Acute Effects of Black Currant Consumption on Salivary Flow Rate and Secretion Rate of Salivary Immunoglobulin A in Healthy Smokers

Summary Background The purpose of the present study was to assess saliva reliability in diagnosis and monitoring type 2 diabetes instead of blood. Methods Blood and unstimulated whole saliva were collected from 300 type 2 diabetic subjects and 300 healthy controls in fasting. Then, the salivary flow rate was calculated. All parameters including glucose, urea, amylase, total protein, albumin, C-reactive protein (CRP), immunoglobulin A (IgA), potassium, calcium and chloride were assessed in the supernatant, using an autoanalyzer. Oral exam was conducted by a single examiner on full mouth excluding third molars. Statistical analysis was performed by the SPSS 20.0 version. Results Saliva screening showed that glucose, urea, amylase, total protein, potassium, calcium and chloride were significantly higher in patients compared to controls (p < 0.05). Whereas, the IgA level and salivary flow rate were significantly reduced in patients (p < 0.05). No significant difference was found in albumin and CRP levels (p = 0.05). There was a significant positive correlation between salivary and plasma glucose levels (r = 0.887, and r = 0.900, p < 0.001), as well as, salivary and blood urea (r = 0.586, and r = 0.688, p < 0.001) in patients and controls, respectively. Conclusions From this study, saliva could be suggested as a useful diagnostic tool for type 2 diabetes.

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Selected Physicochemical Properties of Saliva in Menopausal Women—A Pilot Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17072604 ◽

2020 ◽

Vol 17 (7) ◽

pp. 2604

Author(s):

Aleksandra Cydejko ◽

Aida Kusiak ◽

Magdalena Emilia Grzybowska ◽

Barbara Kochańska ◽

Jolanta Ochocińska ◽

...

Keyword(s):

Physicochemical Properties ◽

Flow Rate ◽

Immunoglobulin A ◽

Premenopausal Women ◽

Salivary Flow ◽

Salivary Flow Rate ◽

Ionized Calcium ◽

Control Group ◽

Menopausal Women ◽

Complete Health

The aim of this study was to estimate differences in selected physicochemical properties of saliva between menopausal and premenopausal women. Methods: The study population consisted of 9 menopausal women and 15 women of the control group. Laboratory tests included the determination of pH saliva, salivary flow rate, and concentrations of lactoferrin, lysozyme, immunoglobulin A, and ionized calcium. Results: Among menopausal women, statistically significant differences were observed in values of salivary flow rate and lysozyme and ionized calcium concentrations; however, no statistically significant differences for pH and concentrations of lactoferrin and immunoglobulin A were found. The salivary flow rate in the study group was significantly lower compared to that in premenopausal women. In relation to lysozyme, statistically significant differences were found between control group and menopausal women to the disadvantage of the latter. However, the concentration of ionized calcium in the saliva of menopausal women was distinctly higher than in the saliva of the control group. Conclusion: The saliva of menopausal women appeared significantly different from that of the control group. Differences in physicochemical parameters such as salivary flow rate and lysozyme and ionized calcium concentrations were observed. These differences in saliva properties observed in menopause can potentially affect the oral environment of women in this particular period, possibly increasing the risk of some pathological changes in the oral cavity and consequently indicating the need to take special care of this group of female patients in order to help them maintain proper oral health. Dentists and gynecologists should be aware of the problems associated with menopause and need to provide these women complete health care, including dental care as an integral part.

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Effect of mobile phone use on salivary concentrations of protein, amylase, lipase, immunoglobulin A, lysozyme, lactoferrin, peroxidase and C-reactive protein of the parotid gland

The Journal of Laryngology & Otology ◽

10.1017/s0022215114000899 ◽

2014 ◽

Vol 128 (5) ◽

pp. 454-462 ◽

Cited By ~ 4

Author(s):

M S Hashemipour ◽

M Yarbakht ◽

A Gholamhosseinian ◽

H Famori

Keyword(s):

Parotid Gland ◽

Mobile Phone ◽

Flow Rate ◽

Immunoglobulin A ◽

Salivary Flow ◽

Salivary Flow Rate ◽

C Reactive Protein ◽

Mobile Phone Use ◽

Reactive Protein ◽

The Right

AbstractBackground:The possibility of side effects associated with the electromagnetic waves emitted from mobile phones is a controversial issue. The present study aimed to evaluate the effect of mobile phone use on parotid gland salivary concentrations of protein, amylase, lipase, immunoglobulin A, lysozyme, lactoferrin, peroxidase and C-reactive protein.Methods:Stimulated salivary samples were collected simultaneously from both parotid glands of 86 healthy volunteers. Salivary flow rate and salivary concentrations of proteins, amylase, lipase, lysozyme, lactoferrin, peroxidase, C-reactive protein and immunoglobulin A, were measured. Data were analysed using t-tests and one-way analyses of variance.Results:Salivary flow rate and parotid gland salivary concentrations of protein were significantly higher on the right side compared to the left in those that predominantly held mobile phones on the right side. In addition, there was a decrease in concentrations of amylase, lipase, lysozyme, lactoferrin and peroxidase.Conclusion:The side of dominant mobile phone use was associated with differences in salivary flow rate and parotid gland salivary concentrations, in right-dominant users. Although mobile phone use influenced salivary composition, the relationship was not significant.

