Natural Fiber Based Antibacterial, Wound Healing Surgical Sutures by the Application of Herbal Antimicrobial Compounds

A therapeutic strategy to improve wound healing has become an increasingly important medical task due to the rising incidence of adiposity and type II diabetes as well as the proceeding population aging. In order to cope with the resulting burdens, new strategies to achieve rapid and complete wound healing must now be developed. Accordingly, the development of a bioactive wound dressing in the form of a messengerRNA (mRNA)-bearing poly(lactide-co-glycolide acid) (PLGA) coating on surgical suture is being pushed further with this study. Furthermore, the evaluation of the polymer-based transfection reagent Viromer RED has shown that it can be used for the transfection of eukaryotic cells: The mRNA gets properly complexed and translated into a functional protein. In addition, the mRNA-PLGA coating triggered the expression of the keratinocyte growth factor (KGF) in HaCat cells although KGF is not expressed under physiological conditions. Moreover, transfection via surgical sutures coated with mRNA does not affect the cell viability and a proinflammatory reaction in the transfected cells is not induced. These properties make the mRNA-PLGA coating very attractive for the in vivo application. For the future, this could mean that through the use of mRNA-coated sutures in surgical wound closure, cells in the wound area can be transfected directly, thus accelerating and improving wound healing.

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Nanohybrids

10.21741/9781644901076 ◽

2021 ◽

Author(s):

Thomas Wohlbier ◽

Keyword(s):

Wound Healing ◽

Biomedical Applications ◽

Electrospun Nanofibers ◽

Plasmonic Nanoparticles ◽

Cell Regeneration ◽

High Cell ◽

Non Invasive ◽

Surgical Sutures ◽

Nanohybrid Materials ◽

Silica Nanostructures

The book covers preparation, designing and utilization of nanohybrid materials for biomedical applications. These materials can improve the effectiveness of drugs, promote high cell growth in new scaffolds, and lead to biodegradable surgical sutures. The use of hybrid magneto-plasmonic nanoparticles may lead to non-invasive therapies. The most promising materials are based on silica nanostructures, polymers, bioresorbable metals, liposomes, biopolymeric electrospun nanofibers, graphene, and gelatin. Much research focuses on the development of biomaterials for cell regeneration and wound healing applications.

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Efficacy of silver coated surgical sutures on bacterial contamination, cellular response and wound healing

Materials Science and Engineering C ◽

10.1016/j.msec.2016.07.074 ◽

2016 ◽

Vol 69 ◽

pp. 884-893 ◽

Cited By ~ 19

Author(s):

Anna Lucia Gallo ◽

Federica Paladini ◽

Alessandro Romano ◽

Tiziano Verri ◽

Angelo Quattrini ◽

...

Keyword(s):

Wound Healing ◽

Cellular Response ◽

Bacterial Contamination ◽

Surgical Sutures

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Bioactive Nano Yarns as Surgical Sutures for Wound Healing

Materials Science and Engineering C ◽

10.1016/j.msec.2021.112334 ◽

2021 ◽

pp. 112334

Author(s):

Arthi Sunil Richard ◽

Rama Shankar Verma

Keyword(s):

Wound Healing ◽

Surgical Sutures

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Antimicrobial Surgical Sutures: Fabrication and Application of Infection Prevention and Wound Healing

Fibers and Polymers ◽

10.1007/s12221-021-0026-x ◽

2021 ◽

Author(s):

Hongbin Li ◽

Zixuan Wang ◽

Juan Antonio Robledo-Lara ◽

Jinmei He ◽

Yudong Huang ◽

...

Keyword(s):

Wound Healing ◽

Infection Prevention ◽

Surgical Sutures

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Tranilast-delivery surgical sutures to ameliorate wound healing by reducing scar formation through regulation of TGF-β expression and fibroblast recruitment

Journal of Industrial and Engineering Chemistry ◽

10.1016/j.jiec.2018.07.021 ◽

2018 ◽

Vol 67 ◽

pp. 469-477 ◽

Cited By ~ 1

Author(s):

Sung Yoon Choi ◽

Byung Hwi Kim ◽

Beom Kang Huh ◽

Woong Jeong ◽

Min Park ◽

...

Keyword(s):

Wound Healing ◽

Scar Formation ◽

Surgical Sutures

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Facile scalable one-step wet-spinning of surgical sutures with shape memory function and antibacterial activity for wound healing

Chinese Chemical Letters ◽

10.1016/j.cclet.2019.11.006 ◽

2020 ◽

Vol 31 (6) ◽

pp. 1499-1503

Author(s):

Xinghan Chen ◽

Pengfei Tan ◽

Ya Wen ◽

Wencheng Zhou ◽

Ying Cen ◽

...

Keyword(s):

Wound Healing ◽

Antibacterial Activity ◽

Shape Memory ◽

Memory Function ◽

Wet Spinning ◽

Surgical Sutures ◽

One Step

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A Systematic Review of the Tensile Strength of Surgical Sutures

Journal of Biomaterials and Tissue Engineering ◽

10.1166/jbt.2019.2177 ◽

2019 ◽

Vol 9 (11) ◽

pp. 1467-1476

Author(s):

Mohammed A. AlSarhan

Keyword(s):

Wound Healing ◽

Tensile Strength ◽

Dietary Habits ◽

Outcome Variable ◽

Suture Materials ◽

Primary Outcome Variable ◽

Tissue Healing ◽

Surgical Sutures ◽

Natural Tissue

Suturing the wound provides temporary mechanical support enabling natural tissue healing. Understanding the inherent material properties of the suture materials facilitates clinical adjustments in the rate of degradation to ensure proper wound healing. This review aimed to summarize the analysis of the factors that contribute to the tensile strength of surgical sutures and the implications of these factors in wound healing. Our initial search criteria used keywords Tensile or Strength or suture material and returned 494 potentially related articles, these were narrowed to just seven key articles pertaining to the analysis of the primary outcome variable which are reviewed in detail here. The physical properties of these materials are substantially affected by the biological conditions of the model system during the period of analysis. Nevertheless, under in vivo conditions decisions on suture materials should take comorbidities like dietary habits, smoking, oral hygiene maintenance into account as they can all have a significant impact on the prevailing physiological conditions at the wound site.

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