Lysophospholipids in the limelight
2002 ◽
Vol 158
(2)
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pp. 197-199
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Keyword(s):
A Cell
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Lysophosphatidic acid (LPA) is a serum phospholipid that evokes growth factor–like responses in many cell types through the activation of its G protein–coupled receptors. Although much is known about LPA signaling, it has remained unclear where and how bioactive LPA is produced. Umezu-Goto et al. (2002)(this issue, page 227) have purified a serum lysophospholipase D that generates LPA from lysophosphatidylcholine and found it to be identical to autotaxin, a cell motility–stimulating ectophosphodiesterase implicated in tumor progression. This result is surprising, as there was previously no indication that autotaxin could act as a phospholipase.
2002 ◽
Vol 1582
(1-3)
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pp. 100-106
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2006 ◽
Vol 84
(3-4)
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pp. 287-297
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2003 ◽
Vol 90
(3)
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pp. 1643-1653
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Keyword(s):
2001 ◽
Vol 276
(30)
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pp. 28578-28585
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Keyword(s):
2006 ◽
Vol 84
(3-4)
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pp. 377-391
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2005 ◽
Vol 41
(1)
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pp. 27-37
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2020 ◽
Vol 21
(6)
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pp. 2015
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2006 ◽
Vol 905
(1)
◽
pp. 25-33
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