Biomechanical analysis of degenerative intervertebral disc enlargement of human spine

AbstractThe biomechanical function of the intervertebral disc (IVD) is a critical indicator of tissue health and pathology. The mechanical responses (displacements, strain) of the IVD to physiologic movement can be spatially complex and depend on tissue architecture, consisting of distinct compositional regions and integrity; however, IVD biomechanics are predominately uncharacterized in vivo. Here, we measured voxel-level displacement and strain patterns in adjacent IVDs in vivo by coupling magnetic resonance imaging (MRI) with cyclic motion of the cervical spine. Across adjacent disc segments, cervical flexion–extension of 10° resulted in first principal and maximum shear strains approaching 10%. Intratissue spatial analysis of the cervical IVDs, not possible with conventional techniques, revealed elevated maximum shear strains located in the posterior disc (nucleus pulposus) regions. IVD structure, based on relaxometric patterns of T2 and T1ρ images, did not correlate spatially with functional metrics of strain. Our approach enables a comprehensive IVD biomechanical analysis of voxel-level, intratissue strain patterns in adjacent discs in vivo, which are largely independent of MRI relaxometry. The spatial mapping of IVD biomechanics in vivo provides a functional assessment of adjacent IVDs in subjects, and provides foundational biomarkers for elastography, differentiation of disease state, and evaluation of treatment efficacy.

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Biomechanical analysis of the camelid cervical intervertebral disc

Journal of Orthopaedic Translation ◽

10.1016/j.jot.2014.12.001 ◽

2015 ◽

Vol 3 (1) ◽

pp. 34-43 ◽

Cited By ~ 4

Author(s):

Dean K. Stolworthy ◽

R. Amy Fullwood ◽

Tyler M. Merrell ◽

Laura C. Bridgewater ◽

Anton E. Bowden

Keyword(s):

Intervertebral Disc ◽

Biomechanical Analysis

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Development of a Detailed Volumetric Finite Element Model of the Spine to Simulate Surgical Correction of Spinal Deformities

BioMed Research International ◽

10.1155/2013/931741 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 7

Author(s):

Mark Driscoll ◽

Jean-Marc Mac-Thiong ◽

Hubert Labelle ◽

Stefan Parent

Keyword(s):

Finite Element ◽

Intervertebral Disc ◽

Finite Element Model ◽

Ex Vivo ◽

Spinal Instrumentation ◽

Element Model ◽

Patient Data ◽

Biomechanical Analysis ◽

Published Data

A large spectrum of medical devices exists; it aims to correct deformities associated with spinal disorders. The development of a detailed volumetric finite element model of the osteoligamentous spine would serve as a valuable tool to assess, compare, and optimize spinal devices. Thus the purpose of the study was to develop and initiate validation of a detailed osteoligamentous finite element model of the spine with simulated correction from spinal instrumentation. A finite element of the spine from T1 to L5 was developed using properties and geometry from the published literature and patient data. Spinal instrumentation, consisting of segmental translation of a scoliotic spine, was emulated. Postoperative patient and relevant published data of intervertebral disc stress, screw/vertebra pullout forces, and spinal profiles was used to evaluate the models validity. Intervertebral disc and vertebral reaction stresses respected publishedin vivo,ex vivo, andin silicovalues. Screw/vertebra reaction forces agreed with accepted pullout threshold values. Cobb angle measurements of spinal deformity following simulated surgical instrumentation corroborated with patient data. This computational biomechanical analysis validated a detailed volumetric spine model. Future studies seek to exploit the model to explore the performance of corrective spinal devices.

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Intervertebral disc biomechanical analysis using the finite element modeling based on medical images

Computerized Medical Imaging and Graphics ◽

10.1016/j.compmedimag.2006.09.004 ◽

2006 ◽

Vol 30 (6-7) ◽

pp. 363-370 ◽

Cited By ~ 23

Author(s):

Haiyun Li ◽

Zheng Wang

Keyword(s):

Finite Element ◽

Intervertebral Disc ◽

Finite Element Modeling ◽

Medical Images ◽

Biomechanical Analysis ◽

Element Modeling

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Intervertebral Disc Segmentation and Diagnostic Application Based on Wavelet Denoising and AAM Model in Human Spine Image

Journal of Medical Systems ◽

10.1007/s10916-019-1357-7 ◽

2019 ◽

Vol 43 (8) ◽

Author(s):

Yang Yang ◽

Jian Wang ◽

Caie Xu

Keyword(s):

Intervertebral Disc ◽

Wavelet Denoising ◽

Diagnostic Application ◽

Human Spine

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The influence of the nucleus pulposus on the stress distribution in the natural and prosthetic intervertebral disc

MATEC Web of Conferences ◽

10.1051/matecconf/201925207006 ◽

2019 ◽

Vol 252 ◽

pp. 07006 ◽

Cited By ~ 3

Author(s):

Robert Karpiński ◽

Łukasz Jaworski ◽

Józef Jonak ◽

Przemysław Krakowski

Keyword(s):

