scholarly journals The effect of rat nerve growth factor combined with vitamin B on peripheral neuropathy in multiple myeloma patients

Hematology ◽  
2020 ◽  
Vol 25 (1) ◽  
pp. 264-269 ◽  
Author(s):  
Minchao Yan ◽  
Yuan Li ◽  
Hui Zeng ◽  
Xiaoyan Zhao ◽  
Haibing Wu ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Nerve Growth Factor ◽  
Peripheral Neuropathy ◽  
Growth Factor ◽  
Vitamin B ◽  
Nerve Growth ◽  
Rat Nerve

Gene transfer and molecular cloning of the rat nerve growth factor receptor

Nature ◽  
1987 ◽  
Vol 325 (6105) ◽  
pp. 593-597 ◽  
Author(s):  
Monte J. Radeke ◽  
Thomas P. Misko ◽  
Charles Hsu ◽  
Leonard A. Herzenberg ◽  
Eric M. Shooter
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Gene Transfer ◽  
Molecular Cloning ◽  
Growth Factor Receptor ◽  
Nerve Growth Factor Receptor ◽  
Nerve Growth ◽  
Rat Nerve

scholarly journals The Changes of Nerve Growth Factor Serum Levels After External Muscle Stimulation and The Correlation with Diabetic Neuropathy Symptom in Diabetic Peripheral Neuropathy

2017 ◽  
Vol 6 (01) ◽  
pp. 7
Author(s):  
Dian Herdiansyah ◽  
Marina Annete Moeliono ◽  
Tertianto Prabowo
Keyword(s):  
Nerve Growth Factor ◽  
Peripheral Neuropathy ◽  
Growth Factor ◽  
Diabetic Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Significant Negative Correlation ◽  
Muscle Stimulation ◽  
Study Objective ◽  
Nerve Growth ◽  
Before And After

Background: Diabetic Peripheral neuropathy (DPN) is a common complication of diabetes mellitus. Recentstudies have demonstrated the involvement of Nerve growth factor (NGF) in the occurrence of DPN. TheDiabetes Mellitus was caused reduced the number and disruption of the function of the NGF. External MuscleStimulation (EMS) might be induced the NGF synthesis. The study objective has to found the effect of EMSon the NGF.Methods: Study design was before and after treatment without control on subjects with DPN. The bloodsample was taken before and after an intervention, as well as the Diabetic Neuropathy symptom (DNSym) andscore (DNSc). The EMS treated all of the participants within three times a week for four weeks.Results: There were 35 subjects were participated. Paired t-test showed a significant increase in NGF serumlevels and decrease both DNSym and DNSc with the difference value 12.64 ± 16.09 (p=0.000), 1.23 ± 0.82(p=0.000), 1.20 ± 0.85 (p=0.000). There was a significant negative correlation between NGF serum level withthe DNS- INA (r= -0.56; p=0.001) and the DNE-INA (r= -0.48; p=0.007).Conclusion: EMS treatment can increase serum NGF level. EMS has a strong correlation with a decrease inthe value of the DNS-INA and DNE-INA.Keywords: Diabetic Peripheral neuropathy, External Muscle Stimulation, Nerve Growth Factor.

scholarly journals Multiple myeloma increases nerve growth factor and other pain-related markers through interactions with the bone microenvironment

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sam W. Z. Olechnowicz ◽  
Megan M. Weivoda ◽  
Seint T. Lwin ◽  
Szi K. Leung ◽  
Sarah Gooding ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Cell Activation ◽  
Cellular Interactions ◽  
Bone Microenvironment ◽  
Related Factors ◽  
Nerve Growth ◽  
Tnf Α

Abstract Interactions between multiple myeloma (MM) and bone marrow (BM) are well documented to support tumour growth, yet the cellular mechanisms underlying pain in MM are poorly understood. We have used in vivo murine models of MM to show significant induction of nerve growth factor (NGF) by the tumour-bearing bone microenvironment, alongside other known pain-related characteristics such as spinal glial cell activation and reduced locomotion. NGF was not expressed by MM cells, yet bone stromal cells such as osteoblasts expressed and upregulated NGF when cultured with MM cells, or MM-related factors such as TNF-α. Adiponectin is a known MM-suppressive BM-derived factor, and we show that TNF-α-mediated NGF induction is suppressed by adiponectin-directed therapeutics such as AdipoRON and L-4F, as well as NF-κB signalling inhibitor BMS-345541. Our study reveals a further mechanism by which cellular interactions within the tumour-bone microenvironment contribute to disease, by promoting pain-related properties, and suggests a novel direction for analgesic development.

