Prediction models establishment and comparison for guiding force of high-temperature superconducting maglev based on deep learning algorithms

Author(s):  
Zhihao Ke ◽  
Xiaoning Liu ◽  
Yining Chen ◽  
Hongfu Shi ◽  
Zigang Deng

Abstract By the merits of self-stability and low energy consumption, high temperature superconducting (HTS) maglev has the potential to become a novel type of transportation mode. As a key index to guarantee the lateral self-stability of HTS maglev, guiding force has strong non-linearity and is determined by multitudinous factors, and these complexities impede its further researches. Compared to traditional finite element and polynomial fitting method, the prosperity of deep learning algorithms could provide another guiding force prediction approach, but the verification of this approach is still blank. Therefore, this paper establishes 5 different neural network models (RBF, DNN, CNN, RNN, LSTM) to predict HTS maglev guiding force, and compares their prediction efficiency based on 3720 pieces of collected data. Meanwhile, two adaptively iterative algorithms for parameters matrix and learning rate adjustment are proposed, which could effectively reduce computing time and unnecessary iterations. And according to the results, it is revealed that, the DNN model shows the best fitting goodness, while the LSTM model displays the smoothest fitting curve on guiding force prediction. Based on this discovery, the effects of learning rate and iterations on prediction accuracy of the constructed DNN model are studied. And the learning rate and iterations at the highest guiding force prediction accuracy are 0.00025 and 90000, respectively. Moreover, the K-fold cross validation method is also applied to this DNN model, whose result manifests the generalization and robustness of this DNN model. The imperative of K-fold cross validation method to ensure universality of guiding force prediction model is likewise assessed. This paper firstly combines HTS maglev guiding force prediction with deep learning algorithms considering different field cooling height, real-time magnetic flux density, liquid nitrogen temperature and motion direction of bulk. Additionally, this paper gives a convenient and efficient method for HTS guiding force prediction and parameter optimization.

2021 ◽  
Vol 17 (2) ◽  
pp. e1008767
Author(s):  
Zutan Li ◽  
Hangjin Jiang ◽  
Lingpeng Kong ◽  
Yuanyuan Chen ◽  
Kun Lang ◽  
...  

N6-methyladenine (6mA) is an important DNA modification form associated with a wide range of biological processes. Identifying accurately 6mA sites on a genomic scale is crucial for under-standing of 6mA’s biological functions. However, the existing experimental techniques for detecting 6mA sites are cost-ineffective, which implies the great need of developing new computational methods for this problem. In this paper, we developed, without requiring any prior knowledge of 6mA and manually crafted sequence features, a deep learning framework named Deep6mA to identify DNA 6mA sites, and its performance is superior to other DNA 6mA prediction tools. Specifically, the 5-fold cross-validation on a benchmark dataset of rice gives the sensitivity and specificity of Deep6mA as 92.96% and 95.06%, respectively, and the overall prediction accuracy is 94%. Importantly, we find that the sequences with 6mA sites share similar patterns across different species. The model trained with rice data predicts well the 6mA sites of other three species: Arabidopsis thaliana, Fragaria vesca and Rosa chinensis with a prediction accuracy over 90%. In addition, we find that (1) 6mA tends to occur at GAGG motifs, which means the sequence near the 6mA site may be conservative; (2) 6mA is enriched in the TATA box of the promoter, which may be the main source of its regulating downstream gene expression.


2021 ◽  
Vol 11 (16) ◽  
pp. 7731
Author(s):  
Rao Zeng ◽  
Minghong Liao

DNA methylation is one of the most extensive epigenetic modifications. DNA N6-methyladenine (6mA) plays a key role in many biology regulation processes. An accurate and reliable genome-wide identification of 6mA sites is crucial for systematically understanding its biological functions. Some machine learning tools can identify 6mA sites, but their limited prediction accuracy and lack of robustness limit their usability in epigenetic studies, which implies the great need of developing new computational methods for this problem. In this paper, we developed a novel computational predictor, namely the 6mAPred-MSFF, which is a deep learning framework based on a multi-scale feature fusion mechanism to identify 6mA sites across different species. In the predictor, we integrate the inverted residual block and multi-scale attention mechanism to build lightweight and deep neural networks. As compared to existing predictors using traditional machine learning, our deep learning framework needs no prior knowledge of 6mA or manually crafted sequence features and sufficiently capture better characteristics of 6mA sites. By benchmarking comparison, our deep learning method outperforms the state-of-the-art methods on the 5-fold cross-validation test on the seven datasets of six species, demonstrating that the proposed 6mAPred-MSFF is more effective and generic. Specifically, our proposed 6mAPred-MSFF gives the sensitivity and specificity of the 5-fold cross-validation on the 6mA-rice-Lv dataset as 97.88% and 94.64%, respectively. Our model trained with the rice data predicts well the 6mA sites of other five species: Arabidopsis thaliana, Fragaria vesca, Rosa chinensis, Homo sapiens, and Drosophila melanogaster with a prediction accuracy 98.51%, 93.02%, and 91.53%, respectively. Moreover, via experimental comparison, we explored performance impact by training and testing our proposed model under different encoding schemes and feature descriptors.


