Topical Grape Seed Proanthocyandin Extract Reduces Sunburn Cells and Mutant p53 Positive Epidermal Cell Formation, and Prevents Depletion of Langerhans Cells in an Acute Sunburn Model

2012 ◽  
Vol 30 (1) ◽  
pp. 20-25 ◽  
Author(s):  
Xiao-Ying Yuan ◽  
Wei Liu ◽  
Jian-Chun Hao ◽  
Wei-Jie Gu ◽  
Yan-Shuang Zhao
Keyword(s):  
Epidermal Cell ◽  
Langerhans Cells ◽  
Cell Formation ◽  
Grape Seed ◽  
Mutant P53

Langerhans Cells in Dupuytren’s Contracture

2001 ◽  
Vol 26 (4) ◽  
pp. 362-367 ◽  
Author(s):  
F. I. QURESHI ◽  
R. HORNIGOLD ◽  
J. D. SPENCER ◽  
S. M. HALL
Keyword(s):  
Immune System ◽  
Inflammatory Cytokines ◽  
Epidermal Cell ◽  
Langerhans Cells ◽  
Disease Process ◽  
Inflammatory Cells ◽  
Dupuytren’S Contracture ◽  
Palmar Fascia ◽  
Dupuytren's Contracture

We have examined biopsies of Dupuytren’s contracture palmar fascia, overlying subcutis and skin, and have correlated the distribution of gross macroscopic changes in the hand, mapped pre- and intraoperatively, with light microscopic immunohistochemical findings. We report increased numbers of S100 positive Langerhans cells (an epidermal cell of dendritic lineage) and CD45 positive cells, both in “nodules” and at dermo-epidermal junctions, in the biopsied tissues. This suggests that Langerhans cells migrate from the epidermis into Dupuytren’s contracture tissue, possibly in response to local changes in levels of inflammatory cytokines within the tissue. Our findings, together with other reports of increased numbers of dermal dendrocytes and inflammatory cells in Dupuytren’s contracture tissue, lend circumstantial support to the “extrinsic theory” of the pathogenesis of Dupuytren’s contracture. However, the earliest stages of the disease process have not been defined, and therefore the events which ultimately produce fibrosis in the palmar fascial complex in susceptible individuals could begin in the skin and/or within deeper tissues, especially where there is dysregulation of the immune system.

Grape seed proanthocyanidins suppressed macrophage foam cell formation by miRNA-9 via targeting ACAT1 in THP-1 cells

2020 ◽  
Vol 11 (2) ◽  
pp. 1258-1269 ◽  
Author(s):  
Dongyan Shao ◽  
Yichao Di ◽  
Ziyang Lian ◽  
Bobo Zhu ◽  
Xiaoguang Xu ◽  
...  
Keyword(s):  
Foam Cell ◽  
Cell Formation ◽  
Grape Seed ◽  
Cholesterol Esterification ◽  
Foam Cell Formation ◽  
Macrophage Foam Cell ◽  
Grape Seed Proanthocyanidins

Grape seed proanthocyanidins inhibited cholesterol esterification by miRNA-9 via targeting ACAT1 to suppress the macrophage foam cell formation.

Ultrastructural immunogold labelling of human langerhans cells enriched epidermal cell suspension

1984 ◽  
Vol 276 (1) ◽  
pp. 27-32 ◽  
Author(s):  
D. Schmitt ◽  
M. Faure ◽  
C. Dezutter-Dambuyant ◽  
D. Tuffery
Keyword(s):  
Cell Suspension ◽  
Epidermal Cell ◽  
Langerhans Cells ◽  
Immunogold Labelling

Inhibitory Effects of Grape Seed Procyanidins on Foam Cell Formation in Vitro

2009 ◽  
Vol 57 (6) ◽  
pp. 2588-2594 ◽  
Author(s):  
Ximena Terra ◽  
Juan Fernández-Larrea ◽  
Gerard Pujadas ◽  
Anna Ardèvol ◽  
Cinta Bladé ◽  
...  
Keyword(s):  
Foam Cell ◽  
Cell Formation ◽  
Grape Seed ◽  
Foam Cell Formation ◽  
Inhibitory Effects
Sign in / Sign up

Export Citation Format

Share Document