Transmembrane TNF drives osteoproliferative joint inflammation reminiscent of human spondyloarthritis

TNF plays a key role in immune-mediated inflammatory diseases including rheumatoid arthritis (RA) and spondyloarthritis (SpA). It remains incompletely understood how TNF can lead to different disease phenotypes such as destructive peripheral polysynovitis in RA versus axial and peripheral osteoproliferative inflammation in SpA. We observed a marked increase of transmembrane (tm) versus soluble (s) TNF in SpA versus RA together with a decrease in the enzymatic activity of ADAM17. In contrast with the destructive polysynovitis observed in classical TNF overexpression models, mice overexpressing tmTNF developed axial and peripheral joint disease with synovitis, enthesitis, and osteitis. Histological and radiological assessment evidenced marked endochondral new bone formation leading to joint ankylosis over time. SpA-like inflammation, but not osteoproliferation, was dependent on TNF-receptor I and mediated by stromal tmTNF overexpression. Collectively, these data indicate that TNF can drive distinct inflammatory pathologies. We propose that tmTNF is responsible for the key pathological features of SpA.

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Incidence and temporal trends of co-occurring personality disorder diagnoses in immune-mediated inflammatory diseases

Epidemiology and Psychiatric Sciences ◽

10.1017/s2045796019000854 ◽

2020 ◽

Vol 29 ◽

Author(s):

C. Blaney ◽

J. Sommer ◽

R. El-Gabalawy ◽

C. Bernstein ◽

R. Walld ◽

...

Keyword(s):

Negative Binomial ◽

Inflammatory Diseases ◽

Temporal Trends ◽

Negative Binomial Regression ◽

Case Definitions ◽

Immune Mediated ◽

Before And After ◽

Shared Risk ◽

Incident Cases ◽

Over Time

Abstract Aims Although immune-mediated inflammatory diseases (IMID) are associated with multiple mental health conditions, there is a paucity of literature assessing personality disorders (PDs) in these populations. We aimed to estimate and compare the incidence of any PD in IMID and matched cohorts over time, and identify sociodemographic characteristics associated with the incidence of PD. Methods We used population-based administrative data from Manitoba, Canada to identify persons with incident inflammatory bowel disease (IBD), multiple sclerosis (MS) and rheumatoid arthritis (RA) using validated case definitions. Unaffected controls were matched 5:1 on sex, age and region of residence. PDs were identified using hospitalisation or physician claims. We used unadjusted and covariate-adjusted negative binomial regression to compare the incidence of PDs between the IMID and matched cohorts. Results We identified 19 572 incident cases of IMID (IBD n = 6,119, MS n = 3,514, RA n = 10 206) and 97 727 matches overall. After covariate adjustment, the IMID cohort had an increased incidence of PDs (incidence rate ratio [IRR] 1.72; 95%CI: 1.47–2.01) as compared to the matched cohort, which remained consistent over time. The incidence of PDs was similarly elevated in IBD (IRR 2.19; 95%CI: 1.69–2.84), MS (IRR 1.79; 95%CI: 1.29–2.50) and RA (IRR 1.61; 95%CI: 1.29–1.99). Lower socioeconomic status and urban residence were associated with an increased incidence of PDs, whereas mid to older adulthood (age 45–64) was associated with overall decreased incidence. In a restricted sample with 5 years of data before and after IMID diagnosis, the incidence of PDs was also elevated before IMID diagnosis among all IMID groups relative to matched controls. Conclusions IMID are associated with an increased incidence of PDs both before and after an IMID diagnosis. These results support the relevance of shared risk factors in the co-occurrence of PDs and IMID conditions.

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The Gut Microbiota of Rats under Experimental Osteoarthritis and Administration of Chondroitin Sulfate and Probiotic

Mikrobiolohichnyi Zhurnal ◽

10.15407/microbiolj82.06.064 ◽

2020 ◽

Vol 82 (6) ◽

pp. 64-73

Author(s):

O.H. Korotkyi ◽

◽

T.V. Luhovska ◽

T.M. Serhiychuk ◽

K.O. Dvorshchenko ◽

...

Keyword(s):

Gut Microbiota ◽

Chondroitin Sulfate ◽

Joint Inflammation ◽

Degenerative Joint Disease ◽

Joint Disease ◽

Quantitative Composition ◽

Combined Administration ◽

Osteoarthritis Progression ◽

Experimental Osteoarthritis ◽

Gut Microbiota Composition

Osteoarthritis is a most widespread chronic degenerative joint disease that causes pain, cartilage deformation, and joint inflammation. Adverse alterations of intestinal microbiota like dysbiosis may lead to metabolic syndrome and inflammation, two important components of osteoarthritis progression. Aim. In this study we investigated the effect of chondroitin sulfate and probiotics on the gut microbiome in monoiodoacetate-induced osteoarthritis model in rats. Methods. The species and quantitative composition of feces were determined using diagnostic media with selective properties. Further identification of isolated microorganisms was carried out according to morphological, tinctorial, physiological and metabolic parameters. The results are presented in the form of lg CFU/g. Results. Induction of osteoarthritis caused significant increasing the number of opportunistic enterobacteria and lactose-negative Escherichia coli against the decreasing of lacto- and bifidobacteria that may indicate a dysbiotic condition. Coadministration of chondroitin sulfate and probiotic bacteria has led to improvement the quantitative composition of the gut microbiota in experimental animals, the numerous of Bifidobacterium, Lactobacillus were increasing against decreasing the quantitative composition of opportunistic microorganisms. Conclusions. Monoiodoacetate-induced osteoarthritis caused dysbiosis of gut in rat. We observed beneficial effect of combined administration of chondroitin sulfate and probiotics on gut microbiota composition in rats with experimental osteoarthritis. Thus, adding of supplements like probiotics to standard treatment of osteoarthritis may have potentials to prevent and treat this disease.

