ◽  
Terminalia Catappa ◽  
In Vivo Effects

Effects of Nutritional, Endocrine and Metabolic State on the Development of Intravascular Coagulation Induced by Human Serum Preparations with Procoagulant Activity

1973 ◽  
Vol 29 (01) ◽  
pp. 033-049 ◽  
Author(s):  
Harry N. Antoniades ◽  
Panayotis G. Iatridis ◽  
Nelson Westmoreland ◽  
James D. Simon ◽  
Kenneth C. Hayes ◽  
...  
Keyword(s):  
Human Serum ◽  
Blood Platelet ◽  
Diabetic Rats ◽  
Procoagulant Activity ◽  
Metabolic State ◽  
Intravascular Coagulation ◽  
Serum Fractions ◽  
In Vivo Effects

SummaryInjection of human serum fractions with procoagulant activity into intact rats initiated hypercoagulability, thrombosis and hemorrhage. These in vivo effects were dependent upon the nutritional, endocrine and metabolic state of the animals. Injection in fed rats produced only transient hypercoagulability. In rats fasted 48 hours, the initial hypercoagulability was followed by prolonged hypocoagulation, a decline in blood platelet count, thrombosis and hemorrhage. These effects were reversed in fasted rats by glucose injected 1 hour before the serum fractions. Alloxan-diabetic fed rats and genetically obese fed rats also exhibited enhanced susceptibility to intravascular coagulation on injection of the serum fraction. However, injection of insulin in the diabetic rats before the serum fractions greatly reduced the susceptibility of these animals. The serum fractions used in these studies exhibited potent factor XIIa-like activity in vitro. The present studies demonstrate that the in vivo clotting process can be greatly influenced by the nutritional, endocrine, and metabolic state of the animal and they provide a basis for the investigation of the factors involved.

scholarly journals In vivo and in vitro Antidiabetic Characterization of Nymphaea alba leaves

2020 ◽  
pp. 565-571
Author(s):  
GURVIRENDER SINGH ◽  
SUPRIYA AGNIHOTRI ◽  
SANTOSH KUMAR VERMA
Keyword(s):  
Methanol Extract ◽  
In Vitro Study ◽  
Diabetic Rats ◽  
Inhibition Assay ◽  
Maximum Inhibition ◽  
Nymphaea Alba

The study was aimed to trace out antihyperglycemic potentials of Nymphaea alba leaves using in vitro and in vivo approaches. In, in vitro study, determination of IC50 of Nymphaea alba extracts was done using α-amylase and α-glucosidase inhibition assay. In α-amylase, Nymphaea alba methanol extract (NAME) exhibited maximum inhibition 56.77±1.23% at 125µg/ml in comparison to 66.7±0.94 % of standard acarbose. In α-glucosidase, NAME exhibits 59.89±0.92, while standard acarbose showed 70.31±1.25 % inhibition. The in vivo study was performed on diabetic rats, made diabetic by Streptozotocin. 200mg/kg and 400mg/kg NAME was administered orally, which significantly (

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