Stress Distribution ◽

Intervertebral Disc ◽

Nucleus Pulposus ◽

Inner Core ◽

Lumbar Vertebrae ◽

Fem Analysis ◽

3D Models ◽

Intervertebral Discs ◽

Biomechanical Analysis ◽

Lumbar Intervertebral Disc

The aim of this article was to present the results of a preliminary study on the stress distribution in the lumbar intervertebral disc [IVD] under loads induced during daily activities. Basic anatomy, biomechanical analysis of the vertebra and intervertebral disc were introduced. The third and fourth lumbar vertebrae were chosen for the study because they carry considerably higher loads, especially while standing or sitting. The static mechanical analyses using the finite element method (FEM) were conducted for four standard loads reflecting patient’s positions: recumbent, standing, sitting and standing with additional loads, and three models: an intervertebral disc with an inner nucleus pulposus and two prosthetic intervertebral discs, with or without an artificial nucleus. The FEM analysis was performed in the SolidWorks Simulation module on reverse-engineered 3D models of vertebrae and the intervertebral disc, based on a series of computed tomography [CT] scans of the patient’s spine, which had been properly processed in Materialise Mimics software and exported to CAD files. The model of the fourth intervertebral disc, placed between third and fourth vertebra, had been additionally modified to include its inner core, the nucleus pulposus.

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A biomechanical analysis of four anterior cervical techniques to treating multilevel cervical spondylotic myelopathy: a finite element study

BMC Musculoskeletal Disorders ◽

10.1186/s12891-021-04150-7 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Zhonghai Li ◽

Hui Liu ◽

Ming Yang ◽

Wentao Zhang

Keyword(s):

Intervertebral Disc ◽

Cervical Spondylotic Myelopathy ◽

Intervertebral Discs ◽

Biomechanical Analysis ◽

Adjacent Segment ◽

Titanium Plate ◽

Cage Subsidence ◽

Adjacent Disc ◽

Multilevel Cervical Spondylotic Myelopathy ◽

Adjacent Segments

Abstract Background The decision to treat multilevel cervical spondylotic myelopathy (MCSM) remains controversial. The purpose of this study is to compare the biomechanical characteristics of the intervertebral discs at the adjacent segments and internal fixation, and to provide scientific experimental evidence for surgical treatment of MCSM. Methods An intact C2-C7 cervical spine model was developed and validated. Four additional models were developed from the fusion model, including multilevel anterior cervical discectomy and fusion (mACDF), anterior cervical corpectomy and fusion (ACCF), hybrid decompression and fusion (HDF), and mACDF with cage alone (mACDF-CA). Biomechanical characteristics on the plate and the disc of adjacent levels (C2/3, C6/7) were comparatively analyzed. Results Of the four models, stress on the upper (C2/3) adjacent intervertebral disc was the lowest in the mACDF-CA group and highest in the ACCF group. Stress on the intervertebral discs at adjacent segments was higher for the upper C2/3 than the lower C6/7 intervertebral disc. In all models, the mACDF-CA group had the lowest stress on the intervertebral disc, while the ACCF group had the highest stress. In the three surgical models with titanium plate fixation (mACDF, ACCF, and HDF), the ACCF group had the highest stress at the titanium plate-screw interface, while the mACDF group had the lowest stress. Conclusion Among the four anterior cervical reconstructive techniques for MCSM, mACDF-CA makes little effect on the adjacent disc stress, which might reduce the incidence of adjacent segment degeneration (ASD) after fusion. However, the accompanying risk of the increased incidence of cage subsidence should never be neglected.

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Characteristic Motion Signatures Derived From the Theken eDisc Under Multi-Axial Loading

ASME 2007 2nd Frontiers in Biomedical Devices ◽

10.1115/biomed2007-38071 ◽

2007 ◽

Author(s):

James P. Price ◽

Brian E. Rich ◽

Christopher P. Cole ◽

Richard R. Navarro

Keyword(s):

Intervertebral Disc ◽

Patient Outcomes ◽

First Generation ◽

Second Generation ◽

Axial Loading ◽

Complex Loading ◽

Disc Arthroplasty ◽

Human Spine ◽

The Subject ◽

Improve Patient

The motions and loads experienced by the human spine are complex and have been the subject of much study over the years. The emerging field of intervertebral disc arthroplasty offers products that must function within this complex loading environment over long periods of time. So called “first generation” intervertebral disc designs accomplish this through one or more articulating surfaces. Second generation artificial discs attempt to mimic the multi-axial disc motion and stiffness exhibited by the natural human disc. The eDisc not only provides this type of viscoelastic motion, but also provides the first capability to sense loads and motions to improve patient outcomes.

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Behavior of the Intervertebral Disc Within the Motion Segment L3-L4 of The Human Spine Under Various Types of Physiological Load / Odozva Medzistavcovej Platničky V Rámci Pohybového Segmentu L3-L4 Ľudskej Chrbtice Na Rôzne Typy Fyziologického Zaťaženia

Transactions of the VŠB - Technical University of Ostrava Civil Engineering Series ◽

10.2478/v10160-012-0024-4 ◽

2012 ◽

Vol 12 (2) ◽

pp. 106-116

Author(s):

Mária Minárová ◽

Jozef Sumec ◽

Mária Tješšová

Keyword(s):

Lumbar Spine ◽

Intervertebral Disc ◽

Mathematical Treatment ◽

Basic Part ◽

Human Spine ◽

Motion Segment ◽

Physiological Load ◽

Human Lumbar Spine ◽

Biomechanical Investigation ◽

Computational Implementation

Abstract The paper deals with the biomechanical investigation on the motion segment - basic part of the human lumbar spine focused on the intervertebral disc response to the various types of load. It contains the description and the reason of the simplification of the model, the biomechanical laws; the mathematical treatment with the computational implementation added. The results are presented and discussed especially for the intervertebral disc.

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