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Changes in salivary hormones, immunoglobulin A, and C-reactive protein in response to ultra-endurance exercises

Applied Physiology Nutrition and Metabolism ◽

10.1139/apnm-2013-0466 ◽

2014 ◽

Vol 39 (5) ◽

pp. 560-565 ◽

Cited By ~ 17

Author(s):

Pedro Tauler ◽

Sonia Martinez ◽

Carlos Moreno ◽

Pau Martínez ◽

Antoni Aguilo

Keyword(s):

Flow Rate ◽

Endurance Exercise ◽

Salivary Cortisol ◽

Immunoglobulin A ◽

Salivary Flow ◽

Salivary Flow Rate ◽

C Reactive Protein ◽

Exercise Tests ◽

Reactive Protein ◽

Ultra Endurance

The aim of the study was to determine the influence of the exercise duration on the changes in salivary stress markers in response to ultra-endurance exercises. The study was developed in 2 ultra-endurance exercise tests: the Ultra-trail Serra de Tramuntana (UTST), a 104 km ultra-marathon competition (n = 64) and the 25 km Cabrera Open Water Race (COWR) (n = 43). Participants in the COWR completed the 25 km at a constant pace of 3 km/h (3K group) or 2.5 km /h (2.5K group). Saliva samples were taken before and after the exercises. Salivary flow rate as well as cortisol, testosterone, C-reactive protein (CRP), and immunoglobulin A (IgA) levels were measured. Salivary flow rate decreased after the UTST but increased after the COWR. The UTST induced significant increases in cortisol and CRP levels and decreases in testosterone and IgA levels. Furthermore, a negative correlation was found between the time the athletes took to complete the exercise and the changes in salivary cortisol. After the COWR, higher increases in salivary cortisol levels were observed in the 3K group than in the 2.5K group. A significant effect of exercise decreasing testosterone and IgA levels was observed in both groups. No changes in the CRP levels were observed during the COWR. In conclusion, shorter times to complete the ultra-endurance exercise were associated with higher increases in cortisol. However, no relationships were found between the time to complete the exercises and the changes in testosterone, CRP, and IgA levels.

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Pseudomembranous Type of Oral Candidiasis is Associated with Decreased Salivary Flow Rate and Secretory Immunoglobulin A Levels

Mycopathologia ◽

10.1007/s11046-015-9874-5 ◽

2015 ◽

Vol 180 (1-2) ◽

pp. 75-80 ◽

Cited By ~ 2

Author(s):

Bela Mahajan ◽

Neeta Bagul ◽

Rajiv Desai ◽

Mamatha Reddy ◽

Amit Mahajan ◽

...

Keyword(s):

Flow Rate ◽

Oral Candidiasis ◽

Immunoglobulin A ◽

Salivary Flow ◽

Salivary Flow Rate ◽

Secretory Immunoglobulin A ◽

Secretory Immunoglobulin

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No relationship of salivary flow rate or secretory immunoglobulin A to dental caries in children

Environmental Health and Preventive Medicine ◽

10.1007/bf02931977 ◽

1997 ◽

Vol 2 (3) ◽

pp. 122-125 ◽

Cited By ~ 2

Author(s):

Yutaka Watanabe ◽

Hiromi Mizoguchi ◽

Kazuhito Masamura ◽

Teruo Nagaya

Keyword(s):

Dental Caries ◽

Flow Rate ◽

Immunoglobulin A ◽

Salivary Flow ◽

Salivary Flow Rate ◽

Secretory Immunoglobulin A ◽

Relationship Of ◽

Secretory Immunoglobulin

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Acute Salivary Flow Rate Response to Transcutaneous Electrical Nerve Stimulation Versus Electro-acupuncture

Case Medical Research ◽

10.31525/ct1-nct04211324 ◽

2019 ◽

Author(s):

Keyword(s):

Flow Rate ◽

Nerve Stimulation ◽

Transcutaneous Electrical Nerve Stimulation ◽

Salivary Flow ◽

Salivary Flow Rate ◽

Electrical Nerve Stimulation

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Effect of a newly developed pastille on the salivary flow rate in subjects with dry mouth symptoms: a randomized, controlled, monocentric clinical study

BMC Oral Health ◽

10.1186/s12903-021-01471-w ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

S. Bielfeldt ◽

D. Wilhelm ◽

C. Neumeister ◽

U. Schwantes ◽

K. -P. Wilhelm

Keyword(s):