2019 ◽  
Author(s):  
Zutan Li ◽  
Hangjin Jiang ◽  
Lingpeng Kong ◽  
Yuanyuan Chen ◽  
Liangyun Zhang ◽  
...  

ABSTRACTN6-methyladenin(6mA) is an important DNA modification form associated with a wide range of biological processes. Identifying accurately 6mA sites on a genomic scale is crucial for understanding of 6mA’s biological functions. In this paper, we developed, without requiring any prior knowledge of 6mA and manually crafted sequence features, a deep learning framework named Deep6mA to identify DNA 6mA sites, and its performance is superior to other DNA 6mA prediction tools. Specifically, the 5-fold cross-validation on a benchmark dataset of rice gives the sensitivity and specificity of Deep6mA as 92.96% and 95.06%, respectively, and the overall prediction accuracy is 94%. Importantly, we find that the sequences with 6mA sites share similar patterns across different species. The model trained with rice data predicts well the 6mA sites of other three species: Arabidopsis thaliana, Fragaria vesca, and Rosa chinensis, with a prediction accuracy over 90%. In addition, we find that (1) 6mA tends to occur at GAGG motifs, which means the sequence near the 6mA site may be conservative; (2) 6mA is enriched in the TATA box of the promoter, which may be the main source of its regulating downstream gene expression.


Author(s):  
Nathan Swanson ◽  
Donald Koban ◽  
Patrick Brundage

AbstractApplying Google’s PageRank model to sports is a popular concept in contemporary sports ranking. However, there is limited evidence that rankings generated with PageRank models do well at predicting the winners of playoffs series. In this paper, we use a PageRank model to predict the outcomes of the 2008–2016 NHL playoffs. Unlike previous studies that use a uniform personalization vector, we incorporate Corsi statistics into a personalization vector, use a nine-fold cross validation to identify tuning parameters, and evaluate the prediction accuracy of the tuned model. We found our ratings had a 70% accuracy for predicting the outcome of playoff series, outperforming the Colley, Massey, Bradley-Terry, Maher, and Generalized Markov models by 5%. The implication of our results is that fitting parameter values and adding a personalization vector can lead to improved performance when using PageRank models.


2020 ◽  
Vol 21 (15) ◽  
pp. 5222 ◽  
Author(s):  
Xiao-Nan Fan ◽  
Shao-Wu Zhang ◽  
Song-Yao Zhang ◽  
Jin-Jie Ni

Long non-coding RNAs (lncRNAs) play crucial roles in diverse biological processes and human complex diseases. Distinguishing lncRNAs from protein-coding transcripts is a fundamental step for analyzing the lncRNA functional mechanism. However, the experimental identification of lncRNAs is expensive and time-consuming. In this study, we presented an alignment-free multimodal deep learning framework (namely lncRNA_Mdeep) to distinguish lncRNAs from protein-coding transcripts. LncRNA_Mdeep incorporated three different input modalities, then a multimodal deep learning framework was built for learning the high-level abstract representations and predicting the probability whether a transcript was lncRNA or not. LncRNA_Mdeep achieved 98.73% prediction accuracy in a 10-fold cross-validation test on humans. Compared with other eight state-of-the-art methods, lncRNA_Mdeep showed 93.12% prediction accuracy independent test on humans, which was 0.94%~15.41% higher than that of other eight methods. In addition, the results on 11 cross-species datasets showed that lncRNA_Mdeep was a powerful predictor for predicting lncRNAs.


2020 ◽  
Vol 10 (14) ◽  
pp. 4870 ◽  
Author(s):  
Luca Coviello ◽  
Marco Cristoforetti ◽  
Giuseppe Jurman ◽  
Cesare Furlanello

We introduce here the Grape Berries Counting Net (GBCNet), a tool for accurate fruit yield estimation from smartphone cameras, by adapting Deep Learning algorithms originally developed for crowd counting. We test GBCNet using cross-validation procedure on two original datasets CR1 and CR2 of grape pictures taken in-field before veraison. A total of 35,668 berries have been manually annotated for the task. GBCNet achieves good performances on both the seven grape varieties dataset CR1, although with a different accuracy level depending on the variety, and on the single variety dataset CR2: in particular Mean Average Error (MAE) ranges from 0.85% for Pinot Gris to 11.73% for Marzemino on CR1 and reaches 7.24% on the Teroldego CR2 dataset.


Diagnostics ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1875
Author(s):  
Yuchi Tian ◽  
Temitope Emmanuel Komolafe ◽  
Jian Zheng ◽  
Guofeng Zhou ◽  
Tao Chen ◽  
...  

