scholarly journals Multibody system simulation as a predictive tool for possible estimation of negative effects caused by vibrations of FDM device

2021 ◽  
Vol 1199 (1) ◽  
pp. 012027
Author(s):  
J Kaščak ◽  
M Kočiško ◽  
L Knapčíková ◽  
T Coranič ◽  
J Tôrôk

Abstract The design of fused deposition modeling (FDM) devices in their current form is associated with many negative effects, which result mainly from their construction deficiency. Due to the constant effort to increase the accuracy and speed of these devices, we often encounter the emergence of various negative factors. One of the most significant factors is the presence of negative vibrations of the frame and individual components. These are directly linked to several shortcomings that FDM devices come with. Efforts to make the structures as simple as possible, their low weight or the use of filament extruders placed directly on the printheads and axis travels, are perceived as well-known shortcomings. These negative phenomena are subsequently manifested by the emergence of specific defects visible on the surface of the manufactured models. The article presents the possibility of predicting the occurrence of these negative phenomena, with the use of multibody simulation. This simulation analyzes the movements of a specific device at different print speeds. The article then presents the results of these simulations and analysis of the transmission of negative oscillations at specific critical points of the FDM device. Finally, the article examines the influence of possible regulation of devices acceleration rates caused by electrical motors in individual axes and their influence on the final surface quality of the manufactured model. The article points out the possibilities of using this type of simulation processes and analysis in the design process of new types of frames and translation mechanisms for FDM devices.

Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.


2019 ◽  
Vol 25 (11) ◽  
pp. 1249-1264 ◽  
Author(s):  
Amoljit Singh Gill ◽  
Parneet Kaur Deol ◽  
Indu Pal Kaur

Background: Solid free forming (SFF) technique also called additive manufacturing process is immensely popular for biofabrication owing to its high accuracy, precision and reproducibility. Method: SFF techniques like stereolithography, selective laser sintering, fused deposition modeling, extrusion printing, and inkjet printing create three dimension (3D) structures by layer by layer processing of the material. To achieve desirable results, selection of the appropriate technique is an important aspect and it is based on the nature of biomaterial or bioink to be processed. Result & Conclusion: Alginate is a commonly employed bioink in biofabrication process, attributable to its nontoxic, biodegradable and biocompatible nature; low cost; and tendency to form hydrogel under mild conditions. Furthermore, control on its rheological properties like viscosity and shear thinning, makes this natural anionic polymer an appropriate candidate for many of the SFF techniques. It is endeavoured in the present review to highlight the status of alginate as bioink in various SFF techniques.


2014 ◽  
Vol 7 (2) ◽  
pp. 122-130 ◽  
Author(s):  
Zhe Shi ◽  
Yonggang Peng ◽  
Wei Wei

2021 ◽  
Vol 14 (2) ◽  
pp. 143
Author(s):  
Julius Krause ◽  
Laura Müller ◽  
Dorota Sarwinska ◽  
Anne Seidlitz ◽  
Malgorzata Sznitowska ◽  
...  

In the treatment of pediatric diseases, suitable dosages and dosage forms are often not available for an adequate therapy. The use of innovative additive manufacturing techniques offers the possibility of producing pediatric dosage forms. In this study, the production of mini tablets using fused deposition modeling (FDM)-based 3D printing was investigated. Two pediatric drugs, caffeine and propranolol hydrochloride, were successfully processed into filaments using hyprolose and hypromellose as polymers. Subsequently, mini tablets with diameters between 1.5 and 4.0 mm were printed and characterized using optical and thermal analysis methods. By varying the number of mini tablets applied and by varying the diameter, we were able to achieve different release behaviors. This work highlights the potential value of FDM 3D printing for the on-demand production of patient individualized, small-scale batches of pediatric dosage forms.


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