Long-term effectiveness of dietary iron and ascorbic acid in the prevention and cure of cadmium toxicity in rats

1978 ◽  
Vol 31 (9) ◽  
pp. 1491-1498 ◽  
Author(s):  
T Suzuki ◽  
A Yoshida
Keyword(s):  
Ascorbic Acid ◽  
Cadmium Toxicity ◽  
Dietary Iron ◽  
Prevention And Cure

Amperometric assay of vitamin C using an ascorbate oxidase enzyme electrode

1979 ◽  
Vol 44 (11) ◽  
pp. 3395-3404 ◽  
Author(s):  
Pavel Posádka ◽  
Lumír Macholán
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Oxygen Electrode ◽  
Ascorbate Oxidase ◽  
Current Response ◽  
Reaction Conditions ◽  
Long Term Storage ◽  
Oxidase Enzyme ◽  
Optimal Reaction

An oxygen electrode of the Clark type, coated by a thin, active layer of chemically insolubilized ascorbate oxidase from squash peelings specifically detects by measuring oxygen uptake 10 to 400 μg of ascorbic acid in 3 ml of phosphate buffer. The record of current response to substrate addition lasts 1-2 min. The ascorbic acid values determined in various samples of fruit juices are in good agreement with the data obtained by titration and polarography. The suitable composition of the membrane and its lifetime and stability during long-term storage are described; optimal reaction conditions of vitamin C determination and the possibilities of interference of other compounds are also examined. Of the 35 phenols, aromatic amines and acids tested chlorogenic acid only can cause a positive error provided that the enzyme membrane has been prepared from ascorbate oxidase of high purity.

Credibility Trap: Japan today and China tomorrow

2006 ◽  
Vol 25 (1) ◽  
pp. 31-50
Author(s):  
Kensei Hiwaki ◽  
Junie Tong
Keyword(s):  
Human Development ◽  
Present Article ◽  
Socioeconomic Development ◽  
Sufficient Conditions ◽  
Theoretical Framework ◽  
Normative Framework ◽  
Specific Culture ◽  
Prevention And Cure ◽  
Necessary And Sufficient

This article provides a theoretical framework for a long-term socioeconomic lethargy (Credibility Trap) that results from the liquidation of holistic society-specific culture. As for example, it deals with the cases of Japan today and China tomorrow, elaborating on the slight of their respective society-specific cultures in a century-long process of “modernization”. The present theoretical framework primarily consists of three pivotal concepts, viz., Credibility Trap, society-specific cultures (Cultures) and market fundamentalism (Market), which facilitates a clear, concise and effective argument that the liquidation of their respective holistic Cultures may intimately relate to their actual and potential socioeconomic lethargy. Also, the present article concentrates on the elaboration of some promising avenues for prevention and cure of Credibility Trap. Such avenues comprise the necessary and sufficient conditions for a balanced socioeconomic development; a theoretical framework for a perpetual “virtuous” circle among cultural enrichment, comprehensive human development and balanced socioeconomic development; and a normative framework of multi-faceted value enhancement for vitality augmentation and cultural enrichment within a society.

scholarly journals Effects of Manganese Porphyrins on Cellular Sulfur Metabolism

Molecules ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 980 ◽  
Author(s):  
Kenneth R. Olson ◽  
Yan Gao ◽  
Andrea K. Steiger ◽  
Michael D. Pluth ◽  
Charles R. Tessier ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Biological Effects ◽  
Sulfur Metabolism ◽  
Hek293 Cells ◽  
Redox Cycle ◽  
Major Site ◽  
Manganese Porphyrins ◽  
Short And Long Term ◽  
H2s Production

Manganese porphyrins (MnPs), MnTE-2-PyP5+, MnTnHex-2-PyP5+ and MnTnBuOE-2-PyP5+, are superoxide dismutase (SOD) mimetics and form a redox cycle between O2 and reductants, including ascorbic acid, ultimately producing hydrogen peroxide (H2O2). We previously found that MnPs oxidize hydrogen sulfide (H2S) to polysulfides (PS; H2Sn, n = 2–6) in buffer. Here, we examine the effects of MnPs for 24 h on H2S metabolism and PS production in HEK293, A549, HT29 and bone marrow derived stem cells (BMDSC) using H2S (AzMC, MeRho-AZ) and PS (SSP4) fluorophores. All MnPs decreased intracellular H2S production and increased intracellular PS. H2S metabolism and PS production were unaffected by cellular O2 (5% versus 21% O2), H2O2 or ascorbic acid. We observed with confocal microscopy that mitochondria are a major site of H2S production in HEK293 cells and that MnPs decrease mitochondrial H2S production and increase PS in what appeared to be nucleoli and cytosolic fibrillary elements. This supports a role for MnPs in the metabolism of H2S to PS, the latter serving as both short- and long-term antioxidants, and suggests that some of the biological effects of MnPs may be attributable to sulfur metabolism.

