Progressive evaluation in spectroscopic sensors for non-invasive blood haemoglobin analysis - a review

2021 ◽  
Author(s):  
Yogesh Kumar ◽  
Ayush Dogra ◽  
Ajeet Kaushik ◽  
Sanjeev Kumar
Keyword(s):  
Standard Method ◽  
Blood Donation ◽  
Haemoglobin Concentration ◽  
Reference Standard ◽  
Blood Constituents ◽  
Non Invasive ◽  
Spot Check ◽  
Frequent Monitoring ◽  
Blood Haemoglobin ◽  
Spectroscopic Sensors

Abstract Frequent monitoring of haemoglobin concentration is highly recommended by physicians to diagnose anaemia and polycythemia Vera. Moreover, Some other conditions also demand assessment of haemoglobin, and these conditions are blood loss, before blood donation, during pregnancy, preoperative, perioperative and postoperative conditions. Cyanmethaemoglobin/haemiglobincyanide method, portable haemoglobinometers and haematology analyzers are few standard methods to diagnose mentioned ailments. However, discomfort, delay and risk of infection are typical limitations of traditional measuring solutions. These limitations create the necessity to develop a non-invasive haemoglobin monitoring technique for a better lifestyle. Various methods and products are already developed and popular due to their non-invasiveness; however, invasive solutions are still considered as the reference standard method. Therefore, this review summarizes the attributes of existing non-invasive solutions. These attributes are finalized as brief details, accuracy, optimal benefits, and research challenges for exploring potential gaps, advancements and possibilities to consider as futuristic alternative methodologies. Non-invasive total haemoglobin assessing techniques are mainly based on optical spectroscopy (reflectance/transmittance) or digital photography or spectroscopic imaging in spot check/continuous monitoring mode. In all these techniques, we have noticed that there is a need to consider different light conditions, motion artefacts, melanocytes, other blood constituents, smoking and precise fixing of the sensor from the sensing spot for exact formulation. Moreover, based on careful and critical analysis of outcomes, none of these techniques or products is used independently or intended to replace invasive laboratory testing. Therefore there is a requirement for a more accurate technique that can eliminate the requirement of blood samples and likely end up as a reference standard method.

scholarly journals Comparison of four methods to measure haemoglobin concentrations in whole blood donors (COMPARE): a diagnostic accuracy study

2020 ◽  
Author(s):  
Steven Bell ◽  
Michael Sweeting ◽  
Anna Ramond ◽  
Ryan Chung ◽  
Stephen Kaptoge ◽  
...  
Keyword(s):  
Whole Blood ◽  
Blood Donors ◽  
Blood Donation ◽  
Haemoglobin Concentration ◽  
Reference Standard ◽  
Non Invasive ◽  
Haematology Analyser ◽  
Haemoglobin Measurement ◽  
Accuracy Study ◽  
Sensitivity Specificity

SUMMARYObjectiveTo compare four haemoglobin measurement methods in whole blood donors.BackgroundTo safeguard donors, blood services measure haemoglobin concentration in advance of each donation. NHS Blood and Transplant’s (NHSBT) usual method has been capillary gravimetry (copper sulphate), followed by venous HemoCue® (spectrophotometry) for donors failing gravimetry. However, gravimetry/venous HemoCue® results in 10% of donors being inappropriately bled (i.e., with haemoglobin values below the regulatory threshold).MethodsThe following were compared in 21,840 blood donors (aged ≥18 years) recruited from 10 mobile centres of NHSBT in England, with each method compared with the Sysmex XN-2000 haematology analyser, the reference standard: 1) gravimetry/venous HemoCue®; 2) “post donation” approach, i.e., estimating current haemoglobin concentration from that measured by a haematology analyser at a donor’s most recent prior donation; 3) capillary HemoCue®; and 4) non-invasive spectrometry (MBR Haemospect® or Orsense NMB200®). We assessed each method for sensitivity; specificity; proportion of donors who would have been inappropriately bled, or rejected from donation (“deferred”) incorrectly; and test preference.ResultsCompared with the reference standard, the methods ranged in test sensitivity from 17.0% (MBR Haemospect®) to 79.0% (HemoCue®) in men, and from 19.0% (MBR Haemospect®) to 82.8% (HemoCue®) in women. For specificity, the methods ranged from 87.2% (MBR Haemospect®) to 99.9% (gravimetry/venous HemoCue®) in men, and from 74.1% (Orsense NMB200®) to 99.8% (gravimetry/venous HemoCue®) in women. The proportion of donors who would have been inappropriately bled ranged from 2.2% in men for HemoCue® to 18.9% in women for MBR Haemospect®. The proportion of donors who would have been deferred incorrectly with haemoglobin concentration above the minimum threshold ranged from 0.1% in men for gravimetry/venous HemoCue® to 20.3% in women for OrSense®. Most donors preferred non-invasive spectrometry.ConclusionIn the largest study reporting head-to-head comparisons of four methods to measure haemoglobin prior to blood donation, our results support replacement of venous HemoCue® with the capillary HemoCue® when donors fail gravimetry. These results have had direct translational implications for NHS Blood and Transplant in England.

