EphB4 Promotes Osteogenesis of CTLA4-Modified Bone Marrow-Derived Mesenchymal Stem Cells Through Cross Talk with Wnt Pathway in Xenotransplantation

2015 ◽  
Vol 21 (17-18) ◽  
pp. 2404-2416 ◽  
Author(s):  
Fei Zhang ◽  
Zehua Zhang ◽  
Dong Sun ◽  
Shiwu Dong ◽  
Jianzhong Xu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Cross Talk ◽  
Wnt Pathway

Limitations of Cross-Talk Between Osteosarcoma and Bone Marrow-Derived Mesenchymal Stem Cells

2019 ◽  
Author(s):  
Yasemin Basbinar ◽  
Tugba Uysal ◽  
Caner Karaca ◽  
Ezgi Daskin ◽  
Hanife Ecenur Meco ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Cross Talk

scholarly journals Epigallocatechin-3-gallate Protects against Hydrogen Peroxide-Induced Inhibition of Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Dawei Wang ◽  
Yonghui Wang ◽  
Shihong Xu ◽  
Fu Wang ◽  
Bomin Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Adverse Effect ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Differentiation ◽  
Wnt Pathway ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Positive Effects

Oxidative stress induces bone loss and osteoporosis, and epigallocatechin-3-gallate (EGCG) may be used to combat these diseases due to its antioxidative property. Herein, oxidative stress in human bone marrow-derived mesenchymal stem cells (BM-MSCs) was induced by H2O2, resulting in an adverse effect on their osteogenic differentiation. However, this H2O2-induced adverse effect was nullified when the cells were treated with EGCG. In addition, treatment of BM-MSCs with EGCG alone also resulted in the enhancement of osteogenic differentiation of BM-MSCs. After EGCG treatment, expressions of β-catenin and cyclin D1 were upregulated, suggesting that the Wnt pathway was involved in the effects of EGCG on the osteogenic differentiation of BM-MSCs. This was also confirmed by the fact that the Wnt pathway inhibitor, Dickkopf-1 (DKK-1), can nullify the EGCG-induced enhancement effect on BM-MSC’s osteogenic differentiation. Hence, our results suggested that EGCG can reduce the effects of oxidative stress on Wnt pathway in osteogenic cells, which supported a potentially promising therapy of bone disorders induced by oxidative stress. Considering its positive effects on BM-MSCs, EGCG may also be beneficial for stem cell-based bone repair.

BMP9 regulates cross-talk between breast cancer cells and bone marrow-derived mesenchymal stem cells

2014 ◽  
Vol 37 (5) ◽  
pp. 363-375 ◽  
Author(s):  
Shaoheng Wan ◽  
Yuehong Liu ◽  
Yaguang Weng ◽  
Wei Wang ◽  
Wei Ren ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Cancer Cells ◽  
Cross Talk ◽  
Breast Cancer Cells
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