scholarly journals Hyperglycaemia, diabetes mellitus and COVID-19 in a tertiary hospital in KwaZulu-Natal

Author(s):  
AS Ikram ◽  
S Pillay
2021 ◽  
Vol 19 (3) ◽  
pp. 122-125
Author(s):  
Rohit Chordia ◽  

Background: Comorbidities are important events in the natural history of the disease and have a negative effect on the morbidity and mortality of COPD patients. It is increasingly recognized that, many patients with COPD have co-morbidities that have a major impact on quality of life and survival. Present study aims at studying the prevalence and effects of comorbidities in COPD patients at a tertiary hospital. Material and Methods: Present study was cross sectional, observational study conducted in COPD patients, diagnosed for more than 5 years, underwent investigations for various comorbidities. Results: In present study, 130 COPD patients were studied for various co-morbidities. Majority of cases were from 50 -64 years age group (49.23 %) and were male (97.69 %). Smoking was major factor noted among cases (73.85 %), out of them 23.96 % were current smoker. Mean duration since quitting of smoking was 7.24 ± 5.83 years. Comorbidities noted in present study were systemic hypertension (42.31 %), GERD and gastric ulceration (31.54 %), type 2 diabetes mellitus (30.77 %), metabolic syndrome (29.23 %), anemia (11.54 %), left sided cardiac abnormalities (10.77 %), depression (8.46 %), obstructive sleep apnea (6.92 %), ischemic heart disease (6.15 %), osteoporosis (4.62 %), bronchiectasis (2.31 %) and lung cancer (0.77 %). Conclusion: Comorbidities noted in present study were hypertension, GERD, type 2 diabetes mellitus, metabolic syndrome, anaemia, left sided cardiac abnormalities and depression.


2020 ◽  
Vol 1 (1) ◽  
pp. 31-40
Author(s):  
Desi Harnis ◽  
Rusmawardiana ◽  
, Fifa Argentina

Background Superficial mycoses is a fungal infection of the skin, nails and hair thatcaused by dematophytes, yeast and mold. Superficial mycoses infections are commonlyfound in high temperature and humidity area such as Indonesia. Palembang is one ofregions in Indonesia has a high temperature and humidity, considered the incidenceof this disease is high. A retrospective study of new cases of superficial mycoses, datataken from medical records and register book at Policlinic of Dermatology andVenereology Dr. Moh. Hoesin Palembang during 5 years from January 2014-December2018. There were 1,236 (17.1%) new cases of superficial mycoses. Incidence ofsuperficial mycoses varies with range 6.9%-23%. The most common superficialmycoses is dermatophytes (38,3%). Microsporum canis, Trichophyton rubrum danTricophyton hmentagrophytes are frequent isolates in this study. The most age groupis 36-45 years (17.6%) with male more than female. Superficial mycoses are often foundin students (26.9%), followed by unskilled workers (20.8%). Of the 1,236 new cases,125 patients had comorbidities, such as malignancy 21 (16.8%) patients,cerebrovascular disease and diabetes mellitus each 16 patients (7.4%). Inguinal andabdomen are the most commonly infected regions. 656 (53.1%) patients was giventopical antifungal. The most common topical antifungal was ketoconazole 2% cream(62%) and systemic antifungal was itraconazole (55,3%).Conclusion: Cases ofsuperficial mycoses, especially dermatophytosis and Malassezia were still commonlyfound, especially in Palembang.


2018 ◽  
Vol 26 (2) ◽  
pp. 104
Author(s):  
AnthonyA Thomas ◽  
OlugbemigaO Ayoola ◽  
Rosemary Ikem ◽  
ToyinH Onakpoya ◽  
AyokunleS Dada ◽  
...  

BMJ Open ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. e029280 ◽  
Author(s):  
Bander Balkhi ◽  
Monira Alwhaibi ◽  
Nasser Alqahtani ◽  
Tariq Alhawassi ◽  
Thamir M Alshammari ◽  
...  