scholarly journals Review: Non-invasive blood haemoglobin level measurement

2021 ◽  
Author(s):  
Irzaman ◽  
Yaya Suryana ◽  
Sabar Pambudi ◽  
Tika Widayanti ◽  
Renan Prasta Jenie ◽  
...  
Keyword(s):  
Haemoglobin Level ◽  
Non Invasive ◽  
Level Measurement ◽  
Blood Haemoglobin

Influence of blood haemoglobin concentration on renal haemodynamics and oxygenation during experimental cardiopulmonary bypass in sheep

2020 ◽  
Author(s):  
Yugeesh R. Lankadeva ◽  
Clive N. May ◽  
Andrew D. Cochrane ◽  
Bruno Marino ◽  
Sally G. Hood ◽  
...  
Keyword(s):  
Cardiopulmonary Bypass ◽  
Haemoglobin Concentration ◽  
Renal Haemodynamics ◽  
Blood Haemoglobin

scholarly journals Detection of Amyotrophic Lateral Sclerosis (ALS) via Acoustic Analysis

2018 ◽  
Author(s):  
Raquel Norel ◽  
Mary Pietrowicz ◽  
Carla Agurto ◽  
Shay Rishoni ◽  
Guillermo Cecchi
Keyword(s):  
Disease Progression ◽  
Acoustic Analysis ◽  
Voice Quality ◽  
Non Invasive ◽  
Frequent Monitoring ◽  
In The Wild ◽  
A Cell ◽  
Speech Features ◽  
Severity Of The Disease ◽  
Lateral Sclerosis

ABSTRACTALS is a fatal neurodegenerative disease with no cure. Experts typically measure disease progression via the ALSFRS-R score, which includes measurements of various abilities known to decline. We propose instead the use of speech analysis as a proxy for ALS progression. This technique enables 1) frequent non-invasive, inexpensive, longitudinal analysis, 2) analysis of data recorded in the wild, and 3) creation of an extensive ALS databank for future analysis. Patients and trained medical professionals need not be co-located, enabling more frequent monitoring of more patients from the convenience of their own homes. The goals of this study are the identification of acoustic speech features in naturalistic contexts which characterize disease progression and development of machine models which can recognize the presence and severity of the disease. We evaluated subjects from the Prize4Life Israel dataset, using a variety of frequency, spectral, and voice quality features. The dataset was generated using the ALS Mobile Analyzer, a cell-phone app that collects data regarding disease progress using a self-reported ALSFRS-R questionnaire and several active tasks that measure speech and motor skills. Classification via leave-five-subjects-out cross-validation resulted in an accuracy rate of 79% (61% chance) for males and 83% (52% chance) for females.

scholarly journals Anaemia and Haemoglobin Status: A New Concept and a New Method of Assessment

1996 ◽  
Vol 17 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Rainer Gross ◽  
Marcus Gliwitzki ◽  
Patrick Gross ◽  
Klaus Frank
Keyword(s):  
Oxygen Supply ◽  
Haemoglobin Concentration ◽  
Tissue Level ◽  
Intervention Strategies ◽  
Blood Oxygenation ◽  
The Body ◽  
Non Invasive ◽  
Method Of Assessment ◽  
The Impact ◽  
Tissue Oxygen Supply

Traditionally, anaemia has been determined and interpreted by the magnitude and severity of iron deficiency and the impact of intervention strategies. Internationally, it is defined as a state in which the quality and/or quantity of circulating red cells are reduced below a normal level The body employs several mechanisms during the development of anaemia to maintain the oxygen supply to the tissues. Thus, applying any quantitative cut-off point as an indicator for anaemia may lead to misclassification, since haemoglobin concentration does not necessarily reflect the level of tissue oxygen supply. Ideally, an assessment strategy should be able to determine both the degree of haemoglobin oxygenation and the haemoglobin concentration at a tissue level. The Erlangen microlight-guide spectrophotometer is a non-invasive instrument that can assess both capillary blood oxygenation and relative haemoglobin concentration.

scholarly journals Estimation of the Microbiological Quality of Meat Using Rapid and Non-Invasive Spectroscopic Sensors

IEEE Access ◽  
2020 ◽  
Vol 8 ◽  
pp. 106614-106628
Author(s):  
Lemonia-Christina Fengou ◽  
Iosif Mporas ◽  
Evgenia Spyrelli ◽  
Alexandra Lianou ◽  
George-John Nychas
Keyword(s):  
Microbiological Quality ◽  
Non Invasive ◽  
Spectroscopic Sensors

scholarly journals The effect of Gypsophila saponins in the diet on mineral status and plasma cholesterol concentration in the rat

