Investigation of magnetically driven passage of magnetic nanoparticles through eye tissues for magnetic drug targeting

2020 ◽  
Vol 31 (49) ◽  
pp. 495101
Author(s):  
Diana Zahn ◽  
Katja Klein ◽  
Patricia Radon ◽  
Dmitry Berkov ◽  
Sergey Erokhin ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Drug Targeting ◽  
Magnetic Drug Targeting ◽  
Eye Tissues

scholarly journals In Vivo Study on Magnetomotive Ultrasound Imaging in the Framework of Nanoparticle based Magnetic Drug Targeting

2020 ◽  
Vol 6 (3) ◽  
pp. 543-546
Author(s):  
Michael Fink ◽  
Stefan J. Rupitsch ◽  
Helmut Ermert ◽  
Stefan Lyer
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Drug Targeting ◽  
Imaging Technique ◽  
Small Animal ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles ◽  
Medical Procedures ◽  
First Time

AbstractVarious medical procedures make use of magnetic nanoparticles, such as Magnetic Drug Targeting (MDT), which boosts the demand for imaging modalities that are capable of in vivo visualizing this kind of particles. Magnetomotive Ultrasound is an imaging technique that can detect tissue, which is perfused by magnetic nanoparticles. In this contribution, we investigate the suitability of Magnetomotive Ultrasound to serve as a monitoring system during MDT. With the conducted measurements, it was possible for the first time to observe in vivo the accumulation of iron-oxide nanoparticles during a Magnetic Drug Targeting cancer treatment applied to a small animal (rabbit).

SIMULATION OF MAGNETIC NANOPARTICLES IN BLOOD FLOW FOR MAGNETIC DRUG TARGETING APPLICATIONS

nano Online ◽  
2016 ◽  
Author(s):  
I Slabu ◽  
A Röth ◽  
G Güntherodt ◽  
T Schmitz-Rode ◽  
M Baumann
Keyword(s):  
Blood Flow ◽  
Magnetic Nanoparticles ◽  
Drug Targeting ◽  
Magnetic Drug Targeting

Magnetic nanoparticles for magnetic drug targeting

2015 ◽  
Vol 60 (5) ◽  
Author(s):  
Stefan Lyer ◽  
Raminder Singh ◽  
Rainer Tietze ◽  
Christoph Alexiou
Keyword(s):  
Magnetic Nanoparticles ◽  
Side Effects ◽  
Drug Targeting ◽  
Superparamagnetic Iron Oxide ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles ◽  
Treatment Concept ◽  
Substantial Progress ◽  
New Treatment ◽  
Tumor Area

AbstractNanomedicine and superparamagnetic iron oxide nanoparticles (SPIONs) are thought to have an important impact on medicine in the future. Especially in cancer therapy, SPIONs offer the opportunity of improving the effectivity of the treatment and reduce side effects by magnetic accumulation of SPION-bound chemotherapeutics in the tumor area. Although still some challenges have to be overcome, before the new treatment concept of magnetic drug targeting will reach the patients, substantial progress has been made, and promising results were shown in the last years.

Quantification of Magnetic Nanoparticles by Magnetorelaxometry and Comparison to Histology After Magnetic Drug Targeting

2006 ◽  
Vol 6 (9) ◽  
pp. 3222-3225 ◽  
Author(s):  
F. Wiekhorst ◽  
C. Seliger ◽  
R. Jurgons ◽  
U. Steinhoff ◽  
D. Eberbeck ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Cross Sections ◽  
Drug Targeting ◽  
Magnetic Particles ◽  
Particle Distribution ◽  
Drug Carrier ◽  
Magnetic Drug Targeting ◽  
Tissue Samples ◽  
Drug Carrier System

Magnetic nanoparticles can be used in medicine in vivo as contrast agents and as a drug carrier system for chemotherapeutics. Thus local cancer therapy is performed with Magnetic Drug Targeting (MDT) and allows a specific delivery of therapeutic agents to desired targets, i.e., tumors, by using a chemotherapeutic substance bound to magnetic nanoparticles and focused with an external magnetic field to the tumor after intraarterial application. Important for this therapeutic principle is the distribution of the particles in the whole organism and especially in the tumor. Therefore we used magnetorelaxometry to quantify ferrofluids delivered after MDT. Tissue samples of some mm3 volume of a VX2 squamous cell carcinoma were measured by magnetic relaxation and the amount of iron was determined using the original ferrofluid suspension as a reference. From this the distribution of the magnetic particles within the slice of tumor was reconstructed. Histological cross-sections of the respective tumor offer the opportunity to map quantitatively the particle distribution and the vascularisation in the targeted tumor on a microscopic scale. Our data show that the integral method magnetorelaxometry and microscopic histological methods can complete each other efficiently.

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