Quantification of Magnetic Nanoparticles by Magnetorelaxometry and Comparison to Histology After Magnetic Drug Targeting

2006 ◽  
Vol 6 (9) ◽  
pp. 3222-3225 ◽  
Author(s):  
F. Wiekhorst ◽  
C. Seliger ◽  
R. Jurgons ◽  
U. Steinhoff ◽  
D. Eberbeck ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Cross Sections ◽  
Drug Targeting ◽  
Magnetic Particles ◽  
Particle Distribution ◽  
Drug Carrier ◽  
Magnetic Drug Targeting ◽  
Tissue Samples ◽  
Drug Carrier System

Magnetic nanoparticles can be used in medicine in vivo as contrast agents and as a drug carrier system for chemotherapeutics. Thus local cancer therapy is performed with Magnetic Drug Targeting (MDT) and allows a specific delivery of therapeutic agents to desired targets, i.e., tumors, by using a chemotherapeutic substance bound to magnetic nanoparticles and focused with an external magnetic field to the tumor after intraarterial application. Important for this therapeutic principle is the distribution of the particles in the whole organism and especially in the tumor. Therefore we used magnetorelaxometry to quantify ferrofluids delivered after MDT. Tissue samples of some mm3 volume of a VX2 squamous cell carcinoma were measured by magnetic relaxation and the amount of iron was determined using the original ferrofluid suspension as a reference. From this the distribution of the magnetic particles within the slice of tumor was reconstructed. Histological cross-sections of the respective tumor offer the opportunity to map quantitatively the particle distribution and the vascularisation in the targeted tumor on a microscopic scale. Our data show that the integral method magnetorelaxometry and microscopic histological methods can complete each other efficiently.

scholarly journals In Vivo Study on Magnetomotive Ultrasound Imaging in the Framework of Nanoparticle based Magnetic Drug Targeting

2020 ◽  
Vol 6 (3) ◽  
pp. 543-546
Author(s):  
Michael Fink ◽  
Stefan J. Rupitsch ◽  
Helmut Ermert ◽  
Stefan Lyer
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Drug Targeting ◽  
Imaging Technique ◽  
Small Animal ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles ◽  
Medical Procedures ◽  
First Time

AbstractVarious medical procedures make use of magnetic nanoparticles, such as Magnetic Drug Targeting (MDT), which boosts the demand for imaging modalities that are capable of in vivo visualizing this kind of particles. Magnetomotive Ultrasound is an imaging technique that can detect tissue, which is perfused by magnetic nanoparticles. In this contribution, we investigate the suitability of Magnetomotive Ultrasound to serve as a monitoring system during MDT. With the conducted measurements, it was possible for the first time to observe in vivo the accumulation of iron-oxide nanoparticles during a Magnetic Drug Targeting cancer treatment applied to a small animal (rabbit).

scholarly journals Nonviral Locally Injected Magnetic Vectors for In Vivo Gene Delivery: A Review of Studies on Magnetofection

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1078
Author(s):  
Artem A. Sizikov ◽  
Marianna V. Kharlamova ◽  
Maxim P. Nikitin ◽  
Petr I. Nikitin ◽  
Eugene L. Kolychev
Keyword(s):  
Magnetic Field ◽  
Magnetic Nanoparticles ◽  
Gene Delivery ◽  
Drug Targeting ◽  
Genetic Material ◽  
Magnetic Drug Targeting ◽  
Local Injections ◽  
In Vivo Gene Delivery ◽  
Magnetic Vectors

Magnetic nanoparticles have been widely used in nanobiomedicine for diagnostics and the treatment of diseases, and as carriers for various drugs. The unique magnetic properties of “magnetic” drugs allow their delivery in a targeted tumor or tissue upon application of a magnetic field. The approach of combining magnetic drug targeting and gene delivery is called magnetofection, and it is very promising. This method is simple and efficient for the delivery of genetic material to cells using magnetic nanoparticles controlled by an external magnetic field. However, magnetofection in vivo has been studied insufficiently both for local and systemic routes of magnetic vector injection, and the relevant data available in the literature are often merely descriptive and contradictory. In this review, we collected and systematized the data on the efficiency of the local injections of magnetic nanoparticles that carry genetic information upon application of external magnetic fields. We also investigated the efficiency of magnetofection in vivo, depending on the structure and coverage of magnetic vectors. The perspectives of the development of the method were also considered.

scholarly journals Two-Phase Biofluid Flow Model for Magnetic Drug Targeting

Symmetry ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1083 ◽  
Author(s):  
Ioannis D. Boutopoulos ◽  
Dimitrios S. Lampropoulos ◽  
George C. Bourantas ◽  
Karol Miller ◽  
Vassilios C. Loukopoulos
Keyword(s):  
Magnetic Field ◽  
Blood Flow ◽  
Magnetic Nanoparticles ◽  
Drug Targeting ◽  
Volume Fraction ◽  
Numerical Results ◽  
Magnetic Drug Targeting ◽  
Two Phase ◽  
The Magnetic Field

Magnetic drug targeting (MDT) is a noninvasive method for the medical treatment of various diseases of the cardiovascular system. Biocompatible magnetic nanoparticles loaded with medicinal drugs are carried to a tissue target in the human body (in vivo) under the applied magnetic field. The present study examines the MDT technique in various microchannels geometries by adopting the principles of biofluid dynamics (BFD). The blood flow is considered as laminar, pulsatile and the blood as an incompressible and non-Newtonian fluid. A two-phase model is adopted to resolve the blood flow and the motion of magnetic nanoparticles (MNPs). The numerical results are obtained by utilizing a meshless point collocation method (MPCM) alongside with the moving least squares (MLS) approximation. The numerical results are verified by comparing with published numerical results. We investigate the effect of crucial parameters of MDT, including (1) the volume fraction of nanoparticles, (2) the location of the magnetic field, (3) the strength of the magnetic field and its gradient, (4) the way that MNPs approach the targeted area, and (5) the bifurcation angle of the vessel.