1988 ◽  
Vol 59 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Susan Southon ◽  
I. T. Johnson ◽  
Jennifer M. Gee ◽  
K. R. Price
Keyword(s):  
Plasma Cholesterol ◽  
Haemoglobin Concentration ◽  
Blood Cholesterol ◽  
Cholesterol Concentration ◽  
Plasma Cholesterol Concentration ◽  
Lower Blood Cholesterol ◽  
Basal Group ◽  
Male Wistar Rats ◽  
Blood Haemoglobin ◽  
Zn Status

1. Immature, male Wistar rats were allocated to one of six groups and caged individually. The first group was given a semi-synthetic diet containing 38 mg iron and 55 mg zinc/kg (basal group). The second and third groups were given a diet containing 10 mg Zn and 12 mg Fe/kg respectively (low-Zn and low-Fe groups). Groups four, five and six were given similar diets containing 20 gGypsophilasaponins/kg. After 21 d the Fe and Zn status of the rats was estimated and plasma cholesterol concentration determined.2. Measurements of whole blood haemoglobin concentration, packed cell volume and liver Fe stores indicated that rats in the basal + saponin and low-Fe + saponin groups had a significantly reduced Fe status when compared with their controls. Rats in the low-Zn + saponin group also showed a trend toward reduced Fe stores.3. Zn status, as judged by femur Zn concentration, was not adversely affected by the inclusion ofGypsophilasaponins in the diet.4. Consumption of the saponins resulted in a significant reduction in blood cholesterol concentration, with rats in both the low-Fe groups having significantly lower concentrations than their basal and low-Zn counterparts.5. In view of suggestions that the consumption of saponins should be encouraged because of their ability to lower blood cholesterol, possible effects on Fe metabolism should be investigated further, particularly with respect to the levels and sources of saponin in the human diet.

scholarly journals Effect of blood haemoglobin concentration on V̇ o2,max and cardiovascular function in lowlanders acclimatised to 5260 m

2002 ◽  
Vol 545 (2) ◽  
pp. 715-728 ◽  
Author(s):  
J. A. L. Calbet ◽  
G. Rådegran ◽  
R. Boushel ◽  
H. Søndergaard ◽  
B. Saltin ◽  
...  
Keyword(s):  
Haemoglobin Concentration ◽  
Cardiovascular Function ◽  
Blood Haemoglobin

scholarly journals Effect of iron supplementation on mild to moderate anaemia in pulmonary tuberculosis

2003 ◽  
Vol 90 (3) ◽  
pp. 541-550 ◽  
Author(s):  
Uma Devi ◽  
C. Mohan Rao ◽  
Vinod K. Srivastava ◽  
Pramod K. Rath ◽  
Bhabani S. Das
Keyword(s):  
Placebo Group ◽  
Pulmonary Tuberculosis ◽  
Binding Capacity ◽  
Haemoglobin Concentration ◽  
Disease Process ◽  
Fe Deficiency ◽  
Adult Males ◽  
Blood Haemoglobin ◽  
Haematological Indices ◽  
Moderate Anaemia

Anaemia is a common complication of pulmonary tuberculosis. The precise mechanism of anaemia in pulmonary tuberculosis is not clearly known, but anaemia of inflammation as well as of Fe deficiency has been implicated. Both are common in developing countries. It is extremely difficult to distinguish anaemia of Fe deficiency from anaemia of inflammation with the haematological indices used routinely. Therefore, Fe preparations are usually prescribed for all anaemic patients irrespective of the aetiology. This approach has been questioned. The present study aimed to assess the effect of Fe supplementation on anaemic patients with pulmonary tuberculosis. Adult male patients 15–60 years of age with pulmonary tuberculosis and a blood haemoglobin concentration 80–110 g/l were included in the study; healthy adult males matched for age and socio-economic status were taken as controls. Blood haemoglobin concentration, total erythrocyte count (TEC), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular haemoglobin and serum Fe, total Fe-binding capacity and ferritin were estimated before treatment and 1, 2 and 6 months after treatment. The patients were divided randomly into three groups and during the initial 2 months of treatment were provided with one of three supplementary regimens consisting of placebo, Fe alone or Fe with other haematinics. Significant improvements in haematological indices and Fe status were noticed in all three groups. Blood haemoglobin concentration, MCV and PCV were significantly higher at 1 month in both Fe-supplemented groups than the placebo group. This difference, however, disappeared at 2 and 6 months with similar values in all three groups. The increase of other haematological indices was similar in all groups. Serum Fe and Fe saturation of transferrin were significantly higher in both Fe-supplemented groups than the placebo group up to 2 months; this effect, however, disappeared at 6 months. There was a consistent increase in TEC and decrease in ferritin values up to 6 months in all groups. Radiological and clinical improvement was similar in all three groups. These observations suggest that Fe supplementation in mild to moderate anaemia associated with pulmonary tuberculosis accelerated the normal resumption of haematopoiesis in the initial phases by increasing Fe saturation of transferrin. However, consistent improvement of haematological status was dependent only on the improvement of the disease process.

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