Generation of quantification maps and weighted images from synthetic magnetic resonance imaging using deep learning network

Objective: The generation of quantification maps and weighted images in synthetic MRI techniques is based on complex fitting equations. This process requires longer image generation times. The objective of this study is to evaluate the feasibility of deep learning method for fast reconstruction of synthetic MRI. Approach: A total of 44 healthy subjects were recruited and random divided into a training set (30 subjects) and a testing set (14 subjects). A multiple-dynamic, multiple-echo (MDME) sequence was used to acquire synthetic MRI images. Quantification maps (T1, T2, and proton density (PD) maps) and weighted (T1W, T2W, and T2W FLAIR) images were created with MAGiC software and then used as the ground truth images in the deep learning (DL) model. An improved multichannel U-Net structure network was trained to generate quantification maps and weighted images from raw synthetic MRI imaging data (8 module images). Quantitative evaluation was performed on quantification maps. Quantitative evaluation metrics, as well as qualitative evaluation were used in weighted image evaluation. Nonparametric Wilcoxon signed-rank tests were performed in this study. Main results: The results of quantitative evaluation show that the error between the generated quantification images and the reference images is small. For weighted images, no significant difference in overall image quality or SNR was identified between DL images and synthetic images. Notably, the DL images achieved improved image contrast with T2W images, and fewer artifacts were present on DL images than synthetic images acquired by T2W FLAIR. Significance: The DL algorithm provides a promising method for image generation in synthetic MRI techniques, in which every step of the calculation can be optimized and faster, thereby simplifying the workflow of synthetic MRI techniques.