Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) accelerates osteoclast formation by regulating signal transducer and activator of transcription 3 (STAT3) signalling

Signal transducer and activator of transcription protein 3 (STAT3) is a latent cytosolic transcription factor that is widely recognized as being a master regulator of the cellular functions that lead to the cancer phenotype. Constitutively activated STAT3 protein activity is routinely observed in human cancers, promoting uncontrolled cell proliferation and suppressing apoptosis. Until relatively recently, inhibition of STAT3 transcriptional activity was achieved indirectly via suppression of upstream kinase activators and extracellular cytokine and (or) growth factor stimuli. However, activated STAT3 forms transcriptionally functional STAT3–STAT3 dimers, providing a valid juncture for targeted downstream molecular inhibition. STAT3's prominent role in cancer has seen a decade of innovative and novel approaches to targeting constitutively active STAT3 protein–protein complexes. This mini-review outlines the progress made towards identifying molecular agents capable of silencing aberrant STAT3 signalling through the disruption of STAT3 complexation events.

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Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells

Bioscience Reports ◽

10.1042/bsr20150165 ◽

2015 ◽

Vol 35 (6) ◽

Cited By ~ 39

Author(s):

Hye-Sook Seo ◽

Jae Kyung Jo ◽

Jin Mo Ku ◽

Han-Seok Choi ◽

Youn Kyung Choi ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Breast Cancer Cells ◽

Signal Transducer ◽

Stat3 Signaling ◽

Extrinsic Apoptosis ◽

Stat3 Signalling ◽

Transcription 3

Apigenin induced caspase-dependent extrinsic apoptosis through inhibition of STAT3 signaling in HER2 overexpressing BT-474 breast cancer cells.

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Mahanimbine Exerts Anticancer Effects on Human Pancreatic Cancer Cells by Triggering Cell Cycle Arrest, Apoptosis, and Modulation of AKT/Mammalian Target of Rapamycin (mTOR) and Signal Transducer and Activator of Transcription 3 (STAT3) Signalling Pathways

Medical Science Monitor ◽

10.12659/msm.911013 ◽

2018 ◽

Vol 24 ◽

pp. 6975-6983 ◽

Cited By ~ 4

Author(s):

Chenlin Pei ◽

Qun He ◽

Shuai Liang ◽

Xuejun Gong

Keyword(s):

Pancreatic Cancer ◽

Mammalian Target Of Rapamycin ◽

Human Pancreatic Cancer ◽

Signalling Pathways ◽

Signal Transducer ◽

Cycle Arrest ◽

Pancreatic Cancer Cells ◽

Anticancer Effects ◽

Stat3 Signalling ◽

Transcription 3

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Hypoxia is a potent inducer of the iron masterswitch hepcidin via Signal Transducer and Activator of Transcription 3 (STAT3)

10.1055/s-0037-1605072 ◽

2017 ◽

Author(s):

I Silva ◽

V Rausch ◽

T Peccerella ◽

G Millonig ◽

HK Seitz ◽

...

Keyword(s):

Signal Transducer ◽

Potent Inducer ◽

Transcription 3

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Faculty Opinions recommendation of Mitochondrial DNA copy number is modulated by genetic variation in the signal transducer and activator of transcription 3 (STAT3).

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.11545959.12597055 ◽

2011 ◽

Author(s):

Anke Hinney ◽

Nadja Knoll

Keyword(s):

Mitochondrial Dna ◽

Genetic Variation ◽

Copy Number ◽

Signal Transducer ◽

Dna Copy Number ◽

Mitochondrial Dna Copy Number ◽

Transcription 3

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Faculty Opinions recommendation of Janus kinase 2/signal transducer and activator of transcription 3 inhibitors attenuate the effect of cardiotrophin-like cytokine factor 1 and human focal segmental glomerulosclerosis serum on glomerular filtration barrier.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725428053.793530397 ◽

2017 ◽

Author(s):

Jochen Reiser

Keyword(s):

Glomerular Filtration ◽

Focal Segmental Glomerulosclerosis ◽

Janus Kinase ◽

Signal Transducer ◽

Janus Kinase 2 ◽

Glomerular Filtration Barrier ◽

Filtration Barrier ◽

Segmental Glomerulosclerosis ◽

Transcription 3

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Magnesium-dependent Phosphatase (MDP) 1 is a Potential Suppressor of Gastric Cancer

Current Cancer Drug Targets ◽

10.2174/1568009619666190620112546 ◽

2019 ◽

Vol 19 (10) ◽

pp. 817-827

Author(s):

Jianbo Zhu ◽

Lijuan Deng ◽

Baozhen Chen ◽

Wenqing Huang ◽

Xiandong Lin ◽

...

Keyword(s):

Gastric Cancer ◽

Dna Methylation ◽

Cell Proliferation ◽

Protein C ◽

Biological Function ◽

Prognostic Markers ◽

Biological Effects ◽

Signal Transducer ◽

Gastric Cancer Cells ◽

Transcription 3

Background:Recurrence is the leading cause of treatment failure and death in patients with gastric cancer (GC). However, the mechanism underlying GC recurrence remains unclear, and prognostic markers are still lacking.Methods:We analyzed DNA methylation profiles in gastric cancer cases with shorter survival (<1 year) or longer survival (> 3 years), and identified candidate genes associated with GC recurrence. Then, the biological effects of these genes on gastric cancer were studied.Results:A novel gene, magnesium-dependent phosphatase 1 (mdp1), was identified as a candidate gene whose DNA methylation was higher in GC samples from patients with shorter survival and lower in patients with longer survival. MDP1 protein was highly expressed in GC tissues with longer survival time, and also had a tendency to be expressed in highly differentiated GC samples. Forced expression of MDP1 in GC cell line BGC-823 inhibited cell proliferation, whereas the knockdown of MDP1 protein promoted cell growth. Overexpression of MDP1 in BGC-823 cells also enhanced cell senescence and apoptosis. Cytoplasmic kinase protein c-Jun N-terminal kinase (JNK) and signal transducer and activator of transcription 3 (Stat3) were found to mediate the biological function of MDP1.Conclusion:These results suggest that MDP1 protein suppresses the survival of gastric cancer cells and loss of MDP expression may benefit the recurrence of gastric cancer.

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