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Faculty Opinions recommendation of Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1014699.195473 ◽

2003 ◽

Author(s):

Carl Ware

Keyword(s):

Tnf Receptor ◽

Tnf Receptor I

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Faculty Opinions recommendation of Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1014699.194704 ◽

2003 ◽

Author(s):

Christoph Borner

Keyword(s):

Tnf Receptor ◽

Tnf Receptor I

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Faculty Opinions recommendation of Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1014699.194170 ◽

2003 ◽

Author(s):

Sharad Kumar

Keyword(s):

Tnf Receptor ◽

Tnf Receptor I

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Faculty Opinions recommendation of Novel therapies for immune-mediated inflammatory diseases: What can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis, Crohn's disease and ulcerative colitis?

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727869572.793564281 ◽

2019 ◽

Author(s):

Ladislav Senolt

Keyword(s):

Rheumatoid Arthritis ◽

Systemic Lupus Erythematosus ◽

Ulcerative Colitis ◽

Crohn’S Disease ◽

Crohn's Disease ◽

Lupus Erythematosus ◽

Inflammatory Diseases ◽

Novel Therapies ◽

Systemic Lupus ◽

Immune Mediated

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HELIOTHERAPY IN THE TREATMENT OF PSORIATIC ARTHRITIS

Knowledge International Journal ◽

10.35120/kij2802483g ◽

2018 ◽

Vol 28 (2) ◽

pp. 483-487

Author(s):

Snezhina Georgieva ◽

Dilyana Zvezdova

Keyword(s):

Psoriatic Arthritis ◽

Clinical Picture ◽

Local Therapy ◽

Severe Form ◽

Climatic Conditions ◽

Joint Disease ◽

Immune Mediated ◽

Social Comfort ◽

Pigment Type ◽

Definition Of

Psoriatic arthritis is an inflammatory joint disease associated with psoriasis vulgaris, with routinely negative rheumatoid factors and the absence of rheumatoid nodules. This is an immune-mediated disease, according to generally accepted definition of Wright and Moll from 1973. American Association against Rheumatism classified psoriatic arthritis as an independent disease in 1964. Psoriatic arthritis is a single disease with a varied clinical picture. It belongs to the group of seronegative spondyloarthropathies with which there are general clinical features. It is believed that similar mechanisms determine the onset of psoriasis and psoriatic arthritis. The clinical picture includes various clinical forms that damage the peripheral and sacroiliac joints, spine, internal organs. The treatment of psoriatic arthritis is directed simultaneously to the influence of skin and joint changes. Purpose: Our study aims to summarize our long-standing experience in the treatment of psoriatic arthritis with heliotherapy. Subject of observation: Monitoring includes 132 patients with moderate and severe form of psoriasis treated at the sanatorium in town of Pomorie for 5 years in the period 2001-2006. Results and discussion: 132 patients with psoriasis with no effect on the local therapy and have proven psoriatic arthritis were selected. In our climatic conditions, heliotherapy is appointed during the warm half-year. Sun treatment was conducted under the conditions of a healing beach, which had shielding, radiation-protective devices. In patients with erythema - pigment and pigment type skin reactivity begins with 1-2 bioadoses reached to 8-10 biodoses, carried out in the area of overcomfort. Conclusion: The studies demonstrated that heliotherapy combined with medications significantly improves the prognosis of patients with this disease. The ultimate success would mean overcoming the frequent depression conditions, better survival and social comfort for patients with psoriatic arthritis.

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Immuno-biological Assessments of Temporomandibular Joint Disease in Patients with Immune-mediated Rheumatic Conditions. A cross sectional study of 273 cases

Revista de Chimie ◽

10.37358/rc.17.12.6023 ◽

2018 ◽

Vol 68 (12) ◽

pp. 2987-2991

Author(s):

Cristina Iordache ◽

Bogdan Vascu ◽

Eugen Ancuta ◽

Rodica Chirieac ◽

Cristina Pomirleanu ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Psoriatic Arthritis ◽

Temporomandibular Joint ◽

Final Analysis ◽

Cross Sectional Study ◽

Joint Disease ◽

Sectional Study ◽

Cross Sectional ◽

Immune Parameters ◽

Immune Mediated

Temporomandibular joint (TMJ) is commonly involved in various immune-mediated rheumatic disorders accounting for significant disability and impaired quality of life. The aim of our study was to assess inflammatory and immune parameters in patients with TMJ arthritis related to rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) and to identify potential relation with severity and dysfunction of TMJ pathology. We performed a cross-sectional study in a cohort of 433 consecutive RA, 32 JIA, 258 AS, and 103 PsA. Only patients presenting with clinically significant TMJ involvement (273) related to their rheumatic condition were included in the final analysis. TMJ involvement is traditionally described in chronic inflammatory rheumatic disorders, particularly in patients with higher levels of inflammation as detected in rheumatoid arthritis and psoriatic arthritis. Disease activity and severity, as well as biological and positive serological assessments (rheumatoid factor, anti-cyclic citrullinated peptide, IL-1) remain significant determinants of the severity of TMJ arthritis.

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