Surface Tension ◽

Flow Rate ◽

Gum Arabic ◽

Salivary Flow ◽

Salivary Flow Rate ◽

Dry Mouth ◽

Main Ingredient ◽

Control Product ◽

Swallowing Problems ◽

The Mean

Abstract Background Xerostomia is associated with several diseases and is a side effect of certain drugs, resulting from reduced saliva secretion. Often, aged and sometimes younger people suffer from (idiopathic) xerostomia. Chewing gum and sucking pastilles may relieve symptoms of xerostomia by increasing the salivary flow rate due to the mechanical effect of sucking and gustatory stimulation. Swallowing problems and the urge to cough or experiencing a tickling sensation in the throat might be alleviated through a reduction in dry mouth symptoms. We investigated whether a pastille containing four polysaccharides increased the salivary flow rate and relieved the symptoms of dry mouth. Methods Participating subjects with xerostomia were randomized into two equally balanced treatment groups. Subjects received the pastille on Day 1 and a control product (Parafilm®) on Day 3, or vice versa. Unstimulated saliva was collected every 2.5 min for 0–10 min. Stimulated saliva was collected after subjects sucked the pastille or the control product. The salivary flow rate was determined gravimetrically, and, in parallel, the feeling of dry mouth was assessed using a visual analog scale. Saliva surface tension was measured in pooled saliva samples (0–5 min of sampling). Additionally, in stimulated saliva from six subjects who sucked the pastille, the presence of the main ingredient—gum arabic—was examined by Raman spectroscopy. Results Chewing the pastille significantly increased the mean salivary flow rate by 8.03 g/10 min compared to the mean changes after chewing the control product (+ 3.71 g/10 min; p < 0.0001). The mean score of dry mouth was significantly alleviated by the pastille (− 19.9 ± 17.9 mm) compared to the control product (− 3.3 ± 18.1 mm). No difference between the two products was seen regarding the saliva surface tension. Gum arabic was present in the saliva of all investigated subjects for up to 10 min after sucking the pastille. Conclusions The pastille was well tolerated and effective in increasing the salivary flow rate and reducing mouth dryness after sucking. These results were in line with the detection of the main ingredient, gum arabic, in saliva for up to 10 min after sucking the pastille. Trial registration German Register Clinical Trials (Deutsches Register Klinische Studien, DRKS) DRKS-ID: DRKS00017393, Registered 29 May 2019, https://www.drks.de/drks_web/navigate.do?navigationId=trial. HTML&TRIAL_ID = DRKS00017393.

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Salivary flow rate and the risk of cognitive impairment among Korean elders: a cross-sectional study

BMC Geriatrics ◽

10.1186/s12877-021-02200-2 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Minh-Tung Do ◽

Huong Vu ◽

Jong-Koo Lee ◽

Sang-Min Park ◽

Joung-Sik Son ◽

...

Keyword(s):

Cognitive Impairment ◽

Flow Rate ◽

Salivary Flow ◽

Cross Sectional Study ◽

Community Dwelling ◽

Salivary Flow Rate ◽

Multivariable Logistic Regression Analysis ◽

Sectional Study ◽

Cross Sectional ◽

Denture Status

Abstract Background Salivary function has been suggested to be associated with cognitive impairment. However, the effect of salivary flow rate (SFR) on cognitive impairment remains unclear. This study aimed to investigate whether SFR is associated with cognitive impairment among Korean elders. Methods This cross-sectional study included 649 elders aged 65 and older in the Korean community-dwelling population. Cognitive impairment was assessed using the Mini-Mental Status Examination. Unstimulated SFR was measured and dichotomized. Denture status, age, sex, education level, smoking, drinking, diabetes, hypertension, and obesity were considered confounders. Multivariable logistic regression analysis was applied to assess the adjusted association. Stratified analysis by sex and denture status was performed to clarify the effect modification. Results Participants without cognitive impairment showed a higher SFR level than those with cognitive impairment (0.81 mL/min for non-cognitive impairment versus 0.52 mL/min for cognitive impairment, p < 0.001). After controlling for confounders, participants with low SFR (< 0.3 mL/min) were more likely to have cognitive impairment by 1.5 times than participants with normal SFR (odds ratio [OR] = 1.5, confidence interval [CI] = 1.05–2.10). The association of low SFR with cognitive impairment was higher in women and dentate participants: about 10% higher in women (OR = 1.63, CI = 1.07–2.50) and about 22% higher in dentate participants (OR = 1.82, CI = 1.41–2.90). Conclusions Salivary flow rate is independently associated with cognitive impairment among Korean elders. The association was modified in females and dentate elders. Physicians and dentists should consider low SFR and cognitive impairment as a risk factor between them in clinics.

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