scholarly journals Serotonin transport in the 21st century

2019 ◽  
Vol 151 (11) ◽  
pp. 1248-1264 ◽  
Author(s):  
Gary Rudnick ◽  
Walter Sandtner
Keyword(s):  
High Resolution ◽  
Serotonin Transporter ◽  
21St Century ◽  
Synaptic Vesicles ◽  
Blood Platelets ◽  
Membrane Vesicles ◽  
Self Consistent ◽  
Slc6 Family ◽  
Consistent Picture ◽  
Serotonin Transport

Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin transporter (SERT), which terminates its extracellular action and provides cytoplasmic 5-HT for refilling of synaptic vesicles. SERT is the target for many antidepressant medications as well as psychostimulants such as cocaine and ecstasy (3,4-methylenedioxymethamphetamine). SERT belongs to the SLC6 family of ion-coupled transporters and is structurally related to several other transporter families. SERT was studied in the 1970s and 1980s using membrane vesicles isolated from blood platelets. These studies led to a proposed stoichiometry of transport that has been challenged by high-resolution structures of SERT and its homologues and by studies of SERT electrophysiology. Here, we review the original evidence alongside more recent structural and electrophysiological evidence. A self-consistent picture emerges with surprising insights into the ion fluxes that accompany 5-HT transport.

Thrombus formation on artificial surfaces: Correlative microscopy

1990 ◽  
Vol 48 (3) ◽  
pp. 840-841
Author(s):  
Quintin J. Lai ◽  
Stuart L. Cooper ◽  
Ralph M. Albrecht
Keyword(s):  
Electron Microscopy ◽  
High Resolution ◽  
Low Voltage ◽  
Thrombus Formation ◽  
Blood Platelets ◽  
Polymer Surfaces ◽  
Flow Conditions ◽  
Transmission Electron ◽  
Adhesion Of Platelets ◽  
Microscopic Techniques

Thrombus formation and embolization are significant problems for blood-contacting biomedical devices. Two major components of thrombi are blood platelets and the plasma protein, fibrinogen. Previous studies have examined interactions of platelets with polymer surfaces, fibrinogen with platelets, and platelets in suspension with spreading platelets attached to surfaces. Correlative microscopic techniques permit light microscopic observations of labeled living platelets, under static or flow conditions, followed by the observation of identical platelets by electron microscopy. Videoenhanced, differential interference contrast (DIC) light microscopy permits high-resolution, real-time imaging of live platelets and their interactions with surfaces. Interference reflection microscopy (IRM) provides information on the focal adhesion of platelets on surfaces. High voltage, transmission electron microscopy (HVEM) allows observation of platelet cytoskeletal structure of whole mount preparations. Low-voltage, high resolution, scanning electron microscopy allows observation of fine surface detail of platelets. Colloidal gold-labeled fibrinogen, used to identify the Gp Ilb/IIIa membrane receptor for fibrinogen, can be detected in all the above microscopies.

scholarly journals Extreme Rainfall Projections for Malaysia at the End of 21st Century Using the High Resolution Non-Hydrostatic Regional Climate Model (NHRCM)

SOLA ◽  
2020 ◽  
Vol 16 (0) ◽  
pp. 132-139
Author(s):  
Sheau Tieh Ngai ◽  
Hidetaka Sasaki ◽  
Akihiko Murata ◽  
Masaya Nosaka ◽  
Jing Xiang Chung ◽  
...  
Keyword(s):  
High Resolution ◽  
Regional Climate Model ◽  
21St Century ◽  
Climate Model ◽  
Regional Climate ◽  
Extreme Rainfall

scholarly journals Interpretation of Extragalactic Jets

1986 ◽  
Vol 89 ◽  
pp. 425-437
Author(s):  
Michael L. Norman
Keyword(s):  
High Resolution ◽  
Visual Inspection ◽  
Physical Parameters ◽  
Model Calculations ◽  
Radio Jets ◽  
Extragalactic Jets ◽  
Self Consistent ◽  
Interferometric Observation ◽  
The Subject

The subject of this paper is the interpretation of extragalactic radio jets. In this paper I will focus on what we have learned about the nature of extragalactic jets on the basis of model calculations. By model I mean any set of calculations, whether analytic, semi-analytic or numerical, which, when carried through from their respective assumptions to their internally self-consistent conclusions, help place constraints on the physical parameters and processes in the jets and their associated radio lobes. In this field, a visual inspection of a modern high-resolution radio interferometric observation (see review by PERLEY in these proceedings) often leads to statements like “that looks just like such and such in Landau and Lifschitz; I betcha that’s what’s going on!” This I call a speculation, or, at best, a hypothesis. I am addressing here the step beyond hypothesis, namely modeling, which is necessary to confront not only the object in question, but more importantly, the hypothesis itself. In the end, we will remember only the hypotheses.

Mapping the distribution of serotonin transporter in the human brainstem with high-resolution PET: Validation using postmortem autoradiography data

NeuroImage ◽  
2016 ◽  
Vol 133 ◽  
pp. 313-320 ◽  
Author(s):  
P. Fazio ◽  
M. Schain ◽  
K. Varnäs ◽  
C. Halldin ◽  
L. Farde ◽  
...  
Keyword(s):  
High Resolution ◽  
Serotonin Transporter

scholarly journals Effect of EGTA on serotonin transport into blood platelets.

1993 ◽  
Vol 61 ◽  
pp. 151
Author(s):  
Ken-ichi Nezasa ◽  
Hiroaki Nishio ◽  
Yoshihiro Nakata
Keyword(s):  
Blood Platelets ◽  
Serotonin Transport

scholarly journals Oil-in-water microemulsion droplets of TDMAO/decane interconnected by the telechelic C18-EO150-C18: clustering and network formation

Soft Matter ◽  
2014 ◽  
Vol 10 (28) ◽  
pp. 5072-5084 ◽  
Author(s):  
Paula Malo de Molina ◽  
Marie-Sousai Appavou ◽  
Michael Gradzielski
Keyword(s):  
Network Formation ◽  
Mixed System ◽  
Polymer Content ◽  
Structure And Dynamics ◽  
Oil In Water ◽  
Self Consistent ◽  
Consistent Picture ◽  
Evolution Of Structure ◽  
Telechelic Polymer

The combination of SANS, DLS, and FCS allows to derive a self-consistent picture of the evolution of structure and dynamics of the mixed system microemulsion/telechelic polymer as a function of the polymer content.

Sign in / Sign up

Export Citation Format

Share Document