Recent Advances in the Development of Magnetic Nanoparticles for Biomedical Applications

2021 ◽  
Vol 21 (5) ◽  
pp. 2705-2741
Author(s):  
Maria Monteserín ◽  
Silvia Larumbe ◽  
Alejandro V. Martínez ◽  
Saioa Burgui ◽  
L. Francisco Martín
Keyword(s):  
Magnetic Nanoparticles ◽  
Physicochemical Properties ◽  
Biomedical Applications ◽  
High Surface ◽  
High Surface Area ◽  
Synthetic Methods ◽  
Magnetic Drug Targeting ◽  
Surface Area Ratio ◽  
Biomedical Field

The unique properties of magnetic nanoparticles have led them to be considered materials with significant potential in the biomedical field. Nanometric size, high surface-area ratio, ability to function at molecular level, exceptional magnetic and physicochemical properties, and more importantly, the relatively easy tailoring of all these properties to the specific requirements of the different biomedical applications, are some of the key factors of their success. In this paper, we will provide an overview of the state of the art of different aspects of magnetic nanoparticles, specially focusing on their use in biomedicine. We will explore their magnetic properties, synthetic methods and surface modifications, as well as their most significative physicochemical properties and their impact on the in vivo behaviour of these particles. Furthermore, we will provide a background on different applications of magnetic nanoparticles in biomedicine, such as magnetic drug targeting, magnetic hyperthermia, imaging contrast agents or theranostics. Besides, current limitations and challenges of these materials, as well as their future prospects in the biomedical field will be discussed.

Investigation of magnetically driven passage of magnetic nanoparticles through eye tissues for magnetic drug targeting

2020 ◽  
Vol 31 (49) ◽  
pp. 495101
Author(s):  
Diana Zahn ◽  
Katja Klein ◽  
Patricia Radon ◽  
Dmitry Berkov ◽  
Sergey Erokhin ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Drug Targeting ◽  
Magnetic Drug Targeting ◽  
Eye Tissues

Functionalized Magnetic Nanoparticles for Selective Targeting of Cells

2008 ◽  
Vol 1140 ◽  
Author(s):  
Wolfgang Tremel ◽  
Mohammed Ibrahim Shukoor ◽  
Filipe Natalio ◽  
Muhammad Nawaz Tahir ◽  
Matthias Wiens ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Drug Carrier ◽  
Optical Detection ◽  
Cpg Odn ◽  
Carrier System ◽  
Functionalized Magnetic Nanoparticles ◽  
Selective Targeting ◽  
Target Molecules ◽  
Drug Carrier System

ABSTRACTMnO nanoparticles were conjugated to single stranded DNA (ssDNA), Cytosin-phosphatidyl-Guanosin oligonucleotide (CpG ODN) to detect and activate Toll-like (TLR9) receptors in cells and to follow nanoparticle cellular trafficking by different means of imaging while at the same time serving as a drug carrier system. By virtue of their magnetic properties these nanoparticles may serve as vehicles for the transport of target molecules into cells, while the fluorescent target ligand allows optical detection simultaneously.x

Nanowires in Magnetic Drug Targeting

2018 ◽  
Author(s):  
Zafar Ali Moghimi ◽  
Fazel Baniasadi ◽  
Gholamreza Naghieh
Keyword(s):  
Magnetic Dipole ◽  
Drug Targeting ◽  
Magnetic Force ◽  
Simple Procedure ◽  
Drug Carrier ◽  
Spherical Particles ◽  
Magnetic Drug Targeting ◽  
Magnetic Targeting ◽  
Magnetic Dipoles ◽  
Fixed Radius

Magnetic drug targeting can be used for locoregional cancer therapy, although the limitation is minuteness of the induced force. A new and simple procedure to enhance the magnetic force is changing the shape of carrier particles. It has been mathematically proved that exerting much stronger magnetic dipoles to nanowires are more possible than to spheres with the same volume. The magnetic dipole of wires having aspect quotient (ratio of length to diameter) of 3 is higher than the spheres of the same volume. Nanowires with α = 5 have magnetic dipoles 1.95 times greater than the spheres with the same volume. At a fixed radius, the magnetic dipole increases with the volume of the drug carrier. Magnetic targeting depth is an important parameter depending on the aspect quotient α of particles. Calculations show that the depth of targeting can exceed 8.5 cm if a nanowire with 15 nm radius and length larger than 150 nm is used as the drug carrier. This depth is 1.7 times more than that reported by previous authors for spherical particles with the same-volume.

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