A novel identified circular RNA, mmu_mmu_circRNA_0000309 involves in Germacrone-mediated the improvement of diabetic nephropathy through regulating ferroptosis by targeting miR-188-3p/GPX4 signaling axis

2021 ◽  
Author(s):  
Juan Jin ◽  
Yunguang Wang ◽  
Danna Zheng ◽  
Mingzhu Liang ◽  
Qiang He
Keyword(s):  
Diabetic Nephropathy ◽  
Circular Rna ◽  
Signaling Axis

scholarly journals Circular RNA circEIF4G2 aggravates renal fibrosis in diabetic nephropathy by sponging miR‐218

2020 ◽  
Author(s):  
Bojin Xu ◽  
Qianqian Wang ◽  
Wenyi Li ◽  
Lili Xia ◽  
Xiaoxu Ge ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Renal Fibrosis ◽  
Circular Rna

Circular RNA Circ_0000064 promotes the proliferation and fibrosis of mesangial cells via miR-143 in diabetic nephropathy

Gene ◽  
2020 ◽  
Vol 758 ◽  
pp. 144952 ◽  
Author(s):  
Xiaoxu Ge ◽  
Liuqing Xi ◽  
Qianqian Wang ◽  
Huihua Li ◽  
Lili Xia ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Mesangial Cells ◽  
Circular Rna

scholarly journals Noncoding RNAs in Diabetic Nephropathy: Pathogenesis, Biomarkers, and Therapy

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Jiarong Lv ◽  
Yu Wu ◽  
Yifeng Mai ◽  
Shizhong Bu
Keyword(s):  
Diabetic Nephropathy ◽  
Noncoding Rna ◽  
Molecular Mechanisms ◽  
Therapeutic Potential ◽  
Human Life ◽  
Noncoding Rnas ◽  
Well Being ◽  
Circular Rna ◽  
Genome Transcription ◽  
End Stage

The correlation between diabetes and systematic well-being on human life has long established. As a common complication of diabetes, the prevalence of diabetic nephropathy (DN) has been increasing globally. DN is known to be a major cause of end-stage kidney disease (ESKD). Till now, the molecular mechanisms for DN have not been fully explored and the effective therapies are still lacking. Noncoding RNAs are a class of RNAs produced by genome transcription that cannot be translated into proteins. It has been documented that ncRNAs participate in the pathogenesis of DN by regulating inflammation, apoptosis, autophagy, cell proliferation, and other pathological processes. In this review, the pathological roles and diagnostic and therapeutic potential of three types of ncRNAs (microRNA, long noncoding RNA, and circular RNA) in the progression of DN are summarized and illustrated.

scholarly journals Circular RNAs regulate cancer stem cells by FMRP against CCAR1 complex in hepatocellular carcinoma

2018 ◽  
Author(s):  
Hong-Yang Wang ◽  
Yan-Jing Zhu ◽  
Bo Zheng ◽  
Xu-Kai Ma ◽  
Xin-Yuan Lu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Wnt Signaling ◽  
Rna Splicing ◽  
Circular Rna ◽  
Circular Rnas ◽  
Signaling Axis ◽  
Rna Immunoprecipitation

Circular RNA (circRNA) possesses great pre-clinical diagnostic and therapeutic potentials in multiple cancers. However, the underlying correlation between circRNAs and cancer stem cells (CSCs) has not been reported. The absence of circZKSCAN1 endowed several malignant properties including cancer stemness and tightly correlated with worse overall and recurrence-free survival rate in HCC cells in vitro and in vivo. Bioinformatics analysis and RNA immunoprecipitation-sequencing (RIP-seq) results revealed that circZKSCAN1 exerted its inhibitive role by competitively binding FMRP, therefore, block the binding between FMRP and β-catenin-binding protein-cell cycle and apoptosis regulator 1 (CCAR1) mRNA, and subsequently restraining the transcriptional activity of Wnt signaling. In addition, RNA-splicing protein Quaking 5 was found downregulated in HCC tissues and responsible for the reduction of circZKSCAN1. Collectively, this study revealed the mechanisms underlying the regulatory role of circZKSCAN1 in HCC CSCs and identified the newly discovered Qki5-circZKSCAN1-FMRP-CCAR1-Wnt signaling axis as a potentially important therapeutic target for HCC treatment.

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