LONG-TERM EFFECTS OF INTRACEREBRAL CORTICOID IMPLANTS

1967 ◽  
Vol 55 (3) ◽  
pp. 440-450 ◽  
Author(s):  
Shaul Feldman ◽  
Nisim Conforti ◽  
Julian M. Davidson
Keyword(s):  
Ascorbic Acid ◽  
Median Eminence ◽  
Adrenal Glands ◽  
Long Term Effects ◽  
Unilateral Adrenalectomy ◽  
Post Operative Period ◽  
Steady Decrease ◽  
Medial Hypothalamus ◽  
Post Implantation

ABSTRACT Chronic implantation of cortisol acetate in the basal medial hypothalamus resulted in a steady decrease in weight of the adrenal glands which remained severely atrophic up to 70 days post-implantation. At this time, however, the adrenal ascorbic acid depletion response to unilateral adrenalectomy was normal. The compensatory adrenal hypertrophy (CAH) response, which was inhibited in the immediate post-operative period, reappeared later, and had returned to normal by 21 days postoperatively. Intramuscular administration of cortisol in unimplanted rats inhibited CAH at 14 or 21 days following onset of treatment, and prevented the recovery of CAH in animals implanted 21 days previously with cortisol in the median eminence. The possibility is discussed that the differential recovery of the responses to unilateral adrenalectomy in implanted animals with continuing atrophy of the adrenal cortex is due to some adaptation of central nervous mechanisms subserving the CAH response.

Iron and copper, and their interactions during development

2008 ◽  
Vol 36 (6) ◽  
pp. 1258-1261 ◽  
Author(s):  
Lorraine Gambling ◽  
Henriette S. Andersen ◽  
Harry J. McArdle
Keyword(s):  
Iron Deficiency ◽  
Growth And Development ◽  
Intracellular Transport ◽  
Developed Countries ◽  
Dietary Iron ◽  
Nutrient Deficiencies ◽  
Nutrient Requirements ◽  
Short And Long Term ◽  
Pregnant State

During development, the fetus is entirely dependent on the mother for its nutrient requirements. Subsequently, it is a period when both are vulnerable to changes in dietary supply, especially of those nutrients that are marginal under normal circumstances. In developed countries, this applies mainly to micronutrients. Even now, iron deficiency is a common disorder, especially in pregnancy. Similarly, copper intake in the U.K. population is rarely above adequate levels. It is now becoming clear that nutrient deficiencies during pregnancy can result in problems for the offspring, in both the short- and long-term. Early studies showed that lambs born to mothers on copper-deficient pastures developed ‘swayback’, with neurological and muscular symptoms that could not be reversed by postnatal supplementation. Our own findings have shown that prenatal iron deficiency results in increased postnatal blood pressure, even though the offspring have normal dietary iron levels from birth. These observations emphasize the importance of iron and copper in growth and development. Complicating the situation further is the fact that copper and iron are known to interact with each other in many ways, including absorption and intracellular transport. However, their interactions during the pregnancy appear to be more complex than during the non-pregnant state. In the present review, we examine the importance of these metals and their interactions, the consequences, both short- and long-term, of deficiency and consider some possible mechanisms whereby these effects may be generated.

Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin

2008 ◽  
Vol 17 (11) ◽  
pp. 946-952 ◽  
Author(s):  
Marek Haftek ◽  
Sophie Mac-Mary ◽  
Marie-Aude Le Bitoux ◽  
Pierre Creidi ◽  
Sophie Seité ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Human Skin ◽  
Topical Treatment ◽  
Long Term Effects ◽  
Structural Evaluation

scholarly journals Long-term culture of primary porcine mature hepatocytes in the medium supplemented with ascorbic acid 2-phosphate

2010 ◽  
Vol 02 (11) ◽  
pp. 1264-1273
Author(s):  
Yohichi Kumaki ◽  
Iku Kumaki ◽  
Xiaomei Guo ◽  
Weilin Shang ◽  
Toshie Koyama ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Long Term Culture

Chemical and colour changes related to the use of sorbates and ascorbic acid in pickled cucumbers and caperberries during long-term storage

2012 ◽  
Vol 48 (1) ◽  
pp. 179-186 ◽  
Author(s):  
Antonio Higinio Sánchez ◽  
Francisco Javier Casado ◽  
Víctor Manuel Beato ◽  
Antonio de Castro ◽  
Alfredo Montaño
Keyword(s):  
Ascorbic Acid ◽  
Long Term Storage ◽  
Colour Changes ◽  
Term Storage
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