Nerve growth factor alleviates a painful peripheral neuropathy in rats

1995 ◽  
Vol 699 (2) ◽  
pp. 286-292 ◽  
Author(s):  
K. Ren ◽  
D.A. Thomas ◽  
R. Dubner
Keyword(s):  
Nerve Growth Factor ◽  
Peripheral Neuropathy ◽  
Growth Factor ◽  
Nerve Growth

Peripheral neuropathy in transgenic diabetic mice: restoration of C-fiber function with human recombinant nerve growth factor

Diabetes ◽  
1998 ◽  
Vol 47 (10) ◽  
pp. 1637-1642 ◽  
Author(s):  
K. A. Elias ◽  
M. J. Cronin ◽  
T. A. Stewart ◽  
R. C. Carlsen
Keyword(s):  
Nerve Growth Factor ◽  
Peripheral Neuropathy ◽  
Growth Factor ◽  
Diabetic Mice ◽  
Nerve Growth ◽  
C Fiber

scholarly journals Investigation of Three Drugs With Neuroregenerative Effects on Inferior Alveolar Nerve Injury in Rats

2021 ◽  
Author(s):  
Ayşem Yurtseven Günay ◽  
Gökçen Ünverengil ◽  
Gülsüm Ak
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Injury ◽  
Peripheral Nerve Regeneration ◽  
Inferior Alveolar Nerve ◽  
Albino Rats ◽  
Vitamin B ◽  
Nerve Injuries ◽  
Nerve Growth ◽  
Inferior Alveolar Nerve Injury

Abstract PurposeNerve injuries formed during oral and maxillofacial surgical operations occur usually by crush or tension-type damages rather than incisions or ruptures. Such nerve injuries can be treated by providing regeneration with pharmacological agents without surgical intervention. The aim of this study was to determine and compare the effects of dexamethasone, B vitamin complex, and nerve growth factor on peripheral nerve regeneration with a local application on the inferior alveolar nerve. Methods Twenty-four Wistar Albino rats weighing 220-250 grams were used in the study. Experimental animals were divided into 4 groups. According to the groups, animals were treated with saline, dexamethasone, vitamin B complex and nerve growth factor. All animals were sacrificed on the 21st day and inferior alveolar nerves were resected for microscopic examination. Results The integrity and irregularities of myelin sheaths and vacuole formation were evaluated under a light microscope. Statistical analysis was performed with SPSS version 17.0. When histopathological findings were evaluated, it was observed that dexamethasone and vitamin B application triggered regeneration. However, regeneration in the group treated with nerve growth factor was much more obvious. Conclusions Local drug applications are beneficial for regeneration in inferior alveolar nerve injury. Considering their success, studies are needed to place growth factors in clinical practice.

scholarly journals The Correlation between Malondialdehyde and Nerve Growth Factor Serum Level with Diabetic Peripheral Neuropathy Score

2019 ◽  
Vol 7 (1) ◽  
pp. 103-106 ◽  
Author(s):  
Eva Decroli ◽  
Asman Manaf ◽  
Syafril Syahbuddin ◽  
Yuliarni Syafrita ◽  
Dwisari Dillasamola
Keyword(s):  
Nerve Growth Factor ◽  
Peripheral Neuropathy ◽  
Growth Factor ◽  
Serum Level ◽  
Diabetic Peripheral Neuropathy ◽  
Thiobarbituric Acid ◽  
Cross Sectional Study ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Nerve Growth

AIM: This study was conducted to identify malondialdehyde (MDA) serum level, nerve growth factor (NGF) serum level, diabetic peripheral neuropathy score and the correlation between MDA and NGF serum level with diabetic peripheral neuropathy score. METHODS: A cross-sectional study was conducted to observe diabetic patients in the internal medicine department in Dr M. Djamil Hospital, Padang, Indonesia. The MDA serum level was measured using Beuge method with thiobarbituric acid. The NGF serum level was analysed using ELISA method. Diabetic peripheral neuropathy score was defined when history score in Michigan Neuropathy Screening Instrument (MNSI) ≥ 7 and physical assessment score in MNSI > 2. RESULTS: Thirty subjects with diabetes has diabetic peripheral neuropathy score 3.53 (± 0.91), MDA serum level 2.16 (± 2.89) nmol/ml, and NGF serum level 10.56 (± 2.89) pg/dl. There were significant correlations between the MDA serum level and the diabetic peripheral neuropathy score (r = 0.364, p = 0.048), and between the NGF serum level with the diabetic peripheral neuropathy score (r = -0.59, p = 0.001). CONCLUSION: There are high MDA serum level and low NGF serum level in patients with diabetic peripheral neuropathy. Low NGF serum level plays a bigger role than high MDA serum level in diabetic peripheral neuropathy.

Sign in / Sign up

Export Citation Format

Share Document