ObjectivesThe purpose of this study is to measure the adherence rates of oral antidiabetic drugs (OADs) in patients with type 2 diabetes mellitus (T2DM) and assess the relationship of glycaemic control and adherence to OADs after controlling for other associated factors.DesignCross-sectional retrospective study.SettingLarge tertiary hospital in the central region of Saudi Arabia.Participants5457patients aged 18 years and older diagnosed with T2DM during the period from 1 January 2016 to 31 December 2016.Primary and secondary outcome measuresThe modified medication possession ratio (mMPR) was calculated as a proxy measure for adherence of OADs. The factors associated with OADs non-adherence and medication oversupply were assessed using multinomial logistic regression models. The secondary outcomes were to measure the association between OADs adherence and glycaemic control.ResultsMajority of patients with T2DM were females (n=3400, 62.3%). The average glycated haemoglobin was 8.2±1.67. Among the study population, 48.6% had good adherence (mMPR >0.8) and 8.6% had a medication oversupply (mMPR >1.2). Good adherence was highest among those using repaglinide (71.0%) followed by pioglitazone (65.0%) and sitagliptin (59.0%). In the multivariate analysis, women with T2DM were more likely to have poor adherence (adjusted OR (AOR)=0.76, 95% CI=0.67, 0.86) compared with men. Also, medication oversupply was more likely among patients with hyperpolypharmacy (AOR=1.88, 95% CI=1.36, 2.63), comorbid osteoarthritis (AOR=1.72, 95% CI=1.20, 02.45) and non-Saudi patients (AOR=1.53, 95% CI=1.16, 2.01). However, no association was found between glycaemic control and adherence to OADs.ConclusionThe study findings support the growing concern of non-adherence to OADs among patients with T2DM in Saudi Arabia. Decision makers have to invest in behavioural interventions that will boost medication adherence rates. This is particularly important in patients with polypharmacy and high burden of comorbid conditions.


2020 ◽  
Vol 11 (1) ◽  
pp. 1-9
Author(s):  
Chizolum Opara Hope ◽  
Nonyem Anarado Agnes ◽  
Juliet Anetekhai Chinenye ◽  
Njideka Iheanacho Peace ◽  
Lewechi Okoronkwo Ijeome ◽  
...  

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Shih Ling Kao ◽  
Ying Chen ◽  
Yilin Ning ◽  
Maudrene Tan ◽  
Mark Salloway ◽  
...  

Abstract Background Diabetes mellitus (DM) is one of the most common chronic diseases. Individuals with DM are more likely to be hospitalised and stay longer than those without DM. Inpatient hypoglycemia and hyperglycemia, which are associated with adverse outcomes, are common, but can be prevented through hospital quality improvement programs. Methods We designed a multi-faceted intervention program with the aim of reducing inpatient hypoglycemia and hyperglycemia. This was implemented over seven phases between September 2013 to January 2016, and covered all the non-critical care wards in a tertiary hospital. The program represented a pragmatic approach that leveraged on existing resources and infrastructure within the hospital. We calculated glucometric outcomes in June to August 2016 and compared them with those in June to August 2013 to assess the overall effectiveness of the program. We used regression models with generalised estimating equations to adjust for potential confounders and account for correlations of repeated outcomes within patients and admissions. Results We observed significant reductions in patient-days affected by hypoglycemia (any glucose reading < 4 mmol/L: OR = 0.71, 95% CI: 0.61 to 0.83, p <  0.001), and hyperglycemia (any glucose reading > 14 mmol/L: OR = 0.84, 95% CI: 0.71 to 0.99, p = 0.041). Similar findings were observed for admission-level hypoglycemia and hyperglycemia. Further analyses suggested that these reductions started to occur four to 6 months post-implementation. Conclusions Our program was associated with sustained improvements in clinically relevant outcomes. Our described intervention could be feasibly implemented by other secondary and tertiary care hospitals by leveraging on existing infrastructure and work force.


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