scholarly journals The optical and electrical non-invasive methods of measurement for glucose concentration in biological liquids

2021 ◽  
Vol 2140 (1) ◽  
pp. 012039
Author(s):  
Y K Zhexenbayev ◽  
T D Bulembayev ◽  
A V Gorst ◽  
K V Zavyalova ◽  
A S Mironchev ◽  
...  

Abstract The article describes the radio-wave and optical methods of determining glucose concentration. The radio-wave method is based on the use of a sensor with a resonant frequency that is displayed when in contact with highly lossy materials and with an extended near-field zone in the resonance area. The optical method is based on studying the influence of glucose concentration (0–20 mmol/l) in bidistilled water on absorption spectra in the range of 190-1000 nm. The article presents the results of the experimental test of the near-field sensor with the pre-produced biological media imitating the human body tissues, and the results of the optical method demonstrate the possibility to measure the concentration with the use of an optical emitter with a wave length of 830 nm.

2021 ◽  
Vol 11 (12) ◽  
pp. 5415
Author(s):  
Aleksandr Gorst ◽  
Kseniya Zavyalova ◽  
Aleksandr Mironchev ◽  
Andrey Zapasnoy ◽  
Andrey Klokov

The article investigates the near-field probe of a special design to account for changes in glucose concentration. The probe is designed in such a way that it emits radiation in both directions from its plane. In this paper, it was proposed to modernize this design and consider the unidirectional emission of the probe in order to maximize the signal and reduce energy loss. We have done extensive research for both bidirectional and unidirectional probe designs. Numerical simulations and field experiments were carried out to determine different concentrations of glucose (0, 4, 5.3, 7.5 mmol/L). Numerical modeling of a unidirectional probe showed that the interaction of radiation generated by such a probe with a multilayer structure simulating a human hand showed a better result and high sensitivity compared to a bidirectional probe. Further, based on the simulation results, a phantom (physical model) of a human hand was recreated from layers with dielectric properties as close as possible to the properties of materials during simulation. The probe was constructed from a copper tube and matched both the geometric and physical parameters of the model. The experimental measurement was carried out using a vector network analyzer in the frequency range 2–10 GHz. The experimental measurement was carried out using a vector network analyzer in the frequency range 2–10 GHz for the unidirectional and bidirectional probes. Further, the results of the experiment were compared with the results of numerical simulation. According to the results of multiple experiments, it was found that the average deviation between the concentrations was 2 dB for a unidirectional probe and 0.4 dB for a bidirectional probe. Thus, the sensitivity of the unidirectional probe was 1.5 dB/(mmol/L) for the bidirectional one 0.3 dB/(mmol/L). Thus, the improved design of the near-field probe can be used to record glucose concentrations.


2000 ◽  
Vol 88 (5) ◽  
pp. 2541-2547 ◽  
Author(s):  
N. Richard ◽  
A. Dereux ◽  
E. Bourillot ◽  
T. David ◽  
J. P. Goudonnet ◽  
...  

2012 ◽  
Vol 100 (22) ◽  
pp. 221101 ◽  
Author(s):  
Benjamin Reinhard ◽  
Klemens M. Schmitt ◽  
Viktoria Wollrab ◽  
Jens Neu ◽  
René Beigang ◽  
...  

Nanomaterials ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. 536 ◽  
Author(s):  
Ignacio Falcón Casas ◽  
Wolfgang Kautek

Optical methods in nanolithography have been traditionally limited by Abbe’s diffraction limit. One method able to overcome this barrier is apertureless scanning probe lithography assisted by laser. This technique has demonstrated surface nanostructuring below the diffraction limit. In this study, we demonstrate how a femtosecond Yb-doped fiber laser oscillator running at high repetition rate of 46 MHz and a pulse duration of 150 fs can serve as the laser source for near-field nanolithography. Subwavelength features were generated on the surface of gold films down to a linewidth of 10 nm. The near-field enhancement in this apertureless scanning probe lithography setup could be determined experimentally for the first time. Simulations were in good agreement with the experiments. This result supports near-field tip-enhancement as the major physical mechanisms responsible for the nanostructuring.


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