To assess if quantitative integrated deep learning and radiomics features can predict the PD-L1 expression level in preoperative MRI of hepatocellular carcinoma (HCC) patients. The data in this study consist of 103 hepatocellular carcinoma patients who received immunotherapy in a single center. These patients were divided into a high PD-L1 expression group (30 patients) and a low PD-L1 expression group (73 patients). Both radiomics and deep learning features were extracted from their MRI sequence of T2-WI, which were merged into an integrative feature space for machine learning for the prediction of PD-L1 expression. The five-fold cross-validation was adopted to validate the performance of the model, while the AUC was used to assess the predictive ability of the model. Based on the five-fold cross-validation, the integrated model achieved the best prediction performance, with an AUC score of 0.897 ± 0.084, followed by the deep learning-based model with an AUC of 0.852 ± 0.043 then the radiomics-based model with AUC of 0.794 ± 0.035. The feature set integrating radiomics and deep learning features is more effective in predicting PD-L1 expression level than only one feature type. The integrated model can achieve fast and accurate prediction of PD-L1 expression status in preoperative MRI of HCC patients.


2020 ◽  
Author(s):  
Xiao-Nan Fan ◽  
Shao-Wu Zhang ◽  
Song-Yao Zhang ◽  
Jin-Jie Ni

Abstract Background: Long non-coding RNAs (lncRNAs) play crucial roles in diverse biological processes and human complex diseases. Distinguishing lncRNAs from protein-coding transcripts is a fundamental step for analyzing lncRNA functional mechanism. However, the experimental identification of lncRNAs is expensive and time-consuming. Results: In this study, we present an alignment-free multimodal deep learning framework (namely lncRNA_Mdeep) to distinguish lncRNAs from protein-coding transcripts. LncRNA_Mdeep incorporates three different input modalities (i.e. OFH modality, k-mer modality, and sequence modality), then a multimodal deep learning framework is built for learning the high-level abstract representations and predicting the probability whether a transcript is lncRNA or not. Conclusions: LncRNA_Mdeep achieves 98.73% prediction accuracy in 10-fold cross-validation test on human. Compared with other eight state-of-the-art methods, lncRNA_Mdeep shows 93.12% prediction accuracy independent test on human, which is 0.94%~15.41% higher than that of other eight methods. In addition, the results on 11 cross-species datasets show that lncRNA_Mdeep is a powerful predictor for identifying lncRNAs. The source code can be downloaded from https://github.com/NWPU-903PR/lncRNA_Mdeep.


SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A236-A236
Author(s):  
A Guillot ◽  
T Moutakanni ◽  
M Harris ◽  
P J Arnal ◽  
V Thorey

Abstract Introduction Polysomnography (PSG) is the gold-standard to diagnose obstructive sleep apnea (OSA). OSA severity diagnosis is defined by the apnea-hypopnea index (AHI) defined as the number of apnea and hypopnea events measured per hour of sleep. The Dreem2 headband (DH) is a self-administered, easy to use device that measure EEG, breathing frequency, heart rate and sound at-home. In our study, we assessed the performance of the DH to automatically detects OSA compared to 3 sleep’s experts scoring on PSG. Methods 41 subjects (8 females, 42.6 ± 13.7 y.o.) having a suspicion of OSA performed a night at-home wearing both a PSG and the DH. Each PSG record was scored for apnea and hypopnea events by 3 independent trained sleep experts following AASM guidelines. The deep learning approach DOSED, was trained on the DH signals using the manual apnea scoring. 10-fold cross-validation was used to provide predictions for each of the 41 subjects with the DH. Results We observed an average AHI expert’s scoring of 13.6 ± 10.1 CI[10.5, 16.5] compared to 12.9 ± 10.3 CI[9.6, 15.8] for the DH. Both, the correlation between the 3 scorers (r= 0.88, p < 0.001) and the DH and the scorers (r=0.79, p< 0.001) were significant. The specificity and sensitivity to detect mild OSA (AHI ≤ 5) was 84.4 % and 96.4 % for the DH and 86.5 % and 86.0% for the scorers. Conclusion The results show that the DH using deep learning can detect OSA with an accuracy similar to the sleep experts. The use of DH paves the way for longitudinal monitoring of patients with a suspicion of OSA and its accessibility could lead to better screening of the general population. Support This Study has been supported by Dreem sas.


Symmetry ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 431 ◽  
Author(s):  
Tomislav Horvat ◽  
Ladislav Havaš ◽  
Dunja Srpak

Interest in sports predictions as well as the public availability of large amounts of structured and unstructured data are increasing every day. As sporting events are not completely independent events, but characterized by the influence of the human factor, the adequate selection of the analysis process is very important. In this paper, seven different classification machine learning algorithms are used and validated with two validation methods: Train&Test and cross-validation. Validation methods were analyzed and critically reviewed. The obtained results are analyzed and compared. Analyzing the results of the used machine learning algorithms, the best average prediction results were obtained by using the nearest neighbors algorithm and the worst prediction results were obtained by using decision trees. The cross-validation method obtained better results than the Train&Test validation method. The prediction results of the Train&Test validation method by using disjoint datasets and up-to-date data were also compared. Better results were obtained by using up-to-date data. In addition, directions for future research are also explained.


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